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Journal Articles

A Calreticulin Neoepitope-Directed Monoclonal Antibody Can Overcome JAK Inhibitor Resistance and Block TPO-Independent Megakaryocyte Differentation

Denis Tvorogov, Chloe AL Thompson-Peach, Johannes Foßelteder, Mara Dottore, Frank Stomski, Kelly SY Lim, Suraiya A Onnesha, David M Ross, Andreas Reinisch, Daniel Thomas, Angel F. Lopez

Blood (2021) 138 (Supplement 1): 3597.

https://doi.org/10.1182/blood-2021-154332

Published: 2021

Journal Articles

Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells

Nadia El Khawanky, Bsc(Biomed), BHlthSc(Hons), Amy Hughes, PhD, Wenbo Yu, PhD, Sanaz Taromi, PhD, Jade Clarson, BSc, Angel F. Lopez, MD PhD, Michael P. Brown, MD PhD, Justus Duyster, MD, Timothy P. Hughes, MDMBBS,FRACP,FRCPA, Deborah L. White, PhD FFSc (RCPA), Agnes S. M. Yong, MD PhD, Robert Zeiser, MD

Blood (2019) 134 (Supplement_1): 3904.

https://doi.org/10.1182/blood-2019-124684

Published: 2019

Journal Articles

Accumulation of JAK Activation-Loop Phosphorylation Promotes Type I JAK Inhibitor Withdrawal Syndrome in Myelofibrosis

Denis Tvorogov, PhD, Daniel Thomas, MD PhD, Nicholas P.D Liau, Mara Dottore, Emma F Barry, Maya Lathi, Winnie L Kan, PhD, Tim R Hercus, PhD, Frank Stomski, PhD, Timothy P. Hughes, MDMBBS,FRACP,FRCPA, Vinay Tergaonkar, PhD, Michael W Parker, PhD, David M Ross, Jeffrey J Babon, PhD, Ravindra Majeti, MD PhD, Angel F. Lopez, MBBS,PhD

Blood (2018) 132 (Supplement 1): 1787.

https://doi.org/10.1182/blood-2018-99-115760

Published: 2018

Journal Articles

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Jason A. Powell, Alexander C. Lewis, Wenying Zhu, John Toubia, Melissa R. Pitman, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Diana Iarossi, Saumya E. Samaraweera, Nik Cummings, Hayley S. Ramshaw, Daniel Thomas, Andrew H. Wei, Angel F. Lopez, Richard J. D’Andrea, Ian D. Lewis, Stuart M. Pitson

Blood (2017) 129 (6): 771–782.

https://doi.org/10.1182/blood-2016-06-720433

Published: 2017

Includes: Supplemental data

Journal Articles

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells

Eva Nievergall, Hayley S. Ramshaw, Agnes S. M. Yong, Mark Biondo, Samantha J. Busfield, Gino Vairo, Angel F. Lopez, Timothy P. Hughes, Deborah L. White, Devendra K. Hiwase

Blood (2014) 123 (8): 1218–1228.

https://doi.org/10.1182/blood-2012-12-475194

Published: 2014

Includes: Supplemental data

Journal Articles

IL3-Receptor Signaling Is Dispensable For The Generation and Maintenance Of Jak2V617F-Induced Myeloproliferative Neoplasm (MPN

Therese Vu, Claudia Bruedigam, Rebecca Austin, Catherine Paine-Kuhn, Hayley S. Ramshaw, PhD, Angel F. Lopez, MBBS, PhD, Geoff Hill, MD, Ann Mullally, MD, Steven W Lane, MD, PhD

Blood (2013) 122 (21): 2841.

https://doi.org/10.1182/blood.V122.21.2841.2841

Published: 2013

Journal Articles

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Blood (2013) 122 (5): 738–748.

