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Journal Articles

Somatic Mutations and DNA Hypermethylation at Enhancers and Promoters Identify Distinct Subtypes within Lower-Risk Myelodysplastic Syndromes

David Rombaut, Tobias Tekath, Sarah Sandmann, Simon Crouch, Aniek O. de Graaf, Olivier Kosmider, Magnus Tobiasson, Andreas Lennartsson, Bert A. Van der Reijden, Sophie Park, Maud D'Aveni, Bohrane Slama, Emmanuelle Clappier, Pierre Fenaux, Lionel Ades, Arjan A. van de Loosdrecht, Saskia MC Langemeijer, Argiris S. Symeonidis, Jaroslav Čermák, Claude Preudhomme, Aleksandar Savic, Ulrich Germing, Reinhard Stauder, David T. Bowen, Corine J. Van Marrewijk, Elsa Bernard, Alexandra Smith, Daniel Painter, Theo J.M. de Witte, Eva Hellstrom Lindberg, Julian Varghese, Martin Dugas, Joost H.A. Martens, Luca Malcovati, Joop H. Jansen, Michaela Fontenay
Journal: Blood
Blood (2023) 142 (Supplement 1): 4587.
https://doi.org/10.1182/blood-2023-180071
Published: 2023
Journal Articles

Mutation Profiles Identify Distinct Clusters of Lower Risk Myelodysplastic Syndromes with Unique Clinical and Biological Features and Clinical Endpoints

Luca Malcovati, MD, Simon Crouch, PhD BA, MA, MSc, Aniek O. De Graaf, PhD, Sarah Sandmann, Magnus Tobiasson, MD, Olivier Kosmider, PharmD, PhD, Bert A. van der Reijden, PhD, Daniel Painter, BSc, Arjan A. Van de Loosdrecht, MD PhD, Argiris Symeonidis, MD PhD, Jaroslav Cermak, MD PhD, Emmanuelle Clappier, PharmD,PhD, Claude Preudhomme, MD PhD, Reinhard Stauder, MD MSc, Moshe Mittelman, MD, Ulrich Germing, David Bowen, MD, Pierre Fenaux, MD PhD, Corine Van Marrewijk, PhD, Alexandra Smith, PhD, Martin Dugas, Eva Hellstrom Lindberg, MD PhD, Theo M de Witte, MD, Michaela Fontenay, Joop Jansen, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29.
https://doi.org/10.1182/blood-2020-138549
Published: 2020
Journal Articles

Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report

Stuart E. Lacy, Sharon L. Barrans, Philip A. Beer, Daniel Painter, Alexandra G. Smith, Eve Roman, Susanna L. Cooke, Camilo Ruiz, Paul Glover, Suzan J. L. Van Hoppe, Nichola Webster, Peter J. Campbell, Reuben M. Tooze, Russell Patmore, Cathy Burton, Simon Crouch, Daniel J. Hodson
Journal: Blood
Blood (2020) 135 (20): 1759–1771.
https://doi.org/10.1182/blood.2019003535
Published: 2020
Includes: Supplemental data
Journal Articles

Targeted Sequencing Predicts the Development of Myeloid Malignancies and Clinical Outcome in Patients with Unexplained Cytopenia

Catherine Cargo, MB, FRCPath, Kelly Bolton, MD PhD, Tumas Beinortas, MBBS, Paul Glover, MSc, Michael Short, Alexandra Smith, PhD, Jan Taylor, PhD MSc, BSc, Paul A S Evans, PhD, Elli Papaemmanuil, PhD, Simon Crouch, PhD BA, MA, MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1712.
https://doi.org/10.1182/blood-2019-131402
Published: 2019
Journal Articles

The use of targeted sequencing and flow cytometry to identify patients with a clinically significant monocytosis

Catherine Cargo, Matthew Cullen, Jan Taylor, Mike Short, Paul Glover, Suzan Van Hoppe, Alex Smith, Paul Evans, Simon Crouch
Journal: Blood
Blood (2019) 133 (12): 1325–1334.
https://doi.org/10.1182/blood-2018-08-867333
Published: 2019
Includes: Supplemental data
Journal Articles

