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Lorenzo Algarra
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Journal Articles

Exploring Potential Molecular Mechanisms of Drug Response in FLT3-ITD Negative AML Patients Treated with Quizartinib Vs Placebo Plus Standard Chemotherapy in the Quiwi Trial

Adrian Mosquera Orgueira, Manuel Perez Encinas, Jose Angel Diaz Arias, Rebeca Rodriguez Veiga, Juan Miguel Bergua Burgues, Lorenzo Algarra, Carmen Botella, Jose Antonio Perez Simon, Teresa Bernal, Mar Tormo, Maria Calbacho, Olga Salamero, Josefina Serrano, Victor Noriega, Juan Antonio Lopez Lopez, Susana Vives, Mercedes Colorado, Jose Luis Lopez Lorenzo, Maria Vidriales Vicente, Raimundo Garcia Boyero, Maria Teresa Olave Rubio, Pilar Herrera Puente, Olga Arce, Manuel Barrios Garcia, Maria Jose Sayas Lloris, Marta Polo, Maria Isabel Gomez Roncero, Eva Barragan, Rosa Ayala, Carmen Chillon, Maria Jose Calasanz, Blanca Boluda, Andres Peleteiro Raindo, Raquel Amigo, Jorge Labrador, David Martinez Cuadron, Pau Montesinos
Journal: Blood
Blood (2023) 142 (Supplement 1): 6037.
https://doi.org/10.1182/blood-2023-180710
Published: 2023
Journal Articles

The FLT3-like Gene Expression Signature Predicts Response to Quizartinib in Wild-Type FLT3 Acute Myeloid Leukemia: An Analysis of the Pethema Quiwi Trial

Adrian Mosquera Orgueira, Manuel Perez Encinas, Jose Angel Diaz Arias, Rebeca Rodriguez Veiga, Juan Miguel Bergua Burgues, Jesús Lorenzo Algarra, Carmen Botella, Jose Antonio Perez Simon, Teresa Bernal, Mar Tormo, Maria Calbacho, Olga Salamero, Josefina Serrano, Victor Noriega, Juan Antonio Lopez Lopez, Susana Vives, Mercedes Colorado, Jose Luis Lopez Lorenzo, Maria Vidriales Vicente, Raimundo Garcia Boyero, Maria Teresa Olave Rubio, Pilar Herrera Puente, Olga Arce, Manuel Barrios Garcia, Maria Jose Sayas Lloris, Marta Polo, Maria Isabel Gomez Roncero, Eva Barragan, Rosa Ayala, Carmen Chillon, Maria Jose Calasanz, Blanca Boluda, Andres Peleteiro Raindo, Raquel Amigo, David Martinez Cuadron, Jorge Labrador, Pau Montesinos
Journal: Blood
Blood (2023) 142 (Supplement 1): 974.
https://doi.org/10.1182/blood-2023-180482
Published: 2023
Journal Articles

Data-Driven Multiparameter Flow Cytometry (MFC) Classification of Blast Differentiation in Elderly Patients with Acute Myeloid Leukemia (AML)

Carmen Gonzalez, Catia Simoes, Beñat Ariceta, David Martinez-Cuadron, Juan Miguel Bergua Burgues, Susana Vives, Lorenzo Algarra, Mar Tormo, Pilar Martinez Sanchez, Josefina Serrano, Pilar Herrera, Fernando Ramos, Olga Salamero, Esperanza Lavilla, Cristina Gil, Jose Luiz Lopez Lorenzo, Maria Vidriales Vicente, Carmen Chillon, Jorge Labrador, Jose Francisco Falantes, Maria Jose Sayas Lloris, Rosa Ayala, Joaquin Martinez-Lopez, Sara Villar, Maria Jose Calasanz, Felipe Prosper, Jesus San Miguel, Miguel A. Sanz, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 1571.
https://doi.org/10.1182/blood-2023-180646
Published: 2023
Journal Articles

Clinical Features and Treatment in Patients Diagnosed with Blastic Plasmacytoid Dendritic Cell Neoplasm: Interim Analysis from the Pethema Epidemiologic Registry (EPI-BLAS study)

