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Journal Articles

Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations

Hartmut Döhner, Courtney D. DiNardo, Frederick R. Appelbaum, Charles Craddock, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Lucy A. Godley, Robert P. Hasserjian, Richard A. Larson, Ross L. Levine, Yasushi Miyazaki, Dietger Niederwieser, Gert Ossenkoppele, Christoph Röllig, Jorge Sierra, Eytan M. Stein, Martin S. Tallman, Hwei-Fang Tien, Jianxiang Wang, Agnieszka Wierzbowska, Andrew H. Wei, Bob Löwenberg
Journal: Blood
Blood (2024) 144 (21): 2169–2173.
https://doi.org/10.1182/blood.2024025409
Published: 2024
Journal Articles

NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients

Clinical Trials & Observations
Mathieu Simonin, Loïc Vasseur, Etienne Lengliné, Ludovic Lhermitte, Aurélie Cabannes-Hamy, Marie Balsat, Aline Schmidt, Marie-Emilie Dourthe, Aurore Touzart, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Françoise Huguet, Stéphane Ducassou, Véronique Lhéritier, Yves Chalandon, Norbert Ifrah, Hervé Dombret, Elizabeth Macintyre, Arnaud Petit, Philippe Rousselot, Jérôme Lambert, André Baruchel, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2024) 144 (15): 1570–1580.
https://doi.org/10.1182/blood.2023023754
Published: 2024
Includes: Supplemental data
Journal Articles

Genomic imbalance analysis provides new insight into prognostic factors in adult and pediatric T-ALL

Estelle Balducci, Mathieu Simonin, Nicolas Duployez, Thomas Steimlé, Marie-Emilie Dourthe, Patrick Villarese, Stéphane Ducassou, Isabelle Arnoux, Jean-Michel Cayuela, Marie Balsat, Lucien Courtois, Guillaume Andrieu, Aurore Touzart, Françoise Huguet, Arnaud Petit, Norbert Ifrah, Hervé Dombret, André Baruchel, Elizabeth Macintyre, Claude Preudhomme, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2024) 144 (9): 988–1000.
https://doi.org/10.1182/blood.2023022154
Published: 2024
Includes: Supplemental data
Journal Articles

Nilotinib with or without cytarabine for Philadelphia-positive acute lymphoblastic leukemia

Clinical Trials & Observations
Yves Chalandon, Philippe Rousselot, Sylvie Chevret, Jean-Michel Cayuela, Rathana Kim, Françoise Huguet, Patrice Chevallier, Carlos Graux, Anne Thiebaut-Bertrand, Sylvain Chantepie, Xavier Thomas, Laure Vincent, Céline Berthon, Yosr Hicheri, Emmanuel Raffoux, Martine Escoffre-Barbe, Isabelle Plantier, Magalie Joris, Pascal Turlure, Florence Pasquier, Amine Belhabri, Gabrielle Roth Guepin, Sabine Blum, Michael Gregor, Marina Lafage-Pochitaloff, Julie Quessada, Véronique Lhéritier, Emmanuelle Clappier, Nicolas Boissel, Hervé Dombret
Journal: Blood
Blood (2024) 143 (23): 2363–2372.
https://doi.org/10.1182/blood.2023023502
Published: 2024
Includes: Supplemental data
Journal Articles

Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel

Nicola Gökbuget, Nicolas Boissel, Sabina Chiaretti, Hervé Dombret, Michael Doubek, Adele Fielding, Robin Foà, Sebastian Giebel, Dieter Hoelzer, Mathilde Hunault, David I. Marks, Giovanni Martinelli, Oliver Ottmann, Anita Rijneveld, Philippe Rousselot, Josep Ribera, Renato Bassan
Journal: Blood
Blood (2024) 143 (19): 1891–1902.
https://doi.org/10.1182/blood.2023020794
Published: 2024
Includes: Supplemental data
Journal Articles

Management of ALL in adults: 2024 ELN recommendations from a European expert panel

