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Journal Articles

Risk prediction for clonal cytopenia: multicenter real-world evidence

Clinical Trials & Observations
Zhuoer Xie, Rami Komrokji, Najla Al Ali, Alexandra Regelson, Susan Geyer, Anand Patel, Caner Saygin, Amer M. Zeidan, Jan Philipp Bewersdorf, Lourdes Mendez, Ashwin Kishtagari, Joshua F. Zeidner, Catherine C. Coombs, Yazan F. Madanat, Stephen Chung, Talha Badar, James Foran, Pinkal Desai, Charlton Tsai, Elizabeth A. Griffiths, Monzr M. Al Malki, Idoroenyi Amanam, Catherine Lai, H. Joachim Deeg, Lionel Ades, Cecilia Arana Yi, Afaf E. G. Osman, Shira Dinner, Yasmin Abaza, Justin Taylor, Namrata Chandhok, Deborah Soong, Andrew M. Brunner, Hetty E. Carraway, Abhay Singh, Chiara Elena, Jacqueline Ferrari, Anna Gallì, Sara Pozzi, Eric Padron, Mrinal M. Patnaik, Luca Malcovati, Michael R. Savona, Aref Al-Kali
Journal: Blood
Blood (2024) 144 (19): 2033–2044.
https://doi.org/10.1182/blood.2024024756
Published: 2024
Includes: Supplemental data
Journal Articles

T-Cells Immune Cluster Analysis Using Cytof Identifies Unique Patient Subgroups with TP53 Mutation and Predicts Complete Remission (CR) in Patients with Acute Myeloid Leukemia (AML) Receiving Venetoclax Plus Hypomethylating Agent Therapy

Talha Badar, Keith Knutson, James M. Foran, Naseema Gangat, Kevin Pavelko, Scott H. Kaufmann, Mark R. Litzow, Hemant S. Murthy, Davitte Cogen, Margaret Ushman, Arini Arsana, Aref Al-Kali, Hassan Alkhateeb, Ayalew Tefferi, Mrinal M. Patnaik, Mithun V Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 1563.
https://doi.org/10.1182/blood-2023-185654
Published: 2023
Journal Articles

Venetoclax + Cladribine + Low-Dose Cytarabine in Acute Myeloid Leukemia Relapsed or Refractory to Venetoclax + Hypomethylating Agent

Nickolas Steinauer, Kristen McCullough, Aref Al-Kali, Hassan Alkhateeb, Kebede Begna, Abhishek A Mangaonkar, Antoine Saliba, Mehrdad Hefazi, Mark R. Litzow, William J. Hogan, Mithun V Shah, Animesh D. Pardanani, Talha Badar, Hemant S. Murthy, James M. Foran, Cecilia Y. Arana Yi, Ayalew Tefferi, Naseema Gangat
Journal: Blood
Blood (2023) 142 (Supplement 1): 2853.
https://doi.org/10.1182/blood-2023-185185
Published: 2023
Journal Articles

Type 1/like Calr Mutation in Momelotinib-Treated Patients with Myelofibrosis Is the Most Prominent Predictor of Drug Survival and Longevity without Transplant

Ayalew Tefferi, Animesh D. Pardanani, Kebede Begna, Aref Al-Kali, William J. Hogan, Mark R. Litzow, Naseema Gangat
Journal: Blood
Blood (2023) 142 (Supplement 1): 4555.
https://doi.org/10.1182/blood-2023-178869
Published: 2023
Journal Articles

Phase 1/2 Multicenter, Open-Label Study of CTX-712 in Patients with Relapsed/Refractory Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndromes

Aref Al-Kali, Antoine Saliba, Cecilia Y. Arana Yi, James M. Foran, Yasushi Tanoue, Maki Yamamoto, Joachim Gullbo, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 3249.
https://doi.org/10.1182/blood-2023-173496
Published: 2023
Journal Articles

Comparison of World Health Organization and International Consensus Classification Guidelines for Myeloid Neoplasms Harboring TP53 -Mutations Using an Independent International Cohort