Irene Navarro Vicente, Pilar Lloret Madrid, Antonio Solana-Altabella, Pilar Martinez Sanchez, Maria Angeles Foncillas, Carlos Cervero, Victor Noriega, Maria Paz Garrastazul Sánchez, Jose Maria Alonso Alonso, Beatriz De Rueda Ciller, Pilar Herrera Puente, Susana Vives, Josefina Serrano, Lourdes Hermosín, Fernando Jesús Ramos-Ortega, Teresa Bernal, Jesús Lorenzo Algarra, Mercedes Colorado, Raimundo García-Boyero, Juan Miguel Bergua Burgues, Lisette Costilla-Barriga, Tamara Castaño, Jorge Labrador, Armando Mena Duran, Maria Dolores Madrigal Toscano, Maria Del Mar Hermosilla-Fernandez, Carmen Couto, Esther Perez Santaolla, Jose Mario Mariz, Sandra Casal Marini, Cristina Gil, David Martinez-Cuadron, Pau Montesinos
Journal: Blood
Blood (2023) 142 (Supplement 1): 4234.
https://doi.org/10.1182/blood-2023-190296
Published: 2023
Journal Articles

Treatment Outcomes in Unfit Patients with Newly Acute Myeloid Leukemia According to IDH1 Mutational Status: Real World Evidence from the Pethema Epidemiologic Registry

David Martinez-Cuadron, Blanca Boluda, Jesús Lorenzo Algarra, Juan Miguel Bergua Burgues, Rebeca Rodriguez Veiga, Pilar Martinez Sanchez, Josefina Serrano, Fernando Jesús Ramos-Ortega, Jose A. Pérez-Simón, Mar Tormo, Jose Luis Lopez Lorenzo, Esperanza Lavilla, Teresa Bernal Del Castillo, Carlos Rodríguez-Medina, Maria Carmen GARCIA Garay, Maria Jose Sayas Lloris, Cristina Gil, Maria Teresa Olave Rubio, Raimundo Garcia Boyero, Susana Vives, Maria Angeles Foncillas, Jorge Labrador, Francisco Ibañez, Ana Cabello, Pilar Herrera Puente, Bernardo Javier González González, Eva Barragán, Claudia Sargas, Rosa Ayala, Carmen Chillon, Pau Montesinos
Journal: Blood
Blood (2023) 142 (Supplement 1): 4223.
https://doi.org/10.1182/blood-2023-189800
Published: 2023
Journal Articles

Indolent Acute Myeloid Leukemia with Long Survival in Patients Treated with Best Supportive Care Only: A Pethema Registry Study

Jorge Labrador, Josefina Serrano, Laura Torres, Evelyn Acuña-Cruz, Jose A. Perez-Simon, Maria Lopez-Pavia, Gabriela Rodriguez Macias, Carmen Botella, Carlos Rodriguez, Pilar Martinez Sanchez, Maria Luz Amigo, Maria Victoria Cuevas, Teresa Bernal del Castillo, María Carmen Montes, Celina Benavente, Juan Ignacio Rodriguez-Gutierrez, Mar Tormo, Raimundo García-Boyero, Aurelio Lopez Martínez, Rafael Lluch Garcia, Jesús Lorenzo Algarra, Esperanza Lavilla, David Martinez-Cuadron, Miguel A. Sanz, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 8919–8920.
https://doi.org/10.1182/blood-2022-162591
Published: 2022
Journal Articles

Evolution of the Genetic and Biological Studies Performed at Diagnosis in Patients with Acute Myeloid Leukemia Included in the Pethema Epidemiological Registry (REALMOL Study)

