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Journal Articles

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or menin inhibitor

Warren Fiskus, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christopher P. Mill, Christine E. Birdwell, Kaberi Das, John A. Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Tapan M. Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K. Reville, Jian Wang, Sanam Loghavi, Rwik Sen, Xinjia Ruan, Xiaoping Su, Lauren B. Flores, Courtney D. DiNardo, Kapil N. Bhalla
Journal: Blood
Blood (2024) 143 (20): 2059–2072.
https://doi.org/10.1182/blood.2023022832
Published: 2024
Includes: Supplemental data
Journal Articles

Phase 2 study of inotuzumab ozogamicin for measurable residual disease in acute lymphoblastic leukemia in remission

Clinical Trials & Observations Brief Report
Elias Jabbour, Fadi G. Haddad, Nicholas J. Short, Jayastu Senapati, Nitin Jain, Koji Sasaki, Jeffrey Jorgensen, Sa A. Wang, Yesid Alvarado, Xuemei Wang, Courtney DiNardo, Lucia Masarova, Tapan Kadia, Rebecca S. Garris, Farhad Ravandi, Hagop Kantarjian
Journal: Blood
Blood (2024) 143 (5): 417–421.
https://doi.org/10.1182/blood.2023022330
Published: 2024
Includes: Supplemental data
Journal Articles

Venetoclax abrogates the prognostic impact of splicing factor gene mutations in newly diagnosed acute myeloid leukemia

Clinical Trials & Observations
Jayastu Senapati, Samuel Urrutia, Sanam Loghavi, Nicholas J. Short, Ghayas C. Issa, Abhishek Maiti, Hussein A. Abbas, Naval G. Daver, Naveen Pemmaraju, Sherry Pierce, Kelly S. Chien, Koji Sasaki, Tapan M. Kadia, Danielle E. Hammond, Gautam Borthakur, Keyur Patel, Farhad Ravandi, Hagop M. Kantarjian, Guillermo Garcia-Manero, Courtney D. DiNardo
Journal: Blood
Blood (2023) 142 (19): 1647–1657.
https://doi.org/10.1182/blood.2023020649
Published: 2023
Includes: Supplemental data
Journal Articles

Ibrutinib, Fludarabine, Cyclophosphamide and Obinutuzumab (iFCG) for Firstline Treatment of Patients with CLL with Mutated IGHV and without Del(17p)/ TP53 Mutation: Six-Year Follow-up Analyses

Nitin Jain, Philip Thompson, Akhil Jain, Jan A. Burger, Alessandra Ferrajoli, Jayastu Senapati, Koichi Takahashi, Mahesh Swaminathan, Zeev Estrov, Gautam Borthakur, Prithviraj Bose, Tapan M. Kadia, Naveen Pemmaraju, Koji Sasaki, Divyam Bansal, Marina Y. Konopleva, Elias Jabbour, Naveen Garg, Xuemei Wang, Rashmi Kanagal-Shamanna, Keyur P. Patel, Wei Wang, Sa A. Wang, Jeffrey L. Jorgensen, Wanda Lopez, Ana Ayala, William Plunkett, Varsha Gandhi, Hagop M. Kantarjian, Susan M. O'Brien, Michael J. Keating, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3267.
https://doi.org/10.1182/blood-2023-188084
Published: 2023
Journal Articles

With up to 8 Years of Therapy, Asciminib (ASC) Monotherapy Demonstrated Continued Favorable Efficacy, Safety, and Tolerability in Patients (Pts) with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase (Ph+ CML-CP) without the T315I Mutation: Final Results from the Phase 1 X2101 Study

Andreas Hochhaus, Dong-Wook Kim, Jorge Cortes, Koji Sasaki, Michael Mauro, Timothy P Hughes, Massimo Breccia, Moshe Talpaz, Hironobu Minami, Yeow Tee Goh, Daniel J. DeAngelo, Fabian Lang, Michael C. Heinrich, Valle Gomez G De Soria, Philipp le Coutre, Gessami Sanchez-Olle, Jomy Jose, Nathalie Pognan, Shruti Kapoor, Delphine Rea
Journal: Blood
Blood (2023) 142 (Supplement 1): 450.
https://doi.org/10.1182/blood-2023-187322
Published: 2023
Journal Articles

