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Adrian Schwarzer
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Journal Articles

In Vivo Modeling of T-Cell Acute Lymphoblastic Leukemia Reveals Synergistic Oncogenic Pathways and Bcl11b Haploinsufficiency As a Potential Therapeutic Vulnerability

Maximilian Schinke, Marc-Jens Kleppa, Dirk Heckl, Michael Heuser, Axel Schambach, Adrian Schwarzer
Journal: Blood
Blood (2023) 142 (Supplement 1): 4149.
https://doi.org/10.1182/blood-2023-190515
Published: 2023
Journal Articles

Fla-IDA Chemotherapy with or without Venetoclax in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Rabia Shahswar, Gernot Beutel, Razif Gabdoulline, Adrian Schwarzer, Arnold Kloos, Christian Koenecke, Michael Stadler, Gudrun Göhring, Brigitte Schlegelberger, Zhixiong Li, Louisa-Kristin Dallmann, Clara Wienecke, Piroska Klement, Catherin Albert, Martin Wichmann, Yasmine Alwie, Axel Benner, Maral Saadati, Arnold Ganser, Felicitas R. Thol, Michael Heuser
Journal: Blood
Blood (2022) 140 (Supplement 1): 3315–3316.
https://doi.org/10.1182/blood-2022-163430
Published: 2022
Journal Articles

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Tina M. Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H. Heidel
Journal: Blood
Blood (2022) 139 (7): 1080–1097.
https://doi.org/10.1182/blood.2021012778
Published: 2022
Includes: Supplemental data
Journal Articles

Btm-3566, a Novel Activator of the Mitochondrial Stress Response Promotes Robust Therapeutic Responses in Vitro and In Vivo in Diffuse Large B-Cell Lymphoma

Adrian Schwarzer, Matheus Oliveira, Marc-Jens Kleppa, Andy Anantha, Alan Cooper, Mark Hannink, Todd Hembrough, Jedd Levine, Michael Luther, Michael Stocum, Marc Liesa-Roig, Matthew Kostura
Journal: Blood
Blood (2021) 138 (Supplement 1): 684.
https://doi.org/10.1182/blood-2021-145637
Published: 2021
Journal Articles

Allogeneic, CD34 + , Umbilical Cordblood-Derived NK Cell Adoptive Immunotherapy for the Treatment of Acute Myeloid Leukemia Patients with Measurable Residual Disease

Michael Heuser, Astrid Tschan-Plessl, Felicitas Thol, Adrian Schwarzer, Arnold Kloos, Nadine Kattre, Jakob Passweg, Kai Pinkernell, Arnold Ganser
Journal: Blood
Blood (2021) 138 (Supplement 1): 1745.
https://doi.org/10.1182/blood-2021-150138
Published: 2021
Journal Articles

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Tina M. Schnoeder, PhD, Adrian Schwarzer, MD PhD, Florian Perner, MD, Joanna Kirkpatrick, Anna Dolnik, Konstanze Döhner, Patricia Arreba-Tutusaus, PhD, Salam A. Assi, PhD, Claudia Bruedigam, PhD, Carolin Kathner, Theresa Eifert, Marcus Buschbeck, PhD, Monica Nafria I Fedi, Anetta Ptasinska, PhD, Andrew Elefanty, Elizabeth Ng, Holger Bierhoff, PhD, Florian Gras, MD, Georg Matziolis, MD, Klaus-Dieter Fischer, Olaf Heidenreich, Steven W. Lane, MD PhD, Lars Bullinger, Björn von Eyss, PhD, Alessandro Ori, PhD, Constanze Bonifer, PhD, Florian H. Heidel
Journal: Blood
Blood (2019) 134 (Supplement_1): 531.
https://doi.org/10.1182/blood-2019-121996
Published: 2019
Journal Articles

Modelling the Progression of a Preleukemic Stage to Overt Leukemia in Children with Down Syndrome

Maurice Labuhn, MSc, Kelly Perkins, PhD, Elli Papaemmanuil, PhD, Catherine Garnett, Soeren Matzk, Vyacheslav Amstislavskiy, Marlen Metzner, Alison Kennedy, Carina Scheer, Kenichi Yoshida, MD PhD, Adrian Schwarzer, MD PhD, John D. Crispino, PhD MBA, Jeffrey W. Taub, MD, Mitchell J. Weiss, MD PhD, Etsuro Ito, MDPhD, Seishi Ogawa, MD PhD, Dirk Reinhardt, Marie-Laure Yaspo, PhD, Peter J. Campbell, PhD, Dirk Heckl, PhD, Jan-Henning Klusmann, Paresh Vyas
Journal: Blood
Blood (2018) 132 (Supplement 1): 543.
https://doi.org/10.1182/blood-2018-99-116661
Published: 2018
Journal Articles

