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Georgia Metzgeroth
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Journal Articles

How I (Diagnose and) Treat Myeloid / Lymphoid Neoplasms with Tyrosine Kinase Gene Fusions

Clinical Trials & Observations
Andreas Reiter, Georgia Metzgeroth, Nicholas C.P. Cross
Journal: Blood
Blood blood.2023022417.
https://doi.org/10.1182/blood.2023022417
Published: 2024
Journal Articles

Diagnosis and Outcome of Patients with Idiopathic Hypereosinophilic Syndrome and Cardiac Involvement

Johannes Lübke, Anna Hohneck, Jan Leipe, Nicole Naumann, Alice Fabarius, Wolf-Karsten Hofmann, Georgia Metzgeroth, Theano Papavassilu, Andreas Reiter, Juliana Schwaab
Journal: Blood
Blood (2023) 142 (Supplement 1): 3196.
https://doi.org/10.1182/blood-2023-187249
Published: 2023
Journal Articles

Instructive Interaction between Myelodysplastic Hematopoiesis and the Bone Marrow Microenvironment at Single Cell Level

Johann-Christoph Jann, Nanni Schmitt, Alexander Streuer, Qingyu Xu, Vladimir Riabov, Nadine Weimer, Verena Nowak, Julia Oblaender, Iris Palme, Melda Göl, Marie Demmerle, Felicitas Rapp, Fabian Siegel, Laurenz Steiner, Angelika Duda, Verena Haselmann, Ali Darwich, Ahmed Jawhar, Mohamad Jawhar, Georgia Metzgeroth, Wolf-Karsten Hofmann, Daniel Nowak
Journal: Blood
Blood (2023) 142 (Supplement 1): 3217.
https://doi.org/10.1182/blood-2023-186130
Published: 2023
Journal Articles

Predicting the Clinical Course of Treatment with Midostaurin in Patients with Advanced Systemic Mastocytosis

Johannes Lübke, Nicole Naumann, Timo Brand, Hans-Peter Horny, Martina Rudelius, Karl Sotlar, Georgia Metzgeroth, Alice Fabarius, Wolf-Karsten Hofmann, Juliana Schwaab, Andreas Reiter
Journal: Blood
Blood (2023) 142 (Supplement 1): 1834.
https://doi.org/10.1182/blood-2023-182322
Published: 2023
Journal Articles

ASXL1 Mutations Are Associated with a Response to the Combination of Alvocidib and 5-Azacytidine in Higher-Risk Myelodysplastic Syndromes

Vladimir Riabov, Qingyu Xu, Nanni Schmitt, Alexander Streuer, Guo Ge, Johann-Christoph Jann, Alina Wein, Eva Altrock, Felicitas Rapp, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Melda Göl, Mark Wunderlich, Ahmed Jawhar, Ali Darwich, Patrick Wuchter, Christel Weiss, Jason M Foulks, Daniel T. Starczynowski, Feng-Chun Yang, Georgia Metzgeroth, Laurenz Steiner, Wolf-Karsten Hofmann, Daniel Nowak, Mohamad Jawhar
Journal: Blood
Blood (2022) 140 (Supplement 1): 9749–9750.
https://doi.org/10.1182/blood-2022-165298
Published: 2022
Journal Articles

Inter-Modality Variance of Blast Quantification in Patients with Myelodysplastic Syndrome (MDS) and Its Impact on Risk Stratification and Overall Survival

Laurenz Steiner, Navkirandeep Kaur, Alexander Streuer, Johann-Christoph Jann, Alice Fabarius, Georgia Metzgeroth, Wolf-Karsten Hofmann, Daniel Nowak, Mohamad Jawhar
Journal: Blood
Blood (2022) 140 (Supplement 1): 9831–9832.
https://doi.org/10.1182/blood-2022-168850
Published: 2022
Journal Articles

Inhibition of Lysyl Oxidases Synergizes with 5-Azacytidine to Restore Erythropoiesis in Myeloid Neoplasms

Qingyu Xu, Alexander Streuer, Johann-Christoph Jann, Eva Altrock, Nanni Schmitt, Johanna Flach, Carla Sens-Albert, Felicitas Rapp, Julia Wolf, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Ahmed Jawhar, Ali Darwich, Cleo-Aron Weis, Alexander Marx, Patrick Wuchter, Victor Costina, Evelyn Jäger, Elena Sperk, Michael Neumaier, Alice Fabarius, Georgia Metzgeroth, Florian Nolte, Laurenz Steiner, Mohamad Jawhar, Wolf-Karsten Hofmann, Vladimir Riabov, Daniel Nowak
Journal: Blood
Blood (2022) 140 (Supplement 1): 3054–3055.
https://doi.org/10.1182/blood-2022-159507
Published: 2022
Journal Articles

Direct Comparison of NSG and NBSGW Mice for MDS Patient-Derived Xenograft Models

Nanni Schmitt, Alexander Streuer, Justine Danner, Eva Altrock, Vladimir Riabov, Qingyu Xu, Felicitas Rapp, Nadine Weimer, Iris Palme, Verena Nowak, Julia Obländer, Melda Göl, Ali Darwich, Laurenz Steiner, Tobias Boch, Mohamad Jawhar, Georgia Metzgeroth, Wolf-Karsten Hofmann, Daniel Nowak
Journal: Blood
Blood (2022) 140 (Supplement 1): 4009–4010.
https://doi.org/10.1182/blood-2022-168709
Published: 2022
Journal Articles