Jorge Labrador, David Martinez-Cuadron, Blanca Boluda, Josefina Serrano, Cristina Gil, Jose A. Perez-Simon, Teresa Bernal del Castillo, Juan Miguel Bergua Burgués, Joaquín Martínez-López, Carlos Rodriguez, María Belén Vidriales, Raimundo García-Boyero, Jesús Lorenzo Algarra, Marta Polo, Maria Jose Sayas, Mar Tormo, Pilar Herrera, Esperanza Lavilla, Fernando Ramos, Maria Luz Amigo, Susana Vives, Joaquín Sánchez-Garcia, Cristina Bilbao, María Carmen Chillón Santos, Maria Jose Larrayoz, Rosa Ayala, Eva Barragán, Miguel A. Sanz, Pau Montesinos, Juan Manuel Alonso-Dominguez
Journal: Blood
Blood (2022) 140 (Supplement 1): 9100–9102.
https://doi.org/10.1182/blood-2022-163016
Published: 2022
Journal Articles

Prognostic Impact of NPM1 and FLT3 -ITD Mutations in Patients Treated with Non-Intensive Regimens: A Pethema Registry Study

Edwin Uriel Suárez, Juan Manuel Alonso, Blanca Boluda, Esperanza Lavilla, Mar Tormo, Carmen Botella, Susana Vives, Carlos Rodriguez, Josefina Serrano, María José Sayas, Pilar Martínez Sánchez, Fernando Ramos, Teresa Bernal del Castillo, Lorenzo Algarra, Juan Miguel Bergua Burgués, José Pérez-Simón, Pilar Herrera, Manuel Barrios-García, Víctor Noriega-Concepción, Jóse Ángel Raposo-Puglia, Rosa Ayala, Eva Barragán, David Martinez-Cuadron, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 6077–6079.
https://doi.org/10.1182/blood-2022-167365
Published: 2022
Journal Articles

Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3 , IDH and NPM1 Mutations in Acute Myeloid Leukemia: Interim Analysis of the PCR-LMA Protocol of the Pethema Group

Blanca Boluda, Claudia Sargas, Rosa Ayala, Maria Jose Larrayoz, María Carmen Chillón Santos, Estrella Carrillo-Cruz, Cristina Bilbao, Esther Prados de La Torre, Irene Navarro-Vicente, David Martinez-Cuadron, Rebeca Rodríguez-Veiga, Cristina Gil, Teresa Bernal del Castillo, Juan Miguel Bergua Burgués, Lorenzo Algarra, Mar Tormo, Pilar Martinez Sanchez, Elena Soria, Josefina Serrano, Juan Manuel Alonso Dominguez, Raimundo García-Boyero, Maria Luz Amigo, Pilar Herrera, Maria Jose Sayas, Esperanza Lavilla, Joaquín Martínez-López, María José Calasanz, Ramón García-Sanz, Jose A. Perez-Simon, María Teresa Gómez-Casares, Joaquín Sánchez-Garcia, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 3438–3440.
https://doi.org/10.1182/blood-2022-160136
Published: 2022
Journal Articles

Transcriptional and Genomic Characterization of Measurable Residual Disease (MRD) Cells in Acute Myeloid Leukemia (AML)

Catia Patricia Simoes, Sara Villar, Beñat Ariceta, Juan-José Garcés, Leire Burgos, Diego Alignani, Sarvide Sarai, David Martinez-Cuadron, Juan Miguel Bergua Burgués, Susana Vives, Lorenzo Algarra, Mar Tormo, Pilar Martinez Sanchez, Josefina Serrano, Pilar Herrera, Fernando Ramos, Olga Salamero, Esperanza Lavilla, Cristina Gil, Jose Luiz Lopez Lorenzo, María Belén Vidriales, María Carmen Chillón Santos, Jorge Labrador, José F. Falantes, Maria Jose Sayas, Rosa Ayala, Joaquín Martínez-López, Ana Alfonso-Pierola, María José Calasanz, Felipe Prosper, Jesús San-Miguel, Miguel A. Sanz, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2022) 140 (Supplement 1): 2270–2272.
https://doi.org/10.1182/blood-2022-163159
Published: 2022
Journal Articles

Pethema NGS-AML Project. Final Analysis and Clinical Validation of New Genomic Classifications

