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Steven M. Kornblau
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Journal Articles

A STAT3 Degrader Demonstrates Pre-Clinical Efficacy in Venetoclax Resistant Acute Myeloid Leukemia

Samarpana Chakraborty, Claudia Morganti, Joyoti Dey, Hui Zhang, Srinivas Aluri, Nadege Gitego, Kith Pradhan, Bianca Rivera, Yogesh Chutake, Anna Skwarska, Ioannis Mantzaris, Mendel Goldfinger, Eric J Feldman, Gaurav S Choudhary, Stefan Hubner, Yihua Qiu, Brandon D. Brown, Amit Verma, Evripidis Gavathiotis, Marina Y. Konopleva, Steven M. Kornblau, Jared Gollob, Keisuke Ito, Aditi Shastri
Journal: Blood
Blood (2023) 142 (Supplement 1): 2787.
https://doi.org/10.1182/blood-2023-186947
Published: 2023
Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

Nathan Duong, Dilshad H. Khan, Geethu Emily Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil Maclean, Marcela Gronda, Vincent Rondeau, Brandon D. Brown, Courtney L Jones, Hong Chang, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Brian Raught, Vito Spadavecchio, Aaron D. Schimmer
Journal: Blood
Blood (2023) 142 (Supplement 1): 5694.
https://doi.org/10.1182/blood-2023-174536
Published: 2023
Journal Articles

STAG2/LMO2 Gamma-Delta (γδ) T-ALL: Identification and Characterization of an Extremely High Risk Group of T-ALL in the Very Young

Shunsuke Kimura, Petri Pölönen, Lindsey Montefiori, Kenneth Caldwell, Ilaria Iacobucci, Chelsey Chen, Anthony Brown, Katie Han, Yen-Chun Liu, Yunchao Chang, Zhongshan Cheng, Zhou Yinmei, Chun Shik Park, Sharnise Mitchell, Noemi Reyes, Allen Yeoh, Andishe Attarbaschi, Andrew Moore, Atsushi Manabe, Barbara Buldini, Kean Hui Chiew, Chi Kong Li, Ching-Hon Pui, Chunxu Qu, Daisuke Tomizawa, Elisabeth Paietta, Franco Locatelli, Gabriele Escherich, Gao Qingsong, Hannah Elisa Muhle, Hanne Vibeke Marquart, Hester A. de Groot-Kruseman, Jacob M. Rowe, Jan Stary, Jan Trka, John Kim Choi, Jules P.P. Meijerink, Junko Takita, Katarzyna Pawinska-Wasikowska, Kjeld Schmiegelow, Mariko Eguchi, Martin Schrappe, Martin Zimmermann, Masatoshi Takagi, Melissa Maybury, Michael Svaton, Michaela Reiterova, Michal Kicinski, Motohiro Kato, Orietta Spinelli, Pauline Mazilier, Paul G. Thomas, Riccardo Masetti, Rishi Sury Kotecha, Rob Pieters, Sarah Elitzur, Selina M Luger, Shuhong Shen, Sima Jeha, Steven M. Kornblau, Szymon Skoczen, Takako Miyamura, Tiffaney Vincent, Toshihiko Imamura, Valentino Conter, Yanjing Tang, Zhaohui Gu, Kathryn G. Roberts, David T. Teachey, Kristine R Crews, Cheng Cheng, Jun J. Yang, Hiroto Inaba, Charles G. Mullighan
Journal: Blood
Blood (2023) 142 (Supplement 1): 845.
https://doi.org/10.1182/blood-2023-178688
Published: 2023
Journal Articles

The Impact of Age and Genomics on Drug Sensitivity in 1,076 Children and Adults with B-Cell Acute Lymphoblastic Leukemia

Satoshi Yoshimura, Zhenhua Li, Yoshihiro Gocho, Wenjian Yang, Kristine R Crews, Shawn H.R. Lee, Kathryn G. Roberts, Charles G. Mullighan, Mary V. Relling, Federico Antillon-Klussmann, Allen Eng Juh Yeoh, Mignon L. Loh, Mark R. Litzow, Sima Jeha, Seth E. Karol, Hiroto Inaba, Ching-Hon Pui, Marina Y. Konopleva, Nitin Jain, Wendy Stock, Elisabeth Paietta, Elias Jabbour, Steven M. Kornblau, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 596.
https://doi.org/10.1182/blood-2023-181788
Published: 2023
Journal Articles

Proteomic Profiling Identifies Unique IDH Mutant Signatures and Novel Therapeutic Opportunities in Adult Acute Myeloid Leukemia Patients

Eduardo Sabino de Camargo Magalhaes, Stefan Hubner, Brandon D. Brown, Yihua Qiu, Steven M. Kornblau
Journal: Blood
Blood (2023) 142 (Supplement 1): 1581.
https://doi.org/10.1182/blood-2023-186723
Published: 2023
Journal Articles

Single-Cell Proteogenomics Analysis of AML Samples Treated with Decitabine and Venetoclax Reveals Divergent Treatment Escape Mechanisms