Azacitidine Plus Venetoclax Maintenance in Acute Myeloid Leukemia Produces Sustained Remissions with Low Toxicity: Results of a Phase 2 Study

Alexandre Bazinet, Hagop M. Kantarjian, Gautam Borthakur, Musa Yilmaz, Prithviraj Bose, Elias Jabbour, Yesid Alvarado Valero, Kelly S. Chien, Naveen Pemmaraju, Koichi Takahashi, Nicholas J. Short, Naval Daver, Ghayas C. Issa, Nitin Jain, Danielle E. Hammond, Debra Bull-Linderman, Courtney D. DiNardo, Jan A. Burger, Alessandra Ferrajoli, Guillermo Montalban-Bravo, Koji Sasaki, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2023) 142 (Supplement 1): 2884.
https://doi.org/10.1182/blood-2023-172882
Published: 2023
Journal Articles

Addition of Inotuzumab Ozogamicin to the Conditioning Regimen of Allogeneic Stem Cell Transplantation (allo-SCT) for Relapsed CD22 (+) Lymphoid Malignancies: Long-Term Survival Results

Issa F. Khouri, Kamal Alzahrani, Alison Gulbis, Koji Sasaki, Nitin Jain, Nicholas J. Short, Tapan M. Kadia, May Daher, MD, Hind Rafei, Jin S Im, David Marin, Amanda L. Olson, Uday R. Popat, Muzaffar H. Qazilbash, Jeremy Ramdial, Gabriela Rondon, Samer A. Srour, Partow Kebriaei, Elizabeth J. Shpall, Hagop M. Kantarjian, Richard E. Champlin, Elias Jabbour
Journal: Blood
Blood (2023) 142 (Supplement 1): 233.
https://doi.org/10.1182/blood-2023-181880
Published: 2023
Journal Articles

IFNÎł Signaling in Acute Myeloid Leukemia Mediates Immunomodulation and Reveals Therapeutic Strategies

Bofei Wang, Patrick K Reville, Fatima Z Jelloul, Poonam N Desai, Pamella Borges, Christopher Ly, Ivo Veletic, Enes Dasdemir, Jared K. Burks, Guilin Tang, Shengnan Guo, Nicole Vaugh, Natalia Baran, Qing Deng, Jairo Matthews, Preethi Gunaratne, Dinler A Antunes, Suhendan Ekmekcioglu, Koji Sasaki, Miriam B. Garcia, Branko Cuglievan, Dapeng Hao, Naval Daver, Michael R. Green, Marina Y. Konopleva, Andy Futreal, Sean M. Post, Hussein A Abbas
Journal: Blood
Blood (2023) 142 (Supplement 1): 2796.
https://doi.org/10.1182/blood-2023-175010
Published: 2023
Journal Articles

Actionable Findings from an Unbiased Drug Screen for Novel Single Agent and Combination Therapies Against AML with Mecom Re-Arrangement

Christine Birdwell, Warren C. Fiskus, Christopher Peter Mill, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo, Koji Sasaki, John Davis, Kaberi Das, Hanxi Hou, Michele Ceribelli, Kapil N. Bhalla
Journal: Blood
Blood (2023) 142 (Supplement 1): 1419.
https://doi.org/10.1182/blood-2023-188371
Published: 2023
Journal Articles

Influence of Co-Mutational Patterns in Disease Phenotype and Clinical Outcomes of Chronic Myelomonocytic Leukemia

Guillermo Montalban-Bravo, David Swanson, Rashmi Kanagal-Shamanna, Juan Jose Rodriguez-Sevilla, Danielle E. Hammond, Kelly S. Chien, Koji Sasaki, Elias Jabbour, Courtney D. DiNardo, Koichi Takahashi, Nicholas J. Short, Ghayas C. Issa, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Naval Daver, Gautam Borthakur, Sanam Loghavi, Sherry Pierce, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 4601.
https://doi.org/10.1182/blood-2023-178061
Published: 2023
Journal Articles

