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Journal Articles

Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia

Eloísa Felipe Fumero, Carolin Walter, Joris Maximillian Frenz, Franca Seifert, Vijay Alla, Thorben Hennig, Linus Angenendt, Wolfgang Hartmann, Sebastian Wolf, Hubert Serve, Thomas Oellerich, Georg Lenz, Carsten Müller-Tidow, Christoph Schliemann, Otmar Huber, Martin Dugas, Matthias Mann, Ashok Kumar Jayavelu, Jan-Henrik Mikesch, Maria Francisca Arteaga
Journal: Blood
Blood (2024) 143 (22): 2284–2299.
https://doi.org/10.1182/blood.2023021640
Published: 2024
Includes: Supplemental data
Journal Articles

Dose Reduced Chemotherapy in Sequence with Blinatumomab for Newly Diagnosed Older Patients with Ph/BCR::ABL Negative B-Precursor Adult Lymphoblastic Leukemia (ALL): Preliminary Results of the GMALL Bold Trial

Nicola Goekbuget, Stefan Schwartz, Christoph Faul, Max S. Topp, Marion Subklewe, Andrea Renzelmann, Andrea Stoltefuss, Bernd Hertenstein, Anne Wilke, Simon Raffel, Nadja Jäkel, Vladan Vucinic, Dirk Markus Niemann, Lena Reiser, Hubert Serve, Monika Brüggemann, Andreas Viardot
Journal: Blood
Blood (2023) 142 (Supplement 1): 964.
https://doi.org/10.1182/blood-2023-180472
Published: 2023
Journal Articles

Secondary-Type Mutations Do Not Impact the Favorable Outcome of NPM1 -Mutated Acute Myeloid Leukemia Patients - Results from a Large Cohort of Intensively Treated Patients

Marius Bill, Jan-Niklas Eckardt, Christian Rausch, Klaus H Metzeler, Karsten Spiekermann, Sebastian Stasik, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Brümmendorf, Utz Krug, Bernhard Wörmann, Wolfgang Hiddemann, Dennis Görlich, Maria Cristina Sauerland, Björn Steffen, Hermann Einsele, Andreas Neubauer, Andreas Burchert, Kerstin Schaefer-Eckart, Wolfgang E. Berdel, Christoph Schliemann, Stefan W. Krause, Mathias Hanel, Maher Hanoun, Martin Kaufmann, Lars Fransecky, Jan Braess, Leo Ruhnke, Johannes Schetelig, Jan Moritz Middeke, Hubert Serve, Claudia D Baldus, Uwe Platzbecker, Carsten Müller-Tidow, Martin Bornhäuser, Tobias Herold, Christian Thiede, Christoph Röllig
Journal: Blood
Blood (2023) 142 (Supplement 1): 721.
https://doi.org/10.1182/blood-2023-186160
Published: 2023
Journal Articles

CNS Irradiation in Adult De Novo B-Precursor ALL / Lbl: Results of the Randomized GMALL T rial 08/2013 Indicate Potential Antileukemic Efficacy

Nicola Goekbuget, Björn Steffen, Kathrin Nachtkamp, Boris Böll, Veit L. Buecklein, Christoph Faul, Jens Panse, Christoph Röllig, Folker Schneller, Bernd Spriewald, Matthias Stelljes, Max S. Topp, Andreas Viardot, Vladan Vucinic, Knut Wendelin, Monika Brüggemann, Monika Szczepanowski, Stefan Schwartz, Thomas Burmeister, Axel Benner, Nicholas Schreck, Lena Reiser, Hubert Serve, Walter Fiedler
Journal: Blood
Blood (2023) 142 (Supplement 1): 828.
https://doi.org/10.1182/blood-2023-179442
Published: 2023
Journal Articles

Impact of KMT2A -PTD Mutational Subgroups on Outcome of AML Patients after Induction Therapy and Allogeneic Hematopoietic Cell Transplantation

