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Yasuhito Nannya
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Journal Articles

Comprehensive Molecular and Functional Analysis of NUTM1-Rearranged Leukemia

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Koutarou Nishimura, Tomoya Isobe, Tsukasa Shigehiro, Masaki Nomura, Weijia Zang, Muran Xiao, Wenjuan Liao, Yui Koike, Akira Nishimura, Aiko Sato-Otsubo, Hiromi Yamazaki, Hiromi Ito, Shinri Okada, Naomi Matsumoto, Wataru Saika, Yifan Zhang, Yumi Aoyama, Chihiro Hasegawa, Takaya Yamasaki, Yasuo Kubota, Kentaro Oki, Nobutaka Kiyokawa, Genta Nagae, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Mariko Eguchi, Yuki Arakawa, Katsuyoshi Koh, Takao Deguchi, Daisuke Tomizawa, Takako Miyamura, EIICHI ISHII, Shuki Mizutani, Satoru Miyano, Hiroyuki Aburatani, Seishi Ogawa, Akifumi Takaori-Kondo, Akihiko Yokoyama, Omar Abdel-Wahab, Patricia Ernst, Junko Takita, Tomokatsu Ikawa, Masatoshi Takagi, Daichi Inoue
Journal: Blood
Blood blood.2024026928.
https://doi.org/10.1182/blood.2024026928
Published: 2025
Includes: Supplemental data
Journal Articles

Bone marrow environmental alterations underlie proliferative clonal expansion in clonal hematopoiesis

Free
Masahiro Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Masanori Motomura, Ryunosuke Saiki, Yotaro Ochi, Ayana Kon, Lanying Zhao, Koji Okazaki, Xingxing Qi, Akinori Yoda, Nobuyuki Kakiuchi, Shuichi Matsuda, Seishi Ogawa
Journal: Blood
Blood (2025) 146 (Supplement 1): 632.
https://doi.org/10.1182/blood-2025-632
Published: 2025
Journal Articles

The prognostic significance (or lack) of achieving marrow complete remission (mCR) with hypomethylating agent-based therapy in patients with myelodysplastic syndrome

Free
Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica Stempel, Luca Lanino, Najla Al Ali, Amy DeZern, Mikkael Sekeres, Geoffrey Uy, Samuel Urrutia, Hetty Carraway, Pinkal Desai, Elizabeth Griffiths, Eytan Stein, Andrew Brunner, Christine McMahon, Rory Shallis, Joshua Zeidner, Michael Savona, Namrata Chandhok, Constantine Logothetis, Aram Bidikian, Theodore Getz, Gail Roboz, Eunice Wang, Maria Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan Madanat, Yasmin Abaza, Talha Badar, Jaclynn Campos, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop Enjeti, Kamal Alrabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Matteo Della Porta, Rami Komrokji, Amer Zeidan, Maximilian Stahl
Journal: Blood
Blood (2025) 146 (Supplement 1): 3865.
https://doi.org/10.1182/blood-2025-3865
Published: 2025
Journal Articles

Clinical implications of TP53 mutations (TP53MT) in patients (pts) with higher risk Myelodysplastic Syndromes (HR-MDS) treated with hypomethylating agents (HMA) and allogeneic hematopoietic transplantation (allo-HCT): An analysis from the international consortium of MDS (icMDS) validate database

Free
Tariq Kewan, Jan Philipp Bewersdorf, Luca Lanino, Ondrej Blaha, Jessica Stempel, Najla Al Ali, Amy DeZern, Mikkael Sekeres, Geoffrey Uy, Samuel Urrutia, Hetty Carraway, Pinkal Desai, Elizabeth Griffiths, Eytan Stein, Andrew Brunner, Christine McMahon, Rory Shallis, Joshua Zeidner, Michael Savona, Namrata Chandhok, Constantine Logothetis, Aram Bidikian, Theodore Getz, Gail Roboz, Benjamin Rolles, Eunice Wang, Amyah Harris, Maria Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan Madanat, Yasmin Abaza, Talha Badar, Jaclynn Campos, Torsten Haferlach, Jaroslaw Maciejewski, Anoop Enjeti, Kamal Al-Rabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Rami Komrokji, Maximilian Stahl, Matteo Della Porta, David Sallman, Amer Zeidan
Journal: Blood
Blood (2025) 146 (Supplement 1): 3863.
https://doi.org/10.1182/blood-2025-3863
Published: 2025
Journal Articles

Comparative evaluation of ipss-m and cpss-mol in CMML: Impact of molecular markers on prognosis