Performance of the Molecular International Prognostic Scoring System (IPSS-M) in Hypomethylating Agent-Treated Patients with Myelodysplastic Syndromes

Kelly S. Chien, Samuel Urrutia, Ziyi Li, Rashmi Kanagal-Shamanna, Ahmed Abdelhakeem, Tareq Abuasab, Emmanuel Almanza, Georgina Gener-Ricos, Alex Bataller, Alexandre Bazinet, Guillermo Montalban-Bravo, Nicholas J. Short, Elias Jabbour, Tapan M. Kadia, Farhad Ravandi, Gautam Borthakur, Danielle E. Hammond, Mahesh Swaminathan, Koji Sasaki, Xiao Qin Dong, Sherry Pierce, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 1857.
https://doi.org/10.1182/blood-2023-189557
Published: 2023
Journal Articles

ASC2ESCALATE: A US Phase 2, Open-Label, Single-Arm, Dose-Escalation Study of Asciminib (ASC) Monotherapy in Patients (Pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) As Second-Line (2L) and First-Line (1L) Treatment

Ehab L. Atallah, Michael Mauro, Koji Sasaki, Moshe Levy, Paul B. Koller, Daisy Yang, Dramane Laine, John Sabo, Ennan GU, Jorge Cortes
Journal: Blood
Blood (2023) 142 (Supplement 1): 6389.
https://doi.org/10.1182/blood-2023-186974
Published: 2023
Journal Articles

Clinicopathologic Predictors of Hypomethylating Agent Failure in Patients with Myelodysplastic Syndromes

Kelly S. Chien, Samuel Urrutia, Ziyi Li, Rashmi Kanagal-Shamanna, Ahmed Abdelhakeem, Tareq Abuasab, Emmanuel Almanza, Georgina Gener-Ricos, Alex Bataller, Alexandre Bazinet, Guillermo Montalban-Bravo, Nicholas J. Short, Elias Jabbour, Tapan M. Kadia, Farhad Ravandi, Gautam Borthakur, Danielle E. Hammond, Mahesh Swaminathan, Koji Sasaki, Xiao Qin Dong, Sherry Pierce, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 4616.
https://doi.org/10.1182/blood-2023-182256
Published: 2023
Journal Articles

Phase Ib/2 Study of Oral Decitabine/Cedazuridine (ASTX727) and Venetoclax in Combination with the Targeted Mutant IDH1 Inhibitor Ivosidenib or the Targeted Mutant IDH2 Inhibitor Enasidenib: 2023 Update

Himachandana Atluri, Jillian Mullin, Koichi Takahashi, Sanam Loghavi, Abhishek Maiti, Koji Sasaki, Naval Daver, Yesid Alvarado Valero, Naveen Pemmaraju, Gautam Borthakur, Danielle E. Hammond, Kelly S. Chien, Alessandra Ferrajoli, Nicholas J. Short, Hussein A Abbas, Elias Jabbour, Michael Andreeff, Farhad Ravandi, Rebecca S.S. Tidwell, Xuemei Wang, Marina Y. Konopleva, Guillermo Garcia-Manero, Hagop M. Kantarjian, Courtney D. DiNardo
Journal: Blood
Blood (2023) 142 (Supplement 1): 968.
https://doi.org/10.1182/blood-2023-182944
Published: 2023
Journal Articles

Phase 2 Study of Dasatinib with and without Venetoclax in Patients with Early Chronic Phase Chronic Myeloid Leukemia (ECP-CML)

Fadi G. Haddad, Elias Jabbour, Koji Sasaki, Lewis Nasr, Xuelin Huang, Ghayas C. Issa, Farhad Ravandi, Guillermo Garcia-Manero, Tapan M. Kadia, Naval Daver, Yesid Alvarado Valero, Cedric Nasnas, Maro Ohanian, Nicholas J. Short, Lucia Masarova, Marianne Zoghbi, Patrice Eric Nasnas, Guillermo Montalban-Bravo, Jeffrey Skinner, Sherry Pierce, Michael Andreeff, Hagop M. Kantarjian
Journal: Blood
Blood (2023) 142 (Supplement 1): 870.
https://doi.org/10.1182/blood-2023-188236
Published: 2023
Journal Articles