Mithun V Shah, Monika Kutyna, Syed Shah, Elizabeth Ngoc Hoa Tran, Anmol Baranwal, Dariusz Ladon, Aref Al-Kali, Anna Brown, Dong Chen, Patricia Greipp, Kebede Begna, Mark R. Litzow, William J. Hogan, Peter Bardy, Sharad Kumar, David T Yeung, Mrinal M. Patnaik, James M. Foran, Rong He, Naseema Gangat, Hamish S Scott, Cecilia Y. Arana Yi, Hassan Alkhateeb, Abhishek A Mangaonkar, Daniel Thomas, Christopher Norman Hahn, Attilio Orazi, Daniel A. Arber, Chung Hoow Kok, Ayalew Tefferi, Devendra Hiwase
Journal: Blood
Blood (2023) 142 (Supplement 1): 3243.
https://doi.org/10.1182/blood-2023-187860
Published: 2023
Journal Articles

Survival and Prognosis Among 301 Patients with Newly-Diagnosed Acute Myeloid Leukemia Following Venetoclax Plus Hypomethylating Agent Therapy

Omer Karrar, Moazah Iftikhar, Kristen McCullough, Isla Johnson, Maymona Abdelmagid, Aref Al-Kali, Hassan Alkhateeb, Kebede Begna, Abhishek A Mangaonkar, Antoine Saliba, Mehrdad Hefazi, Mark R. Litzow, William J. Hogan, Mithun V Shah, Mrinal M. Patnaik, Animesh D. Pardanani, Talha Badar, Hemant S. Murthy, James M. Foran, Jeanne Palmer, Lisa Sproat, Nandita Khera, Cecilia Y. Arana Yi, Ayalew Tefferi, Naseema Gangat
Journal: Blood
Blood (2023) 142 (Supplement 1): 591.
https://doi.org/10.1182/blood-2023-178837
Published: 2023
Journal Articles

Older Adults with Acute Myeloid Leukemia (AML) Experience Improvement in Health-Related Quality of Life (HRQoL) Scores with Intensive Therapy: Prospective Study from ECOG-ACRIN (EA) E2906 Phase 3 Trial

James M. Foran, Li Chen, Selina M Luger, Zhuoxin Sun, Heidi Klepin, David F. Claxton, Hillard M. Lazarus, Jacob M. Rowe, Jessica K. Altman, Aref Al-Kali, Hong Zheng, Keith W Pratz, Edward R. Broun, Bayard L Powell, Kristen M. O'Dwyer, Yishai Ofran, John E. Godwin, Mark R. Litzow, Martin S. Tallman, Lynne Wagner
Journal: Blood
Blood (2023) 142 (Supplement 1): 594.
https://doi.org/10.1182/blood-2023-189734
Published: 2023
Journal Articles

Clinical and Molecular Spectrum of Somatic Mosaic States in DDX41 mutant Germline Predisposition Syndromes

Talha Badar, Terra L Lasho, Yael Kusne, Ludovica Marando, Abhishek A Mangaonkar, Christy M Finke, James M. Foran, Aref Al-Kali, Hassan Alkhateeb, Naseema Gangat, Rong He, David Viswanatha, Mark R. Litzow, Timothy Chlon, Alejandro Ferrer, Mrinal M. Patnaik
Journal: Blood
Blood (2023) 142 (Supplement 1): 4618.
https://doi.org/10.1182/blood-2023-187310
Published: 2023
Journal Articles

Reclassification of Ascertain (ASTX727-02) Myelodysplastic Syndrome (MDS) Patients: Outcomes Including Clinical Response, Overall Survival (OS), and Leukemia Free Survival (LFS) Based on IPSS-R and IPSS-M Scoring Systems

Guillermo Garcia-Manero, James McCloskey, Elizabeth A. Griffiths, Amer M. Zeidan, Karen W.L. Yee, Aref Al-Kali, H. Joachim Deeg, Prapti A. Patel, Mitchell Sabloff, Mary-Margaret Keating, Nancy Zhu, Nashat Y. Gabrail, Salman Fazal, Joseph J. Maly, Olatoyosi Odenike, Hagop M. Kantarjian, Amy E. DeZern, Casey L. O'Connell, Gail J. Roboz, Lambert Busque, Rena Buckstein, Harsh Amin, Jasleen K. Randhawa, Brian Leber, Shannon Lee, Winny Chan, Sonia Souza, Yuri Sano, Harold N. Keer, Michael R. Savona
Journal: Blood
Blood (2023) 142 (Supplement 1): 4619.
https://doi.org/10.1182/blood-2023-188258
Published: 2023
Journal Articles

