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Journal Articles

Impact of Mutational Burden and IPSS-M on Response to ESAs in Lower Risk Myelodysplastic Neoplasms

Marco Gabriele Raddi, Angela Consagra, Luca Rigodanza, Cristina Amato, Alessandro Sanna, Giorgio Mattiuz, Sven De Pourcq, Elena Tofacchi, Maria Diez-Campelo, Juan Carlos Caballero Berrocal, Sophie Park, Mathieu Meunier, Celia Orlando, Michaela Fontenay, Olivier Kosmider, Nicolas Chapuis, Uwe Platzbecker, Katharina Zoldan, Anne Sophie Kubasch, Valeria Santini
Journal: Blood
Blood (2023) 142 (Supplement 1): 4595.
https://doi.org/10.1182/blood-2023-189053
Published: 2023
Journal Articles

Efficacy and Safety of Luspatercept +/- Erythropoiesis-Stimulating Agent (ESA) in Patients with Myelodysplastic Syndromes with Ring Sideroblasts (MDS-RS): A French Multicenter Prospective Real-Life Registry

Thibault Comont, Maud D'Aveni, Laurence Schenone, Jose Miguel Torregrosa-Díaz, Lorea Aguinaga, Juan Pardo, Marie Sebert, Sorin Visanica, Clemence Santana, Lenaig Le Clech, Aspasia Stamatoullas, Sylvain Thepot, Etienne Daguindau, Guillaume Beziat, Teresa Botin, Sophie Dimicoli, Sophie Park, Etienne Paubelle, Bohrane Slama, Lise Willems, Houria Debarri, Emmanuel Gyan, Claire Calmettes, Odile Rauzy, Fatiha Chermat, Michaela Fontenay, Lionel Ades, Pierre Fenaux
Journal: Blood
Blood (2023) 142 (Supplement 1): 6471.
https://doi.org/10.1182/blood-2023-177787
Published: 2023
Journal Articles

FLT3 Ligand Kinetic Profile Predicts Response to Treatment and Event-Free Survival (EFS) in Adults with High-Risk MDS/CMML Receiving CPX-351: A GFM Study

Pierre Peterlin, Joëlle Gaschet, Pascal Turlure, Marie-Pierre Gourin, Pierre-Yves Dumas, Sylvain Thepot, Ana Berceanu, Sophie Park, Marie Anne Hospital, Thomas Cluzeau, Jose-Miguel Torregrosa-Diaz, Louis Drevon, Rosa Sapena, Fatiha Chermat, Sophie Dimicoli-Salazar, Maxime Jullien, Pierre Fenaux, Patrice Chevallier
Journal: Blood
Blood (2023) 142 (Supplement 1): 6469.
https://doi.org/10.1182/blood-2023-173741
Published: 2023
Journal Articles

A Phase II Study of Single Agent Aspacytarabine (BST-236) in Adults Unfit for Intensive Chemotherapy with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML) or Higher Risk Myelodysplastic Syndromes (R/R HR MDS)

Marie Anne Hospital, Thomas Cluzeau, Alice Garnier, Giovanni Marconi, Emmanuelle Tavernier, Sylvain Thepot, Aspasia Stamatoullas, Cristina Papayannidis, Sophie Park, Noemie Bigot, Lamya AIT SI Selmi, Fatiha Chermat, Sylvie Chevret, Pierre Fenaux
Journal: Blood
Blood (2023) 142 (Supplement 1): 2923.
https://doi.org/10.1182/blood-2023-185609
Published: 2023
Journal Articles

Somatic Mutations and DNA Hypermethylation at Enhancers and Promoters Identify Distinct Subtypes within Lower-Risk Myelodysplastic Syndromes

