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Gautam Borthakur
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Journal Articles

Combination of CPX-351 and Gemtuzumab Ozogamicin (GO) in Relapsed Refractory (R/R) Acute Myeloid Leukemia and Post Hypomethylating Agent (HMA) Failure High-Risk Myelodysplastic Syndrome (HR-MDS)

Jayastu Senapati, Farhad Ravandi, Emmanuel Almanza, Tapan M. Kadia, Guillermo Montalban-Bravo, Stefan Faderl, Koji Sasaki, Nicholas J. Short, Naval Daver, Courtney D. DiNardo, Lucia Masarova, Alessandra Ferrajoli, Fadi G. Haddad, Elias Jabbour, Gautam Borthakur, Sheila Tan, Sherry Pierce, Guillermo Garcia-Manero, Michael Andreeff, Yesid Alvarado Valero
Journal: Blood
Blood (2024) 144 (Supplement 1): 2903.
https://doi.org/10.1182/blood-2024-207962
Published: 2024
Journal Articles

Fully Oral Combination of Decitabine/Cedazuridine (ASTX727) Plus Venetoclax for the Treatment of Newly Diagnosed Acute Myeloid Leukemia in Patients Ineligible for Intensive Chemotherapy

Alexandre Bazinet, Guillermo Garcia-Manero, Alex Bataller, Yesid Alvarado Valero, Musa Yilmaz, Elias Jabbour, Guillermo Montalban-Bravo, Naveen Pemmaraju, Ghayas C. Issa, Nicholas J. Short, Tapan M. Kadia, Nitin Jain, Lucia Masarova, Naval Daver, Danielle Hammond, Gautam Borthakur, Abhishek Maiti, Koichi Takahashi, Kelly S. Chien, Steven M. Kornblau, Hussein A. Abbas, Maro Ohanian, Jayastu Senapati, Courtney D. DiNardo, Hagop M. Kantarjian, Farhad Ravandi
Journal: Blood
Blood (2024) 144 (Supplement 1): 2896.
https://doi.org/10.1182/blood-2024-198541
Published: 2024
Journal Articles

ERK1/2 Inhibition Mediates Bax Dependent Proteolysis of OPA1 and Induces Mitochondrial Cristae Remodeling to Overcome Resistance to Venetoclax

Priyanka Sharma, Natalia Baran, Qi Zhang, M. Anna Zal, Joanne Munck, Martin Sims, Bing Z. Carter, Michael Andreeff, Gautam Borthakur
Journal: Blood
Blood (2024) 144 (Supplement 1): 2759.
https://doi.org/10.1182/blood-2024-210698
Published: 2024
Journal Articles

Clinical Outcomes Using Frontline “Triplet” Regimens for Newly Diagnosed IDH -Mutated Acute Myeloid Leukemia (AML): A Pooled Analysis of Two Phase Ib/2 Clinical Trials

Jennifer Marvin-Peek, Himachandana Atluri, Nicholas J. Short, Abhishek Maiti, Koichi Takahashi, Sanam Loghavi, Curtis A Lachowiez, Yesid Alvarado Valero, Guillermo Montalban-Bravo, Koji Sasaki, Fadi G. Haddad, Ghayas C. Issa, Lucia Masarova, Hussein A. Abbas, Michael Andreeff, Gautam Borthakur, Jillian Mullin, George Donovan Tippett, Kelly S. Chien, Danielle Hammond, Jo Ishizawa, Nitin Jain, Patrick K. Reville, Mahesh Swaminathan, Musa Yilmaz, Naval Daver, Tapan M. Kadia, Farhad Ravandi, Guillermo Garcia-Manero, Hagop M. Kantarjian, Courtney D. DiNardo
Journal: Blood
Blood (2024) 144 (Supplement 1): 2883.
https://doi.org/10.1182/blood-2024-200387
Published: 2024
Journal Articles

A Phase I/II Study of Gilteritinib and Momelotinib for Patients with Relapsed/Refractory FLT3 -Mutated Acute Myeloid Leukemia: A Trial in Progress

Nicholas J. Short, Farhad Ravandi, Naval Daver, Courtney D. DiNardo, Gautam Borthakur, Tapan M. Kadia, Musa Yilmaz, Ghayas C. Issa, Regina Abramova, Araceli Isabella Garza, Hagop M. Kantarjian, Hussein A. Abbas
Journal: Blood
Blood (2024) 144 (Supplement 1): 4288.1.
https://doi.org/10.1182/blood-2024-200923
Published: 2024
Journal Articles

