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Journal Articles

Randomized study of high-dose cytarabine with or without dexamethasone as post-remission therapy in younger adults with newly diagnosed AML – the french backbone intergroup (BIG)-1 study on behalf of the filo, ALFA, and SFGM-TC study groups

Free
Christian Recher, Marie-Anne Hospital, Thibaut Leguay, Martin Carre, Corentin Orvain, Caroline Bonmati, Emmanuel Raffoux, Celestine Simand, Romain Guieze, Jamilé Frayfer, Juliette Lambert, Sylvain Chantepie, Marc Bernard, Pierre Peterlin, Magda Alexis, Pascal Turlure, Cecile Pautas, Sarah Bertoli, Ludovic Gabellier, Edouard Forcade, Nicolas Duployez, Isabelle Luquet, Dominique Penther, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Pierre-Yves Dumas, Eric Delabesse, Claude Preudhomme, Jean-François Hamel, Herve Dombret, Arnaud Pigneux, Hunault-Berger Mathilde, Stephane De Botton
Journal: Blood
Blood (2025) 146 (Supplement 1): 881.
https://doi.org/10.1182/blood-2025-881
Published: 2025
Journal Articles

Outcomes of older or unfit AML patients admitted to intensive care unit in the venetoclax era

Free
Sylvain Garciaz, Louison Brac de La Perriere, Sarah Bertoli, Urbain Tauveron-Jalenques, Pierre-Yves Dumas, Gaëlle Guillerm, Rudy Birsen, Célestine Simand, Corentin Orvain, Pierre Peterlin, Emmanuelle Tavernier, Adrien Contejean, Franciane Paul, Kamel Laribi, Lenaïg Le Clech, Ariane Mineur, Colombe Saillard, Magali Bisbal, Mohamed Atmane, Muriel Picard, Djamel Mokart, Marie-Anne Hospital, Arnaud Pigneux, Norbert Vey, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 5225.
https://doi.org/10.1182/blood-2025-5225
Published: 2025
Journal Articles

Final results of a first-in-human Phase I study of INA03, a novel CD71/TfR1-targeted antibody-drug conjugate, in patients with relapsed or refractory acute leukemia.

Free
Sylvain Garciaz, Pierre Bories, Jean-Marie Boher, Léonor Lopez Almeida, Marie-Anne Hospital, Christian Recher, Colombe Saillard, Yosr Hicheri, Coralie Belanger, Emmanuel Gomez, Renato Monteiro, Pierre Launay, Olivier Hermine, Norbert Vey
Journal: Blood
Blood (2025) 146 (Supplement 1): 5203.
https://doi.org/10.1182/blood-2025-5203
Published: 2025
Journal Articles

Frequency and impact of FLT3-ITD microclones in younger AML patients

Free
Nicolas Duployez, Romane Joudinaud, Augustin Boudry, Mathilde Hunault, Emmanuelle Tavernier, Cecile Pautas, Sarah Bertoli, Suzanne Tavitian, Emmanuel Raffoux, Marie-Anne Hospital, Raja Prince-Eladnani, Mael Heiblig, Sylvain Chantepie, Martin Carre, Pierre Peterlin, Maria Pilar Gallego Hernanz, Romain Guieze, Célestine Simand, Pascal Turlure, Anne Huynh, Emilie Lemasle, Ludovic Gabellier, Juliette Lambert, Felipe Suarez, Samy Chraibi, Laurence Sanhes, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Isabelle Luquet, Dominique Penther, Raphael Itzykson, Eric Delabesse, Jean-François Hamel, Stephane De Botton, Arnaud Pigneux, Herve Dombret, Christian Recher, Claude Preudhomme, Pierre-Yves Dumas
Journal: Blood
Blood (2025) 146 (Supplement 1): 456.
https://doi.org/10.1182/blood-2025-456
Published: 2025
Journal Articles

Relationship between salvage strategy and outcomes in patients with CBF or NPM1-mutated AML and first molecular relapse

Free
Corentin Orvain, Jules Higue, Pierre Peterlin, Pierre Yves Dumas, Yohan Desbrosses, Marie-Anne Hospital, Emmanuelle Tavernier, Martin Carre, Sabrina Barriere, Audrey Couturier, Thomas Cluzeau, Areti Chantzi, Gaspar Aspas Requena, Eric Delabesse, Anne Bouvier, Audrey Bidet, Florian Renosi, Marie Joelle Mozziconacci, Pascale Flandrin-Gresta, Sylvie Tondeur, Véronèse Lauren, Cedric Pastoret, Berengere Dadone-Montaudie, Sebastien Lachot, Sarah Bertoli, Patrice Chevallier, Hunault-Berger Mathilde, Arnaud Pigneux, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 347.
https://doi.org/10.1182/blood-2025-347
Published: 2025
Journal Articles

