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Journal Articles

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

Blood (2023) 141 (6): 634–644.

https://doi.org/10.1182/blood.2022016090

Published: 2023

Includes: Supplemental data

Journal Articles

Clonal hematopoiesis, myeloid disorders and BAX -mutated myelopoiesis in patients receiving venetoclax for CLL

Piers Blombery, Thomas E. Lew, Michael A. Dengler, Ella R. Thompson, Victor S. Lin, Xiangting Chen, Tamia Nguyen, Ashish Panigrahi, Sasanka M. Handunnetti, Dennis A. Carney, David A. Westerman, Constantine S. Tam, Jerry M. Adams, Andrew H. Wei, David C. S. Huang, John F. Seymour, Andrew W. Roberts, Mary Ann Anderson

Blood (2022) 139 (8): 1198–1207.

https://doi.org/10.1182/blood.2021012775

Published: 2022

Includes: Supplemental data

Journal Articles

BCL2 and MCL1 inhibitors for hematologic malignancies

Andrew W. Roberts, Andrew H. Wei, David C. S. Huang

Blood (2021) 138 (13): 1120–1136.

https://doi.org/10.1182/blood.2020006785

Published: 2021

Journal Articles

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Blood (2021) 137 (20): 2721–2735.

https://doi.org/10.1182/blood.2020010167

Published: 2021

Includes: Supplemental data

Journal Articles

Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax

Piers Blombery, Ella R. Thompson, Tamia Nguyen, Richard W. Birkinshaw, Jia-nan Gong, Xiangting Chen, Michelle McBean, Rachel Thijssen, Thomas Conway, Mary Ann Anderson, John F. Seymour, David A. Westerman, Peter E. Czabotar, David C. S. Huang, Andrew W. Roberts

Blood (2020) 135 (10): 773–777.

https://doi.org/10.1182/blood.2019004205

Published: 2020

Includes: Supplemental data

Journal Articles

IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos

Pasquale L. Fedele, Simon N. Willis, Yang Liao, Michael S. Low, Jai Rautela, David H. Segal, Jia-Nan Gong, Nicholas D. Huntington, Wei Shi, David C. S. Huang, George Grigoriadis, Julie Tellier, Stephen L. Nutt

Blood (2018) 132 (20): 2166–2178.

https://doi.org/10.1182/blood-2018-05-850727

Published: 2018

Includes: Supplemental data

Journal Articles

Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax

Mary Ann Anderson, Constantine Tam, Thomas E. Lew, Surender Juneja, Manu Juneja, David Westerman, Meaghan Wall, Stephen Lade, Alexandra Gorelik, David C. S. Huang, John F. Seymour, Andrew W. Roberts

Blood (2017) 129 (25): 3362–3370.

https://doi.org/10.1182/blood-2017-01-763003

Published: 2017

Includes: Supplemental data

Journal Articles

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

Jia-Nan Gong, Tiffany Khong, David Segal, Yuan Yao, Chris D. Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessene, Andrew Spencer, Marco J. Herold, Andrew W. Roberts, David C. S. Huang

Blood (2016) 128 (14): 1834–1844.

https://doi.org/10.1182/blood-2016-03-704908

Published: 2016

Includes: Supplemental data

Journal Articles

Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia

Seong Lin Khaw, Santi Suryani, Kathryn Evans, Jennifer Richmond, Alissa Robbins, Raushan T. Kurmasheva, Catherine A. Billups, Stephen W. Erickson, Yuelong Guo, Peter J. Houghton, Malcolm A. Smith, Hernan Carol, Andrew W. Roberts, David C. S. Huang, Richard B. Lock

Blood (2016) 128 (10): 1382–1395.

https://doi.org/10.1182/blood-2016-03-707414

Published: 2016

Includes: Supplemental data

Journal Articles

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism

Mary Ann Anderson, Jing Deng, John F. Seymour, Constantine Tam, Su Young Kim, Joshua Fein, Lijian Yu, Jennifer R. Brown, David Westerman, Eric G. Si, Ian J. Majewski, David Segal, Sari L. Heitner Enschede, David C. S. Huang, Matthew S. Davids, Anthony Letai, Andrew W. Roberts

Blood (2016) 127 (25): 3215–3224.

https://doi.org/10.1182/blood-2016-01-688796

Published: 2016

Includes: Supplemental data

Journal Articles

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Blood (2013) 122 (5): 738–748.

https://doi.org/10.1182/blood-2012-08-447441

Published: 2013

Includes: Supplemental data

Journal Articles

Bcl-2, Bcl-x L , and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

Delphine Mérino, Seong L. Khaw, Stefan P. Glaser, Daniel J. Anderson, Lisa D. Belmont, Chihunt Wong, Peng Yue, Mikara Robati, Belinda Phipson, Walter D. Fairlie, Erinna F. Lee, Kirsteen J. Campbell, Cassandra J. Vandenberg, Suzanne Cory, Andrew W. Roberts, Mary J. C. Ludlam, David C. S. Huang, Philippe Bouillet

Blood (2012) 119 (24): 5807–5816.

https://doi.org/10.1182/blood-2011-12-400929

Published: 2012

Includes: Supplemental data

Journal Articles

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Michael J. White, Simone M. Schoenwaelder, Emma C. Josefsson, Kate E. Jarman, Katya J. Henley, Chloé James, Marlyse A. Debrincat, Shaun P. Jackson, David C. S. Huang, Benjamin T. Kile

Blood (2012) 119 (18): 4283–4290.

https://doi.org/10.1182/blood-2011-11-394858

Published: 2012

Includes: Supplemental data

Journal Articles

Bcl-x L –inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Simone M. Schoenwaelder, Kate E. Jarman, Elizabeth E. Gardiner, My Hua, Jianlin Qiao, Michael J. White, Emma C. Josefsson, Imala Alwis, Akiko Ono, Abbey Willcox, Robert K. Andrews, Kylie D. Mason, Hatem H. Salem, David C. S. Huang, Benjamin T. Kile, Andrew W. Roberts, Shaun P. Jackson

Blood (2011) 118 (6): 1663–1674.

https://doi.org/10.1182/blood-2011-04-347849

Published: 2011

Includes: Supplemental data

Journal Articles

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

Simone M. Schoenwaelder, Yuping Yuan, Emma C. Josefsson, Michael J. White, Yu Yao, Kylie D. Mason, Lorraine A. O'Reilly, Katya J. Henley, Akiko Ono, Sarah Hsiao, Abbey Willcox, Andrew W. Roberts, David C. S. Huang, Hatem H. Salem, Benjamin T. Kile, Shaun P. Jackson

Blood (2009) 114 (3): 663–666.

https://doi.org/10.1182/blood-2009-01-200345

Published: 2009

Includes: Supplemental data

Journal Articles

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells

Marc Pellegrini, Sue Bath, Vanessa S. Marsden, David C. S. Huang, Donald Metcalf, Alan W. Harris, Andreas Strasser

Blood (2005) 106 (5): 1581–1589.

https://doi.org/10.1182/blood-2005-01-0284

Published: 2005

Includes: Supplemental data

NARROW

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia

Clonal hematopoiesis, myeloid disorders and BAX -mutated myelopoiesis in patients receiving venetoclax for CLL

BCL2 and MCL1 inhibitors for hematologic malignancies

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax

IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos

Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Bcl-2, Bcl-x L , and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Bcl-x L –inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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