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Ghayas C. Issa
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Journal Articles

How I Treat: Differentiation Therapy in Acute Myeloid Leukemia

Ghayas C. Issa, Eytan M. Stein, Courtney D. D DiNardo
Journal: Blood
Blood blood.2024024008.
https://doi.org/10.1182/blood.2024024008
Published: 2024
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemia: Topline Efficacy and Safety Results from the Pivotal Augment-101 Phase 2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel N. Mannis, Alexander Perl, David S. Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J. Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G. Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-5.
https://doi.org/10.1182/blood-2023-192042
Published: 2023
Journal Articles

Venetoclax abrogates the prognostic impact of splicing factor gene mutations in newly diagnosed acute myeloid leukemia

Clinical Trials & Observations
Jayastu Senapati, Samuel Urrutia, Sanam Loghavi, Nicholas J. Short, Ghayas C. Issa, Abhishek Maiti, Hussein A. Abbas, Naval G. Daver, Naveen Pemmaraju, Sherry Pierce, Kelly S. Chien, Koji Sasaki, Tapan M. Kadia, Danielle E. Hammond, Gautam Borthakur, Keyur Patel, Farhad Ravandi, Hagop M. Kantarjian, Guillermo Garcia-Manero, Courtney D. DiNardo
Journal: Blood
Blood (2023) 142 (19): 1647–1657.
https://doi.org/10.1182/blood.2023020649
Published: 2023
Includes: Supplemental data
Journal Articles

Revumenib Maintenance Therapy Following Revumenib-Induced Remission and Transplant

Andrius Zucenka, Ghayas C. Issa, Martha Arellano, Sajad Khazal, Nandita Khera, Wendy Stock, Branko Cuglievan, Yu Gu, Huy Van Nguyen, Angela R. Smith, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 4950.
https://doi.org/10.1182/blood-2023-189036
Published: 2023
Journal Articles

Asciminib (ASC) Once-Daily (QD) Dosing Demonstrates Comparable Tolerability and Efficacy to Twice-Daily (BID) Dosing: Results from the ASC in Monotherapy 4 CML (AIM4CML) Study in Patients (Pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP)

David Andorsky, Ghayas C. Issa, Edward R Broun, Camille N. Abboud, Michael W. Deininger, Michael Mauro, Andrea Damon, Natasha Porter, Najma Ashraf, Moshe Levy
Journal: Blood
Blood (2023) 142 (Supplement 1): 3172.
https://doi.org/10.1182/blood-2023-187357
Published: 2023
Journal Articles

Phase 2 Study of CPX-351 in Combination with Venetoclax in Patients with Newly Diagnosed, High Risk Acute Myeloid Leukemia

Wei-Ying Jen, Courtney D. DiNardo, Kelly S. Chien, Yesid Alvarado-Valero, Lucia Masarova, Mark Brandt, Debra Bull-Linderman, Naval Daver, Guillermo Montalban-Bravo, Alex Bataller, Guillermo Garcia-Manero, Ghayas C. Issa, Amin Alousi, Nicholas J. Short, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2023) 142 (Supplement 1): 4273.
https://doi.org/10.1182/blood-2023-182969
Published: 2023
Journal Articles

Impact of High-Risk Cytogenetics (HR-CTG) on the Outcome of Newly Diagnosed Adult Patients with Philadelphia Negative B-Cell Acute Lymphoblastic Leukemia (B-ALL) Treated with Frontline Blinatumomab (Blina) and/or Inotuzumab Ozogamicin (Ino) Containing Hypercvad (HCVAD) Therapy

Jayastu Senapati, Elias Jabbour, Nicholas J. Short, Guilin Tang, Fadi G. Haddad, Nitin Jain, Ghayas C. Issa, Tapan M. Kadia, Naval Daver, Alessandra Ferrajoli, Monica Kwari, Guillermo Garcia-Manero, Guillermo Montalban-Bravo, Patrice Eric Nasnas, Naveen Pemmaraju, Rebecca Garris, Farhad Ravandi, Hagop M. Kantarjian
Journal: Blood
Blood (2023) 142 (Supplement 1): 1500.
https://doi.org/10.1182/blood-2023-181379
Published: 2023
Journal Articles

Outcomes of Patients (pts) with Newly Diagnosed Acute Myeloid Leukemia (AML) and TP53 mutation/Loss Treated on the Phase 2 Study of Venetoclax (Ven) Added to Alternating Cladribine (Clad) Plus Low-Dose Cytarabine (LDAC) and Azacitidine (Aza): A Subgroup Analysis