Free
Alexander Streuer, Yotaro Ochi, Yasuhito Nannya, Laurenz Steiner, Vladimir Riabov, Mohammed Abba, Eva Altrock, Felicitas Rapp, Verena Nowak, Georgia Metzgeroth, Seishi Ogawa, Wolf-Karsten Hofmann, Nanni Schmitt
Journal: Blood
Blood (2025) 146 (Supplement 1): 3860.
https://doi.org/10.1182/blood-2025-3860
Published: 2025
Journal Articles

Functional classification of monoallelic TP53 mutations refines prognostic stratification in myelodysplastic neoplasms

Free
Alexander Streuer, Vladimir Riabov, Yotaro Ochi, Yasuhito Nannya, Laurenz Steiner, Mohammed Abba, Georgia Metzgeroth, Eva Altrock, Felicitas Rapp, Verena Nowak, Daniel Nowak, Seishi Ogawa, Wolf-Karsten Hofmann, Nanni Schmitt
Journal: Blood
Blood (2025) 146 (Supplement 1): 3835.
https://doi.org/10.1182/blood-2025-3835
Published: 2025
Journal Articles

Single-cell multiomic profiling of gene mutation, chromatin accessibility, and gene expression in TET2-mutant clonal hematopoiesis

Free
Masanori Motomura, Yotaro Ochi, Yasuhito Nannya, Nobuyuki Kakiuchi, Nobuo Sezaki, Senji Kasahara, Tomoe Nakagawa, Lanying Zhao, Shuichi Matsuda, Masahiro Nakagawa, Seishi Ogawa
Journal: Blood
Blood (2025) 146 (Supplement 1): 3164.
https://doi.org/10.1182/blood-2025-3164
Published: 2025
Journal Articles

Repertoire of driver events in coding and non-coding regions identified by whole-genome sequencing of myeloid neoplasms

Free
Koji Okazaki, Ryunosuke Saiki, Yotaro Ochi, Kenichi Yoshida, Kotoe Katayama, Hidehito Fukushima, Kaito Mimura, Masahiro Nakagawa, Masanori Motomura, Akinori Yoda, Rurika Okuda, Lanying Zhao, Motohiro Kato, Tatsuki Ogasawara, Shigeo Fuji, Lee-Yung Shih, Nobuhiko Uoshima, Mitsumasa Watanabe, Yasushi Miyazaki, Motoshi Ichikawa, Takeshi Maeda, Toshiyuki Kitano, Satoshi Yoshihara, Kazunori Imada, Kinuko Mitani, Joop Jansen, Mamiko Sakata-Yanagimoto, Luca Malcovati, Akihiko Gotoh, Hitoshi Kiyoi, Nobuhiro Kanemura, Nobuo Sezaki, Nobuhiro Hiramoto, Senji Kasahara, Seiya Imoto, Akifumi Takaori-Kondo, Yasuhito Nannya, Seishi Ogawa
Journal: Blood
Blood (2025) 146 (Supplement 1): 1450.
https://doi.org/10.1182/blood-2025-1450
Published: 2025
Journal Articles

Transcriptional and splicing dysregulation by U2AF1 mutations contribute to inflammatory and migratory alterations in MDS

Free
Yuki Hodo, Azumi Tomita, Xingxing Qi, Manabu Nakayama, Haruhiko Koseki, Yasuhito Nannya, Seishi Ogawa, Ayana Kon
Journal: Blood
Blood (2025) 146 (Supplement 1): 5018.
https://doi.org/10.1182/blood-2025-5018
Published: 2025
Journal Articles

Single-cell multi-omics uncovers differentiation-dependent transcriptional programs shaping epigenetic subgroups in AML

Free
Yotaro Ochi, Markus Liew-Littorin, Yasuhito Nannya, Sofia Bengtzen, Benedicte Piauger, Stefan Deneberg, Martin Jadersten, Vladimir Lazarevic, Jörg Cammenga, Anna Robelius, Lovisa Wennström, Emma Olander, Senji Kasahara, Nobuhiro Hiramoto, Nobuhiro Kanemura, Nobuo Sezaki, Maki Sakurada, Makoto Iwasaki, Junya Kanda, Yasunori Ueda, Satoshi Yoshihara, Tom Erkers, Nona Struyf, Yu Watanabe, Masanori Motomura, Masahiro Nakagawa, Ryunosuke Saiki, Hidehito Fukushima, Koji Okazaki, Suguru Morimoto, Akinori Yoda, Rurika Okuda, Shintaro Komatsu, Guoxiang Xie, Albin Osterroos, Ayana Kon, Lanying Zhao, Yuichi Shiraishi, Takayuki Ishikawa, Satoru Miyano, Shuichi Matsuda, Akifumi Takaori-Kondo, Hiroyuki Aburatani, Hiroshi Suzuki, Olli Kallioniemi, Gunnar Juliusson, Martin Höglund, Soren Lehmann, Seishi Ogawa
Journal: Blood
Blood (2025) 146 (Supplement 1): 5005.
https://doi.org/10.1182/blood-2025-5005
Published: 2025
Journal Articles