Claudia Sargas, Rosa Ayala, Maria Jose Larrayoz, Carmen Chillon, Estrella Carrillo, Cristina Bilbao, Esther Prados de La Torre, David Martinez-Cuadron, Rebeca Rodríguez-Veiga, Cristina Gil, Teresa Bernal, Juan Miguel Bergua Burgués, Lorenzo Algarra, Mar Tormo, Pilar Martínez Sánchez, Elena Soria, Josefina Serrano, Juan Manuel Alonso Dominguez, Raimundo García-Boyero, Maria Luz Amigo, Pilar Herrera, María J. Sayas, Esperanza Lavilla, Joaquín Martínez-López, María José Calasanz, Ramón García-Sanz, Jose A. Perez-Simon, María Teresa Gómez-Casares, Joaquín Sánchez-Garcia, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 3422–3424.
https://doi.org/10.1182/blood-2022-166639
Published: 2022
Journal Articles

Characteristics and Outcome of Patients with Acute Myeloid Leukemia and Trisomy 4

Sabine Kayser, David Martínez-Cuadrón, Maher Hanoun, Friedrich Stölzel, Cristina Gil, H. Christian Reinhardt, Eliana Aguiar, Kerstin Schäfer-Eckart, Juan Miguel Bergua Burgues, Björn Steffen, Teresa Bernal, Stefan W. Krause, Rosalia Riaza, Christoph Schliemann, Jose Cervera, Martin Kaufmann, Laura Torres, Mathias Haenel, Evelyn Acuña-Cruz, Edgar Jost, Jesús Lorenzo Algarra, Martina Crysandt, Lars Fransecky, Javier Cornago Navascués, Sabrina Kraus, Joaquin Martinez-Lopez, Hermann Einsele, Dirk Niemann, Andreas Neubauer, Ruth Seggewiss-Bernhardt, Sebastian Scholl, Stefan Klein, Christoph Schmid, Markus Schaich, Martin Schmidt-Hieber, Anthony D. Ho, Uwe Platzbecker, Claudia D. Baldus, Carsten Müller-Tidow, Christian Thiede, Martin Bornhäuser, Hubert Serve, Mark Levis, Pau Montesinos, Christoph Röllig, Richard F. Schlenk
Journal: Blood
Blood (2021) 138 (Supplement 1): 1307.
https://doi.org/10.1182/blood-2021-150281
Published: 2021
Journal Articles

Nationwide Laboratory Network for AML Cross-Validated NGS Studies: Results from a Real-Life Cohort of the Pethema Group

Claudia Sargas, Rosa Ayala, Carmen Chillon, Maria Jose Larrayoz, Estrella Carrillo, Cristina Bilbao, Manuel Yébenes, Marta Llop, Inmaculada Rapado, Ramon Garcia-Sanz, Iria Vazquez, Elena Soria, Santiago Sánchez-Sosa, Kamila Janusz, Carmen Botella, Josefina Serrano, David Martinez-Cuadron, Juan-Miguel Bergua, Maria Luz Amigo, Pilar Martinez Sanchez, Mar Tormo, Teresa Bernal, Pilar Herrera-Puente, Raimundo García-Boyero, Lorenzo Algarra, Maria Jose Sayas, Lisette Costilla-Barriga, Esther Pérez-Santolalla, Inmaculada Marchante, Esperanza Lavilla-Rubira, Víctor Noriega, Juan Manuel Alonso Dominguez, Miguel A. Sanz, Joaquín Sánchez, María Teresa Gómez-Casares, Jose A. Perez-Simon, María José Calasanz, Marcos González, Joaquín Martínez-López, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1302.
https://doi.org/10.1182/blood-2021-152353
Published: 2021
Journal Articles

Impact of Measurable Residual Disease (MRD) By Multiparameter Flow Cytometry (MFC): A Real-World Study in 1,076 Patients with Acute Myeloid Leukemia (AML)

