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Juan Manuel Alonso-Dominguez
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Journal Articles

A First-in-Human Phase 1 Study of the Menin-KMT2A (MLL1) Inhibitor JNJ-75276617 in Adult Patients with Relapsed/Refractory Acute Leukemia Harboring KMT2A or NPM1 Alterations

Elias Jabbour, Emma Searle, Maher Abdul-Hay, Sameem Abedin, Ibrahim Aldoss, Ana Alfonso Piérola, Juan Manuel Alonso-Dominguez, Patrice Chevallier, Carrye Cost, Nikki Daskalakis, Richard Dillon, Neil Dunavin, Jordi Esteve, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Sylvain Garciaz, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Min Chul Kwon, Jonathan Miller, Teng Fong Ng, Kathryn Packman, Ulrike Philippar, Arnaud Pigneux, Christian Recher, Olga Salamero, Madhu Sanga, Richard M Stone, Peter Tan, Jan Willem Thuring, Trevor Tucker, Paresh Vyas
Journal: Blood
Blood (2023) 142 (Supplement 1): 57.
https://doi.org/10.1182/blood-2023-172422
Published: 2023
Journal Articles

Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3 , IDH and NPM1 Mutations in Acute Myeloid Leukemia: Interim Analysis of the PCR-LMA Protocol of the Pethema Group

Blanca Boluda, Claudia Sargas, Rosa Ayala, Maria Jose Larrayoz, María Carmen Chillón Santos, Estrella Carrillo-Cruz, Cristina Bilbao, Esther Prados de La Torre, Irene Navarro-Vicente, David Martinez-Cuadron, Rebeca Rodríguez-Veiga, Cristina Gil, Teresa Bernal del Castillo, Juan Miguel Bergua Burgués, Lorenzo Algarra, Mar Tormo, Pilar Martinez Sanchez, Elena Soria, Josefina Serrano, Juan Manuel Alonso Dominguez, Raimundo García-Boyero, Maria Luz Amigo, Pilar Herrera, Maria Jose Sayas, Esperanza Lavilla, Joaquín Martínez-López, María José Calasanz, Ramón García-Sanz, Jose A. Perez-Simon, María Teresa Gómez-Casares, Joaquín Sánchez-Garcia, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 3438–3440.
https://doi.org/10.1182/blood-2022-160136
Published: 2022
Journal Articles

End-of-Life Care in Hospitalized Patients with Hematologic Malignancies: A Retrospective Unicentric Study

Alberto Lázaro García, Marta González Rodríguez, Edwin Uriel Suárez Merchán, Gonzalo Castellanos Arias, Alicia de las Heras Moreno, María Pilar Llamas Sillero, Eduardo García Romo, Antonio Noguera Tejedor, Laura Solán Blanco, Antonio Herrero, Juan Manuel Alonso Dominguez
Journal: Blood
Blood (2022) 140 (Supplement 1): 8094–8095.
https://doi.org/10.1182/blood-2022-165525
Published: 2022
Journal Articles

Pethema NGS-AML Project. Final Analysis and Clinical Validation of New Genomic Classifications

Claudia Sargas, Rosa Ayala, Maria Jose Larrayoz, Carmen Chillon, Estrella Carrillo, Cristina Bilbao, Esther Prados de La Torre, David Martinez-Cuadron, Rebeca Rodríguez-Veiga, Cristina Gil, Teresa Bernal, Juan Miguel Bergua Burgués, Lorenzo Algarra, Mar Tormo, Pilar Martínez Sánchez, Elena Soria, Josefina Serrano, Juan Manuel Alonso Dominguez, Raimundo García-Boyero, Maria Luz Amigo, Pilar Herrera, María J. Sayas, Esperanza Lavilla, Joaquín Martínez-López, María José Calasanz, Ramón García-Sanz, Jose A. Perez-Simon, María Teresa Gómez-Casares, Joaquín Sánchez-Garcia, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 3422–3424.
https://doi.org/10.1182/blood-2022-166639
Published: 2022
Journal Articles

Toxicity of Asciminib in Real Clinical Practice; Analysis of Side Effects and Cross-Intolerance with Tyrosine Kinase Inhibitors

