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Journal Articles

The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β–mediated AML progression

Hsin-Yun Lin, Mona Mohammadhosseini, John McClatchy, Marina Villamor-Payà, Sophia Jeng, Daniel Bottomly, Chia-Feng Tsai, Camilo Posso, Jeremy Jacobson, Andrew Adey, Sara Gosline, Tao Liu, Shannon McWeeney, Travis H. Stracker, Anupriya Agarwal

Blood (2024) 143 (26): 2749–2762.

https://doi.org/10.1182/blood.2023022079

Published: 2024

Includes: Supplemental data

Journal Articles

Genomic Profiles and Associated Survival Prognosticators in Black Patients with Acute Myeloid Leukemia

Blood (2023) 142 (Supplement 1): 837.

https://doi.org/10.1182/blood-2023-181876

Published: 2023

Journal Articles

Acute Myeloid Leukemia Differentiation State and Genotype Influence Anti-Apoptotic Protein Expression, Venetoclax Sensitivity, and Survival in AML

Blood (2023) 142 (Supplement 1): 978.

https://doi.org/10.1182/blood-2023-179527

Published: 2023

Journal Articles

Cebpβ/IL1/TNFα Positive Feedback Loop Drives Drug Resistance of BCL2 and MDM2 Inhibitors in Monocytic Leukemia Cells

Basil Allen, Daniel Bottomly, Anthony Wang, Thomas Koehnke, Lindsey Savoy, Peter Ryabini, Reid Chen, Kara Johnson, Stephen E. Kurtz, Anupriya Agarwal, Michelle Barton, Brian J. Druker, Ravi Majeti, Jeffrey W Tyner, Shannon K McWeeney, Haijiao Zhang

Blood (2023) 142 (Supplement 1): 2937.

https://doi.org/10.1182/blood-2023-178096

Published: 2023

Journal Articles

A Rapid Test to Evaluate the Tumor Differentiation State of Acute Myeloid Leukemias

Stephen E. Kurtz, Christopher A. Eide, Nicola Long, Daniel Bottomly, Shannon K McWeeney, Akosha Taylor, Brian J. Druker, Sudarshan Anand, Curtis A. Lachowiez, Jeffrey W Tyner

Blood (2023) 142 (Supplement 1): 3643.

https://doi.org/10.1182/blood-2023-180105

Published: 2023

Journal Articles

The sWT1+ - Transcript Confers Cytarabine Resistance Via Upregulation of HOXA3 and GATA2 Axis

Reid Chen, Daniel Bottomly, Lindsey Savoy, Peter Ryabinin, Schannon K Mcweeney, Haijiao Zhang

Blood (2022) 140 (Supplement 1): 11778.

https://doi.org/10.1182/blood-2022-159260

Published: 2022

Journal Articles

The Aryl Hydrocarbon Receptor Defines a Unique Genomic and Immune Signature in AML Characterized By Monocytic Differentiation, Venetoclax Resistance and Is Targetable By Ahr Antagonist

Jennifer N. Saultz, Daniel Bottomly, Faith Burns, Kaelan Byrd, Yoko Kosaka, Shannon K. McWeeney, Stephen E. Kurtz, Guang Fan, Andy Kaempf, Karen McGovern, Lei Wang, Marta Sanchez-Martin, Dan S Kaufman, Evan F. Lind, Jeffrey W. Tyner

Blood (2022) 140 (Supplement 1): 3071–3072.

https://doi.org/10.1182/blood-2022-163166

Published: 2022

Journal Articles

Defining Clinical and Molecular Biomarkers for Venetoclax-Based Drug Combinations to Augment AML Therapy

Christopher A. Eide, Stephen E. Kurtz, Andy Kaempf, Nicola Long, Sunil K Joshi, Tamilla Nechiporuk, Ariane Huang, Charles Dibb, Daniel Bottomly, Shannon K. McWeeney, Bill H. Chang, Brian J. Druker, Jeffrey W. Tyner

Blood (2022) 140 (Supplement 1): 1025–1027.