David Rombaut, Tobias Tekath, Sarah Sandmann, Simon Crouch, Aniek O. de Graaf, Olivier Kosmider, Magnus Tobiasson, Andreas Lennartsson, Bert A. Van der Reijden, Sophie Park, Maud D'Aveni, Bohrane Slama, Emmanuelle Clappier, Pierre Fenaux, Lionel Ades, Arjan A. van de Loosdrecht, Saskia MC Langemeijer, Argiris S. Symeonidis, Jaroslav Čermák, Claude Preudhomme, Aleksandar Savic, Ulrich Germing, Reinhard Stauder, David T. Bowen, Corine J. Van Marrewijk, Elsa Bernard, Alexandra Smith, Daniel Painter, Theo J.M. de Witte, Eva Hellstrom Lindberg, Julian Varghese, Martin Dugas, Joost H.A. Martens, Luca Malcovati, Joop H. Jansen, Michaela Fontenay
Journal: Blood
Blood (2023) 142 (Supplement 1): 4587.
https://doi.org/10.1182/blood-2023-180071
Published: 2023
Journal Articles

Molecular Response Analysis By High Throughput Sequencing in Higher Risk Myelodysplastic Syndrome (HR-MDS) Treated Intensively with CPX-351

Yannick Le Bris, Simon Bouzy, Audrey Ménard, Pascal Turlure, Patrice Chevallier, Marie-Pierre Gourin, Pierre-Yves Dumas, Sylvain Thepot, Anna Berceanu, Sophie Park, Marie-Anne Hospital, Thomas Cluzeau, Jose-Miguel Torregrosa Diaz, Louis Devron, Rosa Sapena, Fatiha Chermat, Sophie Dimicoli Salazar, Marie C Béné, Pierre Fenaux, Pierre Peterlin
Journal: Blood
Blood (2022) 140 (Supplement 1): 9821–9823.
https://doi.org/10.1182/blood-2022-162278
Published: 2022
Journal Articles

DNA Replication Stress Due to Loss of R-Loops in Myelodysplastic Syndromes with SF3B1 Mutation

David Rombaut, Carine Lefevre, Batoul Farhat, Sabrina Bondu, Anne Letessier, Auriane Lesieur-Pasquier, Daisy Castillo-Guzman, Marjorie Leduc, Emilie-Fleur Gautier, Virginie Chesnais, Alice Rousseau, Ismael Boussaid, Sarah Battault, Alexandre Houy, Didier Bouscary, Lise Willems, Nicolas Chapuis, Sophie Park, Sophie Raynaud, Thomas Cluzeau, Emmanuelle Clappier, Pierre Fenaux, Lionel Ades, Eric Solary, Raphael Margueron, Michel Wassef, Olivier Kosmider, Samar Alsafadi, Nathalie Droin, Angelos Constantinou, Marc-Henri Stern, Benoit Miotto, Frederic Chedin, Michaela Fontenay
Journal: Blood
Blood (2022) 140 (Supplement 1): 215–216.
https://doi.org/10.1182/blood-2022-164584
Published: 2022
Journal Articles

CPX 351 As First Line Treatment in Higher Risk MDS. a Phase II Trial By the GFM

Pierre Peterlin, Pascal Turlure, Patrice Chevallier, Marie-Pierre Gourin, Pierre-Yves Dumas, Sylvain Thepot, Anna Berceanu, Sophie Park, Marie Anne Hospital, Thomas Cluzeau, Jose Miguel Torregrosa Diaz, Louis Devron, Sylvie Chevret, Marie C Bene, Yannick Le Bris, Rosa Sapena, Fatiha Chermat, Sophie Dimicoli-Salazar, Pierre Fenaux
Journal: Blood
Blood (2021) 138 (Supplement 1): 243.
https://doi.org/10.1182/blood-2021-145123
Published: 2021
Journal Articles

Allogeneic Hematopoietic Stem Cell Transplantation (allo HSCT) in Patients with IPSS Low or Intermediate-1 Myelodysplastic Syndrome (MDS): A Prospective Multicenter Phase II Study Based on Donor Availability By the GFM & SFGM-TC "MDS-ALLO-Risk"