Response and Resistance to Cladribine in Patients with Advanced Systemic Mastocytosis: A Registry-Based Analysis

Johannes Lübke, Nicole Naumann, Sebastian Kreil, Georgia Metzgeroth, Hans-Peter Horny, Karl Sotlar, Nicholas C.P. Cross, Alice Fabarius, Peter Valent, Wolf-Karsten Hofmann, Juliana Schwaab, Andreas Reiter
Journal: Blood
Blood (2022) 140 (Supplement 1): 3970–3971.
https://doi.org/10.1182/blood-2022-163650
Published: 2022
Journal Articles

Mesenchymal Stromal Cells (MSCs) from Myelodysplastic Syndromes (MDS) Are Not Clonally Mutated I n Vivo

Johann-Christoph Jann, Maximilian Mossner, Vladimir Riabov, Eva Altrock, Nanni Schmitt, Johanna Flach, Qingyu Xu, Verena Nowak, Julia Obländer, Iris Palme, Nadine Weimer, Alexander Streuer, Ahmed Jawhar, Ali Darwich, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak
Journal: Blood
Blood (2021) 138 (Supplement 1): 1514.
https://doi.org/10.1182/blood-2021-150244
Published: 2021
Journal Articles

Preclinical Assessment of Alvocidib in Combination with 5-Azacytidine in High-Risk Myelodysplastic Syndromes

Vladimir Riabov, Qingyu Xu, Nanni Schmitt, Alexander Streuer, Johann-Christoph Jann, Alina Wein, Eva Altrock, Arwin Mehralivand, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Mohamad Jawhar, Christel Weiss, Georgia Metzgeroth, Jason M Foulks, Wolf-Karsten Hofmann, Daniel Nowak
Journal: Blood
Blood (2021) 138 (Supplement 1): 4649.
https://doi.org/10.1182/blood-2021-150778
Published: 2021
Journal Articles

A Molecular-Based Response Prediction Model to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome and Severe Thrombocytopenia

Anne Sophie Kubasch, Aristoteles Giagounidis, Georgia Metzgeroth, Anna Jonasova, MD PhD, Regina Herbst, MD, Jose Miguel Torregrosa Diaz, Benoit De Renzis, MD, Katharina S. Götze, Marie-Luise Huetter-Kroenke, MD, Marie-Pierre Gourin, Bohrane Slama, MD, Sophie Dimicoli-Salazar, MD, Pascale Cony-Makhoul, MD, Kamel Laribi, MD, Sophie Park, MD PhD, Katja Jersemann, Dorothea Schipp, Klaus H. Metzeler, MD, Oliver Tiebel, MD, Katja Sockel, MD, Silke Gloaguen, Msc, Anna Mies, Fatiha Chermat, Christian Thiede, MD, Rosa Sapena, Richard F. Schlenk, Pierre Fenaux, MD PhD, Uwe Platzbecker, Lionel Ades, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-139291
Published: 2020
Journal Articles

Decitabine Versus Hydroxyurea for Advanced Proliferative CMML: Results of the Emsco Randomized Phase 3 Dacota Trial

Raphael Itzykson, MD PhD, Valeria Santini, Cendrine Chaffaut, Ades Lionel, Sylvain Thepot, MD, Aristoteles Giagounidis, Margot Morabito, Nathalie Droin, Michael Luebbert, Rosa Sapena, Stanislas Nimubona, MD, Jean E. Goasguen, MD PhD, Eric Wattel, MD PhD, Gina Zini, MDPhD, Jose Miguel Torregrosa Diaz, Ulrich Germing, Anna Maria Pelizzari, Sophie Park, MD PhD, Nadja Jaekel, Georgia Metzgeroth, Francesco Onida, MD, Robert Navarro, Andrea Patriarca, MD, Aspasia Stamatoulas Bastard, MD, Martin Puttrich, Sandra Mossuto, Eric Solary, MD PhD, Silke Gloaguen, Msc, Sylvie Chevret, MD PhD, Fatiha Chermat, Uwe Platzbecker, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 53–54.
https://doi.org/10.1182/blood-2020-138680
Published: 2020
Journal Articles

Comparison of Four Different Humanized Hematopoietic Niche Xenotransplantation Methods to Engraft Myelodysplastic Syndromes (MDS)

Eva Altrock, PhD, Carla Sens-Albert, PhD, Johann-Christoph Jann, Johanna Flach, PhD, Vladimir Ryabov, PhD, Nanni Schmitt, MSc, Alexander Streuer, Qingyu Xu, MD, Verena Nowak, Justine Danner, Julia Obländer, Nina Draeger, Iris Palme, Ahmed Jawhar, MD, Cleo-Aron Weis, MD, Vanessa Weyer, Florian Nolte, MD, Georgia Metzgeroth, Alexander Marx, MD, Christoph Groden, MD, Wolf-Karsten Hofmann, MD PhD, Daniel Nowak, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4227.
https://doi.org/10.1182/blood-2019-128075
Published: 2019
Journal Articles