Bruno Paiva, PhD, María Belén Vidriales, Maria Desamparados Sampere Talens, Fabian Tarin, Enrique Colado, Celina Benavente, María Teresa Cedena, MD, Joaquin Sanchez, MD, Teresa Caballero-Velázquez, MD PhD, Lourdes Cordon, David Martínez-Cuadron, MD, Teresa Bernal del Castillo, MD PhD, Carmen Botella, Sofia Grille, MDPhD, Josefina Serrano, MD, Carlos Rodriguez, Jesús Lorenzo Algarra, Juan Manuel Alonso Dominguez, MD PhD MSc, Maria Luz Amigo, MD, Manuel BARRIOS García, MDPhD, Raimundo García-Boyero, MD, Mercedes Colorado, MD, Jaime Perez De Oteyza, MDPhD, Manuel Perez Encinas, MD, Lissette Del Pilar Costilla, MD, Maria Jose Sayas, Olga Pérez-López, Marcos González, Jose A. Perez-Simon, MD PhD, Joaquin Martinez-Lopez, MD PhD, Claudia Lucia Sossa, Alberto Orfao, MD PhD, Jesús F. San-Miguel, Miguel Sanz, MD PhD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–15.
https://doi.org/10.1182/blood-2020-134349
Published: 2020
Journal Articles

Measurable Residual Disease (MRD) in Elderly Acute Myeloid Leukemia (AML): Results from the Pethema-Flugaza Phase III Clinical Trial

Catia Patricia Simoes, MD, Bruno Paiva, PhD, David Martínez-Cuadron, MD, Juan-Miguel Bergua, MD, Susana Vives, MD, Jesús Lorenzo Algarra, Mar Tormo, MD, Pilar Martinez, MD, Josefina Serrano, MD, Pilar Herrera, MD, Fernando Ramos, MDPhD, Olga Salamero, MD, Esperanza Lavilla, Cristina Gil, Jose Luiz Lopez Lorenzo, MD, Maria-Belen Vidriales, MD, Jorge Labrador, José F. Falantes, Maria Jose Sayas, Rosa Ayala, MD PhD, Joaquin Martinez-Lopez, MD, Sara Villar, María José Calasanz, PhD, Felipe Prosper, MD, Jesús F. San-Miguel, Miguel A. Sanz, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-134651
Published: 2020
Journal Articles

Impact of Sars-Cov-2 Infection in Acute Myeloid Leukemia Patients: Experience of the Pethema Registry

Pilar Martínez, MD, Tomás Palanques Pastor, Jose Luiz Lopez Lorenzo, MD, Javier Cornago Navascués, MD, Gabriela Rodriguez-Macías, MD, Isabel Cano, MD, Montserrat Arnan Sangerman, María-Belén Vidriales, MDPhD, Jesús Lorenzo Algarra, Maria Angeles Foncillas, Pilar Herrera Puente, Carmen Botella, Susana Vives, MD, Angela Figuera Alvarez, MD PhD, Laida Cuevas Palomares, Marta Sobas, MDPhD, Alejandro Contento-Gonzalo, MD, Rebeca Cuello, MD, María Elena Amutio Diez, MD, Maria Dunia De Miguel, MD, Begoña Navas, MD, Juan Miguel Bergua Burgues, MD, Teresa Bernal del Castillo, MD PhD, María Carmen Mateos Rodríguez, MD, Erik de Cabo López, MD, Ana Carolina Franco Villegas, MD, Raimundo García-Boyero, MD, Cristian Escolano Escobar, MD, Cristina Seri, MD, Carlos Cervero, MD, Alicia Roldán Pérez, Maria Lourdes Hermosin, MD, Marta Cervera, MD, María Teresa Olave, MD, Paola Sandra Villafuerte Gutierrez, MD, Almudena De Laiglesia, MD, Josefina Serrano, MD, María Josefa Najera Irazu, MD, Jose Luis Piñana Sanchez, Miguel Ángel Sanz, MD, Joaquin Martinez-Lopez, MD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-138471
Published: 2020
Journal Articles

Mutational Profiling Predicts Clinical Outcomes to Azacytidine and Low Dose Cytarabine Plus Fludarabine (FLUGA) in Elderly Acute Myeloid Leukemia Patients Enrolled in the Pethema Phase III Flugaza Trial