A Phase II Trial of Azacitidine with Ipilimumab, Nivolumab, or Ipilimumab and Nivolumab in Previously Untreated Myelodysplastic Syndrome

Ian M. Bouligny, Guillermo Montalban-Bravo, Koji Sasaki, Naval Daver, Elias Jabbour, Yesid Alvarado Valero, Courtney D. DiNardo, Farhad Ravandi, Gautam Borthakur, Prithviraj Bose, Naveen Pemmaraju, Steven M. Kornblau, Tapan M. Kadia, Lucia Masarova, Koichi Takahashi, Michael Andreeff, Alexandre Bazinet, Hui Yang, Rashmi Kanagal-Shamanna, Chitra Hosing, Sherry Pierce, Meghan Anne Meyer, Xuelin Huang, Guillermo Garcia-Manero
Journal: Blood
Blood (2024) 144 (Supplement 1): 4601.
https://doi.org/10.1182/blood-2024-204040
Published: 2024
Journal Articles

Characteristics and Outcomes of Patients (pts) with Acute Myeloid Leukemia (AML) and FLT3 -Tyrosine Kinase Domain (TKD) Mutations

Sankalp Arora, Musa Yilmaz, Wei-Ying Jen, Nicholas J. Short, Sanam Loghavi, Tapan M. Kadia, Courtney D. DiNardo, Gautam Borthakur, Indraneel Deshmukh, Ghayas C. Issa, Joseph E. Jabbour, Naveen Pemmaraju, Michael Andreeff, Koichi Takahashi, Kapil N. Bhalla, Hussein A. Abbas, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M. Kantarjian, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 841.
https://doi.org/10.1182/blood-2024-204042
Published: 2024
Journal Articles

Phase II Study of Cladribine with Low Dose Cytarabine and Venetoclax Alternating with Azacytidine and Venetoclax for Newly Diagnosed Acute Myeloid Leukemia

Alex Bataller, Hagop M. Kantarjian, Alexandre Bazinet, Jayastu Senapati, Gautam Borthakur, Nicholas J. Short, Elias Jabbour, Koichi Takahashi, Naval Daver, Ghayas C. Issa, Courtney D. DiNardo, Naveen Pemmaraju, Nitin Jain, Guillermo Montalban-Bravo, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2024) 144 (Supplement 1): 56.
https://doi.org/10.1182/blood-2024-202620
Published: 2024
Journal Articles

Safety and Efficacy of G-CSF with Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia: A Subgroup Analysis of the Phase II Trial of Venetoclax in Combination with Cladribine, Idarubicin, and Cytarabine

Ian M. Bouligny, Hagop M. Kantarjian, Musa Yilmaz, Naval Daver, Gautam Borthakur, Courtney D. DiNardo, Guillermo Montalban-Bravo, Nicholas J. Short, Yesid Alvarado Valero, Nitin Jain, Naveen Pemmaraju, Danielle Hammond, Kelly S. Chien, Koichi Takahashi, Ghayas C. Issa, Hussein A. Abbas, Elias Jabbour, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2024) 144 (Supplement 1): 446.
https://doi.org/10.1182/blood-2024-203938
Published: 2024
Journal Articles

Phase 1b/2 Study of Magrolimab (Magro), Azacitidine (AZA) and Venetoclax (VEN) in Patients (pts) with Newly Diagnosed (ND) Older/Unfit or High Risk Acute Myeloid Leukemia (AML) and Relapsed Refractory (R/R) AML: Final Clinical Data and Genomic Markers of Resistance/Relapse

Sankalp Arora, Jayastu Senapati, Sanam Loghavi, Patrick K. Reville, Bofei Wang, Tapan M. Kadia, Courtney D. DiNardo, Naveen Pemmaraju, Musa Yilmaz, Joseph E. Jabbour, Nicholas J. Short, Guillermo Montalban-Bravo, Abhishek Maiti, Guilin Tang, Koji Sasaki, Gautam Borthakur, Joie Alvarez, Sherry Pierce, Graciela M. Nogueras González, Jing Ning, Ghayas C. Issa, Michael Andreeff, Farhad Ravandi, Guillermo Garcia-Manero, Hussein A. Abbas, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 735.
https://doi.org/10.1182/blood-2024-203706
Published: 2024
Journal Articles

