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David T. Yeung
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Journal Articles

Asciminib monotherapy as frontline treatment of chronic-phase chronic myeloid leukemia: results from the ASCEND study

Clinical Trials & Observations
David T. Yeung, Naranie Shanmuganathan, John Reynolds, Susan Branford, Mannu Walia, Agnes S. M. Yong, Jake Shortt, Lynette Chee, Nicholas Viiala, Ilona Cunningham, David M. Ross, Alwyn D’Souza, Matthew Wright, Rosemary Harrup, Cecily Forsyth, Robin Filshie, Steven Lane, Peter Browett, Carolyn Grove, Andrew P. Grigg, Timothy P. Hughes
Journal: Blood
Blood (2024) 144 (19): 1993–2001.
https://doi.org/10.1182/blood.2024024657
Published: 2024
Includes: Supplemental data
Journal Articles

Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy

Laura N. Eadie, Elias Lagonik, Elyse C. Page, Caitlin E. Schutz, Susan L. Heatley, Barbara J. McClure, Michelle O. Forgione, David T. Yeung, Timothy P. Hughes, Deborah L. White
Journal: Blood
Blood (2024) 144 (9): 1022–1026.
https://doi.org/10.1182/blood.2024024776
Published: 2024
Includes: Supplemental data
Journal Articles

IDH -mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation

Lih En Hong, Mihir D. Wechalekar, Monika Kutyna, Annabelle Small, Kelly Lim, Chloe Thompson-Peach, Joule J. Li, Rakchha Chhetri, Hamish S. Scott, Anna Brown, Christopher N. Hahn, David T. Yeung, Salvia Sajid, Nirmal Robinson, Ranjeny Thomas, Susan Branford, Richard J. D’Andrea, Saumya E. Samaraweera, Mrinal Patnaik, Susanna Proudman, Daniel Thomas, Chung Hoow Kok, Mithun V. Shah, Devendra K. Hiwase
Journal: Blood
Blood (2024) 143 (18): 1873–1877.
https://doi.org/10.1182/blood.2023023593
Published: 2024
Includes: Supplemental data
Journal Articles

Lineage-specific detection of residual disease predicts relapse in patients with chronic myeloid leukemia stopping therapy

Brief Report
Ilaria S. Pagani, Naranie Shanmuganathan, Phuong Dang, Verity A. Saunders, Randall Grose, Chung H. Kok, Jane James, Molly Tolland, Jodi A. Braley, Haley K. Altamura, David T. Yeung, Susan Branford, Agnes S. M. Yong, Timothy P. Hughes, David M. Ross
Journal: Blood
Blood (2023) 142 (25): 2192–2197.
https://doi.org/10.1182/blood.2023021119
Published: 2023
Includes: Supplemental data
Journal Articles

Age-Related Clonal Hematopoiesis Mutations Detected at the Time of Stopping Tyrosine Kinase Inhibitor Therapy Predict the Achievement of Treatment-Free Remission for Patients with CML

Susan Branford, Carol Wadham, Naranie Shanmuganathan, Adelina Fernandes, Nur Hezrin Shahrin, Jinghua Feng, John Toubia, Paul Wang, Chung Hoow Kok, Muneeza Maqsood, Verity Saunders, Rob King, Ming Lin, Rosalie Kenyon, Ilaria Stefania Pagani, David T Yeung, David M. Ross, Agnes S. M. Yong, Timothy P Hughes
Journal: Blood
Blood (2023) 142 (Supplement 1): 447.
https://doi.org/10.1182/blood-2023-174425
Published: 2023
Journal Articles

Improved MRD Negativity Rates in Adverse Genomic Risk B-ALL Patients with Chemotherapy / Blinatumomab Induction: Experience from the Australasian Leukaemia Lymphoma Group (ALLG) ALL06/09 Studies