https://doi.org/10.1182/blood-2012-08-447441

Published: 2013

Includes: Supplemental data

Journal Articles

Effective Elimination of CML Progenitor and Stem Cells Through Combination of α-CD123 Antibody-Dependent Cell-Mediated Cytotoxicity and Tyrosine Kinase Inhibitor Treatment

Eva Nievergall, PhD, Deborah L. White, PhD, FFSc(RCPA), Agnes S.M. Yong, MD, PhD, Hayley S. Ramshaw, PhD, Samantha J. Busfield, PhD, Gino Vairo, PhD, Angel F. Lopez, MBBS, PhD, Timothy P. Hughes, MD, MBBS, Devendra K. Hiwase, MBBS, MD, PhD, FRACP, FRCPA

Blood (2012) 120 (21): 32.

https://doi.org/10.1182/blood.V120.21.32.32

Published: 2012

Journal Articles

CSL362: A Monoclonal Antibody to Human Interleukin-3 Receptor (CD123), Optimized for NK Cell-Mediated Cytotoxicity of AML Stem Cells

Samantha J. Busfield, PhD, Mark Biondo, PhD, Mae Wong, PhD, Hayley S. Ramshaw, PhD, Erwin M Lee, PhD, Kirstee Martin, PhD, Souravi Ghosh, PhD, Hal Braley, Vesna Tomasetig, Con Panousis, PhD, Gino Vairo, PhD, Andrew W. Roberts, MBBS, PhD, Simon Z. He, MBBS, Naomi Sprigg, Daniel Thomas, MBBS, PhD, Mark DeWitte, VMD, Richard B. Lock, PhD, Angel F. Lopez, MBBS, PhD, Andrew Nash, PhD

Blood (2012) 120 (21): 3598.

https://doi.org/10.1182/blood.V120.21.3598.3598

Published: 2012

Journal Articles

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

Blood (2012) 119 (24): 5918–5930.

https://doi.org/10.1182/blood-2011-12-398164

Published: 2012

Journal Articles

Antibody-Targeting of IL-3 Receptor-α Increases the Susceptibility of CD34 + CML Progenitors to Dasatinib-Induced Cell Death,

Eva Nievergall, Deborah L. White, PhD. FFSc(RCPA), Hayley Ramshaw, PhD, Angel F. Lopez, MBBS, PhD, Timothy P. Hughes, MD, MBBS, Devendra K Hiwase, MBBS, MD, PhD, FRACP, FRCPA

Blood (2011) 118 (21): 3745.

https://doi.org/10.1182/blood.V118.21.3745.3745

Published: 2011

Journal Articles

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit

Michelle Perugini, Anna L. Brown, Diana G. Salerno, Grant W. Booker, Cvetan Stojkoski, Timothy R. Hercus, Angel F. Lopez, Margaret L. Hibbs, Thomas J. Gonda, Richard J. D'Andrea

Blood (2010) 115 (16): 3346–3353.

https://doi.org/10.1182/blood-2009-08-235846

Published: 2010

Includes: Supplemental data

Journal Articles

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

Blood (2009) 114 (23): 4859–4870.

https://doi.org/10.1182/blood-2009-02-204818

Published: 2009

Includes: Supplemental data

Journal Articles

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

Timothy R. Hercus, Daniel Thomas, Mark A. Guthridge, Paul G. Ekert, Jack King-Scott, Michael W. Parker, Angel F. Lopez

Blood (2009) 114 (7): 1289–1298.

https://doi.org/10.1182/blood-2008-12-164004

Published: 2009

Journal Articles

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation

Claudine S. Bonder, Wai Y. Sun, Tyson Matthews, Carlos Cassano, Xiaochun Li, Hayley S. Ramshaw, Stuart M. Pitson, Angel F. Lopez, P. Toby Coates, Richard L. Proia, Mathew A. Vadas, Jennifer R. Gamble

Blood (2009) 113 (9): 2108–2117.