Desiree Kunadt, Sven Zukunft, Klaus H Metzeler, Christoph Röllig, Christoph Schliemann, Jan Braess, Carsten Müller-Tidow, Alwin Kraemer, Sebastian Scholl, Inken Hilgendorf, Edgar Jost, Björn Steffen, Gesine Bug, Hermann Einsele, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Thomas Schroeder, Martin Kaufmann, Jan Moritz Middeke, Katja Sockel, Leo Ruhnke, Uwe Platzbecker, Hubert Serve, Matthias Stelljes, Claudia D Baldus, Andreas Neubauer, Johannes Schetelig, David Poitz, Christian Thiede, Martin Bornhäuser, Friedrich Stölzel
Journal: Blood
Blood (2023) 142 (Supplement 1): 2236.
https://doi.org/10.1182/blood-2023-187273
Published: 2023
Journal Articles

Immune Responses after One Versus Two Influenza A/B Vaccinations in Patients with Multiple Myeloma

Julius Enssle, Tonio Brinkschmidt, Ralf Dürrwald, Sebastian Wolf, David Zurmeyer, Björn Steffen, Evelyn Ullrich, Hubert Serve, Thomas Oellerich, Ivana von Metzler
Journal: Blood
Blood (2023) 142 (Supplement 1): 4737.
https://doi.org/10.1182/blood-2023-180096
Published: 2023
Journal Articles

LSD1 Inhibition Synergizes with Venetoclax in Acute Myeloid Leukemia By Targeting Cellular Metabolism

Kanwaldeep Singh, Emily Hartung, Christina Muhs, Islam Alshamleh, Monisha Divakaran, Anna Dvorkin-Gheva, Sara Pishyar, Pradhariny Prabagaran, Dina Khalaf, Alejandro Garcia-Horton, Stephen Ronan Foley, Brian Leber, Irwin Walker, Kylie Lepic, Harald Schwalbe, Hubert Serve, Maria Kleppe, Hugh Young Rienhoff, Jr., Tobias Berg
Journal: Blood
Blood (2023) 142 (Supplement 1): 4156.
https://doi.org/10.1182/blood-2023-189515
Published: 2023
Journal Articles

Mimicking Clinical Trials with Synthetic Acute Myeloid Leukemia Patients Using Generative Artificial Intelligence

Jan-Niklas Eckardt, Waldemar Hahn, Christoph Röllig, Sebastian Stasik, Uwe Platzbecker, Carsten Müller-Tidow, Hubert Serve, Claudia D Baldus, Christoph Schliemann, Kerstin Schäfer-Eckart, Maher Hanoun, Martin Kaufmann, Andreas Burchert, Christian Thiede, Johannes Schetelig, Martin Bornhäuser, Markus Wolfien, Jan Moritz Middeke
Journal: Blood
Blood (2023) 142 (Supplement 1): 2268.
https://doi.org/10.1182/blood-2023-179817
Published: 2023
Journal Articles

Risk Stratification of Patients with RUNX1- mutated Acute Myeloid Leukemia

Christian Rausch, Roman Hornung, Aarif M. N. Batcha, Maja Rothenberg-Thurley, Stefanos A. Bamopoulos, Vindi Jurinovic, Bianka Ksienzyk, Stephanie Schneider, Annika Maria Dufour, Michaela Neusser, Maria Cristina Sauerland, Dennis Görlich, Utz Krug, Wolfgang E. Berdel, Bernhard J. Woermann, Jan Braess, Wolfgang Hiddemann, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Johannes Schetelig, Moritz Middeke, Sebastian Stasik, Katharina Egger-Heidrich, Christoph Röllig, Martin Bornhäuser, Christian Thiede, Claudia D Baldus, Carsten Müller-Tidow, Uwe Platzbecker, Hubert Serve, Wendy Stock, Geoffrey L Uy, John C. Byrd, Deedra Nicolet, Ann-Kathrin Eisfeld, Ulrich Mansmann, Karsten Spiekermann, Klaus H Metzeler, Tobias Herold
Journal: Blood
Blood (2023) 142 (Supplement 1): 2934.
https://doi.org/10.1182/blood-2023-174059
Published: 2023
Journal Articles

