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Florian Perner
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Journal Articles

Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A - and NPM1 -altered leukemias

Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Vineet Pande, Ann Marien, Dries Goffin, Daniela V. Wenge, Hong Yue, Jevon A. Cutler, Cyrus Jin, Florian Perner, Shanna M. Hogeling, Paul L. Shaffer, Frank Jacobs, Petra Vinken, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Balpreet Bhogal, Karin Verstraeten, Sara El Ashkar, Jennifer A. Perry, Prathiba Jayaguru, Laura Barreyro, Anna Kuchnio, Nicolas Darville, Daniel Krosky, Gregor Urbanietz, Bie Verbist, James P. Edwards, Glenn S. Cowley, Robert Kirkpatrick, Ruth Steele, Lucille Ferrante, Christina Guttke, Nikki Daskalakis, E. Christine Pietsch, David M. Wilson, Ricardo Attar, Yusri Elsayed, Eric S. Fischer, Jan Jacob Schuringa, Scott A. Armstrong, Kathryn Packman, Ulrike Philippar
Journal: Blood
Blood (2024) 144 (11): 1206–1220.
https://doi.org/10.1182/blood.2023022480
Published: 2024
Includes: Supplemental data
Journal Articles

Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A -r and NPM1c AML

Wallace Bourgeois, Jevon A. Cutler, Brandon J. Aubrey, Daniela V. Wenge, Florian Perner, Cynthia Martucci, Jill A. Henrich, Kelly Klega, Radosław P. Nowak, Katherine A. Donovan, Meaghan Boileau, Yanhe Wen, Charlie Hatton, Athina A. Apazidis, Sarah Naomi Olsen, Nadia Kirmani, Yana Pikman, Jessica A. Pollard, Jennifer A. Perry, Adam S. Sperling, Benjamin L. Ebert, Gerard M. McGeehan, Brian D. Crompton, Eric S. Fischer, Scott A. Armstrong
Journal: Blood
Blood (2024) 143 (15): 1513–1527.
https://doi.org/10.1182/blood.2023021105
Published: 2024
Includes: Supplemental data
Journal Articles

Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic Stretch and Nuclear Export Factor CRM1 and Regulates Oncogenic Transcription in Acute Myeloid Leukemia

Hannah J Uckelmann, Elena L Haarer, Reina Takeda, Eric Wong, Christian Marinaccio, Charles Hatton, Yanhe Wen, Florian Perner, Masooma Rajput, Noa J.C. Antonissen, Chun-Wei David Chen, Lorenzo Brunetti, Scott A. Armstrong
Journal: Blood
Blood (2022) 140 (Supplement 1): 5835–5836.
https://doi.org/10.1182/blood-2022-166630
Published: 2022
Journal Articles

Pre-Clinical Investigation of a Novel Small Molecule Inhibitor Targeting YBX1 in AML

Tina M Schnoeder, Florian Perner, Ashok Kumar Jayavelu, Lianghao Mao, Qirui Zhang, Chen-Jen Hsu, Theresa Eifert, Uwe Grunwald, Peter Mertens, Dhanir Tailor, Akram Taherinasab, Theodore P. Braun, Sanjay Malhotra, Florian H. Heidel
Journal: Blood
Blood (2022) 140 (Supplement 1): 491–492.
https://doi.org/10.1182/blood-2022-157574
Published: 2022
Journal Articles

Functional Role of Histone Variant macroH2A1 (H2AFY) in Acute Myeloid Leukemia (AML)

Chen-Jen Hsu, Tina M. M Schnoeder, Theresa Eifert, Qirui Zhang, Oliver Meers, David Corujo, Maximilian Lassi, Raffaele Teperino, Stefan Dimitrov, Holger Bierhoff, Björn von Eyss, Florian Perner, Marcus Buschbeck, Florian H. Heidel
Journal: Blood
Blood (2022) 140 (Supplement 1): 726–727.
https://doi.org/10.1182/blood-2022-157245
Published: 2022
Journal Articles

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Tina M. Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H. Heidel
Journal: Blood
Blood (2022) 139 (7): 1080–1097.
https://doi.org/10.1182/blood.2021012778
Published: 2022
Includes: Supplemental data
Journal Articles

The menin-MLL1 interaction is a molecular dependency in NUP98 -rearranged AML

Emily B. Heikamp, Jill A. Henrich, Florian Perner, Eric M. Wong, Charles Hatton, Yanhe Wen, Sonali P. Barwe, Anilkumar Gopalakrishnapillai, Haiming Xu, Hannah J. Uckelmann, Sumiko Takao, Yaniv Kazansky, Yana Pikman, Gerard M. McGeehan, Edward A. Kolb, Alex Kentsis, Scott A. Armstrong
Journal: Blood
Blood (2022) 139 (6): 894–906.
https://doi.org/10.1182/blood.2021012806
Published: 2022
Includes: Supplemental data
Journal Articles

Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis

Brief Report
Peter G. Miller, Adam S. Sperling, Christopher J. Gibson, Kaushik Viswanathan, Cecilia Castellano, Marie McConkey, John Ceremsak, Martin S. Taylor, Sebastian Birndt, Florian Perner, Jon Arnason, Mridul Agrawal, Alison M. Schram, Sarah Nikiforow, German Pihan, Robert P. Hasserjian, Jon C. Aster, Paul La Rosée, Elizabeth A. Morgan, Nancy Berliner, Benjamin L. Ebert
Journal: Blood
Blood (2020) 136 (26): 3051–3055.
https://doi.org/10.1182/blood.2020008206
Published: 2020
Includes: Supplemental data
Journal Articles

Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts

Florian Perner, Jayant Y. Gadrey, Yijun Xiong, Charles Hatton, Benjamin K. Eschle, Andreas Weiss, Frédéric Stauffer, Christoph Gaul, Ralph Tiedt, Jennifer A. Perry, Scott A. Armstrong, Andrei V. Krivtsov
Journal: Blood
Blood (2020) 136 (17): 1983–1988.
https://doi.org/10.1182/blood.2020006113
Published: 2020
Includes: Supplemental data
Journal Articles

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Tina M. Schnoeder, PhD, Adrian Schwarzer, MD PhD, Florian Perner, MD, Joanna Kirkpatrick, Anna Dolnik, Konstanze Döhner, Patricia Arreba-Tutusaus, PhD, Salam A. Assi, PhD, Claudia Bruedigam, PhD, Carolin Kathner, Theresa Eifert, Marcus Buschbeck, PhD, Monica Nafria I Fedi, Anetta Ptasinska, PhD, Andrew Elefanty, Elizabeth Ng, Holger Bierhoff, PhD, Florian Gras, MD, Georg Matziolis, MD, Klaus-Dieter Fischer, Olaf Heidenreich, Steven W. Lane, MD PhD, Lars Bullinger, Björn von Eyss, PhD, Alessandro Ori, PhD, Constanze Bonifer, PhD, Florian H. Heidel
Journal: Blood
Blood (2019) 134 (Supplement_1): 531.
https://doi.org/10.1182/blood-2019-121996
Published: 2019
Journal Articles

Selective Dependency of MLL-Rearranged Leukemia on Immunoproteasome Function

Nuria Tubío Santamaría, Jonas Tönsing, Tina M. Schnoeder, PhD, Ulrike Seifert, Clemens Cammann, Juliane Mohr, PhD, Aniruddha J. Deshpande, PhD, Joanna Kirkpatrick, Alessandro Ori, PhD, Florian Perner, MD, Florian H. Heidel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 529.
https://doi.org/10.1182/blood-2019-122100
Published: 2019
Journal Articles

The Cold-Shock Protein Ybx1 Is Required for Development and Maintenance of Acute Myeloid Leukemia (AML) in Vitro and In Vivo

Florian Perner, Ashok K. Jayavelu, PhD, Tina Maria Schnoeder, PhD, Nomusa Mashamba, Juliane Mohr, PhD, Maximilian Hartmann, Kristin Odenwald, PhD, Nikolas Schroeder, MD, Sabine Brandt, PhD, Peter Mertens, MD, Lars Bullinger, MD, Florian H. Heidel, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 792.
https://doi.org/10.1182/blood.V130.Suppl_1.792.792
Published: 2017
Journal Articles

Specificity of JAK-Kinase Inhibition Determines Impact on T-Cell Function

Florian Perner, Felix C Saalfeld, cand.MD, Tina M Schnoeder, PhD, Denise Wolleschak, MD, Corinna Fahldieck, Satish Ranjan, Berend H Isermann, MD, Katrin Hebel, PhD, Monika Brunner-Weinzierl, PhD, Thomas Fischer, MD, Florian H Heidel, MD
Journal: Blood
Blood (2014) 124 (21): 1410.
https://doi.org/10.1182/blood.V124.21.1410.1410
Published: 2014
Journal Articles

FLT3-Kinase Inhibitors Quizartinib and Midostaurin Do Not Impair T-Cell Reactivity and Activation

Denise Wolleschak, MD, Thomas S. Mack, MSc, Florian Perner, Tina M Schnoeder, PhD, Marie-Christine Wagner, Stefanie Kliche, PhD, Burkhart Schraven, Satish Ranjan, Berend H. Isermann, MD, Daniel B. Lipka, MD, Thomas Fischer, MD, Florian H Heidel, MD
Journal: Blood
Blood (2012) 120 (21): 1045.
https://doi.org/10.1182/blood.V120.21.1045.1045
Published: 2012