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Michael W. Deininger
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Journal Articles

Genomic Characterization of Newly Diagnosed Acute Myeloid Leukemia in Patients Age 60 Years and Older; A Report from the Beat AML Master Trial

Fieke W Hoff, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L Lin, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F. Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Uma M. Borate, Alice Mims, John C. Byrd, Yazan F. Madanat
Journal: Blood
Blood (2023) 142 (Supplement 1): 4296.
https://doi.org/10.1182/blood-2023-187044
Published: 2023
Journal Articles

In Vitro Evidence of Synergistically Enhanced Efficacy of Axitinib When Combined with Asciminib in T315I Mutated Chronic Myeloid Leukemia

Ho-Jae Han, Eun-Ju Park, Jaeyoon John Kim, Danielle Pyne, Anthea Travas, Amirthagowri Ambalavanan, Shinya Kimura, Michael W. Deininger, Jong-Won Kim, Dennis D. H. Kim
Journal: Blood
Blood (2023) 142 (Supplement 1): 6336.
https://doi.org/10.1182/blood-2023-185440
Published: 2023
Journal Articles

HJKC3-0006: Outcome of Patients with CML Treated on Second Line or Later Therapy in Routine Clinical Practice

James E Thompson, Yan Gao, Alexis Visotcky, Kathryn E Flynn, Michael Mauro, Emily Giever, Arielle Baim, Idayat Akinola, Richard Larson, Omer Jamy, Anthony M. Hunter, Vamsi K. Kota, Jorge Cortes, Brian J. Druker, Neil P. Shah, Javier Pinilla-Ibarz, Jay Yang, Ellen K. Ritchie, Lindsay A.M Rein, B. Douglas Smith, Srinivas K. Tantravahi, Talha Badar, Michael W. Deininger, Ehab L. Atallah
Journal: Blood
Blood (2023) 142 (Supplement 1): 7420.
https://doi.org/10.1182/blood-2023-179963
Published: 2023
Journal Articles

Asciminib Enhances Its Treatment Efficacy Synergistically in the Treatment of Chronic Myeloid Leukemia Harboring ABL1 Kinase Domain Mutation When Combined with a Reduced Dose of Ponatinib, Dasatinib, or Bosutinib, but Not with Nilotinib or Imatinib

Ho-Jae Han, Jaeyoon John Kim, Danielle Pyne, Anthea Travas, Amirthagowri Ambalavanan, Shinya Kimura, Michael W. Deininger, Jong-Won Kim, Dennis D. H. Kim
Journal: Blood
Blood (2023) 142 (Supplement 1): 6337.
https://doi.org/10.1182/blood-2023-188135
Published: 2023
Journal Articles

Asciminib (ASC) Once-Daily (QD) Dosing Demonstrates Comparable Tolerability and Efficacy to Twice-Daily (BID) Dosing: Results from the ASC in Monotherapy 4 CML (AIM4CML) Study in Patients (Pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP)

David Andorsky, Ghayas C. Issa, Edward R Broun, Camille N. Abboud, Michael W. Deininger, Michael Mauro, Andrea Damon, Natasha Porter, Najma Ashraf, Moshe Levy
Journal: Blood
Blood (2023) 142 (Supplement 1): 3172.
https://doi.org/10.1182/blood-2023-187357
Published: 2023
Journal Articles

Influence of Pre-Treatment Features and Therapy Choice By Physicians on Overall Survival in Older Adults with Acute Myeloid Leukemia: A Report from the Beat AML Master Trial

Uma M. Borate, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L Lin, Yazan F. Madanat, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F. Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Alice Mims, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 4332.
https://doi.org/10.1182/blood-2023-181886
Published: 2023
Journal Articles

HJKC3-007: Outcomes of Patients with Chronic Myeloid Leukemia in Chronic Phase Treated with Asciminib and Other Tyrosine Kinase Inhibitors in Routine Clinical Practice

Michael Mauro, Ehab L. Atallah, James E Thompson, Yan Gao, Alexis Visotcky, Emily Giever, Arielle Baim, Idayat Akinola, Richard A. Larson, Omer Jamy, Jorge Cortes, Brian J. Druker, Neil P. Shah, Javier Pinilla-Ibarz, Jay Yang, Ellen K. Ritchie, Lindsay A.M Rein, Srinivas K. Tantravahi, Talha Badar, B. Douglas Smith, Michael W. Deininger, Kathryn E Flynn
Journal: Blood
Blood (2023) 142 (Supplement 1): 7434.
https://doi.org/10.1182/blood-2023-188683
Published: 2023
Journal Articles