Excess Mortality in Low-Risk MDS Can be Explained By MDS and AML Related Causes of Death

Krzysztof Madry, Ge Yu, MSc., Karol Lis, MD, Pierre Fenaux, MD PhD, David Bowen, MD PhD, Argiris Symeonidis, MD PhD, Moshe Mittelman, MD, Reinhard Stauder, MD MSc, Jaroslav Cermak, MD PhD, Guillermo Sanz, Eva Hellström-Lindberg, MD PhD, Luca Malcovati, MD, Saskia Langemeijer, MD PhD, Ulrich Germing, MD, Mette Skov Holm, MD PhD, Agnès Guerci-Bresler, MD, Dominic Culligan, MD, Laurence Sanhes, MD, Juliet Mills, MD, Ioannis Kotsianidis, MD PhD, Corine van Marrewijk, PhD, Simon Crouch, PhD BA, MA, MSc, Theo M de Witte, MD, Alexandra Smith, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4385.
https://doi.org/10.1182/blood-2018-99-115928
Published: 2018
Journal Articles

MDS Diagnosis: Many Patients May Not Require Bone Marrow Examination

Howard S. Oster, MD PhD, Simon Crouch, MSc, PhD, Alexandra Smith, PhD, Ge Yu, MSc, Bander Abu Shrkihe, MD, Shoham Baruch, Albert Kolomansky, MD, Jonathan Ben-Ezra, MD, Shachar Naor, MD, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, Reinhard Stauder, MD MSc, Jaroslav Cermak, MD PhD, Guillermo Sanz, Eva Hellström-Lindberg, MD PhD, Luca Malcovati, MD, Saskia Langemeijer, MD PhD, Ulrich Germing, MD, Mette Skov Holm, MD PhD, Krzysztof Madry, Agnes Guerci-Bresler, MD, Dominic Culligan, MD, Laurence Sanhes, MD, Juliet Mills, MD, Ioannis Kotsianidis, PhD, Corine van Marrewijk, PhD, David Bowen, MD PhD, Theo de Witte, MD PhD, Moshe Mittelman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4357.
https://doi.org/10.1182/blood-2018-99-111838
Published: 2018
Journal Articles

Impact of Treatment with Iron Chelation Therapy in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry

Marlijn Hoeks, MD, Ge Yu, MSc., Saskia Langemeijer, MD PhD, Simon Crouch, MSc, PhD, Louise De Swart, MD, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, Jaroslav Cermak, MD PhD, Eva Hellstrom-Lindberg, MD PhD, Guillermo Sanz, MD, Reinhard Stauder, MD, Mette skov-Holm, Moshe Mittelman, MD, Krzysztof Madry, MD PhD, Luca Malcovati, MD, Aurelia Tatic, MD, Antonio Medina de Almeida, MD PhD, Ulrich Germing, MD, Aleksandar Savic, MD PhD, Njetočka Gredelj-Šimec, MD, Dominic Culligan, MD, Raphael Itzykson, MD PhD, Agnes Guerci-Bresler, Borhane Slama, MD, Corine van Marrewijk, PhD, Jackie Droste, PhD, Marian van Kraaij, MD PhD, David T. Bowen, MD, T. M. M de Witte, MD PhD, Alex Smith, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 425.
https://doi.org/10.1182/blood.V130.Suppl_1.425.425
Published: 2017
Journal Articles

Can We Diagnose MDS without Bone Marrow Examination? a Proposed EUMDS-Based Non-Invasive Diagnostic Model