Identification of Novel Lncrnas That Predict Survival in AML Patients and Modulate Leukemic Cells

Sarah Grasedieck, MSc, Christoph Rueß, MSc, Nicole Pochert, MSc, Susanne Lux, MSc, Adrian Schwarzer, MD PhD, Jan-Henning Klusmann, Mojca Jongen-Lavrencic, MD PhD, Jonathan R. Pollack, MD PhD, Arefeh Rouhi, PhD, Florian Kuchenbauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3909.
https://doi.org/10.1182/blood-2018-99-118331
Published: 2018
Journal Articles

Serially Transplantable Patient-Derived Xenograft Model of Chronic Myelomonocytic Leukemia (CMML)

Arnold Kloos, PhD, Felicitas Thol, MD, Lina Winckler, Razif Gabdoulline, PhD, Konstantinos Mintzas, Nidhi Jyotsana, PhD, Renate Schottmann, Felix F. Adams, Adrian Schwarzer, MD PhD, Dirk Heckl, PhD, Suzan Imren, MD, R. Keith Humphries, Arnold Ganser, MD, Michael Heuser, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4236.
https://doi.org/10.1182/blood.V130.Suppl_1.4236.4236
Published: 2017
Journal Articles

New Molecular Surrogate Assay for Genotoxicity Assessment of Gene Therapy Vectors (SAGA)

Adrian Schwarzer, MD PhD, Steven R Talbot, PhD, Oliver Dittrich-Breiholz, PhD, Adrian J Thrasher, MD PhD, Bobby Gaspar, MD, Ute Modlich, Christopher Baum, MD, Axel Schambach, MD PhD, Michael Rothe, PhD
Journal: Blood
Blood (2016) 128 (22): 4710.
https://doi.org/10.1182/blood.V128.22.4710.4710
Published: 2016
Journal Articles

Integrated Analysis of the Human Hematopoietic Non-Coding RNA Landscape Reveals Lnc-RNA Stem Cell Signature in AML

Adrian Schwarzer, MD PhD, Stephan Emmrich, PhD MSc, Franziska Schmidt, Damian Witte, Aliaksandra Maroz, Dirk Reinhardt, MD, Jan-Henning Klusmann, MD
Journal: Blood
Blood (2015) 126 (23): 45.
https://doi.org/10.1182/blood.V126.23.45.45
Published: 2015
Journal Articles

Targeting Rac-Gtpases Reverses Stroma-Induced Resistance to Notch and mTOR-Inhibition in Acute T-Cell Leukemia

Adrian Schwarzer, MD PhD, Martin May, Harald Genth, Zhixiong Li, MD, Christopher Baum, MD, Axel Schambach, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1326.
https://doi.org/10.1182/blood.V126.23.1326.1326
Published: 2015
Journal Articles

The Metabolite R-2-Hydroxyglutarate (R2HG) Collaborates with HoxA9 to Induce Monocytic Leukemia

Anuhar Chaturvedi, PhD, Michelle Maria Araujo Cruz, Nidhi Jyotsana, Amit Sharma, PhD, Ramya Goparaju, Vishwas Sharma, PhD, Adrian Schwarzer, MDPhD, Kerstin Goerlich, Renate Schottmann, Eduard A. Struys, PhD, Erwin E. Jansen, Robert Geffers, PhD, Gudrun Goehring, MD, Felicitas Thol, MD, Arnold Ganser, Michael Heuser, MD
Journal: Blood
Blood (2014) 124 (21): 366.
https://doi.org/10.1182/blood.V124.21.366.366
Published: 2014
Journal Articles

Investigating Synthetic Lethality Between mTOR Hyperactivation and Cap-Dependent mRNA Translation In a Receptor Tyrosine Kinase Driven Model Of Acute T-Cell Leukemia

Adrian Schwarzer, MD PhD, Helmut Holtmann, PhD, Celina Schauerte, M.Sc., Nomme Benn, Jan Völkel, Sabine Knöß, Johannes Zuber, MD, Zhixiong Li, MD, Axel Schambach, MD PhD, Christopher Baum, MD
Journal: Blood
Blood (2013) 122 (21): 3913.
https://doi.org/10.1182/blood.V122.21.3913.3913
Published: 2013
Journal Articles

