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Christine Dierks
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Journal Articles

Activated granulocytes and inflammatory cytokine signaling drive T-cell lymphoma progression and disease symptoms

Amelie Jaeger, Sudheer Madan Mohan Gambheer, Xiaoyang Sun, Dmitry Chernyakov, Oleksandra Skorobohatko, Thomas Mack, Sandra Kissel, Dietmar Pfeifer, Robert Zeiser, Paul Fisch, Geoffroy Andrieux, Daniela Bräuer-Hartmann, Marcus Bauer, Susann Schulze, Marie Follo, Melanie Boerries, Nikolas von Bubnoff, Cornelius Miething, Jose Villacorta Hidalgo, Claudius Klein, Thomas Weber, Claudia Wickenhauser, Mascha Binder, Christine Dierks
Journal: Blood
Blood (2023) 141 (23): 2824–2840.
https://doi.org/10.1182/blood.2022015653
Published: 2023
Includes: Supplemental data
Journal Articles

Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers

Alexandre Fagnan, Frederik Otzen Bagger, Maria-Riera Piqué-Borràs, Cathy Ignacimouttou, Alexis Caulier, Cécile K. Lopez, Elie Robert, Benjamin Uzan, Véronique Gelsi-Boyer, Zakia Aid, Cécile Thirant, Ute Moll, Samantha Tauchmann, Amina Kurtovic-Kozaric, Jaroslaw Maciejewski, Christine Dierks, Orietta Spinelli, Silvia Salmoiraghi, Thomas Pabst, Kazuya Shimoda, Virginie Deleuze, Hélène Lapillonne, Connor Sweeney, Véronique De Mas, Betty Leite, Zahra Kadri, Sébastien Malinge, Stéphane de Botton, Jean-Baptiste Micol, Benjamin Kile, Catherine L. Carmichael, Ilaria Iacobucci, Charles G. Mullighan, Martin Carroll, Peter Valent, Olivier A. Bernard, Eric Delabesse, Paresh Vyas, Daniel Birnbaum, Eduardo Anguita, Loïc Garçon, Eric Soler, Juerg Schwaller, Thomas Mercher
Journal: Blood
Blood (2020) 136 (6): 698–714.
https://doi.org/10.1182/blood.2019003062
Published: 2020
Includes: Supplemental data
Journal Articles

The Fanconi Anemia-Associated Protein NIPA Is Essential for the Nuclear Abundance of FANCD2

Stefanie Kreutmair, Miriam Erlacher, Geoffroy Andrieux, Rouzanna Istvanffy, Alina Rudorf, Melissa Zwick, Tamina Rückert, Milena Pantic, Teresa Poggio, Khalid Shoumariyeh, MD, Tony Andreas Müller, Hiroyuki Kawaguchi, Marie Follo, Cathrin Klingeberg, Marcin Wlodarski, Irith Baumann, Dietmar Pfeifer, Michal Kulinski, Martina Rudelius, Simone Lemeer, Bernhard Kuster, Christine Dierks, Christian Peschel, Nina Cabezas-Wallscheid, Jesus Duque-Afonso, Robert Zeiser, MD, Michael Cleary, Detlev Schindler, Annette Schmitt-Graeff, Melanie Boerries, Charlotte M. Niemeyer, MD, Robert A.J. Oostendorp, Justus Duyster, MD, Anna Lena Illert
Journal: Blood
Blood (2019) 134 (Supplement_1): 3741.
https://doi.org/10.1182/blood-2019-125973
Published: 2019
Journal Articles

BCR-Induced VLA-4 Activation in the TCL1 Transgenic Mouse Model for Chronic Lymphocytic Leukemia

Eva Szenes, Andrea Härzschel, Erika Tissino, PhD, Pischeli Justine, Julia Gutjahr, Sandra Pennisi, Jan Höpner, Alexander Egle, MD, Nadja Zaborsky, Marie Follo, Sarah Decker, PhD, Christine Dierks, Alexandre Chigaev, Antonella Zucchetto, Valter Gattei, MD, Richard Greil, MD, Tanja Nicole Hartmann, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1730.
https://doi.org/10.1182/blood-2019-125634
Published: 2019
Journal Articles

