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Steven W. Lane
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Journal Articles

Identifying disease-modifying potential in myelofibrosis clinical trials

Clinical Trials & Observations
David M. Ross, Steven W. Lane, Claire N. Harrison
Journal: Blood
Blood (2024) 144 (16): 1679–1688.
https://doi.org/10.1182/blood.2024024220
Published: 2024
Journal Articles

Prospective MRI and Neurocognitive Assessment of “Chemobrain” in Acute Myeloid Leukaemia: The Mineral Study

Ashleigh Scott, Ada Lo, Kate Thompson, Ying Xia, Harriet Bodimeade, Amir Fazlollahi, Cameron Curley, Steven W. Lane, Kirk Lachlan Morris, Caroline Jane McNamara, Elango S. Pillai, Nicholas Weber, Olivier Salvado, Katie L McMahon, Glen A Kennedy
Journal: Blood
Blood (2023) 142 (Supplement 1): 5850.
https://doi.org/10.1182/blood-2023-190301
Published: 2023
Journal Articles

Trp53 -Loss in Hematopoietic Stem Cells Drives the Evolutionary Process of Leukemic Transformation in a Jak2 V617F -Driven Myeloproliferative Neoplasms Mouse Model

Ranran Zhang, Yashaswini Janardhanan, Rohit Haldar, Leanne Cooper, Sebastien Jaquelin, Jasmin Straube, Megan Bywater, Steven W Lane
Journal: Blood
Blood (2023) 142 (Supplement 1): 4522.
https://doi.org/10.1182/blood-2023-188150
Published: 2023
Journal Articles

Excellent Early and Major Molecular Responses Observed with Asciminib Treatment for CP-CML: Results from the ALLG CML13 Ascend-CML Study

David T Yeung, Naranie Shanmuganathan, John Reynolds, Susan Branford, Mannu Walia, Agnes S. M. Yong, Jake Shortt, Kate Burbury, Lynette C.Y. Chee, Nick Viiala, Ilona Cunningham, David M. Ross, Alwyn Bernard D'Souza, Matthew P.F. Wright, Rosemary Anne Harrup, Cecily Forsyth, Robin Filshie, Peter J. Browett, Steven W. Lane, Carolyn Grove, Andrew P Grigg, Timothy P Hughes, on Behalf Of The ALLG
Journal: Blood
Blood (2023) 142 (Supplement 1): 865.
https://doi.org/10.1182/blood-2023-172583
Published: 2023
Journal Articles

Suppression of KRAS and CBL Mutations and Hematological Improvement By Lenzilumab and Azacitidine Treatment in Proliferative Chronic Myelomonocytic Leukemia

Maha M Kamel, Monika Kutyna, David M. Ross, Steven W. Lane, Chloe Thompson-Peach, Chun Yew Fong, Agnes S. M. Yong, David T Yeung, Timothy P Hughes, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2023-188340
Published: 2023
Journal Articles

Early Generation Telomerase Deficient Mice to Investigate Clonal Hematopoiesis in Aging

Claudia Bruedigam, Amy H Porter, Jasmin Straube, Guidan Cheng, Florian H Heidel, Steven W Lane
Journal: Blood
Blood (2023) 142 (Supplement 1): 5598.
https://doi.org/10.1182/blood-2023-191246
Published: 2023
Journal Articles

Cytokine and Mutation Profiling Reveal Patterns of Complete Remission Rates with Lenzilumab Combination Therapy in Chronic Myelomonocytic Leukemia

Monika Kutyna, Maha M Kamel, David M. Ross, Agnes S. M. Yong, Chun Yew Fong, Chloe Thompson-Peach, Steven W. Lane, David T Yeung, Timothy P Hughes, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 1852.
https://doi.org/10.1182/blood-2023-179706
Published: 2023
Journal Articles

Lenzilumab in Addition to Azacitidine Improves Complete Response Rates in Chronic Myelomonocytic Leukemia