A Phase II Trial of Venetoclax in Combination with Cladribine, Idarubicin, and Cytarabine in Newly Diagnosed Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome

Ian M. Bouligny, Hagop M. Kantarjian, Musa Yilmaz, Naval Daver, Gautam Borthakur, Courtney D. DiNardo, Guillermo Montalban-Bravo, Nicholas J. Short, Yesid Alvarado Valero, Elias Jabbour, Nitin Jain, Naveen Pemmaraju, Danielle Hammond, Kelly S. Chien, Koichi Takahashi, Ghayas C. Issa, Hussein A. Abbas, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2024) 144 (Supplement 1): 734.
https://doi.org/10.1182/blood-2024-203459
Published: 2024
Journal Articles

Establishing Benchmarks for Relapse-Free and Overall Survival Among Patients (Pts) with Newly Diagnosed AML Not Undergoing Allogeneic Stem Cell Transplantation (SCT) in First Remission

Eitan Kugler, Hagop M. Kantarjian, Alexandre Bazinet, Wei-Ying Jen, Naval Daver, Courtney D. DiNardo, Nicholas J. Short, Jayastu Senapati, Gautam Borthakur, Naveen Pemmaraju, Ghayas C. Issa, Alex Bataller, Patrick K. Reville, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2024) 144 (Supplement 1): 2861.
https://doi.org/10.1182/blood-2024-199903
Published: 2024
Journal Articles

Incidence, Characteristics, and Outcomes of Patients with Newly Diagnosed, De Novo KIT -Mutated Non-Core Binding Factor Acute Myeloid Leukemia without Systemic Mastocytosis

Eitan Kugler, Sanam Loghavi, Farhad Ravandi, Courtney D. DiNardo, Naval Daver, Tapan M. Kadia, Gautam Borthakur, Ghayas C. Issa, Hussein A. Abbas, Prithviraj Bose, Jayastu Senapati, Hagop M. Kantarjian, Nicholas J. Short
Journal: Blood
Blood (2024) 144 (Supplement 1): 2857.
https://doi.org/10.1182/blood-2024-199917
Published: 2024
Journal Articles

Clinical Outcomes Associated with NPM1 Mutations in Newly Diagnosed AML

Aziz Farhat, Hagop M. Kantarjian, Koji Sasaki, Nicholas J. Short, Branko Cuglievan, Sanam Loghavi, Keyur P. Patel, Alex Bataller, Musa Yilmaz, Guillermo Montalban-Bravo, Danielle Hammond, Naveen Pemmaraju, Naval Daver, Farhad Ravandi, Elias Jabbour, Tapan M. Kadia, Gautam Borthakur, Guillermo Garcia-Manero, Courtney D. DiNardo, Ghayas C. Issa
Journal: Blood
Blood (2024) 144 (Supplement 1): 2853.
https://doi.org/10.1182/blood-2024-205504
Published: 2024
Journal Articles

Treatment Intensity in Acute Myeloid Leukemia with Extramedullary Disease

Jennifer Marvin-Peek, Wei-Ying Jen, Nicholas J. Short, Ghayas C. Issa, Musa Yilmaz, Guillermo Montalban-Bravo, Alexandre Bazinet, Koji Sasaki, Abhishek Maiti, Gautam Borthakur, Danielle Hammond, Kelly S. Chien, Hussein A. Abbas, Naveen Pemmaraju, Guillermo Garcia-Manero, Elias Jabbour, Farhad Ravandi, Tapan M. Kadia, Naval Daver, Courtney D. DiNardo
Journal: Blood
Blood (2024) 144 (Supplement 1): 2851.
https://doi.org/10.1182/blood-2024-202429
Published: 2024
Journal Articles

Long-Term Survival Outcomes and Cytogenetic/Molecular Patterns of Relapse in Adults with FLT3 -Mutated AML Receiving Frontline Triplet Therapy with a Hypomethylating Agent, Venetoclax and FLT3 Inhibitor

Nicholas J. Short, Sanam Loghavi, Musa Yilmaz, Omer Karrar, Joseph E. Jabbour, Courtney D. DiNardo, Tapan M. Kadia, Gautam Borthakur, Ghayas C. Issa, Hussein A. Abbas, Marina Konopleva, Farhad Ravandi, Hagop M. Kantarjian, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 220.
https://doi.org/10.1182/blood-2024-210891
Published: 2024
Journal Articles