Nicola Gökbuget, Nicolas Boissel, Sabina Chiaretti, Hervé Dombret, Michael Doubek, Adele Fielding, Robin Foà, Sebastian Giebel, Dieter Hoelzer, Mathilde Hunault, David I. Marks, Giovanni Martinelli, Oliver Ottmann, Anita Rijneveld, Philippe Rousselot, Josep Ribera, Renato Bassan
Journal: Blood
Blood (2024) 143 (19): 1903–1930.
https://doi.org/10.1182/blood.2023023568
Published: 2024
Includes: Supplemental data
Journal Articles

Genetic alterations and MRD refine risk assessment for KMT2A -rearranged B-cell precursor ALL in adults: a GRAALL study

Rathana Kim, Hugo Bergugnat, Cédric Pastoret, Florence Pasquier, Emmanuel Raffoux, Lise Larcher, Marie Passet, Nathalie Grardel, Eric Delabesse, Susanne Kubetzko, Aurélie Caye-Eude, Claus Meyer, Rolf Marschalek, Marine Lafage-Pochitaloff, Anne Thiebaut-Bertrand, Marie Balsat, Martine Escoffre-Barbe, Sabine Blum, Michael Baumann, Anne Banos, Nicole Straetmans, Maria-Pilar Gallego-Hernanz, Yves Chalandon, Carlos Graux, Jean Soulier, Thibaut Leguay, Mathilde Hunault, Françoise Huguet, Véronique Lhéritier, Hervé Dombret, Nicolas Boissel, Emmanuelle Clappier
Journal: Blood
Blood (2023) 142 (21): 1806–1817.
https://doi.org/10.1182/blood.2023021501
Published: 2023
Includes: Supplemental data
Journal Articles

Venetoclax in Combination with Intermediate Doses of Cytarabine in Consolidation Phase for Acute Myeloid Leukemia Patients in First Complete Remission; Results of the Part 1 of the Phase 1/2 Multicentric Covenidac Study

Lauris Gastaud, Pierre Peterlin, Mathilde Hunault, Emmanuel Raffoux, Sarah Bertoli, Martin Carré, Cecile Pautas, Sylvain Chantepie, Juliette Lambert, Nicolas Duployez, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Vey, Arnaud Pigneux, Eric Delabesse, Claude Preudhomme, Adriana Plesa, Francois Vergez, Jean-François Hamel, Herve Dombret, Christian Recher
Journal: Blood
Blood (2023) 142 (Supplement 1): 4261.
https://doi.org/10.1182/blood-2023-173656
Published: 2023
Journal Articles

Hyperleukocytosis Increases the Risk of Early Relapses Independently of Genetics in AML

Raphaël Liévin, Nicolas Duployez, Loïc Vasseur, Juliette Lambert, Mael Heiblig, Mathilde Hunault, Claude Gardin, Stephane De Botton, Elise Fournier, Cecile Pautas, Christine Terré, Eric Delabesse, Norbert Ifrah, Arnaud Pigneux, Celli-Lebras Karine, Christian Recher, Claude Preudhomme, Herve Dombret, Raphael Itzykson
Journal: Blood
Blood (2023) 142 (Supplement 1): 4322.
https://doi.org/10.1182/blood-2023-173614
Published: 2023
Journal Articles

Exploring the Heterogeneity of Response to Blinatumomab in High-Risk Philadelphia-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: An Analysis from the QUEST Sub-Study of the Graall-2014/B Trial

Nicolas Boissel, Francoise Huguet, Thibaut Leguay, Mathilde Hunault, Rathana KIM, Yosr Hicheri, Marie Passet, Patrice Chevallier, Marie Balsat, Sebastien Maury, Anne Thiebaut, Florence Van Obbergh, Thomas Cluzeau, Martine Escoffre Barbe, Nicole Straetmans, Johanna Konopacki, Amine Belhabri, Alban Villate, Florence Pasquier, Didier Bouscary, Thorsten Braun, Sabine Blum, Victoria Cacheux, Caroline Bonmati, Sebastian Wittnebel, Véronique Lhéritier, Norbert Ifrah, Carlos Graux, Yves Chalandon, Emmanuelle Clappier, Herve Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 4349.
https://doi.org/10.1182/blood-2023-177847
Published: 2023
Journal Articles

NGS-Based Stratification Refines the Risk Stratification in T-ALL and Identifies a Very High-Risk Subgroup of Patients