Outcomes of patients (pts) with higher-risk myelodysplastic syndromes (HR-MDS) treated with hypomethylating agents (HMA) + venetoclax (VEN) – a large analysis from the international consortium for MDS (icMDS) validate database

Free
Jan Philipp Bewersdorf, Tariq Kewan, Luca Lanino, Wei Wei, Najla Al Ali, Amy DeZern, Mikkael Sekeres, Geoffrey Uy, Samuel Urrutia, Hetty Carraway, Pinkal Desai, Elizabeth Griffiths, Eytan Stein, Andrew Brunner, Christine McMahon, Rory Shallis, Joshua Zeidner, Michael Savona, Hayley Hawkins, Namrata Chandhok, Constantine Logothetis, Aram Bidikian, Theodore Getz, Gail Roboz, Benjamin Rolles, Eunice Wang, Amyah Harris, Maria Amaya, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan Madanat, Yasmin Abaza, Jaclynn Campos, Talha Badar, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop Enjeti, Kamal Alrabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Max Stahl, Matteo Della Porta, Rami Komrokji, Amer Zeidan
Journal: Blood
Blood (2025) 146 (Supplement 1): 606.
https://doi.org/10.1182/blood-2025-606
Published: 2025
Journal Articles

Requirements for achievement of treatment-free remission in long-term survivor of multiple myeloma

Free
Masataka Takeshita, Nobuyuki Kodama, Tomoko Hishima, Hiroshi Suzuki, Chigusa Kitayama, Risen Hirai, Akira Tanimura, Seishi Ogawa, Yasuhito Nannya, Akiyoshi Miwa
Journal: Blood
Blood (2025) 146 (Supplement 1): 7539.
https://doi.org/10.1182/blood-2025-7539
Published: 2025
Journal Articles

Molecular Taxonomy Classification for Transplant Decision Making of Myelodysplastic Syndromes

Free
Rurika Okuda, Yotaro Ochi, Tetsuichi Yoshizato, Yasuhito Nannya, Yoshiko Atsuta, Yuichi Shiraishi, Yusuke Shiozawa, Hiroko Tanaka, Makoto Onizuka, Kenichi Chiba, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Keizo Horibe, Satoru Miyano, Hideki Makishima, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3203.
https://doi.org/10.1182/blood-2024-206498
Published: 2024
Journal Articles

Installment of Automation and Modernized Culture Methods Updates a Drug-Sensitivity Screening Platform and Paves the Way to Next-Generation of Precision Medicine

Free
Kimihito Cojin Kawabata, Chao Li, Hideaki Kakinuma, Yoshiharu Takama, Hayato Tsuji, Hironobu Komori, Bo Gong, Yasumasa Kimura, Hideki Tanomura, Atsushi Okamoto, Maiko Morita, Hiroyuki Takamori, Hidehito Fukushima, Kazuaki Yokoyama, Takaaki Konuma, Nobuhiro Ohno, Susumu Goyama, Satoshi Yamazaki, Tetsushi Oka, Gen Kudo, Ari M Melnick, Yasuhito Nannya, Seiya Imoto, Satoshi Takahashi
Journal: Blood
Blood (2024) 144 (Supplement 1): 7475.
https://doi.org/10.1182/blood-2024-199921
Published: 2024
Journal Articles

Impact of Response to Hypomethylating Agent-Based Therapy on Survival Outcomes in the Context of Baseline Clinical-Molecular Risk and Transplant Status in Patients with Myelodysplastic Syndromes/Neoplasms (MDS): An Analysis from the International Consortium for MDS (icMDS) Validate Database

Free
Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica M. Stempel, Luca Lanino, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine M. McMahon, Rory M. Shallis, Joshua F Zeidner, Michael R. Savona, Stacey M. Frumm, Shougat Barua, Namrata S. Chandhok, Constantine Logothetis, Aram Bidikian, Ted M. Getz, Gail J. Roboz, Eunice S. Wang, Amyah C. Harris, Maria L Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Zhuoer Xie, Yazan F Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop K Enjeti, Kamal Al-Rabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vassiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Matteo Giovanni Della Porta, Rami S. Komrokji, Amer M. Zeidan, Maximilian Stahl
Journal: Blood
Blood (2024) 144 (Supplement 1): 664.
https://doi.org/10.1182/blood-2024-208034
Published: 2024
Journal Articles

Clinical Outcomes and Variability Based on Baseline Cytogenetic Risk of Patients with MDS Treated with Hypomethylating Agents: An Analysis from the International Consortium for MDS (icMDS) Validate Database