Venetoclax Plus High-Dose Cytarabine and Mitoxantrone (HAM-Ven) As Salvage Treatment for Relapsed/Refractory AML: Updated Results of the Phase-I/II SAL Relax Trial

Leo Ruhnke, Christoph Schliemann, Jan-Henrik Mikesch, Matthias Stelljes, Lars Fransecky, Björn Steffen, Martin Kaufmann, Andreas Burchert, Andreas Rank, Maher Hanoun, Alexander Höllein, Sabrina Kraus, Mathias Hänel, Kerstin Schäfer-Eckart, Annett Haake, Frank Fiebig, Sven Zukunft, Jan Moritz Middeke, Désirée Kunadt, Johannes Schetelig, Malte von Bonin, Maximilian Alexander Röhnert, Uta Oelschlägel, Friedrich Stölzel, Claudia D Baldus, Hubert Serve, Martin Wermke, Martin Bornhäuser, Christoph Röllig
Journal: Blood
Blood (2023) 142 (Supplement 1): 160.
https://doi.org/10.1182/blood-2023-184445
Published: 2023
Journal Articles

Overlapping features of therapy-related and de novo NPM1 -mutated AML

Clinical Trials & Observations
Jad Othman, Manja Meggendorfer, Enrico Tiacci, Christian Thiede, Richard Schlenk, Richard Dillon, Sebastian Stasik, Alessandra Venanzi, Sarah Bertoli, Eric Delabesse, Pierre-Yves Dumas, Arnaud Pigneux, Audrey Bidet, Amanda F. Gilkes, Ian Thomas, Maria Teresa Voso, Alessandro Rambaldi, Lorenzo Brunetti, Vincenzo M. Perriello, Vibeke Andresen, Bjorn T. Gjertsen, Maria Paola Martelli, Christian Récher, Christoph Röllig, Martin Bornhäuser, Hubert Serve, Carsten Müller-Tidow, Claudia D. Baldus, Tortsten Haferlach, Nigel Russell, Brunangelo Falini
Journal: Blood
Blood (2023) 141 (15): 1846–1857.
https://doi.org/10.1182/blood.2022018108
Published: 2023
Includes: Supplemental data
Journal Articles

Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1

Maike Janssen, Christina Schmidt, Peter-Martin Bruch, Maximilian F. Blank, Christian Rohde, Alexander Waclawiczek, Daniel Heid, Simon Renders, Stefanie Göllner, Lisa Vierbaum, Birgit Besenbeck, Sophie A. Herbst, Mareike Knoll, Carolin Kolb, Adriana Przybylla, Katharina Weidenauer, Anne Kathrin Ludwig, Margarete Fabre, Muxin Gu, Richard F. Schlenk, Friedrich Stölzel, Martin Bornhäuser, Christoph Röllig, Uwe Platzbecker, Claudia Baldus, Hubert Serve, Tim Sauer, Simon Raffel, Caroline Pabst, George Vassiliou, Binje Vick, Irmela Jeremias, Andreas Trumpp, Jeroen Krijgsveld, Carsten Müller-Tidow, Sascha Dietrich
Journal: Blood
Blood (2022) 140 (24): 2594–2610.
https://doi.org/10.1182/blood.2021014241
Published: 2022
Includes: Supplemental data
Journal Articles

Translatome Proteomics Identifies Autophagy As a Resistance Mechanism to on-Target FLT3 Inhibitors in Acute Myeloid Leukemia

Sebastian E. Koschade, Kevin Klann, Shabnam Shaid, Binje Vick, Jan A. Stratmann, Marlyn Thölken, Laura M. Meyer, The Duy Nguyen, Julia Campe, Laura M. Moser, Susanna Hock, Fatima Baker, Christian Meyer, Frank Wempe, Hubert Serve, Evelyn Ullrich, Irmela Jeremias, Christian Münch, Christian H. Brandts
Journal: Blood
Blood (2022) 140 (Supplement 1): 3100.
https://doi.org/10.1182/blood-2022-168824
Published: 2022
Journal Articles

Venetoclax Plus High-Dose Cytarabine and Mitoxantrone As Feasible and Effective Novel Treatment for Relapsed AML: Results of the Phase-I SAL Relax Trial