Yi June Kim, Zongrui Li, Abhishek Maiti, Tomoyuki Tanaka, Hidetaka Uryu, Ken Furudate, Kala Hayes, Naval Daver, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Nicholas J. Short, Maro Ohanian, Gautam Borthakur, Nitin Jain, Ghayas C. Issa, Lucia Masarova, Steven M. Kornblau, William G. Wierda, Sanam Loghavi, Sa A. Wang, Guillermo Garcia-Manero, Hagop Kantarjian, Courtney D. DiNardo, Marina Y. Konopleva, Koichi Takahashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2931.
https://doi.org/10.1182/blood-2023-190400
Published: 2023
Journal Articles

A Phase 2 Study of the Fully Oral Combination of ASTX727 (Decitabine/Cedazuridine) Plus Venetoclax for Older and/or Unfit Patients with Acute Myeloid Leukemia

Alexandre Bazinet, Guillermo Garcia-Manero, Nicholas J. Short, Yesid Alvarado Valero, Tareq Abuasab, Md Rabiul Islam, Kathryn Montalbano, Ghayas C. Issa, Abhishek Maiti, Musa Yilmaz, Nitin Jain, Lucia Masarova, Steven M. Kornblau, Elias Jabbour, Guillermo Montalban-Bravo, Sherry Pierce, Courtney D. DiNardo, Tapan M. Kadia, Naval Daver, Marina Y. Konopleva, Hagop M. Kantarjian, Farhad Ravandi
Journal: Blood
Blood (2023) 142 (Supplement 1): 833.
https://doi.org/10.1182/blood-2023-172658
Published: 2023
Journal Articles

Optimizing FLT3 Inhibitor Use in Adult Acute Myeloid Leukemia with FLT3 Mutations Using Proteomics

Eduardo Sabino Magalhaes, Stefan Hubner, Brandon D. Brown, Yihua Qiu, Steven M. Kornblau
Journal: Blood
Blood (2023) 142 (Supplement 1): 165.
https://doi.org/10.1182/blood-2023-186508
Published: 2023
Journal Articles

Phase I/II Study of Quizartinib, Venetoclax, and Decitabine Triple Combination in FLT3-ITD Mutated AML

Musa Yilmaz, Muharrem Muftuoglu, Courtney D. DiNardo, Tapan M. Kadia, Marina Y. Konopleva, Gautam Borthakur, Naveen Pemmaraju, Nicholas J. Short, Yesid Alvarado Valero, Abhishek Maiti, Lucia Masarova, Guillermo Montalban-Bravo, Carissa Jurisprudencia, Allison Pike, Sanam Loghavi, Keyur P. Patel, Guilin Tang, Jairo Matthews, Steven M. Kornblau, Elias Jabbour, Guillermo Garcia-Manero, Farhad Ravandi, Michael Andreeff, Naval Daver
Journal: Blood
Blood (2023) 142 (Supplement 1): 158.
https://doi.org/10.1182/blood-2023-186699
Published: 2023
Journal Articles

Update of a Phase II Trial of Guadecitabine in Higher-Risk Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia Under the International Working Group 2023 Criteria

Samuel Urrutia, Kelly S. Chien, Ziyi Li, Gautam Borthakur, Yesid Alvarado Valero, Tapan M. Kadia, Steven M. Kornblau, Naval Daver, Farhad Ravandi, Prithviraj Bose, Musa Yilmaz, Maro Ohanian, Rashmi Kanagal-Shamanna, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 1877.
https://doi.org/10.1182/blood-2023-184690
Published: 2023
Journal Articles

First in Human Study of Anti-Viral Veto Cells Enabling Successful Engraftment without Severe Gvhd in Non-Myeloablative T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation (HSCT)

Richard E Champlin, Esther Bachar Lustig, Qaiser Bashir, Betul Oran, Steven M. Kornblau, Chitra Hosing, Amin M Alousi, Uday R Popat, Jessica M McCarty, Peter F Thall, Bouthaina S. Dabaja, Wei-Hsin Liu, Giang Dang, Karla Castro, Alejandro Ramirez, Michael Spiotto, Susan Wu, Penny Fang, Indreshpal Kaur, Katy Rezvani, Elizabeth J Shpall, Yair Reisner
Journal: Blood
Blood (2022) 140 (Supplement 1): 2120–2122.
https://doi.org/10.1182/blood-2022-159183
Published: 2022
Journal Articles

The Addition of Inotuzumab Ozogamicin to Hyper-CVAD Plus Blinatumomab Further Improves Outcomes in Patients with Newly Diagnosed B-Cell Acute Lymphoblastic Leukemia: Updated Results from a Phase II Study

Nicholas Short, Elias Jabbour, Farhad Ravandi, Musa Yilmaz, Tapan M. Kadia, Philip A. Thompson, Xuelin Huang, Marina Konopleva, Alessandra Ferrajoli, Nitin Jain, Koji Sasaki, Walid Macaron, Yesid Alvarado, Gautam Borthakur, Courtney D. DiNardo, Maro Ohanian, Steven M. Kornblau, Min Zhao, Monica Kwari, Jennifer Thankachan, Christopher Loiselle, Ricardo Delumpa, Rebecca Garris, Hagop Kantarjian
Journal: Blood
Blood (2022) 140 (Supplement 1): 8966–8968.
https://doi.org/10.1182/blood-2022-157358
Published: 2022
Journal Articles