The Pan-PIM Kinase Inhibitor LGB321 Strongly Increases Ibrutinib Effects in CLL, By Blocking Anti-Apoptotic Pathways and Microenvironmental Interactions

Sarah Decker, PhD, Shifa Saleem, Sandra Kissel, Anabel Zwick, Konrad Aumann, Katja Zirlik, MD, Justus Duyster, Prof., Christine Dierks
Journal: Blood
Blood (2018) 132 (Supplement 1): 1840.
https://doi.org/10.1182/blood-2018-99-114424
Published: 2018
Journal Articles

The Pan-PIM Kinase Inhibitor LGB321 Affects Apoptotic Pathways and Microenvironmental Interactions in CLL

Sarah Decker, PhD, Sandra Kissel, Konrad Aumann, MD, Thorsten Zenz, Katja Zirlik, MD, Rainer Claus, MD, Justus Duyster, MD, Christine Dierks, MD
Journal: Blood
Blood (2016) 128 (22): 4370.
https://doi.org/10.1182/blood.V128.22.4370.4370
Published: 2016
Journal Articles

PIM1 Inhibition Enhances and Prolongs Plerixafor-Induced Mobilization of HSCs

Tony Andreas Müller, PhD, Anabel Zwick, Sarah Decker, PhD, Claudius Klein, PhD, Benjamin Rister, MD, Alina Rudorf, Sandra Kissel, Marie Follo, PhD, Ralph Wäsch, MD, Anna Lena Illert, MD, Claudia Waskow, PhD, Christine Dierks, MD, Justus Duyster, MD
Journal: Blood
Blood (2016) 128 (22): 655.
https://doi.org/10.1182/blood.V128.22.655.655
Published: 2016
Journal Articles

NIPA As a Novel Regulator of Aging and Stress Response of the Primitive HSC Pool

Stefanie Kreutmair, Rouzanna Istvanffy, PhD, Cathrin Klingeberg, PhD, Christine Dierks, MD, Christian Peschel, MD, Robert A.J. Oostendorp, BSc, MSc, PhD, Justus Duyster, MD PhD, Anna Lena Illert, MD
Journal: Blood
Blood (2015) 126 (23): 1155.
https://doi.org/10.1182/blood.V126.23.1155.1155
Published: 2015
Journal Articles

Depletion of Ptch2 Activates Canonical and Non-Canonical HH Signaling within the Niche Leading to Myeloproliferation, Stem Cell Exhaustion and Accelerates JAK2V617F Driven Disease

Claudius Klein, Anabel Kuhn, Sandra Kissel, Marie Follo, PhD, Anna Lena Illert, MD, Dietmar Pfeifer, Heike L Pahl, PhD, Robert A.J. Oostendorp, PhD, Justus Duyster, MD, Christine Dierks, MD
Journal: Blood
Blood (2015) 126 (23): 3593.
https://doi.org/10.1182/blood.V126.23.3593.3593
Published: 2015
Journal Articles

Preclinical Analysis of Linsitinib for the Treatment of Polycythemia Vera

Titiksha Basu, Albert Gruender, PhD, Christine Dierks, MD, Heike L Pahl, PhD
Journal: Blood
Blood (2015) 126 (23): 2825.
https://doi.org/10.1182/blood.V126.23.2825.2825
Published: 2015
Journal Articles

SYK Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia

Marco Benkisser-Petersen, Maike Buchner, Arlette Dörffel, Marcus Dühren von Minden, Kerstin Leberecht, Kathrin Kläsener, Rainer Claus, MD, Ariane Ott, Christine Dierks, Hassan Jumaa, Fabio Malavasi, Michael Reth, Hendrik Veelken, Katja Zirlik, MD
Journal: Blood
Blood (2015) 126 (23): 2910.
https://doi.org/10.1182/blood.V126.23.2910.2910
Published: 2015
Journal Articles

Combination Of Kinase Inhibitors Overcomes B-Raf Inhibitor-Induced Paradoxical ERK Activation In CLL Cells In Vitro – Potential Implications For CLL Treatment