Howard S. Oster, MD PhD, Bander Abu Shrkihe, MD, Simon Crouch, MSc, PhD, Alexandra Smith, PhD, Ge Yu, PhD, Gal Carmi, MD, Jonathan Ben-Ezra, MD, Shachar Naor, MD, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, Reinhard Stauder, MD, Jaroslav Cermak, MD PhD, Guillermo Sanz, MD, Eva Hellstrom-Lindberg, MD PhD, Luca Malcovati, MD, Saskia Langemeijer, MD PhD, Ulrich Germing, MD, Mette Skov Holm, MD PhD, Krzysztof Madry, MD PhD, Aurelia Tatic, MD, Antonio Medina de Almeida, MD PhD, Aleksandar Savic, MD PhD, Njetočka Gredelj-Šimec, MD, Agnes Guerci Bresler, Corine van Marrewijk, PhD, David T. Bowen, MD, T. M. M de Witte, MD PhD, Moshe Mittelman, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2975.
https://doi.org/10.1182/blood.V130.Suppl_1.2975.2975
Published: 2017
Journal Articles

A Prognostic Classifier Based on Early Platelet Drop in Lower-Risk MDS. a Study from the European Leukemianet Lower-Risk MDS (EUMDS) Registry

Raphael Itzykson, MD PhD, Simon Crouch, MSc, PhD, Alex Smith, PhD, Argiris Symeonidis, MD PhD, Eva Hellstrom-Lindberg, MD PhD, Guillermo Sanz, MD, Jaroslav Cermak, MD PhD, Reinhard Stauder, MD, Luca Malcovati, MD, Ulrich Germing, MD, Moshe Mittelman, MD, Saskia Langemeijer, MD PhD, Krzysztof Madry, MD PhD, Aurelia Tatic, MD, Mette Skov Holm, MD PhD, Antonio Medina de Almeida, MD PhD, Aleksandar Savic, MD PhD, Njetočka Gredelj-Šimec, MD, Elisa Luño Fernandez, MD, Dominic Culligan, MD, Agnes Guerci Bresler, Corine van Marrewijk, PhD, David T. Bowen, MD, T. M. M de Witte, MD PhD, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 158.
https://doi.org/10.1182/blood.V130.Suppl_1.158.158
Published: 2017
Journal Articles

Impact of Red Blood Cell Transfusion Intensity on Progression-Free Survival in Lower-Risk MDS Patients Included in the European Leukemianet MDS Registry

Louise De Swart, MD, Simon Crouch, MSc, PhD, Marlijn Hoeks, MD, Alex Smith, PhD, Saskia Langemeijer, MD PhD, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, Jaroslav Cermak, MD PhD, Reinhard Stauder, MD, Moshe Mittelman, MD, Guillermo Sanz, MD, Eva Hellstrom-Lindberg, MD PhD, Luca Malcovati, MD, Mette Skov Holm, MD PhD, Ulrich Germing, MD, Krzysztof Madry, MD PhD, Antonio Medina de Almeida, MD PhD, Aurelia Tatic, MD, Aleksandar Savic, Njetočka Gredelj-Šimec, MD, Agnes Guerci Bresler, Dominic Culligan, MD, Raphael Itzykson, MD PhD, Odile Beyne-Rauzy, MD, Sophie Park, MD PhD, Corine van Marrewijk, PhD, Nicole M A Blijlevens, David T. Bowen, MD, T. M. de Witte, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1690.
https://doi.org/10.1182/blood.V130.Suppl_1.1690.1690
Published: 2017
Journal Articles

Similarity Search Methods As an Alternative to Sub-Type Characterisation in Aggressive Lymphomas

Chulin Sha, PhD, Sharon Barrans, PhD, Andrew Jack, Cathy H Burton, Alexandra Smith, PhD, Eve Roman, Dan Painter, Simon Crouch, PhD, Reuben M Tooze, PhD FRCP, Matthew Care, PhD, David R Westhead, PhD
Journal: Blood
Blood (2016) 128 (22): 3052.
https://doi.org/10.1182/blood.V128.22.3052.3052
Published: 2016
Journal Articles

Mutational Profiling of Peripheral Blood and Bone Marrow Samples Discriminates Reactive Monocytosis from Chronic Myelomonocytic Leukaemia

Catherine Cargo, MB, FRCPath, Matt Cullen, PhD, Jan Taylor, PhD, Mike Short, BSc, Paul Evans, PhD, Simon Crouch, PhD
Journal: Blood
Blood (2016) 128 (22): 3181.
https://doi.org/10.1182/blood.V128.22.3181.3181
Published: 2016
Journal Articles