Impact of midostaurin in younger AML patients intensively treated with high-dose anthracycline

Free
Pierre-Yves Dumas, Mathieu Leclerc, Mathilde Hunault, Emmanuelle Tavernier, Cecile Pautas, Sarah Bertoli, Thibaut Leguay, Suzanne Tavitian, Emmanuel Raffoux, Marie-Anne Hospital, Sylvain Chantepie, Mael Heiblig, Martin Carre, Pierre Peterlin, Maria Pilar Gallego Hernanz, Romain Guieze, Célestine Simand, Pascal Turlure, Anne Huynh, Emilie Lemasle, Ludovic Gabellier, Juliette Lambert, Delphine Lebon, Madalina Uzunov, Jean-Valère Malfuson, Thomas Cluzeau, Samy Chraibi, Laurence Sanhes, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Isabelle Luquet, Dominique Penther, Eric Delabesse, Jean-François Hamel, Raphael Itzykson, Claude Preudhomme, Stephane De Botton, Nicolas Duployez, Arnaud Pigneux, Herve Dombret, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 1682.
https://doi.org/10.1182/blood-2025-1682
Published: 2025
Journal Articles

Induction chemotherapy with a single anthracycline-containing cycle in younger adults with newly diagnosed AML – the french backbone intergroup (BIG)-1 study on behalf of the filo, ALFA, and SFGM-TC study groups

Free
Christian Recher, Cecile Pautas, Sarah Bertoli, Pierre-Yves Dumas, Emmanuel Raffoux, Marie-Anne Hospital, Raja Prince-Eladnani, Mael Heiblig, Martin Carre, Sylvain Chantepie, Pierre Peterlin, Maria Pilar Gallego Hernanz, Juliette Lambert, Corentin Orvain, Romain Guieze, Pascal Turlure, Celestine Simand, Emilie Lemasle, Chantal Himberlin, Caroline Bonmati, Jean Valère Malfuson, Delphine Lebon, Thomas Cluzeau, Emmanuelle Tavernier, Jean-Baptiste Micol, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Anne Huynh, Thibaut Leguay, Isabelle Luquet, Dominique Penther, Nicolas Duployez, Eric Delabesse, Claude Preudhomme, Herve Dombret, Jean-François Hamel, Arnaud Pigneux, Hunault-Berger Mathilde
Journal: Blood
Blood (2025) 146 (Supplement 1): 43.
https://doi.org/10.1182/blood-2025-43
Published: 2025
Journal Articles

Therapy-related core binding factor Acute Myeloid Leukemia – a Study of the french acute leukemia intergroup

Free
Mathilde Chanut, Loïc Vasseur, Matthieu Duchmann, Pierre Hirsch, Céline Berthon, Mael Heiblig, Thorsten Braun, Mathieu Leclerc, Jean Valère Malfuson, Delphine Lebon, Madalina Uzunov, Jean-Noel Bastie, Gian Matteo Pica, Marie-Anne Hospital, Thomas Cluzeau, Juliette Lambert, Lauris Gastaud, Karine Celli-Lebras, Arnaud Pigneux, Stephane De Botton, Christian Recher, Claude Preudhomme, Eric Jourdan, Herve Dombret, Nicolas Boissel, Nicolas Duployez, Raphael Itzykson, Jean-Baptiste Micol
Journal: Blood
Blood (2025) 146 (Supplement 1): 37.
https://doi.org/10.1182/blood-2025-37
Published: 2025
Journal Articles

Real-World Multicenter Evaluation of Venetoclax and Azacitidine for Molecular Relapse after First Line Intensive Chemotherapy in Patients with NPM1 Mutated or Core Binding Factor (CBF) AML. a Filo Study

Free
Jules Higué, Corentin Orvain, Pierre-Yves Dumas, Pierre Peterlin, Marie Anne Hospital, Sabrina Barriere, Areti Chantzi, Audrey Couturier, Martin Carre, Emmanuelle Tavernier, Eric Delabesse, Audrey Bidet, Anne Bouvier, Marie Joelle Mozziconacci, Lauren Veronese, Cedric Pastoret, Sylvie Tondeur, Pascale Flandrin-Gresta, Sébastien Lachot, Sarah Bertoli, Arnaud Pigneux, Christian Récher
Journal: Blood
Blood (2024) 144 (Supplement 1): 58.
https://doi.org/10.1182/blood-2024-205592
Published: 2024
Journal Articles