Christoph Röllig, Lars Fransecky, Maher Hanoun, Björn Steffen, Sabrina Kraus, Christoph Schliemann, Annett Haake, Frank Fiebig, Sven Zukunft, Nael Alakel, Jan Moritz Middeke, Martin Bornhaeuser, Friedrich Stoelzel, Johannes Schetelig, Leo Ruhnke, Michael Kramer, Malte Von Bonin, Maximilian Alexander Röhnert, Uta Oelschlägel, Claudia D. Baldus, Hubert Serve, Martin Wermke
Journal: Blood
Blood (2022) 140 (Supplement 1): 3327–3328.
https://doi.org/10.1182/blood-2022-159897
Published: 2022
Journal Articles

In Patients with Relapsed/Refractory AML Sequential Conditioning and Immediate Allogeneic Stem Cell Transplantation (allo-HCT) Results in Similar Overall and Leukemia-Free Survival Compared to Intensive Remission Induction Chemotherapy Followed By Allo-HCT: Results from the Randomized Phase III ASAP Trial

Matthias Stelljes, Jan Moritz Middeke, Gesine Bug, Eva-Maria Wagner, Lutz Peter Mueller, Schmid Christoph, Stefan W. Krause, Wolfgang Bethge, Edgar Jost, Uwe Platzbecker, Stefan Klein, Jörg Schubert, Judith Niederland, Martin Kaufmann, Kerstin Schäfer-Eckart, Markus Schaich, Henning Baldauf, Friedrich Stölzel, Cathleen Petzold, Christoph Röllig, Nael Alakel, Björn Steffen, Beate Hauptrock, Christian Reicherts, Christoph Schliemann, Hubert Serve, Alexander H. Schmidt, Martin Bornhäuser, Jan-Henrik Mikesch, Johannes Schetelig
Journal: Blood
Blood (2022) 140 (Supplement 1): 9–11.
https://doi.org/10.1182/blood-2022-159962
Published: 2022
Journal Articles

Single Versus Double Induction with "7+3" Containing 60 Versus 90 Mg Daunorubicin for Newly Diagnosed AML: Results from the Randomized Controlled SAL Dauno-Double Trial

Christoph Röllig, Björn Steffen, Christoph Schliemann, Jan-Henrik Mikesch, Nael Alakel, Regina Herbst, Mathias Haenel, Richard Noppeney, Maher Hanoun, Martin Kaufmann, Zdenek Racil, Kerstin Schäfer-Eckart, Tim Sauer, Andreas Neubauer, Claudia D. Baldus, Jolana Mertova, Edgar Jost, Dirk Niemann, Jan Novak, Stefan W. Krause, Sebastian Scholl, Andreas Hochhaus, Gerhard Held, Tomáš Szotkowski, Christoph Schmid, Andreas Rank, Lars Fransecky, Michael Kramer, Frank Fiebig, Annett Haake, Friedrich Stoelzel, Johannes Schetelig, Jan Moritz Middeke, Uwe Platzbecker, Christian Thiede, Carsten Müller-Tidow, Wolfgang E. Berdel, Hubert Serve, Gerhard Ehninger, Jiří Mayer, Martin Bornhaeuser
Journal: Blood
Blood (2022) 140 (Supplement 1): 523–525.
https://doi.org/10.1182/blood-2022-157126
Published: 2022
Journal Articles

Interventional Antibiotic Treatment Replacing Antibiotic Prophylaxis during Allogeneic Hematopoietic Stem Cell Transplantation Is Safe and Feasible: A Single-Center Analysis

Rosa Toenges, Fabian Lang, Rakhshinda Ghaffar, Vera Schlipfenbacher, Julia Riemann, Salem Ajib, Khouloud Kouidri, Anjali Cremer, Weber Bodo, Thu Nguyen, Antje Knoch, Janne Vehreschild, Hubert Serve, Gesine Bug
Journal: Blood
Blood (2022) 140 (Supplement 1): 10478–10479.
https://doi.org/10.1182/blood-2022-163303
Published: 2022
Journal Articles