https://doi.org/10.1182/blood-2022-159264

Published: 2022

Journal Articles

Characterize Biomarkers and Mechanisms of Resistance for MDM2 Inhibitors in AML

Lindsey Savoy, Daniel Bottomly, Reid Chen, Basil Allen, Jeffrey W. Tyner, Shannon K. McWeeney, Haijiao Zhang

Blood (2022) 140 (Supplement 1): 8778–8779.

https://doi.org/10.1182/blood-2022-157622

Published: 2022

Journal Articles

Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML

Blood (2022) 139 (8): 1208–1221.

https://doi.org/10.1182/blood.2021011354

Published: 2022

Includes: Supplemental data

Journal Articles

Associating Ex Vivo Drug Sensitivity with Differentiation Status Identifies Effective Drug Combinations for Acute Myeloid Leukemia

Christopher A. Eide, Stephen E. Kurtz, Andy Kaempf, Nicola Long, Daniel Bottomly, Olga Nikolova, Brian J. Druker, Shannon K. McWeeney, Jeffrey W. Tyner, Anupriya Agarwal

Blood (2021) 138 (Supplement 1): 1301.

https://doi.org/10.1182/blood-2021-152043

Published: 2021

Journal Articles

Evolution of Gilteritinib Resistance from Residual Disease to Relapse

Blood (2020) 136 (Supplement 1): 4–5.

https://doi.org/10.1182/blood-2020-139084

Published: 2020

Journal Articles

Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

Sunil K. Joshi, Kristin Qian, William H. Bisson, Kevin Watanabe-Smith, Ariane Huang, Daniel Bottomly, Elie Traer, Jeffrey W. Tyner, Shannon K. McWeeney, Monika A. Davare, Brian J. Druker, Cristina E. Tognon

Blood (2020) 135 (24): 2159–2170.

https://doi.org/10.1182/blood.2019003691

Published: 2020

Includes: Supplemental data

Journal Articles

Genome-Wide CRISPR Screening Identifies MAPK and Mtorc Pathways As Regulators of Sorafenib Resistance in Acute Myeloid Leukemia

Alisa Damnernsawad, PhD, Tamilla Nechiporuk, PhD, Daniel Bottomly, MS, Stephen E Kurtz, PhD, Christopher A. Eide, Shannon K. McWeeney, PhD, Jeffrey W. Tyner

Blood (2019) 134 (Supplement_1): 2557.

https://doi.org/10.1182/blood-2019-128877

Published: 2019

Journal Articles

Framework to Identify and Prioritize Candidate Inherited Myeloid Malignancy Germline Variants Leveraging the BEAT AML Cohort

Daniel Bottomly, Nicola Long, Fei Yang, MD, Tiffany Lee, MD, Uma Borate, MD, Beth Wilmot, PhD, Adam S DuVall, MD, Andrea Monteblanco, BS, Karina Thiel-Klare, Gabby Dewson, BA, Richard D. Press, MD PhD, Cristina E. Tognon, Brian J. Druker, Jeffrey W. Tyner, Shannon K. McWeeney, PhD, Anupriya Agarwal, PhD

Blood (2019) 134 (Supplement_1): 1407.

https://doi.org/10.1182/blood-2019-132224

Published: 2019

Journal Articles

Genome-Wide CRISPR Screening in Acute Myeloid Leukemia Cells Identifies Genes in the PI3K/AKT/mTOR and MEK/ERK Pathways That Define Sensitivity to Trametinib

Tamilla Nechiporuk, PhD, Alisa Damnernsawad, PhD, Daniel Bottomly, MS, Quinlan Morrow, BS, Suyoun Choi, Sofia Beer, Stephen E Kurtz, PhD, Shannon K. McWeeney, PhD, Jeffrey W. Tyner

Blood (2019) 134 (Supplement_1): 1395.

https://doi.org/10.1182/blood-2019-129117

Published: 2019

Journal Articles

Genomic landscape of neutrophilic leukemias of ambiguous diagnosis

Blood (2019) 134 (11): 867–879.

