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Hans Christian Reinhardt
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Journal Articles

Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Daria Frank, Pradeep Kumar Patnana, Jan Vorwerk, Lianghao Mao, Lavanya Mokada Gopal, Noelle Jung, Thorben Hennig, Leo Ruhnke, Joris Maximillian Frenz, Maithreyan Kuppusamy, Robert Autry, Lanying Wei, Kaiyan Sun, Helal Mohammed Mohammed Ahmed, Axel Künstner, Hauke Busch, Heiko Müller, Stephan Hutter, Gregor Hoermann, Longlong Liu, Xiaoqing Xie, Yahya Al-Matary, Subbaiah Chary Nimmagadda, Fiorella Charles Cano, Michael Heuser, Felicitas Thol, Gudrun Göhring, Doris Steinemann, Jürgen Thomale, Theo Leitner, Anja Fischer, Roland Rad, Christoph Röllig, Heidi Altmann, Desiree Kunadt, Wolfgang E. Berdel, Jana Hüve, Felix Neumann, Jürgen Klingauf, Virginie Calderon, Bertram Opalka, Ulrich Dührsen, Frank Rosenbauer, Martin Dugas, Julian Varghese, Hans Christian Reinhardt, Nikolas von Bubnoff, Tarik Möröy, Georg Lenz, Aarif M. N. Batcha, Marianna Giorgi, Murugan Selvam, Eunice Wang, Shannon K. McWeeney, Jeffrey W. Tyner, Friedrich Stölzel, Matthias Mann, Ashok Kumar Jayavelu, Cyrus Khandanpour
Journal: Blood
Blood (2023) 142 (25): 2175–2191.
https://doi.org/10.1182/blood.2022015752
Published: 2023
Includes: Supplemental data
Journal Articles

ATG/ATLG Improves GvHD-Free and Relapse-Free Survival in Myelofibrosis Undergoing Hematopoietic Stem Cell Transplantation

Kristin Rathje, Nico Gagelmann, Rachel B. Salit, Thomas Schroeder, Carmelo Gurnari, Simona Pagliuca, Victoria Panagiota, Christina Rautenberg, Bruno Cassinat, Felicitas Thol, Christine Wolschke, Marie Robin, Michael Heuser, Marie-Thérèse Rubio, Jaroslaw P. Maciejewski, Hans Christian Reinhardt, Bart L. Scott, Nicolaus Kroeger
Journal: Blood
Blood (2023) 142 (Supplement 1): 3572.
https://doi.org/10.1182/blood-2023-185991
Published: 2023
Journal Articles

An In Vivo PiggyBac Insertional Mutagenesis Screen Reveals Oncogenic Lesions Cooperating with Myd88 L265P

Svenja Höfmann, Ruth Flümann, Julia Hansen, Sebastian Klein, Jörn Meinel, Pauline Pfeiffer, Hannah Goldfarb-Wittkopf, Anna Lütz, Jessica Wirtz, Michael Möllmann, Tanja Zhou, Areya Tabatabai, Tim Lohmann, Filippo Beleggia, Benedikt Pelzer, Fabian Ullrich, Aastha Arora, Thorsten Persigehl, Reinhard Büttner, Bastian von Tresckow, Ron Jachimowicz, Gero Knittel, Hans Christian Reinhardt
Journal: Blood
Blood (2023) 142 (Supplement 1): 525.
https://doi.org/10.1182/blood-2023-179915
Published: 2023
Journal Articles

New Suitable Eµ-Tcl1 Mouse Model for Research on BH3-Mimetics Therapy Response In Vivo

Ismini Halmer, Laura Beckmann, Gero Knittel, Hamid Kashkar, Hans Christian Reinhardt, Michael Hallek, Alexandra Da Palma Guerreiro, Lukas Peter Frenzel
Journal: Blood
Blood (2023) 142 (Supplement 1): 1454.
https://doi.org/10.1182/blood-2023-186330
Published: 2023
Journal Articles

Impact of TP53 on outcome of patients with myelofibrosis undergoing hematopoietic stem cell transplantation

Clinical Trials & Observations
Nico Gagelmann, Anita Badbaran, Rachel B. Salit, Thomas Schroeder, Carmelo Gurnari, Simona Pagliuca, Victoria Panagiota, Christina Rautenberg, Bruno Cassinat, Felicitas Thol, Christine Wolschke, Marie Robin, Michael Heuser, Marie-Thérèse Rubio, Jaroslaw P. Maciejewski, Hans Christian Reinhardt, Bart L. Scott, Nicolaus Kröger
Journal: Blood
Blood (2023) 141 (23): 2901–2911.
https://doi.org/10.1182/blood.2023019630
Published: 2023
Includes: Supplemental data
Journal Articles