Lucía Pérez-Lamas, Alejandro Luna, Concepcion Boque, María Alicia Senin, Blanca Xicoy, Pilar Giraldo, Raul Perez Lopez, Concepción Ruiz Nuño, Natalia De las Heras, Elvira Mora Casterá, Carmen Garcia-Hernandez, Adrian Segura Diaz, Juan Luis Steegmann, Patricia Velez Tenza, Fermin Sanchez-Guijo, Ana Maria Garcia-Noblejas Moya, Juan Antonio Juan Vera Goñi, Melania Moreno Vega, Alberto Alvarez-Larran, Montse Cortes, Manuel Perez Encinas, Luis Serrano, Anna Angona, Ana Rosell, Sunil Lakhwani, Mercedes Colorado, Elena Ramila, Carlos Cervero, Beatriz Cuevas, Lucia Villalon Blanco, Juan Carlos Hernandez Boluda, Antonio Paz Coll, Valle Gómez García de Soria, Maria Jose Fernández, Luis Felipe Casado, Juan Manuel Alonso-Dominguez, Maria Magdalena Anguita Arance, Patricia Carrascosa Mastell, Araceli Salamanca Cuenca, Antonio Jiménez-Velasco, María José Ramírez, Miguel López Esteban, Magdalena Sierra Pacho, Marta Santaliestra, Olga Alda Alvarez, Raquel de Paz, Valentín García Gutiérrez
Journal: Blood
Blood (2022) 140 (Supplement 1): 3925–3928.
https://doi.org/10.1182/blood-2022-167453
Published: 2022
Journal Articles

Evolution of the Genetic and Biological Studies Performed at Diagnosis in Patients with Acute Myeloid Leukemia Included in the Pethema Epidemiological Registry (REALMOL Study)

Jorge Labrador, David Martinez-Cuadron, Blanca Boluda, Josefina Serrano, Cristina Gil, Jose A. Perez-Simon, Teresa Bernal del Castillo, Juan Miguel Bergua Burgués, Joaquín Martínez-López, Carlos Rodriguez, María Belén Vidriales, Raimundo García-Boyero, Jesús Lorenzo Algarra, Marta Polo, Maria Jose Sayas, Mar Tormo, Pilar Herrera, Esperanza Lavilla, Fernando Ramos, Maria Luz Amigo, Susana Vives, Joaquín Sánchez-Garcia, Cristina Bilbao, María Carmen Chillón Santos, Maria Jose Larrayoz, Rosa Ayala, Eva Barragán, Miguel A. Sanz, Pau Montesinos, Juan Manuel Alonso-Dominguez
Journal: Blood
Blood (2022) 140 (Supplement 1): 9100–9102.
https://doi.org/10.1182/blood-2022-163016
Published: 2022
Journal Articles

Asciminib in Real-Life Clinical Practice, Safety and Efficacy Profile in Chronic Myeloid Leukemia Pretreated Patients

Lucía Pérez-Lamas, Alejandro Luna, Concepcion Boque, Pilar Giraldo, Blanca Xicoy, Luis Felipe Casado, Fermin Sanchez-Guijo, Concepción Ruiz Nuño, Melania Moreno Vega, Alberto Alvarez-Larran, Araceli Salamanca Cuenca, Ana García-Noblejas, Ferran Vall-Llovera, Manuel Perez Encinas, Lucia Villalon, Natalia De las Heras, Sunil Lakhwani, Elena Ramila, Beatriz Cuevas, Raul Perez Lopez, Antonio Jiménez-Velasco, Ana Rosell, Angeles Escola, Maria Jose Fernández, Carmen Garcia-Hernandez, Carlos Cervero, Elvira Mora Casterá, Miguel Sagüés, Sara Suarez-Varela, Patricia Vélez, Patricia Carrascosa Mastell, Rocio Fé Bitaube, Luis Serrano, Montse Cortes, Juan Antonio Juan Vera Goñi, Juan Luis Steegmann, Juan Carlos Hernandez Boluda, Valle Gomez, Juan Manuel Alonso-Dominguez, Mercedes Colorado Araujo, Antonio Paz Coll, Valentín Garcia Gutierrez
Journal: Blood
Blood (2021) 138 (Supplement 1): 2563.
https://doi.org/10.1182/blood-2021-150813
Published: 2021
Journal Articles