Multicenter Retrospective Analysis of Eosinophilic Myeloid Neoplasms

Eoghan Molloy, William Shomali, Maggie J Cox, Joseph Butterfield, Julien Catherine, Michael W. Deininger, Juehua Gao, Grzegorz Helbig, Gabriela S. Hobbs, Fuli Jia, Jean Emmanuel Kahn, Paneez Khoury, Hirsh Komarow, Andrew T. Kuykendall, Orly Leiva, Guillaume Lefèvre, Hana I Lim, Bridget Marcellino, Irina Maric, John Mascarenhas, Elena Mishchenko, Stephen T. Oh, Eric Padron, Sandhya R Panch, Ami Patel, Cecelia Perkins, Thanai Pongdee, Florence Roufosse, Andrew I. Schafer, Brady L. Stein, Srdan Verstovsek, Sa A. Wang, Ling Zhang, Jason Gotlib, Amy D Klion
Journal: Blood
Blood (2023) 142 (Supplement 1): 4576.
https://doi.org/10.1182/blood-2023-187092
Published: 2023
Journal Articles

Entospletinib (ENTO) in Combination with Cytarabine (Ara-C) and Daunorubicin (DNR) in Newly Diagnosed (ND) Adult Patients with NPM1 -Mutated and FLT3 -ITD Wild-Type Acute Myeloid Leukemia (AML) Is Associated with Good Response and Survival: A Phase 2 Sub-Study of the Beat AML Master Trial

Uma Borate, Rui Li, Ying Huang, Ronan T. Swords, Elie Traer, Eytan Stein, James M. Foran, Maria R. Baer, Vu H. Duong, Wendy Stock, Olatoyosi Odenike, Prapti Patel, Robert H. Collins, Yazan F. Madanat, Tibor Kovacsovics, Michael W. Deininger, Catherine Smith, Rebecca L. Olin, Martha L. Arellano, William G. Blum, Gary J. Schiller, Tara L. Lin, Matthew C. Foster, Michael M. Boyiadzis, Robert L. Redner, Zeina Al-Mansour, Emily K Curran, Nyla A. Heerema, Theophilus J Gana, Molly Martycz, Leonard Rosenberg, Sonja Marcus, Ashley O. Yocum, Timothy Chen, Mona Stefanos, Franchesca Druggan, Amy Burd, Ross L. Levine, Brian J. Druker, John C. Byrd, Alice S. Mims
Journal: Blood
Blood (2022) 140 (Supplement 1): 6200–6203.
https://doi.org/10.1182/blood-2022-167316
Published: 2022
Journal Articles

Molecular Response of ≤10% BCR::ABL1 IS Is Predictive of Positive Outcomes in Treatment-Resistant Patients with Chronic Phase Chronic Myeloid Leukemia (CP-CML) Treated with Ponatinib from the Phase 2 Optic Trial

Jane F. Apperley, Jorge E. Cortes, Elias Jabbour, Andreas Hochhaus, Timothy Hughes, Charles Chuah, Hugues de Lavallade, Michael W. Deininger, Jeffrey H. Lipton, Elza Lomaia, Lori Maness, Michael Mauro, James McCloskey, Beatriz Moiraghi, Carolina Pavlovsky, Christine Rojas, Philippe Rousselot, Tomasz Sacha, Moshe Talpaz, Anna Turkina, Maria Undurraga Sutton, Xiaowei Ren, Alexander Vorog, Gianantonio Rosti
Journal: Blood
Blood (2022) 140 (Supplement 1): 6760–6762.
https://doi.org/10.1182/blood-2022-157956
Published: 2022
Journal Articles

An Updated Analysis on Safety and Efficacy of Avapritinib in Patients with Advanced Systemic Mastocytosis from the Explorer Clinical Study: Long-Term Efficacy and Safety

Daniel J. DeAngelo, Deepti H. Radia, Tracy I. George, William A. Robinson, Albert T. Quiery, Mark W. Drummond, Prithviraj Bose, Elizabeth O. Hexner, Elliott Winton, Hans-Peter Horny, Meera Tugnait, Hui-Min Lin, Saša Dimitrijević, Javier I. Munoz-Gonzalez, Ilda Bidollari, Michael W. Deininger, Jason Gotlib
Journal: Blood
Blood (2022) 140 (Supplement 1): 3932–3934.
https://doi.org/10.1182/blood-2022-167593
Published: 2022
Journal Articles

Efficacy and Safety of Bosutinib Vs Imatinib By Charlson Comorbidity Index in Newly Diagnosed Patients with Chronic Myeloid Leukemia