Allogeneic Hematopoietic Stem Cell Transplantation Achieves Long-Term Survival in Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Analysis of the EBMT Lymphoma Working Party

Philipp Berning, Maud Ngoya, Norbert Schmitz, Hervé Finel, Ariane Boumendil, Won-Seog Kim, Fengrong Wang, Xiao-jun Huang, Olivier Hermine, Laure Philippe, Lucile Couronne, Arnaud Jaccard, Daihong Liu, Depei Wu, Hans Christian Reinhardt, Yves Chalandon, Eva Maria Wagner, Mi Kwon, Xi Zhang, Ben Carpenter, Ibrahim Yakoub-Agha, Gerald Wulf, Javier López Jiménez, Jaime Sanz, Hélène Labussière-Wallet, Avichai Shimoni, Peter Dreger, Anna Sureda, Bertram Glass
Journal: Blood
Blood (2022) 140 (Supplement 1): 2306–2307.
https://doi.org/10.1182/blood-2022-164637
Published: 2022
Journal Articles

Novel Autochthonous Mouse Models of Serve As Preclinical Tools to Investigate Pathogenesis and Treatment of MCD/C5 DLBCL

Ruth Flümann, Julia Hansen, Benedikt Pelzer, Ilmars Kisis, Tim Lohmann, Thorsten Persigehl, Nima Abedpour, Martin Peifer, Reinhard Buettner, Bastian von Tresckow, Ron Jachimowicz, Hans Christian Reinhardt, Gero Knittel
Journal: Blood
Blood (2022) 140 (Supplement 1): 3493–3494.
https://doi.org/10.1182/blood-2022-169607
Published: 2022
Journal Articles

Venetoclax and Hypomethylating Agents Followed By Allogeneic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia

Christina Rautenberg, Anja Ragette, Jennifer Kaivers, Nina Neuendorff, Maher Hanoun, Hans Christian Reinhardt, Thomas Schroeder
Journal: Blood
Blood (2022) 140 (Supplement 1): 12943–12944.
https://doi.org/10.1182/blood-2022-169893
Published: 2022
Journal Articles

TP53 and Complex Karyotype Represent a Very High-Risk Group in Myelofibrosis Undergoing Hematopoietic Stem Cell Transplantation: An International Collaborative Analysis

Nico Gagelmann, Anita Badbaran, Rachel Beth Salit, Thomas Schroeder, Carmelo Gurnari, Simona Pagliuca, Arnold Ganser, Christina Rautenberg, Bruno Cassinat, Felicitas R Thol, Christine Wolschke, Marie Robin, Michael Heuser, Marie Thérèse Rubio, Jaroslaw P. Maciejewski, Hans Christian Reinhardt, Bart L. Scott, Nicolaus Kroeger
Journal: Blood
Blood (2022) 140 (Supplement 1): 828–829.
https://doi.org/10.1182/blood-2022-158900
Published: 2022
Journal Articles

Glomerular Fitration Rate and Lactate Dehydrogenase Predicts Survival in Mayo Iiib Stage Light-Chain Amyloidosis

Alexander Carpinteiro, Sara Oubari, Hans Christian Reinhardt
Journal: Blood
Blood (2022) 140 (Supplement 1): 12571–12572.
https://doi.org/10.1182/blood-2022-168767
Published: 2022
Journal Articles

Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone (Isa-KRd) in Patients with High-Risk Newly Diagnosed Multiple Myeloma: Planned Interim Analysis of the GMMG-Concept Trial

Katja Weisel, Britta Besemer, Mathias Haenel, Raphael Lutz, Christoph Mann, Markus Munder, Martin Goerner, Hans Christian Reinhardt, Axel Nogai, Yon-Dschun Ko, Maike De Wit, Hans Salwender, Christoph Scheid, Ullrich Graeven, Rudolf Peceny, Peter Staib, Annette Dieing, Anna Jauch, Manola Zago, Axel Benner, Diana Tichy, Carsten Bokemeyer, Hartmut Goldschmidt, Lisa B. Leypoldt
Journal: Blood
Blood (2022) 140 (Supplement 1): 1836–1838.
https://doi.org/10.1182/blood-2022-156309
Published: 2022
Journal Articles