Free
Ted M. Getz, Tariq Kewan, Jan Philipp Bewersdorf, Jessica M. Stempel, Luca Lanino, Wei Wei, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine M. McMahon, Rory M. Shallis, Joshua F Zeidner, Michael R. Savona, Somedeb Ball, Namrata S. Chandhok, Constantine Logothetis, Aram Bidikian, Gail J. Roboz, Benjamin Rolles, Eunice S. Wang, Amyah C. Harris, Maria L Amaya, Hayley Hawkins, Justin Grenet, Zhuoer Xie, Yazan F. Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach, Jaroslaw Maciejewski, David Sallman, Anoop K Enjeti, Kamal Al-Rabi, Khalid Halahleh, Devendra Hiwase, Maria Diez-Campelo, David Valcarcel, Claudia Haferlach, Lisa Pleyer, Ioannis Kotsianidis, Vasiliki Pappa, Valeria Santini, Angela Consagra, Aref Al-Kali, Seishi Ogawa, Yasuhito Nannya, Maximilian Stahl, Matteo Giovanni Della Porta, Rami S. Komrokji, Amer M. Zeidan
Journal: Blood
Blood (2024) 144 (Supplement 1): 3219.
https://doi.org/10.1182/blood-2024-202075
Published: 2024
Journal Articles

Impacts of Monoallelic and Biallelic DDX41 Mutations on Hematopoiesis and the Development of Myeloid Malignancies

Free
Ayana Kon, Masahiro M Nakagawa, Azumi Tomita, Keisuke Kataoka, Nobuyuki Kakiuchi, Manabu Nakayama, Haruhiko Koseki, Hideki Makishima, Yasuhito Nannya, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 4116.
https://doi.org/10.1182/blood-2024-209922
Published: 2024
Journal Articles

Deciphering the Heterogeneity of Acute Myeloid Leukemia through Chromatin Accessibility Profiling

Free
Yotaro Ochi, Markus Liew-Littorin, Yasuhito Nannya, Sofia Bengtzén, Petar Antunovic, Stefan Deneberg, Martin Jadersten, Vladimir Lazarevic, Bertil Uggla, Lovisa Wennström, Emma Olander, Senji Kasahara, Nobuhiro Hiramoto, Nobuhiro Kanemura, Nobuo Sezaki, Maki Sakurada, Makoto Iwasaki, Junya Kanda, Yasunori Ueda, Satoshi Yoshihara, Tom Erkers, Nona Struyf, Masanori Motomura, Masahiro M Nakagawa, Ryunosuke Saiki, Hidehito Fukushima, Koji Okazaki, Akinori Yoda, Rurika Okuda, Guoxiang Xie, Albin Osterroos, Lanying Zhao, Yuichi Shiraishi, Takayuki Ishikawa, Satoru Miyano, Hiroshi I Suzuki, Akifumi Takaori-Kondo, Olli Kallioniemi, Gunnar Juliusson, Martin Höglund, Soren Lehmann, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 639.
https://doi.org/10.1182/blood-2024-200415
Published: 2024
Journal Articles

A Dedicated System Accounting for Specific Germline/Somatic Genomic Constellations Is Essential to Predict Outcomes in DDX41 -Mutant Myeloid Neoplasia

Free
Carmelo Gurnari, Hideki Makishima, Arda Durmaz, Enrico Attardi, Ryunosuke Saiki, Alex Bataller, Guilherme Mendes Sapinho, Lukasz P. Gondek, Yasuhito Nannya, Steve Best, Pramila Krishnamurthy, Kar Lok Kong, Yoshiko Atsuta, Senji Kasahara, Kazuma Ohyashiki, Yasushi Miyazaki, Nobuhiro Kanemura, Nobuhiro Hiramoto, Hussein Awada, Valeria Visconte, Courtney D. DiNardo, Maria Teresa Voso, Amy E. DeZern, Guillermo Garcia-Manero, Austin G. Kulasekararaj, Jaroslaw Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 1332.
https://doi.org/10.1182/blood-2024-194024
Published: 2024
Journal Articles

High-Throughput and Highly Sensitive Single Cell Genotyping with Simultaneous Chromatin Accessibility Measurement in Myeloid Precursor Conditions

Free
Masanori Motomura, Yotaro Ochi, Masahiro M Nakagawa, Yasuhito Nannya, Nobuyuki Kakiuchi, Yutaka Kuroda, Nobuo Sezaki, Tomoe Nakagawa, Lanying Zhao, Satoru Miyano, Shuichi Matsuda, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 5635.
https://doi.org/10.1182/blood-2024-206815
Published: 2024