STAG2 and PHF6 : Comparison of 2 X-Linked Gene Mutations in Myeloid Neoplasms

Bahga Katamesh, Amrutha Mittapalli, Rong He, David Viswanatha, Dragan Jevremovic, Mehrdad Hefazi, Antoine Saliba, Abhishek A Mangaonkar, Kebede Begna, William J. Hogan, Naseema Gangat, Mrinal M. Patnaik, Mithun V Shah, Ayalew Tefferi, Mark R. Litzow, Hassan Alkhateeb, Aref Al-Kali
Journal: Blood
Blood (2023) 142 (Supplement 1): 4304.
https://doi.org/10.1182/blood-2023-178244
Published: 2023
Journal Articles

ASXL1 Mutation and Leukocytosis Undermine Spleen Response to Pacritinib in Myelofibrosis

Maymona Abdelmagid, Jeanne Palmer, James M. Foran, Aref Al-Kali, Omer Karrar, Kaaren K. Reichard, Animesh D. Pardanani, Naseema Gangat, Ayalew Tefferi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3194.
https://doi.org/10.1182/blood-2023-180235
Published: 2023
Journal Articles

Prognostic Relevance of Truncating ASXL1 Mutations and ASXL1 -Integrated Molecular Models in Proliferative CMML

Clifford M Csizmar, Mark Gurney, Terra L Lasho, Rashmi Kanagal-Shamanna, Kelly S. Chien, Danielle E. Hammond, Christy M Finke, Abhishek A Mangaonkar, Aref Al-Kali, Naseema Gangat, Ayalew Tefferi, Hassan Alkhateeb, Guillermo Garcia-Manero, Guillermo Montalban-Bravo, Mrinal M. Patnaik
Journal: Blood
Blood (2023) 142 (Supplement 1): 3241.
https://doi.org/10.1182/blood-2023-186881
Published: 2023
Journal Articles

Single-Hit TP53 mut Is Associated with Poor Outcomes in Therapy-Related but Not De Novo Myelodysplastic Syndromes: Importance of Clinical History

Devendra Hiwase, Anmol Baranwal, Syed Shah, Monika Kutyna, Christopher Norman Hahn, Maymona Abdelmajid, Danielle Rud, Rakchha Chhetri, Kaaren K. Reichard, Dong Chen, Thomas Wiseman, Anna Brown, Hamish S Scott, David T Yeung, David M. Ross, Daniel Thomas, Aref Al-Kali, Hassan Alkhateeb, James M. Foran, Cecilia Y. Arana Yi, Naseema Gangat, Mrinal M. Patnaik, Ayalew Tefferi, Chung Hoow Kok, Rong He, Mithun V Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 4608.
https://doi.org/10.1182/blood-2023-187905
Published: 2023
Journal Articles

IPSS-M - Use for Predicting Survival and Progression in Patients with Ccus - a Retrospective Multi-Institutional Study

Ahmad Nanaa, Aref Al-Kali, Dragan Jevremovic, Phuong L. Nguyen, Patricia Greipp, Rong He, Mrinal M. Patnaik, Abhishek A Mangaonkar, Hassan Alkhateeb, Julia Anderson, Weina Chen, Olga Weinberg, Stephen Chung, Yazan F. Madanat
Journal: Blood
Blood (2023) 142 (Supplement 1): 4590.
https://doi.org/10.1182/blood-2023-191048
Published: 2023
Journal Articles

TP53 Variant Allele Frequency and Therapy-Related Setting Independently Predict Survival in Myelodysplastic Syndromes with Del(5q)