A Phase Ib/II Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Hematologic Malignancies: A 2024 Update

Jennifer Marvin-Peek, Jacqueline S. Garcia, Gautam Borthakur, Guillermo Garcia-Manero, Nicholas J. Short, Tapan M. Kadia, Sanam Loghavi, Lucia Masarova, Naval Daver, Abhishek Maiti, Koichi Takahashi, Koji Sasaki, Danielle Hammond, George Donovan Tippett, Dylan Wilson, Kelly S. Chien, Prithviraj Bose, Patrick K. Reville, Curtis A Lachowiez, Akriti G. Jain, Ghayas C. Issa, Nitin Jain, Guillermo Montalban-Bravo, Marlise R. Luskin, Hetty E. Carraway, Farhad Ravandi, Hagop M. Kantarjian, Courtney D. DiNardo
Journal: Blood
Blood (2024) 144 (Supplement 1): 219.
https://doi.org/10.1182/blood-2024-200393
Published: 2024
Journal Articles

Phase I/II Study of the All-Oral Combination of Revumenib (SNDX-5613) with Decitabine/Cedazuridine (ASTX727) and Venetoclax (SAVE) in R/R AML

Ghayas C. Issa, Branko Cuglievan, Naval Daver, Courtney D. DiNardo, Aziz Farhat, Nicholas J. Short, David McCall, Allison Pike, Sheila Tan, Brianna Kammerer, Aimee Marshal, Musa Yilmaz, Tapan M. Kadia, Naveen Pemmaraju, Maro Ohanian, Hussein A. Abbas, Abhishek Maiti, Alexandre Bazinet, Elias Jabbour, Koji Sasaki, Gautam Borthakur, Guillermo Montalban-Bravo, Nitin Jain, Yesid Alvarado Valero, Farhad Ravandi, Guillermo Garcia-Manero, Michael Andreeff, Hagop M. Kantarjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 216.
https://doi.org/10.1182/blood-2024-204375
Published: 2024
Journal Articles

Combined Pirtobrutinib, Venetoclax, and Obinutuzumab As First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL)

Nitin Jain, Alessandra Ferrajoli, Mahesh Swaminathan, Patrick K. Reville, Jan A. Burger, Vanthana Bharathi, Himachandana Atluri, Hua-Jay J Cherng, Alex Bataller, Elias Jabbour, Tapan M. Kadia, Gautam Borthakur, Koichi Takahashi, Kelly S. Chien, Musa Yilmaz, Naveen Pemmaraju, Naval Daver, Fadi G. Haddad, Yesid Alvarado Valero, Jo Ishizawa, Guillermo Montalban-Bravo, Naveen Garg, Hyunsoo Hwang, Wei Qiao, Cameron Garcia, Anna Evangelio, Ana Ayala, Deepa Sampath, Varsha Gandhi, Michael J. Keating, Hagop M. Kantarjian, William G. Wierda
Journal: Blood
Blood (2024) 144 (Supplement 1): 1011.
https://doi.org/10.1182/blood-2024-211454
Published: 2024
Journal Articles

Early Obinutuzumab Significantly Increases Bone Marrow Undetectable MRD (10 -4 sensitivity) (uMRD4) Rate When Combined with Acalabrutinib and Venetoclax in a Randomized Phase II Trial for Treatment Naïve CLL

Mahesh Swaminathan, Philip A. Thompson, Jan A. Burger, Musa Yilmaz, Nitin Jain, Tapan M. Kadia, Lucia Masarova, Yesid Alvarado Valero, Prithviraj Bose, Alessandra Ferrajoli, Ghayas C. Issa, Steven M. Kornblau, Farhad Ravandi, Koji Sasaki, Gautam Borthakur, Kelly S. Chien, Courtney D. DiNardo, Danielle Hammond, Elias Jabbour, Guillermo Montalban-Bravo, Naveen Pemmaraju, Nicholas J. Short, Koichi Takahashi, Francesco Paolo Tambaro, Wei Qiao, Naveen Garg, Michael J. Keating, William G. Wierda
Journal: Blood
Blood (2024) 144 (Supplement 1): 1855.
https://doi.org/10.1182/blood-2024-211110
Published: 2024