Epigenetic Landscape Predicts Overall Survival and Remission Duration in Adult Acute Myeloid Leukemia

Eduardo Sabino de Camargo Magalhaes, Yihua Qiu, Steven M. Kornblau
Journal: Blood
Blood (2022) 140 (Supplement 1): 6331–6332.
https://doi.org/10.1182/blood-2022-169962
Published: 2022
Journal Articles

Phase 2 Study of ASTX727 (cedazuridine/decitabine) Plus Venetoclax in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML) or Previously Untreated, Elderly Patients with AML Unfit for Chemotherapy

Tareq Abuasab, Guillermo Garcia-Manero, Nicholas Short, Yesid Alvarado, Ghayas C. Issa, Rubiul Islam, Abhishek Maiti, Musa Yilmaz, Nitin Jain, Lucia Masarova, Steven M. Kornblau, Elias Jabbour, Naveen Pemmaraju, Guillermo Montalban-Bravo, Sherry A. Pierce, Courtney D. DiNardo, Tapan M. Kadia, Naval Daver, Marina Konopleva, Hagop Kantarjian, Farhad Ravandi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3324–3326.
https://doi.org/10.1182/blood-2022-158566
Published: 2022
Journal Articles

Targeting Vimentin (VIM) in Acute Myelogenous Leukemia (AML)

Stefan Hubner, Marina Konopleva, Zhihong Zeng, Fieke W Hoff, Yihua Qiu, Vivian Ruvolo, Terzah M. Horton, Steven M. Kornblau
Journal: Blood
Blood (2022) 140 (Supplement 1): 6260–6261.
https://doi.org/10.1182/blood-2022-163664
Published: 2022
Journal Articles

The Exportin, XPO2, Is a Novel Therapeutic Target in Pediatric, Adolescent and Young Adult AML

Grace Egan, Rose Hurren, Chaitra Sarathy, Geethu Emily Thomas, Dilshad H. Khan, Yongran Yan, Yue Feng, Brandon Brown, Steven M. Kornblau, Aaron D. Schimmer
Journal: Blood
Blood (2022) 140 (Supplement 1): 11504–11505.
https://doi.org/10.1182/blood-2022-157322
Published: 2022
Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is Necessary for AML Viability and Regulates Mitotic Spindle and Centrosome Formation

Nathan Duong, Dilshad H. Khan, Geethu Emily Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D Brown, Brian Raught, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadevecchio, Aaron D. Schimmer
Journal: Blood
Blood (2022) 140 (Supplement 1): 3005–3006.
https://doi.org/10.1182/blood-2022-157626
Published: 2022
Journal Articles

Epigenetic Fine Mapping and Functional Dissection of Inherited Non-Coding Variation Impacting the Pharmacogenomics of Acute Lymphoblastic Leukemia Treatment

Kashi Raj Bhattarai, Kelly R. Barnett, Robert J. Mobley, Daniel C. Ferguson, Jonathan D. Diedrich, Brennan P. Bergeron, Wenjian Yang, Kristine R. Crews, Wendy Stock, Elisabeth Paietta, Steven M. Kornblau, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Cheng Cheng, Mary V. Relling, William E. Evans, Jun J.J. Yang, Daniel Savic
Journal: Blood
Blood (2022) 140 (Supplement 1): 3027–3028.
https://doi.org/10.1182/blood-2022-167419
Published: 2022
Journal Articles

Updated Phase IIb Results of Venetoclax with FLAG-IDA in Relapsed or Refractory Acute Myeloid Leukemia

Sai Prasad Desikan, Marina Konopleva, Koichi Takahashi, Curtis A Lachowiez, Sanam Loghavi, Lian-Chun Xiao, Tapan M. Kadia, Naval Daver, Nicholas Short, Koji Sasaki, Gautam Borthakur, Ghayas C. Issa, Abhishek Maiti, Kelly S. Chien, Yesid Alvarado, Guillermo Montalban-Bravo, Lucia Masarova, Musa Yilmaz, Michael Andreeff, Elias Jabbour, Guillermo Garcia-Manero, Steven M. Kornblau, Farhad Ravandi, Hagop Kantarjian, Courtney D. DiNardo
Journal: Blood
Blood (2022) 140 (Supplement 1): 534–536.
https://doi.org/10.1182/blood-2022-164922
Published: 2022
Journal Articles

Chromatin Accessibility Landscapes of B-Cell Acute Lymphoblastic Leukemia Identify Extensive Epigenomic Reprogramming and Heterogeneity Among Subtypes

Kelly R. Barnett, Jonathan D. Diedrich, Brennan P. Bergeron, Wenjian Yang, Kristine R. Crews, Wendy Stock, Elisabeth Paietta, Steven M. Kornblau, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Mary V. Relling, William E. Evans, Jun J.J. Yang, Daniel Savic
Journal: Blood
Blood (2022) 140 (Supplement 1): 5907–5908.
https://doi.org/10.1182/blood-2022-166528
Published: 2022