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Leo Ruhnke
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Journal Articles

Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Daria Frank, Pradeep Kumar Patnana, Jan Vorwerk, Lianghao Mao, Lavanya Mokada Gopal, Noelle Jung, Thorben Hennig, Leo Ruhnke, Joris Maximillian Frenz, Maithreyan Kuppusamy, Robert Autry, Lanying Wei, Kaiyan Sun, Helal Mohammed Mohammed Ahmed, Axel Künstner, Hauke Busch, Heiko Müller, Stephan Hutter, Gregor Hoermann, Longlong Liu, Xiaoqing Xie, Yahya Al-Matary, Subbaiah Chary Nimmagadda, Fiorella Charles Cano, Michael Heuser, Felicitas Thol, Gudrun Göhring, Doris Steinemann, Jürgen Thomale, Theo Leitner, Anja Fischer, Roland Rad, Christoph Röllig, Heidi Altmann, Desiree Kunadt, Wolfgang E. Berdel, Jana Hüve, Felix Neumann, Jürgen Klingauf, Virginie Calderon, Bertram Opalka, Ulrich Dührsen, Frank Rosenbauer, Martin Dugas, Julian Varghese, Hans Christian Reinhardt, Nikolas von Bubnoff, Tarik Möröy, Georg Lenz, Aarif M. N. Batcha, Marianna Giorgi, Murugan Selvam, Eunice Wang, Shannon K. McWeeney, Jeffrey W. Tyner, Friedrich Stölzel, Matthias Mann, Ashok Kumar Jayavelu, Cyrus Khandanpour
Journal: Blood
Blood (2023) 142 (25): 2175–2191.
https://doi.org/10.1182/blood.2022015752
Published: 2023
Includes: Supplemental data
Journal Articles

Secondary-Type Mutations Do Not Impact the Favorable Outcome of NPM1 -Mutated Acute Myeloid Leukemia Patients - Results from a Large Cohort of Intensively Treated Patients

Marius Bill, Jan-Niklas Eckardt, Christian Rausch, Klaus H Metzeler, Karsten Spiekermann, Sebastian Stasik, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Brümmendorf, Utz Krug, Bernhard Wörmann, Wolfgang Hiddemann, Dennis Görlich, Maria Cristina Sauerland, Björn Steffen, Hermann Einsele, Andreas Neubauer, Andreas Burchert, Kerstin Schaefer-Eckart, Wolfgang E. Berdel, Christoph Schliemann, Stefan W. Krause, Mathias Hanel, Maher Hanoun, Martin Kaufmann, Lars Fransecky, Jan Braess, Leo Ruhnke, Johannes Schetelig, Jan Moritz Middeke, Hubert Serve, Claudia D Baldus, Uwe Platzbecker, Carsten Müller-Tidow, Martin Bornhäuser, Tobias Herold, Christian Thiede, Christoph Röllig
Journal: Blood
Blood (2023) 142 (Supplement 1): 721.
https://doi.org/10.1182/blood-2023-186160
Published: 2023
Journal Articles

Impact of KMT2A -PTD Mutational Subgroups on Outcome of AML Patients after Induction Therapy and Allogeneic Hematopoietic Cell Transplantation

Desiree Kunadt, Sven Zukunft, Klaus H Metzeler, Christoph Röllig, Christoph Schliemann, Jan Braess, Carsten Müller-Tidow, Alwin Kraemer, Sebastian Scholl, Inken Hilgendorf, Edgar Jost, Björn Steffen, Gesine Bug, Hermann Einsele, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Thomas Schroeder, Martin Kaufmann, Jan Moritz Middeke, Katja Sockel, Leo Ruhnke, Uwe Platzbecker, Hubert Serve, Matthias Stelljes, Claudia D Baldus, Andreas Neubauer, Johannes Schetelig, David Poitz, Christian Thiede, Martin Bornhäuser, Friedrich Stölzel
Journal: Blood
Blood (2023) 142 (Supplement 1): 2236.
https://doi.org/10.1182/blood-2023-187273
Published: 2023
Journal Articles

