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Journal Articles

Whole genome transcriptome sequencing in inherited bone marrow failure syndromes and related diseases – the ibmdx study

Free
Lucy Fox, William Stevenson, Graham Lieschke, Nicole Den Elzen, Erin Goode, Vahid Pazhakh, Kelsey Man, Lin Cheng, Stephanie Best, Hasan Shamsi, Ella Thompson, Laura Barth, Simon Wu, MIchelle Tan, Caroline Wong, Francis Baumgartner, Tracy Bryan, Cas Simons, Daniel MacArthur, Hadi Khorshidi, Juntao Lyu, David Ritchie, Mark Dawson, Anna Brown, Meg Wall, Paul James, Zornitza Stark, Erica Wood, Piers Blombery
Journal: Blood
Blood (2025) 146 (Supplement 2): LBA-4.
https://doi.org/10.1182/blood-2025-LBA-4
Published: 2025
Journal Articles

Durable efficacy of lenzilumab plus azacitidine in newly diagnosed proliferative CMML patients: Interim analysis after four years of study commencement

Free
Devendra Hiwase, David Ross, David Yeung, Agnes Yong, Steven Lane, Anna Brown, Chun Yew Fong, Timothy Hughes, John Reynolds, Daniel Thomas
Journal: Blood
Blood (2025) 146 (Supplement 1): 3855.
https://doi.org/10.1182/blood-2025-3855
Published: 2025
Journal Articles

High dose ascorbate downregulates innate immune cytokines in the bone marrow of TET2 mutant chronic myelomonocytic leukemia

Free
Maha Kamel, Monika Kutyna, Nirmal Robinson, David Ross, David Yeung, Agnes Yong, Anna Brown, Timothy Hughes, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2025) 146 (Supplement 1): 2065.
https://doi.org/10.1182/blood-2025-2065
Published: 2025
Journal Articles

Unravelling the epigenetic drivers of chip – MDS/CMML – AML progression through novel methylation-sensitive regulatory elements

Free
Yanjing Liu, Li Chai, Devendra Hiwase, David Ross, David Yeung, Agnes Yong, Steven Lane, Anna Brown, Chun Yew Fong, Timothy Hughes, John Reynolds, Daniel Thomas, Daniel Tenen, Mahmoud Bassal
Journal: Blood
Blood (2025) 146 (Supplement 1): 3231.
https://doi.org/10.1182/blood-2025-3231
Published: 2025
Journal Articles

ANKRD26-related thrombocytopenia: Hematologic malignancy characteristics, clinical outcomes, and precursor states

Free
Lauren Banaszak, Bianca Barredo, Marcin Wlodarski, Sara Lewis, Alejandro Ferrer, Mrinal Patnaik, Lucy Fox, Peng Li, Afaf Osman, Jennie Vagher, Courtney DiNardo, Sarah Pelletier, Brittany Stewart, Hetty Carraway, Moshe Mittelman, Howard Oster, Noa Goldschmidt, Anat Sinai, May Basood, Amy Trottier, Valeria Santini, Gloria Andreossi, Brian Druker, Michael Heinrich, Diana Brewer, Kelcy Smith-Simmer, Kyle Shoger, Gustavo Fonseca, Elise Fiala, Yelena Kemel, Ozge Birsoy-Ceyhan, Diana Mandelker, Andrew Marderstein, Zsofia Stadler, Kenneth Offit, Molly McGuinness, Michael Drazer, Alan Cantor, Jacob Bledsoe, Alexandra Satty, Adrianna Vlachos, Claire Homan, Anna Brown, Jane Churpek
Journal: Blood
Blood (2025) 146 (Supplement 1): 1440.
https://doi.org/10.1182/blood-2025-1440
Published: 2025
Journal Articles

Pathogenic Germline Variants in the DNA Damage Repair Pathway Are Enriched in Patients with Hematologic Malignancies with Prior Exposure to Cytotoxic Therapies Compared to Patients with Multiple Cancers without Prior Exposure