Hematopoietic Stem Cell Gene Therapy For Wiskott- Aldrich Syndrome

Maximilian GW Witzel, MD, Christian J. Braun, MD, Kaan Boztug, MD, Anna Paruzynski, PhD, Michael H. Albert, MD, Adrian Schwarzer, MD PhD, Ute Modlich, DVM, PhD, Rita Beier, MD, Gudrun Göhring, MD, Sonja Naundorf, Klaus Kühlcke, Martina Rose, MD, Christopher Fraser, MD, Liesl Mathias, MD, Rudolf Ferrari, MD, Miguel R. Abboud, MD, MHA, Waleed Al-Herz, MD, Irina Kondratenko, MD, László Maródi, MD, Brigitte Schlegelberger, MD, PhD, Christopher Baum, MD, Manfred Schmidt, PhD, Christof von Kalle, MD, Christoph Klein, MD PhD
Journal: Blood
Blood (2013) 122 (21): 718.
https://doi.org/10.1182/blood.V122.21.718.718
Published: 2013
Journal Articles

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

Anuhar Chaturvedi, Michelle Maria Araujo Cruz, Nidhi Jyotsana, Amit Sharma, Haiyang Yun, Kerstin Görlich, Martin Wichmann, Adrian Schwarzer, Matthias Preller, Felicitas Thol, Johann Meyer, Reinhard Haemmerle, Eduard A. Struys, Erwin E. Jansen, Ute Modlich, Zhixiong Li, Laura M. Sly, Robert Geffers, Robert Lindner, Dietmar J. Manstein, Ulrich Lehmann, Jürgen Krauter, Arnold Ganser, Michael Heuser
Journal: Blood
Blood (2013) 122 (16): 2877–2887.
https://doi.org/10.1182/blood-2013-03-491571
Published: 2013
Includes: Supplemental data
Journal Articles

Mutated IDH1 Has 2-Hydroxyglutarate-Independent Functions in Leukemogenesis

Anuhar Chaturvedi, PhD, Michelle Maria Araujo Cruz, Nidhi Jyotsana, Amit Sharma, Haiyang Yun, Kerstin Görlich, Martin Wichmann, Adrian Schwarzer, MD, Matthias Preller, PhD, Felicitas Thol, MD, Johann Meyer, PhD, Reinhard Haemmerle, Eduard A. Struys, PhD, Erwin E. Jansen, Ute Modlich, DVM, PhD, Zhixiong Li, MD, Laura M. Sly, PhD, Robert Geffers, PhD, Robert Lindner, PhD, Dietmar J. Manstein, PhD, Urlich Lehmann, PhD, Jürgen Krauter, MD, Arnold Ganser, Michael Heuser, MD
Journal: Blood
Blood (2012) 120 (21): 770.
https://doi.org/10.1182/blood.V120.21.770.770
Published: 2012
Journal Articles

Receptor Tyrosine Kinases, Notch Mutations and PTEN Loss Converge On mTOR in T-ALL and Cause Addiction to Cap Dependent mRNA Translation.

Adrian Schwarzer, MD, Helmut Holtmann, PhD, Martijn Brugman, PhD, Johann Meyer, PhD, Doris Steinemann, PhD, Brigitte Schlegelberger, Zhixiong Li, MD, Christopher Baum, MD
Journal: Blood
Blood (2012) 120 (21): 2415.
https://doi.org/10.1182/blood.V120.21.2415.2415
Published: 2012
Journal Articles

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Leukemia in a Murine Bone Marrow Transplantation Model

Dirk Heckl, PhD, Adrian Schwarzer, MD, Reinhard Haemmerle, Johann Meyer, PhD, Doris Steinemann, PhD, Cornelia Rudolph, PhD, Britta Skawran, PhD, Brigitte Schlegelberger, MD, Christopher Baum, MD, Ute Modlich, DVM, PhD
Journal: Blood
Blood (2011) 118 (21): 671.
https://doi.org/10.1182/blood.V118.21.671.671
Published: 2011
Journal Articles

Evidence for Cooperation of Receptor Tyrosine Kinases and Activating NOTCH Mutations to Hyperactivate mTOR in T-Cell Leukemia: A Rationale Basis for Targeted Therapy

Adrian Schwarzer, MD, Johann Meyer, PhD, Martijn Brugman, PhD, Axel Schambach, MD PhD, Martin Stanulla, MD, MSc, Martin Schrappe, MD, Doris Steinemann, PhD, Brigitte Schlegelberger, M.D., Christopher Baum, MD, Zhixiong Li, MD
Journal: Blood
Blood (2011) 118 (21): 1381.
https://doi.org/10.1182/blood.V118.21.1381.1381
Published: 2011