Mathieu Simonin, Loïc Vasseur, Etienne Lengline, Ludovic Lhermitte, Aurelie Cabannes-Hamy, Marie Balsat, Aline Schmidt, Marie Emilie Dourthe, Aurore Touzart, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Françoise Huguet, Stephane Ducassou, Véronique Lhéritier, Yves Chalandon, Norbert Ifrah, Herve Dombret, Elizabeth A. Macintyre, Arnaud Petit, Philippe Rousselot, Jerome Lambert, André Baruchel, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2023) 142 (Supplement 1): 844.
https://doi.org/10.1182/blood-2023-179298
Published: 2023
Journal Articles

Chromothripsis and Genomic Complexity As Pejorative Prognostic Markers in Pediatric and Adult T-ALL

Estelle Balducci, Mathieu Simonin, Nicolas Duployez, Thomas Steimlé, Marie-Emilie Dourthe, Patrick Villarese, Stéphane Ducassou, Isabelle Arnoux, Jean-Michel Cayuela, Marie Balsat, Lucien Courtois, Guillaume P Andrieu, Aurore Touzart, Françoise Huguet, Arnaud Petit, Norbert Ifrah, Hervé Dombret, André Baruchel, Claude Preudhomme, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2980.
https://doi.org/10.1182/blood-2023-185831
Published: 2023
Journal Articles

Clonal Dynamics of FLT3 -ITD Positive Acute Myeloid Leukemia Patients with Relapsed/Refractory Disease Following Intensive Chemotherapy +/- Midostaurin

Romane Joudinaud, Augustin Boudry, Laurène Fenwarth, Sandrine Geffroy, Mikaël Salson, Herve Dombret, Céline Berthon, Arnaud Pigneux, Delphine Lebon, Lamya Haddaoui, Raphael Itzykson, Christian Recher, Audrey Bidet, Eric Delabesse, Mathilde Hunault, Claude Preudhomme, Nicolas Duployez, Pierre-Yves Dumas
Journal: Blood
Blood (2023) 142 (Supplement 1): 976.
https://doi.org/10.1182/blood-2023-182018
Published: 2023
Journal Articles

Kinetics of Complete Remission (CR) and CR Duration and Its Impact on Overall Survival (OS) and Event-Free Survival (EFS) in Quantum-First

Pau Montesinos, Alexander Perl, Mikkael A. Sekeres, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Richard F Schlenk, Harry P. Erba, Hervé Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 4254.
https://doi.org/10.1182/blood-2023-187286
Published: 2023
Journal Articles

Quantum-First Trial: FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3 -ITD)-Specific Measurable Residual Disease (MRD) Clearance Assessed through Induction (IND) and Consolidation (CONS) Is Associated with Improved Overall Survival (OS) in Newly Diagnosed (nd) FLT3 -ITD+ AML Patients (pts)

Alexander Perl, Harry P. Erba, Pau Montesinos, Radovan Vrhovac, Elzbieta Patkowska, Heeje Kim, Pavel Zak, Po-Nan Wang, Jaime E Rohrbach, Ken C N Chang, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Arnaud Lesegretain, Jorge Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Richard F Schlenk, Mark J. Levis
Journal: Blood
Blood (2023) 142 (Supplement 1): 832.
https://doi.org/10.1182/blood-2023-186785
Published: 2023
Journal Articles

Oncogenetic-Driven Targeted Therapy for Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia : A French ALL-Target Observatory Report

Aurelie Cabannes-Hamy, Lucien Courtois, Marie Balsat, Mathieu Simonin, Françoise Huguet, Martine Escoffre-Barbe, Florence Pasquier, Caroline Bonmati, Pascal Turlure, Thomas Cluzeau, Delphine Lebon, Eve Gehlkopf, Eolia Brissot, Justine Decroocq, Patrice Chevallier, Sylvain Chantepie, Victoria Cacheux, Sebastien Maury, Safia Chebrek, Thibaut Leguay, Melody Fort, Natacha Mauz, Mathlide Lamarque, Hunault-Berger Mathilde, Stefan Wickenhauser, Jamilé Frayfer, Anne Banos, Emmanuelle Tavernier, Denis Caillot, Anne Marie Ronchetti, Celine Berthon, Etienne Lengline, Véronique Lhéritier, Hervé Dombret, Ambroise Marçais, Antoine Pinton, Guillaume P Andrieu, Nicolas Boissel, Ludovic Lhermitte, Vahid Asnafi, Philippe Rousselot
Journal: Blood
Blood (2023) 142 (Supplement 1): 518.
https://doi.org/10.1182/blood-2023-179192
Published: 2023
Journal Articles