Marie Sebert, Cendrine Chaffaut, Sylvain Thepot, Corentin Orvain, Thomas Cluzeau, Michael Loschi, Pierre Peterlin, Patrice Chevallier, Maud d'Aveni, Marie-Thérèse Rubio, Odile Beyne Rauzy, Anne Huynh, Amandine Charbonnier, Nathalie Fegueux, Gaelle Fossard, Stephanie N'guyen-Quoc, Sophie Park, Rosa Sapena, Fatiha Chermat, Lionel Ades, Sylvie Chevret, Pierre Fenaux, Marie Robin
Journal: Blood
Blood (2021) 138 (Supplement 1): 1842.
https://doi.org/10.1182/blood-2021-146846
Published: 2021
Journal Articles

Ivosidenib Monotherapy Is Effective in Patients with IDH1 Mutated Myelodysplastic Syndrome (MDS): The Idiome Phase 2 Study By the GFM Group

Marie Sebert, Thomas Cluzeau, Odile Beyne Rauzy, Aspasia Stamatoulas Bastard, Sophie Dimicoli-Salazar, Sylvain Thepot, Pierre Peterlin, Sophie Park, Marie-Pierre Gourin, Oana Brehar, Cécile Bally, Sébastien Maury, Gaelle Fossard, Lamya Ait Si Selmi, Cendrine Chaffaut, Emmanuelle Clappier, Raphael Itzykson, Fatiha Chermat, Sylvie Chevret, Pierre Fenaux, Lionel Ades
Journal: Blood
Blood (2021) 138 (Supplement 1): 62.
https://doi.org/10.1182/blood-2021-146932
Published: 2021
Journal Articles

Red Blood Cell Transfusion Burden in Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS): A Retrospective Multicenter Study By the Groupe Francophone Des Myélodysplasies (GFM)

Claire Jouzier, Amina Cherait, Pascale Cony-Makhoul, MD, Sylvain Thepot, MD, Thomas Cluzeau, MD PhD, Aspasia Stamatoulas Bastard, MD, Pierre Peterlin, MD, Agnes Guerci Bresler, MD, Sophie Dimicoli-Salazar, MD, Gian-Matteo Pica, MD, Stephane Cheze, MD, Clémence Santana, MD, Fatiha Chermat, Pierre Fenaux, MD PhD, Sophie Park, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–43.
https://doi.org/10.1182/blood-2020-138722
Published: 2020
Journal Articles

A Molecular-Based Response Prediction Model to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome and Severe Thrombocytopenia

Anne Sophie Kubasch, Aristoteles Giagounidis, Georgia Metzgeroth, Anna Jonasova, MD PhD, Regina Herbst, MD, Jose Miguel Torregrosa Diaz, Benoit De Renzis, MD, Katharina S. Götze, Marie-Luise Huetter-Kroenke, MD, Marie-Pierre Gourin, Bohrane Slama, MD, Sophie Dimicoli-Salazar, MD, Pascale Cony-Makhoul, MD, Kamel Laribi, MD, Sophie Park, MD PhD, Katja Jersemann, Dorothea Schipp, Klaus H. Metzeler, MD, Oliver Tiebel, MD, Katja Sockel, MD, Silke Gloaguen, Msc, Anna Mies, Fatiha Chermat, Christian Thiede, MD, Rosa Sapena, Richard F. Schlenk, Pierre Fenaux, MD PhD, Uwe Platzbecker, Lionel Ades, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-139291
Published: 2020
Journal Articles

Decitabine Versus Hydroxyurea for Advanced Proliferative CMML: Results of the Emsco Randomized Phase 3 Dacota Trial