Results of a Phase 1, First-in-Human Study of INA03, an Anti-CD71 Antibody-Drug Conjugate in Patients with Relapsed or Refractory (R/R) Acute Leukemias

Free
Sylvain Garciaz, Pierre Bories, Jean-Marie Boher, Marie Anne Hospital, Christian Récher, Colombe Saillard, Yosr Hicheri, Renato Monteiro, Olivier Hermine, Pierre Launay, Norbert Vey
Journal: Blood
Blood (2024) 144 (Supplement 1): 1496.
https://doi.org/10.1182/blood-2024-207436
Published: 2024
Journal Articles

Dasatinib Overcomes AML Resistance to BCL2 Inhibition By Indirectly Inhibiting MCL1: From Ex Vivo drug Sensitivity/Resistance Profiling to a Phase II Clinical Trial: A Hemato-BIO Study

Free
Sylvain Garciaz, Rémy Castellano, Arnaud Jacquel, Arnaud Guille, Maxence Bourgoin, Camille Montersino, José Adélaïde, Patrick Auberger, Daniel Birnbaum, Marie Anne Hospital, Yves Collette, Norbert Vey
Journal: Blood
Blood (2024) 144 (Supplement 1): 1378.
https://doi.org/10.1182/blood-2024-207352
Published: 2024
Journal Articles

Current Results of Intensive Therapy in Younger Adults with Acute Myeloid Leukemia (AML): The Large Randomized French Backbone Intergroup (BIG)-1 Study on Behalf of the Filo, ALFA, and SFGM-TC Study Groups

Free
Hunault-Berger Mathilde, Cécile Pautas, Sarah Bertoli, Pierre-Yves Dumas, Emmanuel Raffoux, Tony Marchand, Marie Anne Hospital, Mael Heiblig, Sylvain Chantepie, Martin Carré, Pierre Peterlin, Emilie Lemasle, Célestine Simand, Maria Pilar Gallego Hernanz, Anne Huynh, Edouard Forcade, Raynier Devillier, Stéphanie Nguyen Quoc, Nicolas Duployez, Isabelle Luquet, Dominique Penther, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Gerard Socié, Jean-Yves Cahn, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Eric Delabesse, Claude Preudhomme, Jean-François Hamel, Arnaud Pigneux, Christian Recher, Hervé Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 967.
https://doi.org/10.1182/blood-2023-179376
Published: 2023
Journal Articles

Molecular Relapse after First-Line Intensive Therapy in Patients with Core-Binding Factor and NPM1 -Mutated Acute Myeloid Leukemia - a Filo Study

Free
Corentin Orvain, Sarah Bertoli, Pierre Peterlin, Yohan Desbrosses, Pierre-Yves Dumas, Alexandre Iat, Marie Anne Hospital, Martin Carre, Emmanuelle Tavernier, Anne Bouvier, Audrey Bidet, Sylvie Tondeur, Florian Renosi, Eric Delabesse, Arnaud Pigneux, Hunault-Berger Mathilde, Christian Recher
Journal: Blood
Blood (2023) 142 (Supplement 1): 421.
https://doi.org/10.1182/blood-2023-184848
Published: 2023
Journal Articles

A Phase II Study of Single Agent Aspacytarabine (BST-236) in Adults Unfit for Intensive Chemotherapy with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML) or Higher Risk Myelodysplastic Syndromes (R/R HR MDS)

Free
Marie Anne Hospital, Thomas Cluzeau, Alice Garnier, Giovanni Marconi, Emmanuelle Tavernier, Sylvain Thepot, Aspasia Stamatoullas, Cristina Papayannidis, Sophie Park, Noemie Bigot, Lamya AIT SI Selmi, Fatiha Chermat, Sylvie Chevret, Pierre Fenaux
Journal: Blood
Blood (2023) 142 (Supplement 1): 2923.
https://doi.org/10.1182/blood-2023-185609
Published: 2023
Journal Articles

Acute Myeloid Leukemia Patients Who Stopped Venetoclax or/and Azacytidine for Other Reasons Than Progression Have a Prolonged Treatment Free Remission and Overall Survival. a Filo Study