Nationwide Laboratory Network for AML Cross-Validated NGS Studies: Results from a Real-Life Cohort of the Pethema Group

Claudia Sargas, Rosa Ayala, Carmen Chillon, Maria Jose Larrayoz, Estrella Carrillo, Cristina Bilbao, Manuel Yébenes, Marta Llop, Inmaculada Rapado, Ramon Garcia-Sanz, Iria Vazquez, Elena Soria, Santiago Sánchez-Sosa, Kamila Janusz, Carmen Botella, Josefina Serrano, David Martinez-Cuadron, Juan-Miguel Bergua, Maria Luz Amigo, Pilar Martinez Sanchez, Mar Tormo, Teresa Bernal, Pilar Herrera-Puente, Raimundo García-Boyero, Lorenzo Algarra, Maria Jose Sayas, Lisette Costilla-Barriga, Esther Pérez-Santolalla, Inmaculada Marchante, Esperanza Lavilla-Rubira, Víctor Noriega, Juan Manuel Alonso Dominguez, Miguel A. Sanz, Joaquín Sánchez, María Teresa Gómez-Casares, Jose A. Perez-Simon, María José Calasanz, Marcos González, Joaquín Martínez-López, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1302.
https://doi.org/10.1182/blood-2021-152353
Published: 2021
Journal Articles

Impact of Measurable Residual Disease (MRD) By Multiparameter Flow Cytometry (MFC): A Real-World Study in 1,076 Patients with Acute Myeloid Leukemia (AML)

Bruno Paiva, PhD, María Belén Vidriales, Maria Desamparados Sampere Talens, Fabian Tarin, Enrique Colado, Celina Benavente, María Teresa Cedena, MD, Joaquin Sanchez, MD, Teresa Caballero-Velázquez, MD PhD, Lourdes Cordon, David Martínez-Cuadron, MD, Teresa Bernal del Castillo, MD PhD, Carmen Botella, Sofia Grille, MDPhD, Josefina Serrano, MD, Carlos Rodriguez, Jesús Lorenzo Algarra, Juan Manuel Alonso Dominguez, MD PhD MSc, Maria Luz Amigo, MD, Manuel BARRIOS García, MDPhD, Raimundo García-Boyero, MD, Mercedes Colorado, MD, Jaime Perez De Oteyza, MDPhD, Manuel Perez Encinas, MD, Lissette Del Pilar Costilla, MD, Maria Jose Sayas, Olga Pérez-López, Marcos González, Jose A. Perez-Simon, MD PhD, Joaquin Martinez-Lopez, MD PhD, Claudia Lucia Sossa, Alberto Orfao, MD PhD, Jesús F. San-Miguel, Miguel Sanz, MD PhD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–15.
https://doi.org/10.1182/blood-2020-134349
Published: 2020
Journal Articles

Results of a Clinical Trial of H3B-8800, a Splicing Modulator, in Patients with Myelodysplastic Syndromes (MDS), Acute Myeloid Leukemia (AML) or Chronic Myelomonocytic Leukemia (CMML)

David P. Steensma, MD, Martin Wermke, MD, Virginia M. Klimek, MD, Peter L Greenberg, MD, Patricia Font, Rami S. Komrokji, MD, Jay Yang, MD, Andrew M. Brunner, MD, Hetty E. Carraway, MD MBA, Lionel Ades, MD PhD, Aref Al-Kali, MD, Juan Manuel Alonso Dominguez, MD PhD MSc, Ana Alonso, MD, Catherine C. Coombs, MD, H. Joachim Deeg, MD, William B. Donnellan, MD, James M. Foran, MD, Guillermo Garcia-Manero, MD, Michael B. Maris, MD, Malgorzata McMasters, MD, Jean-Baptiste Micol, MD, Jaime Perez De Oteyza, MD PhD, Felicitas Thol, MD, Eunice S. Wang, MD, Justin M. Watts, MD, Silvia Buonamici, PhD, Amy Kim, MSPh PhD, Vikram Gourineni, MS, PharmD, Alyssa J Marino, Nathalie Rioux, MSc, PhD, Joanne Schindler, MD, Sherri Smith, MS, Huilan Yao, PhD, Xiaobin Yuan, Kun Yu, PhD, Uwe Platzbecker
Journal: Blood
Blood (2019) 134 (Supplement_1): 673.
https://doi.org/10.1182/blood-2019-123854
Published: 2019
Journal Articles