https://doi.org/10.1182/blood.2019000611

Published: 2019

Includes: Supplemental data

Journal Articles

Biomarkers Predicting Venetoclax Sensitivity and Strategies for Venetoclax Combination Treatment

Haijiao Zhang, Beth Wilmot, PhD, Daniel Bottomly, Stephen E Kurtz, PhD, Christopher A. Eide, Alisa Damnernsawad, Kyle Romine, Shyam Patel, Brian J. Druker, MD, Schannon K Mcweeney, Ravi Majeti, MD PhD, Jeffrey W. Tyner, PhD

Blood (2018) 132 (Supplement 1): 175.

https://doi.org/10.1182/blood-2018-175

Published: 2018

Journal Articles

Therapeutically Targetable Activating c-ABL1 Mutations in Philadelphia Chromosome-Negative Leukemias

Samantha L Savage, Julia E. Maxson, PhD, Christopher A. Eide, Chelsea Jenkins, B.S., Melissa L Abel, Anna M. Reister Schultz, Daniel Bottomly, Beth Wilmot, PhD, Shannon Mcweeney, PhD, Cristina E. Tognon, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD

Blood (2017) 130 (Supplement 1): 3930.

https://doi.org/10.1182/blood.V130.Suppl_1.3930.3930

Published: 2017

Journal Articles

Coexisting Oncogenic Signaling Pathway Mutations in Cnl/Acml/CMML/MPN-U

Haijiao Zhang, Daniel Bottomly, Libbey K. White, Beth Wilmot, PhD, Shannon Mcweeney, PhD, Jeffrey W. Tyner, PhD

Blood (2017) 130 (Supplement 1): 4213.

https://doi.org/10.1182/blood.V130.Suppl_1.4213.4213

Published: 2017

NARROW

The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β–mediated AML progression

Genomic Profiles and Associated Survival Prognosticators in Black Patients with Acute Myeloid Leukemia

Acute Myeloid Leukemia Differentiation State and Genotype Influence Anti-Apoptotic Protein Expression, Venetoclax Sensitivity, and Survival in AML

Cebpβ/IL1/TNFα Positive Feedback Loop Drives Drug Resistance of BCL2 and MDM2 Inhibitors in Monocytic Leukemia Cells

A Rapid Test to Evaluate the Tumor Differentiation State of Acute Myeloid Leukemias

The sWT1+ - Transcript Confers Cytarabine Resistance Via Upregulation of HOXA3 and GATA2 Axis

The Aryl Hydrocarbon Receptor Defines a Unique Genomic and Immune Signature in AML Characterized By Monocytic Differentiation, Venetoclax Resistance and Is Targetable By Ahr Antagonist

Defining Clinical and Molecular Biomarkers for Venetoclax-Based Drug Combinations to Augment AML Therapy

Characterize Biomarkers and Mechanisms of Resistance for MDM2 Inhibitors in AML

Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML

Associating Ex Vivo Drug Sensitivity with Differentiation Status Identifies Effective Drug Combinations for Acute Myeloid Leukemia

Evolution of Gilteritinib Resistance from Residual Disease to Relapse

Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

Genome-Wide CRISPR Screening Identifies MAPK and Mtorc Pathways As Regulators of Sorafenib Resistance in Acute Myeloid Leukemia

Framework to Identify and Prioritize Candidate Inherited Myeloid Malignancy Germline Variants Leveraging the BEAT AML Cohort

Genome-Wide CRISPR Screening in Acute Myeloid Leukemia Cells Identifies Genes in the PI3K/AKT/mTOR and MEK/ERK Pathways That Define Sensitivity to Trametinib

Genomic landscape of neutrophilic leukemias of ambiguous diagnosis

Biomarkers Predicting Venetoclax Sensitivity and Strategies for Venetoclax Combination Treatment

Therapeutically Targetable Activating c-ABL1 Mutations in Philadelphia Chromosome-Negative Leukemias

Coexisting Oncogenic Signaling Pathway Mutations in Cnl/Acml/CMML/MPN-U

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American Society of Hematology

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ASH Publications

American Society of Hematology

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