Free
Devendra Hiwase, Zoe Price, Chung How Kok, Monika Kutyna, Deepak Singhal, Naranie Shanmuganathan, Lesley Rawlings, David M Ross, David T Yeung, Anna Brown, Christopher N. Hahn, Lucy Godley, Caner Saygin, Hamish S Scott
Journal: Blood
Blood (2024) 144 (Supplement 1): 4596.
https://doi.org/10.1182/blood-2024-211795
Published: 2024
Journal Articles

Evidence-Based Risk Stratification of TP53 -Mutated Myeloid Neoplasms

Free
Mithun V Shah, Kevin Hung, Anmol Baranwal, Zoe Price, Aref Al-Kali, Carla Toop, Patricia Greipp, Anna Brown, Dariusz Ladon, Dong Chen, Kebede Begna, Monika Kutyna, Danielle Rud, Mark R. Litzow, William J. Hogan, Peter Bardy, Talha Badar, Sharad Kumar, David T Yeung, Mrinal M. Patnaik, James M. Foran, Rong He, Naseema Gangat, Hamish S Scott, Cecilia Y. Arana Yi, Hassan B Alkhateeb, Abhishek A. Mangaonkar, Daniel Thomas, Christopher N. Hahn, Attilio Orazi, Daniel A. Arber, Chung Hoow Kok, Ayalew Tefferi, Devendra Hiwase
Journal: Blood
Blood (2024) 144 (Supplement 1): 3213.
https://doi.org/10.1182/blood-2024-198269
Published: 2024
Journal Articles

CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity

Free
Kelly Lim, Monika Kutyna, Winnie Kan, Angel F. Lopez, Anna Brown, Agnes S. M. Yong, Steven W Lane, Chun Yew Fong, Timothy P Hughes, David T Yeung, David M Ross, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 3196.
https://doi.org/10.1182/blood-2024-202682
Published: 2024
Journal Articles

Durable Responses Observed in Chronic Myelomonocytic Leukemia Treated with Lenzilumab and Azacitidine

Free
Devendra Hiwase, David M Ross, David T Yeung, Agnes S. M. Yong, Steven W Lane, Anna Brown, Chun Yew Fong, Timothy P Hughes, John Reynolds, Daniel Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 1006.
https://doi.org/10.1182/blood-2024-202867
Published: 2024
Journal Articles

Durvalumab and Acalabrutinib for Relapsed/Refractory (r/r) High-Grade B-Cell Lymphoma: MoST15, Open Label Phase II Sub-Study of the Molecular Screening and Therapeutics in Leukaemia and Lymphoma (MoST-LLy) Framework

Free
Danielle N Blunt, Rosemary Harrup, Gerlinda Amor, Helen Christensen, Sarah Finlayson, Frank Lin, David M Ross, Julia Dobbins, Anna Brown, Hamish S Scott, Steven W Lane
Journal: Blood
Blood (2024) 144 (Supplement 1): 1727.
https://doi.org/10.1182/blood-2024-207463
Published: 2024
Journal Articles

Dynamic Assessment of RBC-Transfusion Dependency (RBC-TD) Improves the Molecular International Prognostic Scoring System (IPSS-M) Risk Stratification of MDS

Free
Thomas Wiseman, Michaela Spooner, Shreyas Khanna, Kevin Hung, Carla Toop, Deepak Singhal, David M Ross, David T Yeung, Anna Brown, Hamish S Scott, Christopher N. Hahn, Daniel Thomas, Chung How Kok, Devendra Hiwase
Journal: Blood
Blood (2024) 144 (Supplement 1): 3208.
https://doi.org/10.1182/blood-2024-209123
Published: 2024
Journal Articles