Venetoclax Plus High-Dose Cytarabine and Mitoxantrone (HAM-Ven) As Salvage Treatment for Relapsed/Refractory AML: Updated Results of the Phase-I/II SAL Relax Trial

Leo Ruhnke, Christoph Schliemann, Jan-Henrik Mikesch, Matthias Stelljes, Lars Fransecky, Björn Steffen, Martin Kaufmann, Andreas Burchert, Andreas Rank, Maher Hanoun, Alexander Höllein, Sabrina Kraus, Mathias Hänel, Kerstin Schäfer-Eckart, Annett Haake, Frank Fiebig, Sven Zukunft, Jan Moritz Middeke, Désirée Kunadt, Johannes Schetelig, Malte von Bonin, Maximilian Alexander Röhnert, Uta Oelschlägel, Friedrich Stölzel, Claudia D Baldus, Hubert Serve, Martin Wermke, Martin Bornhäuser, Christoph Röllig
Journal: Blood
Blood (2023) 142 (Supplement 1): 160.
https://doi.org/10.1182/blood-2023-184445
Published: 2023
Journal Articles

Venetoclax Plus High-Dose Cytarabine and Mitoxantrone As Feasible and Effective Novel Treatment for Relapsed AML: Results of the Phase-I SAL Relax Trial

Christoph Röllig, Lars Fransecky, Maher Hanoun, Björn Steffen, Sabrina Kraus, Christoph Schliemann, Annett Haake, Frank Fiebig, Sven Zukunft, Nael Alakel, Jan Moritz Middeke, Martin Bornhaeuser, Friedrich Stoelzel, Johannes Schetelig, Leo Ruhnke, Michael Kramer, Malte Von Bonin, Maximilian Alexander Röhnert, Uta Oelschlägel, Claudia D. Baldus, Hubert Serve, Martin Wermke
Journal: Blood
Blood (2022) 140 (Supplement 1): 3327–3328.
https://doi.org/10.1182/blood-2022-159897
Published: 2022
Journal Articles

Prevalence, Clinical and Molecular Features, and Prognostic Value of Tetraploidy/Near-Tetraploidy in Patients with Acute Myeloid Leukemia

Leo Ruhnke, Julia Frimmel, Christoph Röllig, Brigitte Mohr, Heidi Altmann, David Poitz, Sven Zukunft, Katrin Schranz, Sebastian Vosberg, Karsten Spiekermann, Michael von Bergwelt, Edgar Jost, Sabine Dressler, Kerstin Schäfer-Eckart, Triantafyllos Chavakis, Daniela Aust, Korinna Jöhrens, Gustavo Baretton, Martin Bornhäuser, Philipp A. Greif, Friedrich Stölzel, Sylvia Herold, Lisa Wagenführ
Journal: Blood
Blood (2022) 140 (Supplement 1): 3454–3455.
https://doi.org/10.1182/blood-2022-166271
Published: 2022
Journal Articles

A Phase I Trial of the Antibody-Cytokine Fusion Protein F16IL2 in Combination with Anti-CD33 Immunotherapy for Posttransplant AML Relapse

Andrew F. Berdel, Christoph Rollig, Martin Wermke, Linus Angenendt, Leo Ruhnke, Jan-Henrik Mikesch, Teresa Hemmerle, Klaus Wethmar, Torsten Kessler, Mirjam Gerwing, Daniel Hescheler, Michael Schäfers, Wolfgang Hartmann, Bianca Altvater, Claudia Rossig, Georg Lenz, Matthias Stelljes, Bjoern Rueter, Dario Neri, Wolfgang E. Berdel, Christoph Schliemann
Journal: Blood
Blood (2021) 138 (Supplement 1): 2345.
https://doi.org/10.1182/blood-2021-145859
Published: 2021
Journal Articles

Diagnostic Red Blood Cell Distribution Width As a Prognostic Factor in Acute Myeloid Leukemia