https://doi.org/10.1182/blood-2008-07-166942

Published: 2009

Includes: Supplemental data

Journal Articles

Lipid and Protein Substrates of PI3K in Cytokine Receptor Survival Signalling: Deregulation in Leukemia

Daniel Thomas, MD, Joanna Woodcock, PhD, Jason A Powell, PhD, Emma F Barry, Angel F Lopez, Mark A Guthridge, PhD

Blood (2008) 112 (11): 3864.

https://doi.org/10.1182/blood.V112.11.3864.3864

Published: 2008

Journal Articles

A functional 14-3-3ζ–independent association of PI3-kinase with glycoprotein Ibα, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

Fi-Tjen Mu, Robert K. Andrews, Jane F. Arthur, Adam D. Munday, Susan L. Cranmer, Shaun P. Jackson, Frank C. Stomski, Angel F. Lopez, Michael C. Berndt

Blood (2008) 111 (9): 4580–4587.

https://doi.org/10.1182/blood-2007-09-111096

Published: 2008

Journal Articles

The Shc-binding site of the β c subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis

Hayley S. Ramshaw, Mark A. Guthridge, Frank C. Stomski, Emma F. Barry, Lisa Ooms, Christina A. Mitchell, C. Glenn Begley, Angel F. Lopez

Blood (2007) 110 (10): 3582–3590.

https://doi.org/10.1182/blood-2007-01-070391

Published: 2007

Includes: Supplemental data

Journal Articles

Primary Acute Myeloid Leukemic Blasts Display Constitutive Serine 585 Phosphorylation within the 14-3-3 Binding Motif of the GM-CSF/IL-3 Receptor Required for Survival Signalling.

Daniel Thomas, MD, Jason Powell, PhD, Szu-Hee Lee, MD, PhD, Angel F. Lopez, MD, PhD, Guthridge Mark, PhD

Blood (2005) 106 (11): 70.

https://doi.org/10.1182/blood.V106.11.70.70

Published: 2005

Journal Articles

The phosphoserine-585–dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-κB and induction of bcl-2

Mark A. Guthridge, Emma F. Barry, Fernando A. Felquer, Barbara J. McClure, Frank C. Stomski, Hayley Ramshaw, Angel F. Lopez

Blood (2004) 103 (3): 820–827.

https://doi.org/10.1182/blood-2003-06-1999

Published: 2004

NARROW

A Calreticulin Neoepitope-Directed Monoclonal Antibody Can Overcome JAK Inhibitor Resistance and Block TPO-Independent Megakaryocyte Differentation

Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells

Accumulation of JAK Activation-Loop Phosphorylation Promotes Type I JAK Inhibitor Withdrawal Syndrome in Myelofibrosis

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells

IL3-Receptor Signaling Is Dispensable For The Generation and Maintenance Of Jak2V617F-Induced Myeloproliferative Neoplasm (MPN

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Effective Elimination of CML Progenitor and Stem Cells Through Combination of α-CD123 Antibody-Dependent Cell-Mediated Cytotoxicity and Tyrosine Kinase Inhibitor Treatment

CSL362: A Monoclonal Antibody to Human Interleukin-3 Receptor (CD123), Optimized for NK Cell-Mediated Cytotoxicity of AML Stem Cells

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

Antibody-Targeting of IL-3 Receptor-α Increases the Susceptibility of CD34 + CML Progenitors to Dasatinib-Induced Cell Death,

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation

Lipid and Protein Substrates of PI3K in Cytokine Receptor Survival Signalling: Deregulation in Leukemia

A functional 14-3-3ζ–independent association of PI3-kinase with glycoprotein Ibα, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

The Shc-binding site of the β c subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis

Primary Acute Myeloid Leukemic Blasts Display Constitutive Serine 585 Phosphorylation within the 14-3-3 Binding Motif of the GM-CSF/IL-3 Receptor Required for Survival Signalling.

The phosphoserine-585–dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-κB and induction of bcl-2

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American Society of Hematology

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American Society of Hematology

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