Raphael Itzykson, MD PhD, Valeria Santini, Cendrine Chaffaut, Ades Lionel, Sylvain Thepot, MD, Aristoteles Giagounidis, Margot Morabito, Nathalie Droin, Michael Luebbert, Rosa Sapena, Stanislas Nimubona, MD, Jean E. Goasguen, MD PhD, Eric Wattel, MD PhD, Gina Zini, MDPhD, Jose Miguel Torregrosa Diaz, Ulrich Germing, Anna Maria Pelizzari, Sophie Park, MD PhD, Nadja Jaekel, Georgia Metzgeroth, Francesco Onida, MD, Robert Navarro, Andrea Patriarca, MD, Aspasia Stamatoulas Bastard, MD, Martin Puttrich, Sandra Mossuto, Eric Solary, MD PhD, Silke Gloaguen, Msc, Sylvie Chevret, MD PhD, Fatiha Chermat, Uwe Platzbecker, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 53–54.
https://doi.org/10.1182/blood-2020-138680
Published: 2020
Journal Articles

Biomarkers of Response to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome (MDS) and Thrombocytopenia - Results of the Europe Trial By the Emsco Network

Uwe Platzbecker, MD, Anne Sophie Kubasch, MD, Aristoteles Giagounidis, MD, Georgia Metzgeroth, Anna Jonasova, MD PhD, Regina Herbst, MD, Jose Miguel Torregrosa Diaz, Benoit De Renzis, MD, Katharina Götze, Marie-Luise Huetter-Kroenke, MD, Marie-Pierre Gourin, Borhane Slama, MD, Sophie Dimicoli-Salazar, MD, Pascale Cony-Makhoul, MD, Kamel Laribi, MD, Sophie Park, MD PhD, Katja Jersemann, Oliver Tiebel, MD, Katja Sockel, MD, Silke Gloaguen, MSc, Anna Mies, Fatiha Chermat, Christian Thiede, MD, Rosa Sapena, Richard F. Schlenk, MD, Pierre Fenaux, MD PhD, Lionel Ades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2998.
https://doi.org/10.1182/blood-2019-129047
Published: 2019
Journal Articles

Effect of Rap-536 on MDS PDX-Murine Models with or without SF3B1 Mutation

Mathieu Meunier, Camille Knosp, Chloe Friedrich, Johanna Zannoni, Jean-Yves Cahn, MD PhD, Olivier Kosmider, PharmD, PhD, Michaela Fontenay, MD PhD, Sophie Park, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1705.
https://doi.org/10.1182/blood-2019-128407
Published: 2019
Journal Articles

A Randomized Phase II Study of Azacitidine (AZA) Alone or with Lenalidomide (LEN), Valproic Acid (VPA) or Idarubicin (IDA) in Higher-Risk MDS: Gfm's 'pick a Winner' Trial

Lionel Ades, MD PhD, Agnès Guerci, Kamel Laribi, MD, Pierre Peterlin, Norbert Vey, MD PhD, Sylvain Thepot, MD, Stefan Wickenhauser, Hacene Zerazhi, Aspasia Stamatoullas, MD, Eric Wattel, MD PhD, Christian Recher, MD PhD, Andrea Toma, MD PhD, Krimo Bouabdallah, MD, Thorsten Braun, MD PhD, Odile Beyne-Rauzy, Berengere Gruson, MD, Stephane Cheze, Sophie Park, MD PhD, Thomas Cluzeau, MDPhD, Stanislas Nimubona, MD, Dominique Bordessoule, MD, Riad Benramdane, Bruno Quesnel, Shanti Ame, MD, Stephane De Botton, MD PhD, Fatiha Chermat, Julie Lejeune, Sylvie Chevret, MD PhD, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 467.
https://doi.org/10.1182/blood-2018-99-111756
Published: 2018
Journal Articles

Tumor Microenvironment and Clonal Monocytes of Chronic Myelomonocytic Leukemia Induce a Procoagulant Climate within the Tumor Niche