IDH -mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation

Free
Lih En Hong, Mihir D. Wechalekar, Monika Kutyna, Annabelle Small, Kelly Lim, Chloe Thompson-Peach, Joule J. Li, Rakchha Chhetri, Hamish S. Scott, Anna Brown, Christopher N. Hahn, David T. Yeung, Salvia Sajid, Nirmal Robinson, Ranjeny Thomas, Susan Branford, Richard J. D’Andrea, Saumya E. Samaraweera, Mrinal Patnaik, Susanna Proudman, Daniel Thomas, Chung Hoow Kok, Mithun V. Shah, Devendra K. Hiwase
Journal: Blood
Blood (2024) 143 (18): 1873–1877.
https://doi.org/10.1182/blood.2023023593
Published: 2024
Includes: Supplemental data
Journal Articles

ERG Is a New Predisposition Gene for Bone Marrow Failure and Hematological Malignancy

Free
Hamish S Scott, Jiarna Zerella, Claire Homan, Peer Arts, Steve Lin, Sam J Spinelli, Milena Babic, Peter J Brautigan, Lynda Truong, Luis Arriola-Martinez, Parvathy Venugopal, Simone K Feurstein, Lise Larcher, Flore Sicre De Fontbrune, Serwet Demirdas, Sonja De Munnik, Hélène Poirel, Benedicte Brichard, Sara Dobbins, Pim Mutsaers, Desiree S DeMille, Josue Flores-Daboub, Michael W Drazer, Alison Crawford, Julie McCarrier, Donald G Basel, Kerry Phillips, Nicola K Poplawski, Graeme Birdsey, Daniela Pirri, Pia Ostergaard, Annet Simons, Lucy Godley, David M. Ross, Devendra Hiwase, Jean Soulier, Anna Brown, Catherine Carmichael, Christopher N. Hahn
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-6.
https://doi.org/10.1182/blood-2023-191986
Published: 2023
Journal Articles

Comparison of World Health Organization and International Consensus Classification Guidelines for Myeloid Neoplasms Harboring TP53 -Mutations Using an Independent International Cohort

Free
Mithun V Shah, Monika Kutyna, Syed Shah, Elizabeth Ngoc Hoa Tran, Anmol Baranwal, Dariusz Ladon, Aref Al-Kali, Anna Brown, Dong Chen, Patricia Greipp, Kebede Begna, Mark R. Litzow, William J. Hogan, Peter Bardy, Sharad Kumar, David T Yeung, Mrinal M. Patnaik, James M. Foran, Rong He, Naseema Gangat, Hamish S Scott, Cecilia Y. Arana Yi, Hassan Alkhateeb, Abhishek A Mangaonkar, Daniel Thomas, Christopher Norman Hahn, Attilio Orazi, Daniel A. Arber, Chung Hoow Kok, Ayalew Tefferi, Devendra Hiwase
Journal: Blood
Blood (2023) 142 (Supplement 1): 3243.
https://doi.org/10.1182/blood-2023-187860
Published: 2023
Journal Articles

Single-Hit TP53 mut Is Associated with Poor Outcomes in Therapy-Related but Not De Novo Myelodysplastic Syndromes: Importance of Clinical History

Free
Devendra Hiwase, Anmol Baranwal, Syed Shah, Monika Kutyna, Christopher Norman Hahn, Maymona Abdelmajid, Danielle Rud, Rakchha Chhetri, Kaaren K. Reichard, Dong Chen, Thomas Wiseman, Anna Brown, Hamish S Scott, David T Yeung, David M. Ross, Daniel Thomas, Aref Al-Kali, Hassan Alkhateeb, James M. Foran, Cecilia Y. Arana Yi, Naseema Gangat, Mrinal M. Patnaik, Ayalew Tefferi, Chung Hoow Kok, Rong He, Mithun V Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 4608.
https://doi.org/10.1182/blood-2023-187905
Published: 2023
Journal Articles

High Prevalence of IDH Mutation in Myeloid Neoplasm with Concomitant Autoimmune Rheumatic Disorders

Free
Lih En Hong, Chung Hoow Kok, Monika Kutyna, Joule J Li, Rakchha Chhetri, David M. Ross, Susan Branford, Hamish S Scott, Anna Brown, Christopher Norman Hahn, David T Yeung, Mrinal M. Patnaik, Mithun V Shah, Susanna Proudman, Mihir Wechalekar, Devendra Hiwase
Journal: Blood
Blood (2023) 142 (Supplement 1): 4621.
https://doi.org/10.1182/blood-2023-190809
Published: 2023
Journal Articles

