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Mark A. Guthridge
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Journal Articles

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P. Cameron, Katherine M. Hannan, Nhu-Y N. Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R. Devlin, Amee J. George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J. Harrison, James D. Rozario, Jason A. Powell, Stuart M. Pitson, Johannes Zuber, Ricky W. Johnstone, Mark A. Dawson, Mark A. Guthridge, Andrew Wei, Grant A. McArthur, Richard B. Pearson, Ross D. Hannan
Journal: Blood
Blood (2017) 129 (21): 2882–2895.
https://doi.org/10.1182/blood-2016-05-718171
Published: 2017
Includes: Supplemental data
Journal Articles

Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML

Clinical Trials & Observations
Sewa Rijal, Shaun Fleming, Nik Cummings, Natalie K. Rynkiewicz, Lisa M. Ooms, Nhu-Y. N. Nguyen, Tse-Chieh Teh, Sharon Avery, Julie F. McManus, Anthony T. Papenfuss, Catriona McLean, Mark A. Guthridge, Christina A. Mitchell, Andrew H. Wei
Journal: Blood
Blood (2015) 125 (18): 2815–2824.
https://doi.org/10.1182/blood-2014-09-603555
Published: 2015
Includes: Supplemental data
Journal Articles

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Daniel Thomas, Jason A. Powell, Francois Vergez, David H. Segal, Nhu-Y. N. Nguyen, Adele Baker, Tse-Chieh Teh, Emma F. Barry, Jean-Emmanuel Sarry, Erwin M. Lee, Tracy L. Nero, Anissa M. Jabbour, Giovanna Pomilio, Benjamin D. Green, Stéphane Manenti, Stefan P. Glaser, Michael W. Parker, Angel F. Lopez, Paul G. Ekert, Richard B. Lock, David C. S. Huang, Susie K. Nilsson, Christian Récher, Andrew H. Wei, Mark A. Guthridge
Journal: Blood
Blood (2013) 122 (5): 738–748.
https://doi.org/10.1182/blood-2012-08-447441
Published: 2013
Includes: Supplemental data
Journal Articles

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

Jason A. Powell, Daniel Thomas, Emma F. Barry, Chung H. Kok, Barbara J. McClure, Anna Tsykin, L. Bik To, Anna Brown, Ian D. Lewis, Kirsten Herbert, Gregory J. Goodall, Terence P. Speed, Norio Asou, Bindya Jacob, Motomi Osato, David N. Haylock, Susan K. Nilsson, Richard J. D'Andrea, Angel F. Lopez, Mark A. Guthridge
Journal: Blood
Blood (2009) 114 (23): 4859–4870.
https://doi.org/10.1182/blood-2009-02-204818
Published: 2009
Includes: Supplemental data
Journal Articles

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

Timothy R. Hercus, Daniel Thomas, Mark A. Guthridge, Paul G. Ekert, Jack King-Scott, Michael W. Parker, Angel F. Lopez
Journal: Blood
Blood (2009) 114 (7): 1289–1298.
https://doi.org/10.1182/blood-2008-12-164004
Published: 2009
Journal Articles

A Molecular Signature for a Cytokine Receptor Survival Pathway in AML Identifies Unique Prognostic Indicators and Therapeutic Targets

Daniel Thomas, MD, Jason A Powell, PhD, Emma F Barry, Luen Bik To, MD, Angel Lopez, Mark A Guthridge
Journal: Blood
Blood (2008) 112 (11): 2893.
https://doi.org/10.1182/blood.V112.11.2893.2893
Published: 2008
Journal Articles

Lipid and Protein Substrates of PI3K in Cytokine Receptor Survival Signalling: Deregulation in Leukemia

Daniel Thomas, MD, Joanna Woodcock, PhD, Jason A Powell, PhD, Emma F Barry, Angel F Lopez, Mark A Guthridge, PhD
Journal: Blood
Blood (2008) 112 (11): 3864.
https://doi.org/10.1182/blood.V112.11.3864.3864
Published: 2008
Journal Articles

CD123 (IL-3 Receptor α Chain) Neutralization by a Monoclonal Antibody Selectively Eliminates Human Acute Myeloid Leukemic Stem Cells.

Richard B. Lock, PhD, Liqing Jin, PhD, Erwin M. Lee, PhD, Hayley S. Ramshaw, PhD, Sam Busfield, PhD, Armando G. Peoppl, BSc, Lucy Wilkinson, BSc, Mark A. Guthridge, PhD, Andrew Boyd, PhD, David Gearing, PhD, Gino Vairo, PhD, Angel Lopez, MD, PhD, John E. Dick, PhD
Journal: Blood
Blood (2007) 110 (11): 161.
https://doi.org/10.1182/blood.V110.11.161.161
Published: 2007
Journal Articles

The Shc-binding site of the β c subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis

Hayley S. Ramshaw, Mark A. Guthridge, Frank C. Stomski, Emma F. Barry, Lisa Ooms, Christina A. Mitchell, C. Glenn Begley, Angel F. Lopez
Journal: Blood
Blood (2007) 110 (10): 3582–3590.
https://doi.org/10.1182/blood-2007-01-070391
Published: 2007
Includes: Supplemental data
Journal Articles

The phosphoserine-585–dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-κB and induction of bcl-2

Mark A. Guthridge, Emma F. Barry, Fernando A. Felquer, Barbara J. McClure, Frank C. Stomski, Hayley Ramshaw, Angel F. Lopez
Journal: Blood
Blood (2004) 103 (3): 820–827.
https://doi.org/10.1182/blood-2003-06-1999
Published: 2004