Free
Sylvain Garciaz, Sarah Bertoli, David A Sallman, Justine Decroocq, Pierre-Yves Dumas, Amine Belhabri, Corentin Orvain, Gaspar Aspas Requena, Celestine Simand, Kamel Laribi, Martin Carré, Alberto Santagostino, Ludovic Gabellier, Marie Anne Hospital, Ariane Mineur, Arnaud Pigneux, Norbert Vey, Christian Récher
Journal: Blood
Blood (2023) 142 (Supplement 1): 161.
https://doi.org/10.1182/blood-2023-185437
Published: 2023
Journal Articles

Preliminary Results of a Phase 1, First-in-Human Study of INA03, an Anti-CD71 Antibody-Drug Conjugate in Patients with Relapsed or Refractory (R/R) Acute Leukemias

Free
Sylvain Garciaz, Pierre Bories, Jean-Marie Boher, Marie Anne Hospital, Christian Récher, Colombe Saillard, Yosr Hicheri, Coralie Belanger, Renato Monteiro, Olivier Hermine, Pierre Launay, Norbert Vey
Journal: Blood
Blood (2023) 142 (Supplement 1): 4290.
https://doi.org/10.1182/blood-2023-185717
Published: 2023
Journal Articles

Clinical, Cytogenetic and Molecular Characterization of a 96 MDS and AML Cohort with TP53 Mutation

Free
Marine Duranjou, Cécile Castoldi, Anne Sophie Alary, Yosr Hicheri, Colombe Saillard, Camille Rouzaud, Aude Charbonnier, Bilal Mohty, Evelyne D'Incan, Jerome Rey, Marie Anne Hospital, Raynier Devillier, Norbert Vey, Véronique Gelsi-Boyer, Anne-Catherine Lhoumeau, Anne Murati, Florence Golesi, Marie Joelle Mozziconacci, Antoine Ittel, Sylvain Garciaz
Journal: Blood
Blood (2023) 142 (Supplement 1): 6483.
https://doi.org/10.1182/blood-2023-186086
Published: 2023
Journal Articles

Poor Prognosis of SRSF2 Gene Mutations in Patients Treated with Venetoclax-Azacitidine (VEN-AZA) for Newly Diagnosed Acute Myeloid Leukemia. a Multicentric Real-Life Study of 117 Patients

Free
Guillaume Berton, Bochra Sedaki, Erwann Collomb, Sami Benachour, Michael Loschi, Bilal Mohty, Colombe Saillard, Yosr Hicheri, Camille Rouzaud, Valerio Maisano, Ferdinand Villetard, Evelyne D'Incan Corda, Aude Charbonnier, Jerome Rey, Marie Anne Hospital, Antoine Ittel, Norman Abbou, Raphaelle Fanciullino, Bérengère Dadone-Montaudié, Norbert Vey, Geoffroy Venton, Thomas Cluzeau, Anne Sophie Alary, Sylvain Garciaz
Journal: Blood
Blood (2023) 142 (Supplement 1): 2848.
https://doi.org/10.1182/blood-2023-180733
Published: 2023
Journal Articles

FLT3 Ligand Kinetic Profile Predicts Response to Treatment and Event-Free Survival (EFS) in Adults with High-Risk MDS/CMML Receiving CPX-351: A GFM Study

Free
Pierre Peterlin, Joëlle Gaschet, Pascal Turlure, Marie-Pierre Gourin, Pierre-Yves Dumas, Sylvain Thepot, Ana Berceanu, Sophie Park, Marie Anne Hospital, Thomas Cluzeau, Jose-Miguel Torregrosa-Diaz, Louis Drevon, Rosa Sapena, Fatiha Chermat, Sophie Dimicoli-Salazar, Maxime Jullien, Pierre Fenaux, Patrice Chevallier
Journal: Blood
Blood (2023) 142 (Supplement 1): 6469.
https://doi.org/10.1182/blood-2023-173741
Published: 2023
Journal Articles

Molecular Response Analysis By High Throughput Sequencing in Higher Risk Myelodysplastic Syndrome (HR-MDS) Treated Intensively with CPX-351

Free
Yannick Le Bris, Simon Bouzy, Audrey Ménard, Pascal Turlure, Patrice Chevallier, Marie-Pierre Gourin, Pierre-Yves Dumas, Sylvain Thepot, Anna Berceanu, Sophie Park, Marie-Anne Hospital, Thomas Cluzeau, Jose-Miguel Torregrosa Diaz, Louis Devron, Rosa Sapena, Fatiha Chermat, Sophie Dimicoli Salazar, Marie C Béné, Pierre Fenaux, Pierre Peterlin
Journal: Blood
Blood (2022) 140 (Supplement 1): 9821–9823.
https://doi.org/10.1182/blood-2022-162278
Published: 2022