TP53 mutation in therapy-related myeloid neoplasm defines a distinct molecular subtype

Free
Devendra Hiwase, Christopher Hahn, Elizabeth Ngoc Hoa Tran, Rakchha Chhetri, Anmol Baranwal, Aref Al-Kali, Kirsty Sharplin, Dariusz Ladon, Rachel Hollins, Patricia Greipp, Monika Kutyna, Hassan Alkhateeb, Talha Badar, Paul Wang, David M. Ross, Deepak Singhal, Naranie Shanmuganathan, Peter Bardy, Ashanka Beligaswatte, David Yeung, Mark R. Litzow, Abhishek Mangaonkar, Pratyush Giri, Cindy Lee, Angie Yong, Noemi Horvath, Nimit Singhal, Raghu Gowda, William Hogan, Naseema Gangat, Mrinal Patnaik, Kebede Begna, Ing S. Tiong, Andrew Wei, Sharad Kumar, Anna Brown, Hamish Scott, Daniel Thomas, Chung H. Kok, Ayalew Tefferi, Mithun Vinod Shah
Journal: Blood
Blood (2023) 141 (9): 1087–1091.
https://doi.org/10.1182/blood.2022018236
Published: 2023
Includes: Supplemental data
Journal Articles

Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease

Free
Clinical Trials & Observations
Susan Branford, Paul Wang, David T. Yeung, Daniel Thomson, Adrian Purins, Carol Wadham, Nur Hezrin Shahrin, Justine E. Marum, Nathalie Nataren, Wendy T. Parker, Joel Geoghegan, Jinghua Feng, Naranie Shanmuganathan, Martin C. Mueller, Christian Dietz, Doris Stangl, Zoe Donaldson, Haley Altamura, Jasmina Georgievski, Jodi Braley, Anna Brown, Christopher Hahn, Ieuan Walker, Soo-Hyun Kim, Soo-Young Choi, Sa-Hee Park, Dong-Wook Kim, Deborah L. White, Agnes S. M. Yong, David M. Ross, Hamish S. Scott, Andreas W. Schreiber, Timothy P. Hughes
Journal: Blood
Blood (2018) 132 (9): 948–961.
https://doi.org/10.1182/blood-2018-02-832253
Published: 2018
Includes: Supplemental data
Journal Articles

Genome-Wide Analysis of Genetic Alterations In Acute Myeloid Leukaemia (Massively parallel, high-throughput, paired-end DNA sequencing and genotyping of an AML genome).

Free
James X Gray, MD, PhD, Paul J Leo, PhD, Pamela Mukhopadhyay, PhD, Evgeny A Glazov, PhD, Patrick Danoy, PhD, Marina Donskoi, BSc, Anna Brown, PhD, Ian D. Lewis, MBBS, PhD, Richard J D'Andrea, PhD, Matthew A Brown, MBBS, MD, Paula Marlton, MBBS, Devinder S Gill, MD, Thomas Gonda, PhD
Journal: Blood
Blood (2010) 116 (21): 1690.
https://doi.org/10.1182/blood.V116.21.1690.1690
Published: 2010
Journal Articles

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

Free
Jason A. Powell, Daniel Thomas, Emma F. Barry, Chung H. Kok, Barbara J. McClure, Anna Tsykin, L. Bik To, Anna Brown, Ian D. Lewis, Kirsten Herbert, Gregory J. Goodall, Terence P. Speed, Norio Asou, Bindya Jacob, Motomi Osato, David N. Haylock, Susan K. Nilsson, Richard J. D'Andrea, Angel F. Lopez, Mark A. Guthridge
Journal: Blood
Blood (2009) 114 (23): 4859–4870.
https://doi.org/10.1182/blood-2009-02-204818
Published: 2009
Includes: Supplemental data