Study of the Clinical Significance of the Length of FLT3-ITD in Acute Myeloid Leukemia Patients

Tamara Castaño, MD, Rosa Ayala, MD PhD, Maria Pilar Llamas Sillero, Joaquin Martinez Lopez, MD, Rocio N Salgado, PhD, Mireia Atance, Jose Luiz Lopez Lorenzo, MD, Jose F. Tomas, MD PhD, Carlos Blas, MD, Juan Manuel Alonso Dominguez, MD PhD MSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 5278.
https://doi.org/10.1182/blood-2018-99-115164
Published: 2018
Journal Articles

Inhibition of the Hedgehog Pathway Decreases the Quiescent CD34+CD38- Population in Acute Myeloid Leukemia

Alicia Arenas, Daniel Lainez, Cristina Serrano del Castillo, MD, Rocio N Salgado, PhD, Carlos Blas, MD, Mireia Atance, Raul Cordoba, MD PhD, Pilar Llamas, MD PhD, Juan Manuel Alonso Dominguez, MD PhD MSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 1509.
https://doi.org/10.1182/blood-2018-99-118636
Published: 2018
Journal Articles

Comparation of Digital PCR and Quantitative Pcr for Molecular Monitorization of Chronic Myeloid Leukemia Patients

Juan Manuel Alonso Dominguez, MD PhD MSc, Rodrigo Iñiguez Garcia, MD, Susana Olmedillas, PhD, Rocio N Salgado, PhD, Tamara Castaño, MD, Carlos Blas, MD, Diego Velasco Rodrgiguez, MD PhD, Gala Vega, MD, Jose Luis Lopez Lorenzo, MD, Pilar Giraldo, PhD, Joaquin Martinez Lopez, MD PhD, Pilar Llamas, MDPhD, Mireia Atance, Arantxa Garcías Raso
Journal: Blood
Blood (2017) 130 (Supplement 1): 2891.
https://doi.org/10.1182/blood.V130.Suppl_1.2891.2891
Published: 2017
Journal Articles

Characterization of Ex-Vivo PTCH1 Expression Under Tyrosine Kinase Inhibitors Treatment and Determination of Downstream Effectors Oh Hedgehog Pathway in CML

Juan Manuel Alonso Dominguez, MD PhD MSc, Alicia Arenas, PhD, Pilar Llamas, MDPhD, Diego Velasco, Aránzazu García-Raso, PhD, Jose Luis Lopez Lorenzo, MD, Mireia Atance, Rocio N Salgado, PhD, Joaquin Martinez Lopez, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5245.
https://doi.org/10.1182/blood.V130.Suppl_1.5245.5245
Published: 2017
Journal Articles

Measurement of PTCH1 Expression at Diagnosis Is an Appropriate Tool for Tyrosine Kinase Inhibitors Selection in Chronic Myeloid Leukemia Patients in Chronic Phase

Juan Manuel Alonso-Dominguez, MD, Felipe Casado, MariaTeresa Gómez Casares, MDPhD, Ismael Buno, Francisca Ferrer-Marin, Eduardo Anguita, MD PhD, Alicia Arenas, Rafael Del Orbe, MD, Rosa M. Ayala, MD PhD, Pilar Llamas, MD, Pedro Sanchez-Godoy, MD, Carmen Burgaleta, MD, Valentín García-Gutierrez, Juan Luis Steegmann, MD PhD, Joaquin Martinez-Lopez
Journal: Blood
Blood (2015) 126 (23): 2791.
https://doi.org/10.1182/blood.V126.23.2791.2791
Published: 2015