Vladan Vucinic, Leo Ruhnke, Katja Sockel, Maximilian Alexander Röhnert, Donata Backhaus, Dominic Brauer, Georg-Nikolaus Franke, Dietger Niederwieser, Martin Bornhäuser, Christoph Rollig, Uwe Platzbecker, Sebastian Schwind, Madlen Jentzsch
Journal: Blood
Blood (2021) 138 (Supplement 1): 1227.
https://doi.org/10.1182/blood-2021-145497
Published: 2021
Journal Articles

Intensified Cytarabine Dose during Consolidation Therapy in AML Patients Under 65 Years Is Not Associated with Survival Benefit

Maher Hanoun, Leo Ruhnke, Michael Kramer, Kerstin Schäfer-Eckhard, Björn Steffen, Tim Sauer, Stefan W. Krause, Christoph Schliemann, Martin Kaufmann, Mathias Haenel, Edgar Jost, Tim H Brummendorf, Lars Fransecky, Sabrina Kraus, Hermann Einsele, Dirk Niemann, Andreas Neubauer, Johannes Kullmer, Ruth Seggewiss-Bernhard, Martin Goerner, Gerhard Held, Ulrich Kaiser, Sebastian Scholl, Hans Christian Reinhardt, Uwe Platzbecker, Claudia D. Baldus, Carsten Mueller-Tidow, Martin Bornhaeuser, Hubert Serve, Christoph Rollig
Journal: Blood
Blood (2021) 138 (Supplement 1): 1242.
https://doi.org/10.1182/blood-2021-146606
Published: 2021
Journal Articles

Impact of Body Mass Index on Patient Outcome in Acute Myeloid Leukemia Patients Receiving Intensive Induction Therapy: A Real-World Registry Experience

Julius Christoph Enssle, Sebastian Wolf, Sebastian Scheich, Sarah Weber, Michael Kramer, Leo Ruhnke, Christoph Schliemann, Jan-Henrik Mikesch, Stefan W. Krause, Tim Sauer, Maher Hanoun, Hans Christian Reinhardt, Sabrina Kraus, Martin Kaufmann, Mathias Haenel, Lars Fransecky, Andreas Burchert, Andreas Neubauer, Martina Crysandt, Edgar Jost, Dirk Niemann, Kerstin Schäfer-Eckhard, Gerhard Held, Ulrich Kaiser, Maxi Wass, Markus Schaich, Carsten Müller-Tidow, Uwe Platzbecker, Claudia D. Baldus, Martin Bornhäuser, Christoph Rollig, Hubert Serve, Björn Steffen
Journal: Blood
Blood (2021) 138 (Supplement 1): 3370.
https://doi.org/10.1182/blood-2021-145917
Published: 2021
Journal Articles

Mutant TET2 Allele Dosage Affects Response to 5-Azacitidine in Acute Myeloid Leukemia

Friedrich Stoelzel, MD, Sarah Elizabeth Fordham, PhD BSc, Wei Yu Lin, PhD, Helen Blair, PhD, Leo Ruhnke, MD, Desireé Kunadt, MD, Brigitte Mohr, PhD, Claire Elstob, PhD, Daniel Allsop, MD, Devi Nandana, BSc, Emmanouela-Niki Soura, MPhil, Catherine Park, PhD, Mohd Fadly, PhD, Thahira Rahman, PhD, Olaf Heidenreich, Heidi Altmann, PhD, Gail Jones, MD, Tobias Menne, MD PhD, Manja Wobus, PhD, Graham Jackson, MA, MB BS, FRCP, FRCPath, MD, Helen Marr, PhD, Kenan Onel, MD PhD, Manja Meggendorfer, PhD, Torsten Haferlach, MD, Martin Bornhäuser, MD, James M. Allan
Journal: Blood
Blood (2019) 134 (Supplement_1): 113.
https://doi.org/10.1182/blood-2019-123047
Published: 2019