Jayastu Senapati, Sanam Loghavi, Patrick K Reville, Naval Daver, Gautam Borthakur, Courtney D. DiNardo, Elias Jabbour, Nicholas J. Short, Naveen Pemmaraju, Abhishek Maiti, Ghayas C. Issa, Uday R. Popat, Amin Alousi, Elizabeth J. Shpall, Koji Sasaki, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2023) 142 (Supplement 1): 4282.
https://doi.org/10.1182/blood-2023-179380
Published: 2023
Journal Articles

Clinical and Prognostic Implications of WT1 Mutations in De Novo and Relapsed Acute Myeloid Leukemia

Himachandana Atluri, Jeremy DiGennaro, Keyur P. Patel, Mark Routbort, Betul Oran, Ghayas C. Issa, Nicholas J. Short, Naval Daver, Tapan M. Kadia, Farhad Ravandi, Uday R. Popat, Richard E. Champlin, Elizabeth J. Shpall, Sherry Pierce, Rashmi Kanagal-Shamanna, Chi Young Ok, Guilin Tang, Sa A. Wang, Raja Luthra, Audrey Lasry, Bettina Nadorp, Antonia Chroni, Ann-Kathrin Eisfeld, Iannis Aifantis, Najla H Al Ali, David A Sallman, Jeffrey Lancet, Onyee Chan, Eric Padron, Zhuoer Xie, L. Jeffrey Medeiros, Courtney D. DiNardo, Rami S. Komrokji, Sanam Loghavi
Journal: Blood
Blood (2023) 142 (Supplement 1): 959.
https://doi.org/10.1182/blood-2023-188319
Published: 2023
Journal Articles

Azacitidine Plus Venetoclax Maintenance in Acute Myeloid Leukemia Produces Sustained Remissions with Low Toxicity: Results of a Phase 2 Study

Alexandre Bazinet, Hagop M. Kantarjian, Gautam Borthakur, Musa Yilmaz, Prithviraj Bose, Elias Jabbour, Yesid Alvarado Valero, Kelly S. Chien, Naveen Pemmaraju, Koichi Takahashi, Nicholas J. Short, Naval Daver, Ghayas C. Issa, Nitin Jain, Danielle E. Hammond, Debra Bull-Linderman, Courtney D. DiNardo, Jan A. Burger, Alessandra Ferrajoli, Guillermo Montalban-Bravo, Koji Sasaki, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2023) 142 (Supplement 1): 2884.
https://doi.org/10.1182/blood-2023-172882
Published: 2023
Journal Articles

Influence of Co-Mutational Patterns in Disease Phenotype and Clinical Outcomes of Chronic Myelomonocytic Leukemia

Guillermo Montalban-Bravo, David Swanson, Rashmi Kanagal-Shamanna, Juan Jose Rodriguez-Sevilla, Danielle E. Hammond, Kelly S. Chien, Koji Sasaki, Elias Jabbour, Courtney D. DiNardo, Koichi Takahashi, Nicholas J. Short, Ghayas C. Issa, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Naval Daver, Gautam Borthakur, Sanam Loghavi, Sherry Pierce, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 4601.
https://doi.org/10.1182/blood-2023-178061
Published: 2023
Journal Articles

Validation of the Prognostic Risk Signatures for Older Patients with Acute Myeloid Leukemia Treated with Hypomethylating Agents and Venetoclax

Alex Bataller, Alexandre Bazinet, Courtney D. DiNardo, Gautam Borthakur, Nicholas J. Short, Elias Jabbour, Koichi Takahashi, Naval Daver, Ghayas C. Issa, Naveen Pemmaraju, Nitin Jain, Guillermo Montalban-Bravo, William G. Wierda, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M. Kantarjian, Tapan M. Kadia
Journal: Blood
Blood (2023) 142 (Supplement 1): 4228.
https://doi.org/10.1182/blood-2023-182841
Published: 2023
Journal Articles

A Phase II Study of Low-Intensity Chemotherapy (Mini-Hyper-CVD) and Ponatinib Followed By Blinatumomab and Ponatinib in Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Wei-Ying Jen, Elias Jabbour, Fadi G. Haddad, Lewis Nasr, Nicholas J. Short, Marianne Zoghbi, Cedric Nasnas, Ghayas C. Issa, Musa Yilmaz, Naval Daver, Naveen Pemmaraju, Lucia Masarova, Farhad Ravandi, Nitin Jain, Wuliamatu Deen, Christopher Loiselle, Lourdes Waller, Glenda Banks, Rebecca Garris, Hagop M. Kantarjian
Journal: Blood
Blood (2023) 142 (Supplement 1): 2868.
https://doi.org/10.1182/blood-2023-182997
Published: 2023
Journal Articles

ASC4START and ASC4FIRST: Two Ongoing Phase 3 Trials Investigating Asciminib Monotherapy As First-Line Therapy Versus Tyrosine Kinase Inhibitors in Patients with Newly Diagnosed Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase

Andreas Hochhaus, Jorge Cortes, Naoto Takahashi, Richard A. Larson, Ghayas C. Issa, Felice Bombaci, Susanne Saussele, Francois Mahon, Tim H. Brümmendorf, Shruti Kapoor, Tracey McCulloch, Peter Schuld, Timothy P Hughes
Journal: Blood
Blood (2023) 142 (Supplement 1): 6388.
https://doi.org/10.1182/blood-2023-186773
Published: 2023
Journal Articles

Early Results of the Phase I/II Study Investigating the All-Oral Combination of the Menin Inhibitor Revumenib (SNDX-5613) with Decitabine/Cedazuridine (ASTX727) and Venetoclax in Acute Myeloid Leukemia (SAVE)

Ghayas C. Issa, Branko Cuglievan, Courtney D. DiNardo, Nicholas J. Short, David McCall, Amber Gibson, Cesar Nunez, Miriam B. Garcia, Michael Roth, Aram Bidikian, Allison Pike, Sheila Tan, Brianna Kammerer, Musa Yilmaz, Tapan M. Kadia, Naveen Pemmaraju, Maro Ohanian, Naval Daver, Elias Jabbour, Gautam Borthakur, Farhad Ravandi, Guillermo Garcia-Manero, Michael Andreeff, Hagop M. Kantarjian
Journal: Blood
Blood (2023) 142 (Supplement 1): 58.
https://doi.org/10.1182/blood-2023-182337
Published: 2023
Journal Articles

Phase II Trial of 10-Day ASTX727 (Decitabine/Cedazuridine) with Venetoclax for Relapsed or Refractory Acute Myeloid Leukemia

Abhishek Maiti, Courtney D. DiNardo, Maro Ohanian, Naval Daver, Gautam Borthakur, Kelly S. Chien, Ghayas C. Issa, Koichi Takahashi, Lucia Masarova, Yesid Alvarado Valero, Elias Jabbour, William G. Wierda, Nicholas J. Short, Melissa MacFarland, Allison Pike, Tapan M. Kadia, Farhad Ravandi, Hagop M. Kantarjian, Guillermo Garcia-Manero, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4289.
https://doi.org/10.1182/blood-2023-182901
Published: 2023
Journal Articles

Nelarabine (NEL), Pegylated Asparginase (PEG) and Venetoclax (VEN) Incorporated to HCVAD Chemotherapy in the Frontline Treatment of Adult Patients with T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma (T-ALL/T-LBL)

Jayastu Senapati, Hagop M. Kantarjian, Elias Jabbour, Rodrick Babakhanlou, Tapan M. Kadia, Gautam Borthakur, Marina Y. Konopleva, William G. Wierda, Jan A. Burger, Ghayas C. Issa, Abhishek Maiti, Hayley S. Balkin, Mary Kelly, Rebecca Garris, Alessandra Ferrajoli, Guillermo Garcia-Manero, Yesid Alvarado Valero, Partow Kebriaei, Nicholas J. Short, Nitin Jain, Farhad Ravandi
Journal: Blood
Blood (2023) 142 (Supplement 1): 963.
https://doi.org/10.1182/blood-2023-179562
Published: 2023
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemias: Efficacy and Safety Results from the Augment-101 Phase 1/2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael J Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel Mannis, Alexander Perl, David Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2023-189762
Published: 2023
Journal Articles

NPM1-Mutated Myeloid Neoplasms: Updated Outcomes with High-Intensive Chemotherapy Regardless of the Blast Percentage

Georgina Gener-Ricos, Alex Bataller, Emmanuel Almanza-Huante, Kelly S. Chien, Danielle E. Hammond, Koji Sasaki, Courtney D. DiNardo, Tapan M. Kadia, Naval Daver, Gautam Borthakur, Ghayas C. Issa, Nicholas J. Short, Guillermo Garcia-Manero, Guillermo Montalban-Bravo
Journal: Blood
Blood (2023) 142 (Supplement 1): 957.
https://doi.org/10.1182/blood-2023-187676
Published: 2023
Journal Articles

Cladribine with Low Dose Cytarabine and Venetoclax Alternated with Azacytidine and Venetoclax for Acute Myeloid Leukemia: Prognostic Analysis of a Phase 2 Clinical Trial

Alex Bataller, Alexandre Bazinet, Gautam Borthakur, Nicholas J. Short, Elias Jabbour, Koichi Takahashi, Naval Daver, Ghayas C. Issa, Courtney D. DiNardo, Naveen Pemmaraju, Nitin Jain, Guillermo Montalban-Bravo, William G. Wierda, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M. Kantarjian, Tapan M. Kadia
Journal: Blood
Blood (2023) 142 (Supplement 1): 4256.
https://doi.org/10.1182/blood-2023-182250
Published: 2023