Mutational Profile and Dynamics of PPM1D -Mutant Clones in the Spectrum of Myeloid Disorders

Jean Pegliasco, David Fandrei, Florence Pasquier, Nathalie Ibrahim, Maria Kfoury, Guillemette Imbert-De-Tremiolles, Nourhan Lizziek, Céline Berthon, Mael Heiblig, Delphine Lebon, Ambroise Marcais, Mathieu Meunier, Ahmad Aljijakli, Emilie Lemasle, Sylvain Chantepie, Cécile Pautas, Pierre-Yves Dumas, Stephanie Haiat, Cyril Quivoron, Ileana antony-Debre, Sophie Cotteret, Raphael Itzykson, Hervé Dombret, Nicolas Duployez, Nathalie Droin, Christophe Marzac, Elsa Bernard, Jean-Baptiste Micol
Journal: Blood
Blood (2023) 142 (Supplement 1): 4064.
https://doi.org/10.1182/blood-2023-189428
Published: 2023
Journal Articles

Frontline Consolidation with Nelarabine for Adults with High-Risk T-Cell Acute Lymphoblastic Leukemia. Results of the Graall-2014/T Atriall Phase 2 Study

Nicolas Boissel, Carlos Graux, Francoise Huguet, Florence Pasquier, Aurore Touzart, Thomas Cluzeau, Ludovic Lhermitte, Eric Delabesse, Patrice Chevallier, Mathilde Hunault, Cedric Pastoret, Sebastien Maury, Nathalie Grardel, Martine Escoffre Barbe, Pascal Turlure, Beat Schafer, Marie Balsat, Philippe Rousselot, Thibaut Leguay, Eric Jourdan, Delphine Pranger, Michael Gregor, Emilie Lemasle, Anne Marie Ronchetti, Ana Berceanu, Ingrid Lafon, Madalina Uzunov, Etienne Lengline, Norbert Ifrah, Yves Chalandon, Véronique Lhéritier, Vahid Asnafi, Herve Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 962.
https://doi.org/10.1182/blood-2023-177696
Published: 2023
Journal Articles

Quantum-First: Safety By Treatment Phase and By Age in Newly Diagnosed (nd) Patients (pts) with FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3 -ITD) Positive Acute Myeloid Leukemia (AML)

Harry P. Erba, Herve Dombret, Alexander Perl, Tsvetomir Mitov, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Youngsook Choi, Mark J. Levis, Richard F Schlenk
Journal: Blood
Blood (2023) 142 (Supplement 1): 972.
https://doi.org/10.1182/blood-2023-186206
Published: 2023
Journal Articles

Current Results of Intensive Therapy in Younger Adults with Acute Myeloid Leukemia (AML): The Large Randomized French Backbone Intergroup (BIG)-1 Study on Behalf of the Filo, ALFA, and SFGM-TC Study Groups

Hunault-Berger Mathilde, Cécile Pautas, Sarah Bertoli, Pierre-Yves Dumas, Emmanuel Raffoux, Tony Marchand, Marie Anne Hospital, Mael Heiblig, Sylvain Chantepie, Martin Carré, Pierre Peterlin, Emilie Lemasle, Célestine Simand, Maria Pilar Gallego Hernanz, Anne Huynh, Edouard Forcade, Raynier Devillier, Stéphanie Nguyen Quoc, Nicolas Duployez, Isabelle Luquet, Dominique Penther, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Gerard Socié, Jean-Yves Cahn, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Eric Delabesse, Claude Preudhomme, Jean-François Hamel, Arnaud Pigneux, Christian Recher, Hervé Dombret
Journal: Blood
Blood (2023) 142 (Supplement 1): 967.
https://doi.org/10.1182/blood-2023-179376
Published: 2023