Rosa M. Ayala, MD PhD, Inmaculada Rapado, David Martínez-Cuadron, MD, Esther Onecha, PhD, Laura Rufian, Miss, Alexandra Juarez, Juan Bergua Burgues, Susana Vives, MD, Jesús Lorenzo Algarra, Mar Tormo, MD PhD, Pilar Martinez, MD, Josefina Serrano, Pilar Herrera, MD, Fernando Ramos, Olga Salamero, MD, Esperanza Lavilla, Cristina Gil, MD, Jose Luis Lopez Lorenzo, MD, Maria-Belen Vidriales, MD, Jorge Labrador, MD, José F. Falantes, Maria Jose Sayas, Bruno Paiva, PhD, Eva Barragán, Felipe Prosper, MD PhD, Miguel A. Sanz, Joaquin Martinez Lopez, MD PhD, Pau Montesinos Fernandez, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3891.
https://doi.org/10.1182/blood-2019-127187
Published: 2019
Journal Articles

Role of Measurable Residual Disease (MRD) in Redefining Complete Response (CR) in Elderly Patients with Acute Myeloid Leukemia (AML): Results from the Pethema-Flugaza Phase III Clinical Trial

Bruno Paiva, MD PhD, David Martínez-Cuadron, MD, Juan Miguel Miguel Bergua Burgues, Susana Vives, MD, Jesús Lorenzo Algarra, Mar Tormo, MD PhD, Pilar Martínez-Sánchez, MD, Josefina Serrano, MD, Pilar Herrera, MD, Fernando Ramos, Olga Salamero, MD, Esperanza Lavilla, Cristina Gil, MD, Jose Luiz Lopez Lorenzo, MD, Maria-Belen Vidriales, MD, Jorge Labrador, MD, José F. Falantes, MD, Maria Jose Sayas, Juana Merino, Ana Alfonso, MD, Felipe Prosper, MD PhD, Jesus F San-Miguel, MD PhD, Miguel A. Sanz, MD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 433.
https://doi.org/10.1182/blood-2018-99-113299
Published: 2018
Journal Articles

Preliminary Results of the Flugaza Trial: A Phase III Randomized, Open Label Study Comparing Azacytidine Versus Fludarabine and Cytarabine (FLUGA Scheme) in Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia

Pau Montesinos, MD PhD, Susana Vives, MD, Maria P Martinez-Sanchez, MD, Juan Bergua, MD, Lorenzo Algarra, MD, Herrera Pilar, MD, Mar Tormo, MD, Jose-Luis Lopez-Lorenzo, MD, Fernando Ramos, MD, Jose Francisco Falantes, MD, Olga Salamero, MD, Josefina Serrano, MD, Cristina Gil, MD, Maria L Amador, MD, Esperanza Lavilla, MD, Maria J Sayas, MD, Maria Teresa Olave, MD, Belen Vidriales, MD, David Martínez-Cuadrón, MD PhD, Miguel Ángel Sanz, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4036.
https://doi.org/10.1182/blood.V128.22.4036.4036
Published: 2016
Journal Articles

Intensive (2+5) Or Semi-Intensive (FLUGA) Chemotherapy For Patients With Acute Myeloid Leukemia Who Are 70 Years Of Age Or Older

Pau Montesinos, David Martínez-Cuadrón, Esperanza Lavilla, Joaquín Díaz-Mediavilla, Pilar Herrera, García Raimundo, Juan Bergua, Pascual Fernandez, Maria Pedreño, Alfons Serrano, Lorenzo Algarra, Edelmira Martí, Chelo Rayón, Francisco Jaramillo, Manuel Perez-Encinas, Andrea Galego, Rosalía Riaza, Mª Pilar Martínez Sánchez, Adriana Simiele, Claudia Sossa, Rebeca Rodríguez-Veiga, José Luís Piñana, Miguel Sanz
Journal: Blood
Blood (2013) 122 (21): 2687.
https://doi.org/10.1182/blood.V122.21.2687.2687
Published: 2013