Double-Blind, Placebo Controlled, Randomized, Multicenter, Phase II Study to Assess the Efficacy of the High Affinity CXCR4 Inhibitor BL-8040 As Addition to Consolidation Therapy in AML By the SAL and OSHO Leukemia Study Groups

Sonia Jaramillo Segura, Maxi Wass, Judith Schaffrath, Kathrin Rieger, Axel Nogai, Mathias Haenel, Regina Herbst, Friedrich Stoelzel, Christoph Röllig, Edgar Jost, Richard F. Schlenk, Richard Noppeney, Christian H. Brandts, Utz Krug, Katharina S. Goetze, Sebastian Buske, Axel Florschütz, Jörg Schubert, Bernhard Opitz, Martin Mohren, Eva Eßeling, Stephan von Witzendorff, Marion Subklewe, Martin Kaufmann, Norbert Frickhofen, Christian W Scholz, Kerstin Schäfer-Eckart, Volker Kunzmann, Martin Schmidt-Hieber, Herbert G. Sayer, Andreas Rank, Philipp Hemmati, Frank Schueler, Simone Kowoll, Marina Scheller, Jörg Steighardt, Bayram Edemir, Lutz Peter Mueller, Irit Gliko-Kabir, Beatrice Ludwig-Kraus, Sabine Edemir, Ella Sorani, Mascha Binder, Abi Vainstein, Shaul Kadosh, Cora Gromann, Andreas Wienke, Claudia D. Baldus, Uwe Platzbecker, Hubert Serve, Martin Bornhaeuser, Christian Junghanss, Carsten Mueller-Tidow
Journal: Blood
Blood (2022) 140 (Supplement 1): 3338–3340.
https://doi.org/10.1182/blood-2022-166748
Published: 2022
Journal Articles

Venetoclax-Based Salvage Therapy Improves Outcome in Relapsed/Refractory AML Patients Eligible for Intensive Treatment: A Propensity Score Matching Analysis

Julia M. Unglaub, Richard F. Schlenk, Maher Hanoun, H. Christian Reinhardt, Jan Moritz Middeke, Kerstin Schäfer-Eckart, Björn Steffen, Stefan W. Krause, Christoph Schliemann, Martin Kaufmann, Mathias Haenel, Edgar Jost, Martina Crysandt, Lars Fransecky, Hermann Einsele, Sabrina Kraus, Dirk Niemann, Andreas Neubauer, Ruth Seggewiss-Bernhardt, Sebastian Scholl, Stefan Klein, Christoph Schmid, Markus Schaich, Uwe Platzbecker, Claudia D. Baldus, Martin Bornhaeuser, Hubert Serve, Christoph Röllig, Michael Kramer, Elena Katelari, Maike Janssen, Caroline Pabst, Thomas Luft, Peter Dreger, Carsten Müller-Tidow, Tim Sauer
Journal: Blood
Blood (2022) 140 (Supplement 1): 3317–3319.
https://doi.org/10.1182/blood-2022-167677
Published: 2022
Journal Articles

Tandem Duplications of the UBTF gene in Adult AML: A Rare but Recurrent Alteration Associated with Myelodysplasia and Poor Outcome

Julia-Annabell Georgi, Sebastian Stasik, Sven Zukunft, Marita Hartwig, Christoph Röllig, Uta Oelschlaegel, Utz Krug, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Tim H Brümmendorf, Ralph Naumann, Björn Steffen, Hermann Einsele, Markus Schaich, Andreas Burchert, Andreas Neubauer, Kerstin Schaefer-Eckart, Christoph Schliemann, Stefan W. Krause, Mathias Haenel, Richard Noppeney, Ulrich Kaiser, Claudia D. Baldus, Martin Kaufmann, Carsten Müller-Tidow, Uwe Platzbecker, Wolfgang E. Berdel, Hubert Serve, Gerhard Ehninger, Martin Bornhaeuser, Johannes Schetelig, Frank P. Kroschinsky, Christian Thiede
Journal: Blood
Blood (2022) 140 (Supplement 1): 6262–6264.
https://doi.org/10.1182/blood-2022-164702
Published: 2022