Michael W. Deininger, Tim H Brummendorf, Jeffrey H. Lipton, Dragana Milojkovic, Leif Stenke, Eric Leip, Simon Purcell, Andrea Viqueira, Jorge E. Cortes
Journal: Blood
Blood (2022) 140 (Supplement 1): 3913–3915.
https://doi.org/10.1182/blood-2022-163276
Published: 2022
Journal Articles

Summit: A 3-Part, Phase 2 Study of Bezuclastinib (CGT9486), an Oral, Selective, and Potent KIT D816V Inhibitor, in Adult Patients with Nonadvanced Systemic Mastocytosis (NonAdvSM)

Cem Akin, Frank Siebenhaar, Michael W. Deininger, Daniel J. DeAngelo, Tracy I. George, Mariana Castells, Matthew Giannetti, Jason Gotlib, Jessica Sachs, Amanda Pilla, Hina A. Jolin, Prithviraj Bose
Journal: Blood
Blood (2022) 140 (Supplement 1): 6838–6839.
https://doi.org/10.1182/blood-2022-156326
Published: 2022
Journal Articles

Efficacy and Safety of Bosutinib Versus Imatinib in US Patients with Newly Diagnosed Chronic Myeloid Leukemia after 5-Years Follow-up in the Bfore Trial

Vamsi K. Kota, Michael W. Deininger, Jason H. Mendler, Wei Shen, Erinn Hoag Goldman, Jorge E. Cortes
Journal: Blood
Blood (2022) 140 (Supplement 1): 6798–6799.
https://doi.org/10.1182/blood-2022-162428
Published: 2022
Journal Articles

Three-Year Update from the Optic Trial: A Dose-Optimization Study of 3 Starting Doses of Ponatinib

Jorge E. Cortes, Michael W. Deininger, Elza Lomaia, Beatriz Moiraghi, Maria Undurraga Sutton, Carolina Pavlovsky, Charles Chuah, Tomasz Sacha, Jeffrey H. Lipton, James McCloskey, Andreas Hochhaus, Philippe Rousselot, Gianantonio Rosti, Hugues de Lavallade, Christine Rojas, Anna Turkina, Lori Maness, Moshe Talpaz, Michael Mauro, Vickie Lu, Alexander Vorog, Jane F. Apperley
Journal: Blood
Blood (2022) 140 (Supplement 1): 1495–1497.
https://doi.org/10.1182/blood-2022-157822
Published: 2022
Journal Articles

Avapritinib As First-Line Therapy in Patients with Advanced Systemic Mastocytosis: Efficacy and Safety from the Pathfinder Clinical Study

Deepti H. Radia, Jason Gotlib, Mark W. Drummond, Tracy I. George, Hui-Min Lin, Saša Dimitrijević, Javier I. Munoz-Gonzalez, Ilda Bidollari, Michael W. Deininger, Daniel J. DeAngelo, Andreas Reiter
Journal: Blood
Blood (2022) 140 (Supplement 1): 1509–1511.
https://doi.org/10.1182/blood-2022-166986
Published: 2022
Journal Articles

LPA81: Discovery of an Exceptionally Potent Protac Degrading Native and Mutant BCR-ABL1 Oncoprotein in CML

Milad Rouhimoghadam, Hua Tang, Junzhuo Liao, Briana Bates, Daniela Uribe-Cano, Helong Zhao, Weiping Tang, Michael W. Deininger
Journal: Blood
Blood (2022) 140 (Supplement 1): 485–486.
https://doi.org/10.1182/blood-2022-158308
Published: 2022
Journal Articles

Clonal Dynamics of ASM-AHN with Avapritinib Treatment

Xiaomeng Huang, Jonathan M. Ahmann, Opal S. Chen, Yi Qiao, Anthony D. Pomicter, Gabor T. Marth, Tracy I. George, Michael W. Deininger
Journal: Blood
Blood (2022) 140 (Supplement 1): 6737–6738.
https://doi.org/10.1182/blood-2022-167701
Published: 2022
Journal Articles

Concerto (NCT04409639): A Phase 2 Trial of Cobimetinib in Newly Diagnosed and HMA-Treated CMML Patients with RAS Pathway Mutations

Ami B. Patel, Afaf Osman, Tony D. Pomicter, Srinivas K. Tantravahi, Michael W. Deininger
Journal: Blood
Blood (2022) 140 (Supplement 1): 4060–4061.
https://doi.org/10.1182/blood-2022-163570
Published: 2022
Journal Articles

CSF3R and SETBP1 getting high on LSD1

Helong Zhao, Michael W. Deininger
Journal: Blood
Blood (2022) 140 (6): 529–530.
https://doi.org/10.1182/blood.2022016740
Published: 2022