Niuscha Yaktapour, Christine Dierks, Dietmar Pfeifer, Hassan Jumaa, Hendrik Veelken, MD PhD, Tilman Brummer, Katja Zirlik
Journal: Blood
Blood (2013) 122 (21): 4121.
https://doi.org/10.1182/blood.V122.21.4121.4121
Published: 2013
Journal Articles

Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia

Niuscha Yaktapour, Rudolf Übelhart, Julia Schüler, Konrad Aumann, Christine Dierks, Meike Burger, Dietmar Pfeifer, Hassan Jumaa, Hendrik Veelken, Tilman Brummer, Katja Zirlik
Journal: Blood
Blood (2013) 122 (9): 1621–1633.
https://doi.org/10.1182/blood-2013-02-484386
Published: 2013
Includes: Supplemental data
Journal Articles

Comparison of the Transforming Effect of Different SYK Oncogenes in Vivo Reveals TEL-SYK As Inducer of an MDS/MPS Overlap Syndrome in Mice

Clara Sprissler, Helga Maurer, Hassan Jumaa, PhD, Hendrik Veelken, MD PhD, Christine Dierks
Journal: Blood
Blood (2012) 120 (21): 1310.
https://doi.org/10.1182/blood.V120.21.1310.1310
Published: 2012
Journal Articles

IGF1R Inhibition Induces Apoptosis in Chronic Lymphocytic Leukemia

Niuscha Yaktapour, Rudolf Uebelhart, Christine Dierks, Meike Burger, Dietmar Pfeifer, Hassan Jumaa, Hendrik Veelken, MD PhD, Tilman Brummer, Katja Zirlik
Journal: Blood
Blood (2012) 120 (21): 3864.
https://doi.org/10.1182/blood.V120.21.3864.3864
Published: 2012
Journal Articles

PIM Kinase Inhibitors Interfere with the Protective CLL Microenvironment by Blocking CXCR4 Surface Expression and Function

Sarah Decker, Johannes Finter, Katja Zirlik, Hendrik Veelken, MD PhD, Christine Dierks
Journal: Blood
Blood (2012) 120 (21): 3867.
https://doi.org/10.1182/blood.V120.21.3867.3867
Published: 2012
Journal Articles

Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL

Sarah Decker, Katja Zirlik, Lauritte Djebatchie, David Hartmann, Gabriele Ihorst, Annette Schmitt-Graeff, Dieter Herchenbach, Hassan Jumaa, Markus Warmuth, Hendrik Veelken, Christine Dierks
Journal: Blood
Blood (2012) 119 (4): 997–1007.
https://doi.org/10.1182/blood-2011-06-359075
Published: 2012
Includes: Supplemental data
Journal Articles

SYK Inhibition Targets CD38−Mediated Survival and Proliferation Signals in Chronic Lymphocytic Leukemia Cells

Maike Buchner, PhD, Natalie Stickel, MS, Arlette Dörffel, BS, Ariane Ott, BS, Marcus Duehren von Minden, MS, Christine Dierks, MD, Hassan Jumaa, PhD, Hendrik J. Veelken, MD, PhD, Katja Zirlik, MD
Journal: Blood
Blood (2011) 118 (21): 800.
https://doi.org/10.1182/blood.V118.21.800.800
Published: 2011
Journal Articles

Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia

Maike Buchner, Constance Baer, Gabriele Prinz, Christine Dierks, Meike Burger, Thorsten Zenz, Stephan Stilgenbauer, Hassan Jumaa, Hendrik Veelken, Katja Zirlik
Journal: Blood
Blood (2010) 115 (22): 4497–4506.
https://doi.org/10.1182/blood-2009-07-233692
Published: 2010
Includes: Supplemental data
Journal Articles

Spleen Tyrosine Kinase (SYK) Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic Leukemia

Maike Buchner, PhD, Simon Fuchs, MS, Gabriele Prinz, BA, Dietmar Pfeifer, PhD, Kilian Bartholomé, PhD, Nina Chevalier, MD, Laurent Vallat, MD, Jens Timmer, PhD, John G Gribben, MD, DSc, Hassan Jumaa, PhD, Hendrik Veelken, MD, Christine Dierks, MD, Katja Zirlik, MD
Journal: Blood
Blood (2008) 112 (11): 543.
https://doi.org/10.1182/blood.V112.11.543.543
Published: 2008