Farah Fleti, Onyee Chan, Najla H Al Ali, Aref Al-Kali, Kebede Begna, James M. Foran, Talha Badar, Nandita Khera, Mithun V Shah, Devendra Hiwase, Eric Padron, David A Sallman, Animesh D. Pardanani, Daniel A. Arber, Attilio Orazi, Kaaren K. Reichard, Rong He, Rhett Ketterling, Naseema Gangat, Rami S. Komrokji, Ayalew Tefferi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3234.
https://doi.org/10.1182/blood-2023-185023
Published: 2023
Journal Articles

Venetoclax (VEN) Improves Response Rates but Not Survival in Patients with Chronic Myelomonocytic Leukemia (CMML) Treated with Hypomethylating Agents (HMA): A Multicenter, Propensity Score Analysis

Douglas Tremblay, Clifford M Csizmar, Courtney D. DiNardo, Somedeb Ball, Noa Rippel, Danielle E. Hammond, Tapan M. Kadia, Farhad Ravandi, Kelly S. Chien, Grace Van Hyfte, Antoine Saliba, Abhishek A Mangaonkar, Terra L Lasho, Aref Al-Kali, Marina Kremyanskaya, Jonathan Feld, Lewis R Silverman, Rami S. Komrokji, John Mascarenhas, Eric Padron, Guillermo Garcia-Manero, David A Sallman, Mrinal M. Patnaik, Guillermo Montalban-Bravo
Journal: Blood
Blood (2023) 142 (Supplement 1): 321.
https://doi.org/10.1182/blood-2023-181795
Published: 2023
Journal Articles

ELN 2022 Favorable Genetic Risk Acute Myeloid Leukemia Treated with Venetoclax Plus Hypomethylating Agent: Predictors of Response and Survival

Kristen McCullough, Omer Karrar, Moazah Iftikhar, Maymona Abdelmagid, Aref Al-Kali, Hassan Alkhateeb, Kebede Begna, Abhishek A Mangaonkar, Antoine Saliba, Mehrdad Hefazi, Mark R. Litzow, William J. Hogan, Mithun V Shah, Mrinal M. Patnaik, Animesh D. Pardanani, Ayalew Tefferi, Naseema Gangat
Journal: Blood
Blood (2023) 142 (Supplement 1): 5925.
https://doi.org/10.1182/blood-2023-182326
Published: 2023
Journal Articles

TP53 mutation in therapy-related myeloid neoplasm defines a distinct molecular subtype

Devendra Hiwase, Christopher Hahn, Elizabeth Ngoc Hoa Tran, Rakchha Chhetri, Anmol Baranwal, Aref Al-Kali, Kirsty Sharplin, Dariusz Ladon, Rachel Hollins, Patricia Greipp, Monika Kutyna, Hassan Alkhateeb, Talha Badar, Paul Wang, David M. Ross, Deepak Singhal, Naranie Shanmuganathan, Peter Bardy, Ashanka Beligaswatte, David Yeung, Mark R. Litzow, Abhishek Mangaonkar, Pratyush Giri, Cindy Lee, Angie Yong, Noemi Horvath, Nimit Singhal, Raghu Gowda, William Hogan, Naseema Gangat, Mrinal Patnaik, Kebede Begna, Ing S. Tiong, Andrew Wei, Sharad Kumar, Anna Brown, Hamish Scott, Daniel Thomas, Chung H. Kok, Ayalew Tefferi, Mithun Vinod Shah
Journal: Blood
Blood (2023) 141 (9): 1087–1091.
https://doi.org/10.1182/blood.2022018236
Published: 2023
Includes: Supplemental data
Journal Articles

Venetoclax Plus Hypomethylating Agent (HMA) Based Induction for Treatment-Naive Older/Unfit Patients with FLT3 -Mutated Acute Myeloid Leukemia (AML)

Ahmad Ghorab, Mark R. Litzow, Naseema Gangat, Aref Al-Kali, Mithun V. Shah, Hemant S. Murthy, Ayalew Tefferi, Hassan B. Alkhateeb, Kebede Begna, Mrinal M. Patnaik, James M. Foran, Talha Badar
Journal: Blood
Blood (2022) 140 (Supplement 1): 9019–9020.
https://doi.org/10.1182/blood-2022-168303
Published: 2022