Characterization of MDS and CMML Patients Harboring Trisomy 8 Abnormality: Clinical, Autoimmune, and Mutational Features

Hussain Alcassab, Koji Sasaki, Danielle E. Hammond, Alex Bataller, David B Beck, Tapan M. Kadia, Guillermo Montalban-Bravo, Kelly S. Chien, L. Jeffrey Medeiros, Hagop Kantarjian, Awdesh Kalia, Manjunath Nimmakayalu, Carlos E. Bueso-Ramos, Guillermo Garcia-Manero, Rashmi Kanagal-Shamanna
Journal: Blood
Blood (2023) 142 (Supplement 1): 1881.
https://doi.org/10.1182/blood-2023-190464
Published: 2023
Journal Articles

Clinical and Molecular Characterization of Patients with Therapy Related Myeloid Neoplasms (TRMN)

Oriol Calvete, Julia Mestre, Guillermo Montalban-Bravo, Koji Sasaki, Courtney D. DiNardo, Ana Manzanares, Pamela Acha, Blanca Xicoy, Lurdes Zamora, Isabel Granada, Alvaro Diaz-Gonzalez, Esperanza Such, Laura Palomo, Maria Julia Montoro, Sara GarcĂ­a, Leonor Arenillas, David Valcarcel Ferreiras, Andres Jerez, Maria Diez-Campelo, Felipe Prosper, Hui Yang, Carlos E. Bueso-Ramos, Guillermo Garcia-Manero, Francesc Sole, Rashmi Kanagal-Shamanna
Journal: Blood
Blood (2023) 142 (Supplement 1): 3224.
https://doi.org/10.1182/blood-2023-188701
Published: 2023
Journal Articles

Oral Decitabine/Cedazuridine with Venetoclax in High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia: Analysis By Different Response Criteria

Alex Bataller, Guillermo Montalban-Bravo, Alexandre Bazinet, Yesid Alvarado Valero, Kelly S. Chien, Sangeetha Venugopal, Jo Ishizawa, Danielle E. Hammond, Mahesh Swaminathan, Koji Sasaki, Ghayas C. Issa, Nicholas J. Short, Lucia Masarova, Naval Daver, Tapan M. Kadia, Simona Colla, Wei Qiao, Xuelin Huang, Rashmi Kanagal-Shamanna, Stephany Hendrickson, Farhad Ravandi, Elias Jabbour, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 3228.
https://doi.org/10.1182/blood-2023-189203
Published: 2023
Journal Articles

Asciminib (ASC) in Combination with Imatinib (IMA), Nilotinib (NIL), or Dasatinib (DAS) May be a Potential Treatment (Tx) Option in Patients (Pts) with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase or Accelerated Phase (Ph+ CML-CP/AP): Final Results from the Asciminib Phase 1 Study

Jorge Cortes, Fabian Lang, Delphine Rea, Andreas Hochhaus, Massimo Breccia, Yeow Tee Goh, Michael C. Heinrich, Timothy P Hughes, Jeroen J.W.M. Janssen, Philipp le Coutre, Hironobu Minami, Koji Sasaki, Daniel J. DeAngelo, Gessami Sanchez-Olle, Nathalie Pognan, Jomy Jose, Matthias Hoch, Michael Mauro
Journal: Blood
Blood (2023) 142 (Supplement 1): 868.
https://doi.org/10.1182/blood-2023-189270
Published: 2023
Journal Articles

Protective Role of Oxaliplatin Among Platinum-Based Therapies in the Development of Therapy-Related Myeloid Neoplasms

Jeremy S Connors, Linda Zhang, Koji Sasaki, Courtney D. DiNardo, Nicholas J. Short, Naval Daver, Gautam Borthakur, Tapan M. Kadia, Hagop Kantarjian, Elias Jabbour, Margaret A Goodell, Guillermo Garcia-Manero, Koichi Takahashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4220.
https://doi.org/10.1182/blood-2023-190672
Published: 2023