Natacha Mauz, Mathieu Meunier, MD, Landry Seyve, Julie Brault, PhD, Jean-Yves Cahn, Fabrice Cognasse, PhD, Benoit Polack, MD PhD, Sophie Park, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4239.
https://doi.org/10.1182/blood.V130.Suppl_1.4239.4239
Published: 2017
Journal Articles

Dyserythropoiesis Evaluated By Red Score and Hepcidin/Ferritin Levels Predicts Response to Epoetin Zeta in Lower Risk MDS

Olivier Kosmider, Frederic Maloisel, Bernard Drenou, MD, Nicolas Chapuis, PharmD, PhD, Anne Sophie Alary, Alice Rousseau, Cecile Bouilloux, Sarah Ducamp, PhD, Frederique Verdier, Thibaud Lefebvre, Zoubida Karim, Marie-Christine Jacob, Agathe Debliquis, Agnes Charpentier, Pierre Fenaux, MD PhD, Emmanuel Gyan, MDPhD, Bruno Anglaret, Cecile Leyronnas, Selim Corm, Borhane Slama, MD, Stephane Cheze, Kamel Laribi, Shanti Ame, MD, Christian Rose, MD, Florence Lachenal, Andrea Toma, MD PhD, Gian Matteo Pica, MD, Martin Carre, Frederic Garban, Brigitte Pegourie, MD, Jean-Yves Cahn, Mathieu Meunier, MD, Orianne Wagner Ballon, Olivier Herault, MDPhD, Francois Dreyfus, Valerie Bardet, Michaela Fontenay, MD PhD, Sophie Park, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1705.
https://doi.org/10.1182/blood.V130.Suppl_1.1705.1705
Published: 2017
Journal Articles

Impact of Red Blood Cell Transfusion Intensity on Progression-Free Survival in Lower-Risk MDS Patients Included in the European Leukemianet MDS Registry

Louise De Swart, MD, Simon Crouch, MSc, PhD, Marlijn Hoeks, MD, Alex Smith, PhD, Saskia Langemeijer, MD PhD, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, Jaroslav Cermak, MD PhD, Reinhard Stauder, MD, Moshe Mittelman, MD, Guillermo Sanz, MD, Eva Hellstrom-Lindberg, MD PhD, Luca Malcovati, MD, Mette Skov Holm, MD PhD, Ulrich Germing, MD, Krzysztof Madry, MD PhD, Antonio Medina de Almeida, MD PhD, Aurelia Tatic, MD, Aleksandar Savic, Njetočka Gredelj-Šimec, MD, Agnes Guerci Bresler, Dominic Culligan, MD, Raphael Itzykson, MD PhD, Odile Beyne-Rauzy, MD, Sophie Park, MD PhD, Corine van Marrewijk, PhD, Nicole M A Blijlevens, David T. Bowen, MD, T. M. de Witte, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1690.
https://doi.org/10.1182/blood.V130.Suppl_1.1690.1690
Published: 2017
Journal Articles

Results of a Phase II Study of Guadecitabine (SGI-110) in Higher Risk MDS, CMML or Low Blast Count AML Patients Refractory to or Relapsing after Azacitidine (AZA) Treatment

Marie Sebert, MD, Cecile Bally, Pierre Peterlin, MD, Odile Beyne-Rauzy, MD PhD, Laurence Legros, MDPhD, marie Pierre Gourin, MD PhD, Laurence Sanhes, MD, Eric Wattel, MDPhD, Emmanuel Gyan, MD PhD, Sophie Park, MD PhD, Aspasia Stamatoullas, MD, Anne Banos, Kamel Laribi, Simone Jueliger, PhD, Luke Bevan, Cendrine Chaffaut, Rosa Sapena, Benedicte Samey, Fatiha Chermat, Sylvie Chevret, Lionel Ades, MD PhD, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2016) 128 (22): 347.
https://doi.org/10.1182/blood.V128.22.347.347
Published: 2016