CART Therapy or Allogeneic Stem Cell Transplantation in ≥ Third Line Treatment of Large B Cell Lymphoma (LBCL)

Bertram Glass, Anna Sureda, Ariane Boumendil, Peter Dreger, Paolo Corradini, Ron Ram, Nicolaus Kroeger, Luca Castagna, Thomas Pabst, Mi Kwon, Gerald Wulf, Alejandro Martín García-Sancho, Carlos Solano, Matthias Stelljes, Hans Christian Reinhardt, Marie Thérèse Rubio, Ram Malladi, Didier Blaise, Caroline Besley, Edouard Forcade, Malte von Bonin, Jürgen Finke, Inken Hilgendorf, Joaquín Martínez-López, Jose A. Perez-Simon, Wolfgang Bethge, Norbert Schmitz
Journal: Blood
Blood (2022) 140 (Supplement 1): 7509–7511.
https://doi.org/10.1182/blood-2022-169459
Published: 2022
Journal Articles

Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53 -deficient B-cell malignancies

Elena Izquierdo, Daniela Vorholt, Stuart Blakemore, Benedict Sackey, Janica L. Nolte, Verena Barbarino, Jan Schmitz, Nadine Nickel, Daniel Bachurski, Liudmila Lobastova, Milos Nikolic, Michael Michalik, Reinhild Brinker, Olaf Merkel, Marek Franitza, Theodoros Georgomanolis, René Neuhaus, Maximilian Koch, Niklas Nasada, Gero Knittel, Björn Chapuy, Nicole Ludwig, Eckart Meese, Lukas Frenzel, Hans Christian Reinhardt, Martin Peifer, Rocio Rebollido-Rios, Heiko Bruns, Marcus Krüger, Michael Hallek, Christian P. Pallasch
Journal: Blood
Blood (2022) 139 (25): 3617–3629.
https://doi.org/10.1182/blood.2021014007
Published: 2022
Includes: Supplemental data
Journal Articles

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

Anne C. Wilke, Carmen Doebele, Alena Zindel, Kwang Seok Lee, Sara A. Rieke, Michele Ceribelli, Federico Comoglio, James D. Phelan, James Q. Wang, Yana Pikman, Dominique Jahn, Björn Häupl, Constanze Schneider, Sebastian Scheich, Frances A. Tosto, Hanibal Bohnenberger, Philipp Stauder, Frank Schnütgen, Mikolaj Slabicki, Zana A. Coulibaly, Sebastian Wolf, Kamil Bojarczuk, Björn Chapuy, Christian H. Brandts, Philipp Stroebel, Caroline A. Lewis, Michael Engelke, Xincheng Xu, Hahn Kim, Thanh Hung Dang, Roland Schmitz, Daniel J. Hodson, Kimberly Stegmaier, Henning Urlaub, Hubert Serve, Clemens A. Schmitt, Fernando Kreuz, Gero Knittel, Joshua D. Rabinowitz, Hans Christian Reinhardt, Matthew G. Vander Heiden, Craig Thomas, Louis M. Staudt, Thorsten Zenz, Thomas Oellerich
Journal: Blood
Blood (2022) 139 (4): 538–553.
https://doi.org/10.1182/blood.2021012081
Published: 2022
Includes: Supplemental data
Journal Articles

Intensified Cytarabine Dose during Consolidation Therapy in AML Patients Under 65 Years Is Not Associated with Survival Benefit

Maher Hanoun, Leo Ruhnke, Michael Kramer, Kerstin Schäfer-Eckhard, Björn Steffen, Tim Sauer, Stefan W. Krause, Christoph Schliemann, Martin Kaufmann, Mathias Haenel, Edgar Jost, Tim H Brummendorf, Lars Fransecky, Sabrina Kraus, Hermann Einsele, Dirk Niemann, Andreas Neubauer, Johannes Kullmer, Ruth Seggewiss-Bernhard, Martin Goerner, Gerhard Held, Ulrich Kaiser, Sebastian Scholl, Hans Christian Reinhardt, Uwe Platzbecker, Claudia D. Baldus, Carsten Mueller-Tidow, Martin Bornhaeuser, Hubert Serve, Christoph Rollig
Journal: Blood
Blood (2021) 138 (Supplement 1): 1242.
https://doi.org/10.1182/blood-2021-146606
Published: 2021
Journal Articles

Impact of Body Mass Index on Patient Outcome in Acute Myeloid Leukemia Patients Receiving Intensive Induction Therapy: A Real-World Registry Experience