Devendra Hiwase, David M. Ross, Steven W. Lane, Chloe Thompson-Peach, Chun Yew Fong, Agnes S. M. Yong, David T Yeung, Timothy P Hughes, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 1847.
https://doi.org/10.1182/blood-2023-179688
Published: 2023
Journal Articles

Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs

Shruthi Subramanian, Julie A. I. Thoms, Yizhou Huang, Paola Cornejo-Páramo, Forrest C. Koch, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S. Woll, Diego Chacon-Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O'Brien, Annette Trickett, Jason A. Powell, Ian D. Lewis, Stuart M. Pitson, Maher K. Gandhi, Steven W. Lane, Fatemeh Vafaee, Emily S. Wong, Berthold Göttgens, Hamid Alinejad-Rokny, Jason W. H. Wong, John E. Pimanda
Journal: Blood
Blood (2023) 142 (17): 1448–1462.
https://doi.org/10.1182/blood.2023021120
Published: 2023
Includes: Supplemental data
Journal Articles

Shelter from the cytokine storm in myelofibrosis

Steven W. Lane
Journal: Blood
Blood (2023) 141 (20): 2415–2416.
https://doi.org/10.1182/blood.2023019779
Published: 2023
Journal Articles

Comparative Analysis of Genome-Scale Gene Regulatory Networks in Human Hematopoietic Stem and Myeloid Progenitor Fractions

Shruthi Subramanian, Julie A.I. Thoms, Yizhou Huang, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S Woll, Diego Chacon Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O' Brien, Annette Trickett, Jason Powell, Stuart M Pitson, Maher K. Gandhi, Paola Cornejo, Emily Wong, Steven W Lane, Bertie Gottgens, Hamid Alinejad Rokny, Jason W.H Wong, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 2846–2848.
https://doi.org/10.1182/blood-2022-165620
Published: 2022
Journal Articles

Loss of Cell Fate Determinant LLGL1 Impairs Leukemia Development in Acute Myeloid Leukemia

Theresa Eifert, Tina M. M Schnoeder, Chen-Jen Hsu, Alicia L Becker, Qirui Zhang, Juliane Mohr, Stephanie Frey, Sebastian Scholl, Lars Bullinger, Steven W Lane, Florian H. Heidel
Journal: Blood
Blood (2022) 140 (Supplement 1): 8680–8681.
https://doi.org/10.1182/blood-2022-157247
Published: 2022
Journal Articles

A Phase 2 Study of the LSD1 Inhibitor Bomedemstat (IMG-7289) for the Treatment of Essential Thrombocythemia (ET)

Harinder Gill, Francesca Palandri, David M Ross, Tara Cochrane, Courtney Tate, Steven W Lane, Stephen R Larsen, Aaron T. Gerds, Anna B. Halpern, Jake Shortt, James M. Rossetti, Kristen M. Pettit, James Liang, Adam J Mead, Monia Marchetti, Alessandro M. Vannucchi, Andrew J Wilson, Joachim R Göthert, Merit Hanna, Francesco Passamonti, William S Stevenson, Claire Harrison, Moshe Talpaz, Nicola Vianelli, Hugh Young Rienhoff, Jr.
Journal: Blood
Blood (2022) 140 (Supplement 1): 1784–1787.
https://doi.org/10.1182/blood-2022-159047
Published: 2022
Journal Articles

Early and Deep Molecular Responses Achieved with Frontline Asciminib in Chronic Phase CML - Interim Results from ALLG CML13 Ascend-CML

David T Yeung, Naranie Shanmuganathan, John Reynolds, Susan Branford, Mannu Walia, Agnes S.M. Yong, Jake Shortt, Kate Burbury, Nicholas Viiala, Ilona Cunningham, David M. Ross, Rosemary Harrup, Matthew Wright, Cecily Forsyth, Alwyn Bernard D'Souza, Robin J Filshie, Peter J. Browett, Steven W Lane, Carolyn Grove, Andrew Grigg, Timothy Hughes
Journal: Blood
Blood (2022) 140 (Supplement 1): 192–194.
https://doi.org/10.1182/blood-2022-157244
Published: 2022
Journal Articles