Biomarkers of Response to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome (MDS) and Thrombocytopenia - Results of the Europe Trial By the Emsco Network

Uwe Platzbecker, MD, Anne Sophie Kubasch, MD, Aristoteles Giagounidis, MD, Georgia Metzgeroth, Anna Jonasova, MD PhD, Regina Herbst, MD, Jose Miguel Torregrosa Diaz, Benoit De Renzis, MD, Katharina Götze, Marie-Luise Huetter-Kroenke, MD, Marie-Pierre Gourin, Borhane Slama, MD, Sophie Dimicoli-Salazar, MD, Pascale Cony-Makhoul, MD, Kamel Laribi, MD, Sophie Park, MD PhD, Katja Jersemann, Oliver Tiebel, MD, Katja Sockel, MD, Silke Gloaguen, MSc, Anna Mies, Fatiha Chermat, Christian Thiede, MD, Rosa Sapena, Richard F. Schlenk, MD, Pierre Fenaux, MD PhD, Lionel Ades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2998.
https://doi.org/10.1182/blood-2019-129047
Published: 2019
Journal Articles

Comparison of RNA-Based Versus DNA-Based Quantitative KIT D816V Mutation Analysis Reveals Significant Disparity in Patients with Advanced Systemic Mastocytosis

Mohamad Jawhar, Nicole Naumann, Johannes Lübke, Juliana Schwaab, Oliver Hofmann, Thomas Kielsgaard Kristensen, Karl Sotlar, Verena Haselmann, Sven Schneider, Georgia Metzgeroth, Henning D. Popp, Alice Fabarius, PhD, Peter Bugert, Wolf-Karsten Hofmann, MD PhD, Andreas Reiter
Journal: Blood
Blood (2019) 134 (Supplement_1): 2955.
https://doi.org/10.1182/blood-2019-128811
Published: 2019
Journal Articles

An Increased Bone Mineral Density As an Adverse Prognostic Factor in Patients with Systemic Mastocytosis

Mohamad Jawhar, Juliana Schwaab, Nicole Naumann, Georgia Metzgeroth, Alice Fabarius, PhD, Stefan O Schoenberg, Wolf-Karsten Hofmann, MD PhD, Philipp Riffel, Andreas Reiter
Journal: Blood
Blood (2019) 134 (Supplement_1): 4185.
https://doi.org/10.1182/blood-2019-129798
Published: 2019
Journal Articles

R-Loops-Induced ATR Signaling As a Potential Therapeutic Target in Myelodysplastic Syndrome

Johann-Christoph Jann, Johanna Flach, PhD, Antje Knaflic, Eva Altrock, PhD, Nanni Schmitt, MSc, Alexander Streuer, Justine Danner, Franziska Hofmann, Verena Nowak, Nina Draeger, Julia Obländer, Iris Palme, Patrick Wuchter, MD, Ahmed Jawhar, MD, Georgia Metzgeroth, MD, Florian Nolte, MD, Wolf-Karsten Hofmann, MD PhD, Daniel Nowak, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4218.
https://doi.org/10.1182/blood-2019-126431
Published: 2019
Journal Articles

KIT D816 Mutated / CBF-Negative Acute Myeloid Leukemia (AML): A New Poor-Risk Subtype Associated with Systemic Mastocytosis (SM-AML)

Mohamad Jawhar, Konstanze Döhner, MD, Sebastian Kreil, Juliana Schwaab, Khalid Shoumariyeh, MD, Manja Meggendorfer, PhD, Lambert L.F. Span, Stephan Fuhrmann, Nicole Naumann, Hans-Peter Horny, Karl Sotlar, Boris Kubuschok, Nikolas von Bubnoff, Karsten Spiekermann, MD, Michael Heuser, MD, Georgia Metzgeroth, MD, Alice Fabarius, Stefan A Klein, MD, Wolf-Karsten Hofmann, Hanneke Kluin-Nelemans, Torsten Haferlach, MD, Hartmut Döhner, MD, Nicholas C.P. Cross, Wolfgang R. Sperr, Peter Valent, Andreas Reiter, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1535.
https://doi.org/10.1182/blood-2018-99-115895
Published: 2018
Journal Articles

Placebo Controlled Functional Analysis of Eltrombopag in a Preclinical Xenograft Model of Myelodysplastic Syndromes (MDS)

Nanni Schmitt, MSc, Eva Altrock, PhD, Johann-Christoph Jann, MD, Johanna Flach, PhD, Carla Sens-Albert, PhD, Justine Danner, Stefanie Uhlig, Jovita Pressler, Iris Palme, Verena Nowak, Julia Obländer, Lena Drangmeister, MD, Franziska La Meir, MD, Georgia Metzgeroth, MD, Florian Nolte, MD, Wolf-Karsten Hofmann, Daniel Nowak, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 942.
https://doi.org/10.1182/blood-2018-99-116341
Published: 2018