Impact of Treatment with Iron Chelators in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry

Saskia Langemeijer, MD PhD, Louise De Swart, MD, Ge Yu, MSc., Alex Smith, Simon Crouch, PhD, Tom Johnston, PhD, Pierre Fenaux, MD PhD, Argiris Symeonidis, Jaroslav Cermak, Eva Hellstrom-Lindberg, MD PhD, Guillermo Sanz, MD, Reinhard Stauder, MD, Luca Malcovati, MD, Ulrich Germing, Mette Skov Holm, Moshe Mittelman, MD, Krzysztof Madry, MD PhD, Aurelia Tatic, MD, Antonio Almeida, MD PhD, Aleksandar Savic, Sophie Park, MD PhD, Odile Beyne-Rauzy, MD, Raphaël Itzykson, MD PhD, Corine van Marrewijk, PhD, David Bowen, MD PhD, Theo de Witte, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3186.
https://doi.org/10.1182/blood.V128.22.3186.3186
Published: 2016
Journal Articles

Predicting Time to Treatment in Follicular Lymphoma Using Population-Based Data

Russell Patmore, MRCP FRCPath, Alexandra Smith, Burton Cathy, Eve Roman, Simon Crouch, PhD
Journal: Blood
Blood (2015) 126 (23): 3912.
https://doi.org/10.1182/blood.V126.23.3912.3912
Published: 2015
Journal Articles

Targeted sequencing identifies patients with preclinical MDS at high risk of disease progression

Clinical Trials & Observations Brief Report
Catherine A. Cargo, Nicola Rowbotham, Paul A. Evans, Sharon L. Barrans, David T. Bowen, Simon Crouch, Andrew S. Jack
Journal: Blood
Blood (2015) 126 (21): 2362–2365.
https://doi.org/10.1182/blood-2015-08-663237
Published: 2015
Includes: Supplemental data
Journal Articles

Early Diagnosis of Myelodysplastic Syndromes Can be Improved By Deep Sequencing and Array Based Cytogenetics

Catherine Cargo, MB FRCPath, Nicola Rowbotham, PhD, Paul Evans, PhD, Sharon Barrans, PhD, Simon Crouch, PhD, Andrew Jack, PhD
Journal: Blood
Blood (2014) 124 (21): 167.
https://doi.org/10.1182/blood.V124.21.167.167
Published: 2014
Journal Articles

Development Of A Cross Platform, 2-Way Gene Expression Classifier To Distinguish Burkitt Lymphoma From DLBCL, and Assessment Of The Potential Impact Of Its Use In Treatment Decision Making

Sharon Barrans, PhD, Sha Chulin, Alex Smith, Simon Crouch, MA PhD, Lisa Worrillow, PhD, Eve Roman, PhD, David Westhead, PhD, Andrew Jack, PhD
Journal: Blood
Blood (2013) 122 (21): 74.
https://doi.org/10.1182/blood.V122.21.74.74
Published: 2013
Journal Articles

A Unified Prognostic Model for Myelodysplastic Syndrome and Acute Myeloid Leukaemia Based on Flow Cytometric Blast Count

Alexandra Smith, BSc PhD, Simon Crouch, MA PhD, Dan Painter, Eve Roman, Matt Cullen, Fiona Bennett, Catherine Cargo, MB, MRCP, Andrew Jack, PhD, MB
Journal: Blood
Blood (2011) 118 (21): 1736.
https://doi.org/10.1182/blood.V118.21.1736.1736
Published: 2011
Journal Articles

RQ-PCR Provides a Superior Alternative to Immunohistochemistry In Defining Prognostic Groups In DLBCL, and Predicts Treatment Failure with CHOP-R

Lisa Worrillow, Sharon Barrans, Simon Crouch, Matthew Care, Alex Smith, Russell Patmore, Reuben Tooze, Eve Roman, Andrew Jack
Journal: Blood
Blood (2010) 116 (21): 2484.
https://doi.org/10.1182/blood.V116.21.2484.2484
Published: 2010