Julius Christoph Enssle, Sebastian Wolf, Sebastian Scheich, Sarah Weber, Michael Kramer, Leo Ruhnke, Christoph Schliemann, Jan-Henrik Mikesch, Stefan W. Krause, Tim Sauer, Maher Hanoun, Hans Christian Reinhardt, Sabrina Kraus, Martin Kaufmann, Mathias Haenel, Lars Fransecky, Andreas Burchert, Andreas Neubauer, Martina Crysandt, Edgar Jost, Dirk Niemann, Kerstin Schäfer-Eckhard, Gerhard Held, Ulrich Kaiser, Maxi Wass, Markus Schaich, Carsten Müller-Tidow, Uwe Platzbecker, Claudia D. Baldus, Martin Bornhäuser, Christoph Rollig, Hubert Serve, Björn Steffen
Journal: Blood
Blood (2021) 138 (Supplement 1): 3370.
https://doi.org/10.1182/blood-2021-145917
Published: 2021
Journal Articles

Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas

Maurice Reimann, Jens Schrezenmeier, Paulina Richter-Pechanska, Anna Dolnik, Timon Pablo Hick, Kolja Schleich, Xiurong Cai, Dorothy N. Y. Fan, Philipp Lohneis, Sven Maßwig, Sophy Denker, Antonia Busse, Gero Knittel, Ruth Flümann, Dorothee Childs, Liam Childs, Ana-Maria Gätjens-Sanchez, Lars Bullinger, Andreas Rosenwald, Hans Christian Reinhardt, Clemens A. Schmitt
Journal: Blood
Blood (2021) 137 (20): 2785–2799.
https://doi.org/10.1182/blood.2020005244
Published: 2021
Includes: Supplemental data
Journal Articles

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

Vivien Kohlhaas, Stuart James Blakemore, Mona Al-Maarri, Nadine Nickel, Martin Pal, Andreas Roth, Nadine Hövelmeyer, Stephan C. Schäfer, Gero Knittel, Philipp Lohneis, Milos Nikolic, Janica L. Wiederstein, Marek Franitza, Theodoros Georgomonolis, Nina Reinart, Marco Herling, Carmen Herling, Elena M. Hartmann, Andreas Rosenwald, Wolfram Klapper, Reinhard Büttner, Riccardo Moia, Davide Rossi, Renzo Boldorini, Gianluca Gaidano, Lukas P. Frenzel, Hans Christian Reinhardt, Jens C. Brüning, Michael Hallek, Marcus Krüger, Martin Peifer, Christian P. Pallasch, F. Thomas Wunderlich
Journal: Blood
Blood (2021) 137 (5): 646–660.
https://doi.org/10.1182/blood.2020005734
Published: 2021
Includes: Supplemental data
Journal Articles

Mechanisms of Venetoclax Resistance in Chronic Lymphocytic Leukemia

Lukas P. Frenzel, MD, Carmen D. Herling, MD PhD, Nima Abedpour, PhD, Jonathan Weiss, PhD, Petra Mayer, Maria Cartolano, PhD, Valeska Berg, PhD, Nadine Kutsch, MD, Paula Cramer, MD, Clemens-Martin Wendtner, MD, Thorsten Persigehl, MD, Andreas Saleh, MD, Janine Altmüller, PhD, Peter Nürnberg, PhD, Christian Pallasch, MD, Viktor Achter, PhD, Ulrich Lang, PhD, Barbara F. Eichhorst, MD, Roberta Castiglione, MD, Stephan C. Schaefer, MD, Reinhard Buettner, MD, Karl-Anton Kreuzer, MD, Hans Christian Reinhardt, MD, Michael J. Hallek, MD, Martin Peifer, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 263.
https://doi.org/10.1182/blood.V130.Suppl_1.263.263
Published: 2017
Journal Articles

Outcome of Patients with Complex Karyotype in a Phase 3 Randomized Study of Idelalisib Plus Rituximab for Relapsed Chronic Lymphocytic Leukemia

Karl-Anton Kreuzer, Richard R. Furman, Stephan Stilgenbauer, Ronald L. Dubowy, Yeonhee Kim, Veerendra Munugalavadla, Esther Lilienweiss, Hans Christian Reinhardt, Andrew R. Pettitt, Michael Hallek
Journal: Blood
Blood (2016) 128 (22): 192.
https://doi.org/10.1182/blood.V128.22.192.192
Published: 2016