Imetelstat-Mediated Alterations in Lipid Metabolism to Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

Claudia Bruedigam, Amy H Porter, Axia Song, Gerjanne Vroeg in de Wei, Thomas Stoll, Jasmin Straube, Leanne T Cooper, Guidan Cheng, Vivian FS Kahl, Alexander Sobinoff, Victoria Y Ling, Billy Michael Chelliah Jebaraj, Laura J Bray, Lars Bullinger, Florian H Heidel, Glen A Kennedy, Michelle M Hill, Hilda Pickett, Omar Abdel-Wahab, Gunter Hartel, Steven W Lane
Journal: Blood
Blood (2022) 140 (Supplement 1): 487–488.
https://doi.org/10.1182/blood-2022-168166
Published: 2022
Journal Articles

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Tina M. Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H. Heidel
Journal: Blood
Blood (2022) 139 (7): 1080–1097.
https://doi.org/10.1182/blood.2021012778
Published: 2022
Includes: Supplemental data
Journal Articles

A Phase-Ib/II Clinical Evaluation of Ponatinib in Combination with Azacitidine in FLT3 -ITD and CBL -Mutant Acute Myeloid Leukemia (PON-AZA study)

David Kipp, Sun Loo, Andrew Charles Perkins, Steven W Lane, Emily Blyth, Anoop Kumar Enjeti, Ashish Bajel, John Reynolds, Andrew H. Wei
Journal: Blood
Blood (2021) 138 (Supplement 1): 2350.
https://doi.org/10.1182/blood-2021-154247
Published: 2021
Journal Articles

Targeting Control of Cell Cycle Enhances the Activity of Conventional Chemotherapy in Chemotherapy-Resistant Acute Myeloid Leukemia

Victoria Y Ling, Sebastien Jacquelin, Jasmin Straube, Rohit Haldar, Yashaswini Janardhanan, Leanne T Cooper, Claudia Bruedigam, Emily Cooper, William Godfrey, Siok-Keen Tey, Lars Bullinger, Marco J Herold, Jonathan Baell, Megan Bywater, Steven W Lane
Journal: Blood
Blood (2021) 138 (Supplement 1): 2241.
https://doi.org/10.1182/blood-2021-148379
Published: 2021
Journal Articles

A Phase 2 Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Essential Thrombocythemia (ET)

Francesca Palandri, Nicola Vianelli, David M Ross, Tara Cochrane, Steven W Lane, Stephen R Larsen, Aaron T. Gerds, Anna B. Halpern, Jake Shortt, James M. Rossetti, Kristen M. Pettit, Amber Jones, Jennifer Peppe, Georges Natsoulis, Willis Navarro, Wan-Jen Hong, William S. Stevenson, Claire N. Harrison, Moshe Talpaz, Hugh Young Rienhoff, Jr.
Journal: Blood
Blood (2021) 138 (Supplement 1): 386.
https://doi.org/10.1182/blood-2021-148210
Published: 2021
Journal Articles

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Andrea S. Henden, Motoko Koyama, Renee J. Robb, Adriana Forero, Rachel D. Kuns, Karshing Chang, Kathleen S. Ensbey, Antiopi Varelias, Stephen H. Kazakoff, Nicole Waddell, Andrew D. Clouston, Rabina Giri, Jakob Begun, Bruce R. Blazar, Mariapia A. Degli-Esposti, Sergei V. Kotenko, Steven W. Lane, Kate L. Bowerman, Ram Savan, Philip Hugenholtz, Kate H. Gartlan, Geoffrey R. Hill
Journal: Blood
Blood (2021) 138 (8): 722–737.
https://doi.org/10.1182/blood.2020006375
Published: 2021
Includes: Supplemental data