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Ashok Kumar Jayavelu
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Journal Articles

Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia

Eloísa Felipe Fumero, Carolin Walter, Joris Maximillian Frenz, Franca Seifert, Vijay Alla, Thorben Hennig, Linus Angenendt, Wolfgang Hartmann, Sebastian Wolf, Hubert Serve, Thomas Oellerich, Georg Lenz, Carsten Müller-Tidow, Christoph Schliemann, Otmar Huber, Martin Dugas, Matthias Mann, Ashok Kumar Jayavelu, Jan-Henrik Mikesch, Maria Francisca Arteaga
Journal: Blood
Blood (2024) 143 (22): 2284–2299.
https://doi.org/10.1182/blood.2023021640
Published: 2024
Includes: Supplemental data
Journal Articles

Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Daria Frank, Pradeep Kumar Patnana, Jan Vorwerk, Lianghao Mao, Lavanya Mokada Gopal, Noelle Jung, Thorben Hennig, Leo Ruhnke, Joris Maximillian Frenz, Maithreyan Kuppusamy, Robert Autry, Lanying Wei, Kaiyan Sun, Helal Mohammed Mohammed Ahmed, Axel Künstner, Hauke Busch, Heiko Müller, Stephan Hutter, Gregor Hoermann, Longlong Liu, Xiaoqing Xie, Yahya Al-Matary, Subbaiah Chary Nimmagadda, Fiorella Charles Cano, Michael Heuser, Felicitas Thol, Gudrun Göhring, Doris Steinemann, Jürgen Thomale, Theo Leitner, Anja Fischer, Roland Rad, Christoph Röllig, Heidi Altmann, Desiree Kunadt, Wolfgang E. Berdel, Jana Hüve, Felix Neumann, Jürgen Klingauf, Virginie Calderon, Bertram Opalka, Ulrich Dührsen, Frank Rosenbauer, Martin Dugas, Julian Varghese, Hans Christian Reinhardt, Nikolas von Bubnoff, Tarik Möröy, Georg Lenz, Aarif M. N. Batcha, Marianna Giorgi, Murugan Selvam, Eunice Wang, Shannon K. McWeeney, Jeffrey W. Tyner, Friedrich Stölzel, Matthias Mann, Ashok Kumar Jayavelu, Cyrus Khandanpour
Journal: Blood
Blood (2023) 142 (25): 2175–2191.
https://doi.org/10.1182/blood.2022015752
Published: 2023
Includes: Supplemental data
Journal Articles

Easyab Unravels Oncokinase Driven Regulation of Splicing Factors in AML

Ashok Kumar Jayavelu, Maithreyan Kuppusamy, Lavanya Mokada Gopal, Joris Frenz, Matthias Mann, Noelle Jung, Andreas Kulozik
Journal: Blood
Blood (2023) 142 (Supplement 1): 1383.
https://doi.org/10.1182/blood-2023-173914
Published: 2023
Journal Articles

Proteomic Characterization of Acute Myeloid Leukemia

Sebastian Wolf, Ashok Kumar Jayavelu, Florian Buettner, Gabriela Alexe, Björn Häupl, Constanze Schneider, Anne C Wilke, Alena Zindel, Dominique Jahn, Bianca Splettstoesser, Julius Christoph Enssle, Anjali Cremer, Christoph Röllig, Christian Thiede, Björn Steffen, Martin Bornhäuser, Henning Urlaub, Kimberly Stegmaier, Hubert Serve, Matthias Mann, Thomas Oellerich
Journal: Blood
Blood (2022) 140 (Supplement 1): 3456–3457.
https://doi.org/10.1182/blood-2022-169242
Published: 2022
Journal Articles

Pre-Clinical Investigation of a Novel Small Molecule Inhibitor Targeting YBX1 in AML

Tina M Schnoeder, Florian Perner, Ashok Kumar Jayavelu, Lianghao Mao, Qirui Zhang, Chen-Jen Hsu, Theresa Eifert, Uwe Grunwald, Peter Mertens, Dhanir Tailor, Akram Taherinasab, Theodore P. Braun, Sanjay Malhotra, Florian H. Heidel
Journal: Blood
Blood (2022) 140 (Supplement 1): 491–492.
https://doi.org/10.1182/blood-2022-157574
Published: 2022
Journal Articles

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Tina M. Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H. Heidel
Journal: Blood
Blood (2022) 139 (7): 1080–1097.
https://doi.org/10.1182/blood.2021012778
Published: 2022
Includes: Supplemental data
Journal Articles

In Vivo CRISPR-Cas9 Screens in PDX Models Reveals ADAM10 As Novel Therapeutic Target in Acute Leukemia

Ehsan Bahrami, Jan Philipp Schmid, Martin Becker, Anna-Katharina Wirth, Rupert Öllinger, Roland Rad, Binje Vick, Ashok Kumar Jayavelu, Matthias Mann, Tobias Herold, Irmela Jeremias
Journal: Blood
Blood (2021) 138 (Supplement 1): 708.
https://doi.org/10.1182/blood-2021-149658
Published: 2021
Journal Articles

NPM1 Mutated AML Is Associated With Lower Expression Of Poor Prognostic Markers BAALC, ERG and MN1 In Adult Patients With Acute Myeloid Leukaemia

Poonkuzhali Balasubramanian, Ph.D, Ashok kumar Jayavelu, M.Sc, Ajay Abraham, M.Sc, Savitha Varatharajan, M.Sc, Sreeja Karathedath, M.Sc, Senthamizhselvi Anandan, M.Sc, Vivi Srivastava, MD, Aby Abraham, MD, Auro Viswabandya, MD, Alok Srivastava, MD, Vikram Mathews, MD, DM
Journal: Blood
Blood (2013) 122 (21): 4945.
https://doi.org/10.1182/blood.V122.21.4945.4945
Published: 2013
Journal Articles

Expression of Ara-C Metabolizing Enzymes Mediates in Vitro Sensitivity to Ara-C in Primary AML Cells From Patients with Denovo AML,

Ajay Abraham, M.Sc, Savitha Varatharajan, M.Sc, Ashok kumar Jayavelu, M.Sc, Shaji R Velayudhan, M.Sc, Ph.D, Rayaz Ahmed, MD, Aby Abraham, MD, Biju George, MD, Mammen Chandy, MD, Alok Srivastava, MD, Vikram Mathews, MD, Poonkuzhali Balasubramanian, M.Sc., Ph.D
Journal: Blood
Blood (2011) 118 (21): 3481.
https://doi.org/10.1182/blood.V118.21.3481.3481
Published: 2011