Deborah L White, Jacqueline A Rehn, Caitlin E Schutz, Susan L Heatley, Laura N Eadie, Ashlee Thomson, Elyse C Page, Michael Osborn, Shane Gangatharan, Ashley P Ng, Shaun Fleming, Pasquale Fedele, Toby Trahair, John Casey, Sally Mapp, Carol CY Cheung, Tasman Armytage, Michelle Henderson, Rosemary Sutton, Stephen Robert Larsen, Peter Presgrave, John Kwan, Samuel Bennett, Chun Yew Fong, Luciano Dalla-Pozza, David T Yeung, Matthew Greenwood
Journal: Blood
Blood (2023) 142 (Supplement 1): 1609.
https://doi.org/10.1182/blood-2023-178473
Published: 2023
Journal Articles

High Prevalence of IDH Mutation in Myeloid Neoplasm with Concomitant Autoimmune Rheumatic Disorders

Lih En Hong, Chung Hoow Kok, Monika Kutyna, Joule J Li, Rakchha Chhetri, David M. Ross, Susan Branford, Hamish S Scott, Anna Brown, Christopher Norman Hahn, David T Yeung, Mrinal M. Patnaik, Mithun V Shah, Susanna Proudman, Mihir Wechalekar, Devendra Hiwase
Journal: Blood
Blood (2023) 142 (Supplement 1): 4621.
https://doi.org/10.1182/blood-2023-190809
Published: 2023
Journal Articles

Synergy of Ruxolitinib and Carfilzomib in Targeting the PAX5::JAK2 fusion I n Vitro : Potential Therapeutic Advantage for a Subset of Ph-like Acute Lymphoblastic Leukemia

Jane Frances Thompson, David T Yeung, Randall Hilton Grose, Deborah L White
Journal: Blood
Blood (2023) 142 (Supplement 1): 5806.
https://doi.org/10.1182/blood-2023-174423
Published: 2023
Journal Articles

Suppression of KRAS and CBL Mutations and Hematological Improvement By Lenzilumab and Azacitidine Treatment in Proliferative Chronic Myelomonocytic Leukemia

Maha M Kamel, Monika Kutyna, David M. Ross, Steven W. Lane, Chloe Thompson-Peach, Chun Yew Fong, Agnes S. M. Yong, David T Yeung, Timothy P Hughes, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2023-188340
Published: 2023
Journal Articles

Comparison of World Health Organization and International Consensus Classification Guidelines for Myeloid Neoplasms Harboring TP53 -Mutations Using an Independent International Cohort

Mithun V Shah, Monika Kutyna, Syed Shah, Elizabeth Ngoc Hoa Tran, Anmol Baranwal, Dariusz Ladon, Aref Al-Kali, Anna Brown, Dong Chen, Patricia Greipp, Kebede Begna, Mark R. Litzow, William J. Hogan, Peter Bardy, Sharad Kumar, David T Yeung, Mrinal M. Patnaik, James M. Foran, Rong He, Naseema Gangat, Hamish S Scott, Cecilia Y. Arana Yi, Hassan Alkhateeb, Abhishek A Mangaonkar, Daniel Thomas, Christopher Norman Hahn, Attilio Orazi, Daniel A. Arber, Chung Hoow Kok, Ayalew Tefferi, Devendra Hiwase
Journal: Blood
Blood (2023) 142 (Supplement 1): 3243.
https://doi.org/10.1182/blood-2023-187860
Published: 2023
Journal Articles

Excellent Early and Major Molecular Responses Observed with Asciminib Treatment for CP-CML: Results from the ALLG CML13 Ascend-CML Study

David T Yeung, Naranie Shanmuganathan, John Reynolds, Susan Branford, Mannu Walia, Agnes S. M. Yong, Jake Shortt, Kate Burbury, Lynette C.Y. Chee, Nick Viiala, Ilona Cunningham, David M. Ross, Alwyn Bernard D'Souza, Matthew P.F. Wright, Rosemary Anne Harrup, Cecily Forsyth, Robin Filshie, Peter J. Browett, Steven W. Lane, Carolyn Grove, Andrew P Grigg, Timothy P Hughes, on Behalf Of The ALLG
Journal: Blood
Blood (2023) 142 (Supplement 1): 865.
https://doi.org/10.1182/blood-2023-172583
Published: 2023
Journal Articles

Asciminib Is Effective Against ABL1 Gene Fusions in Acute Lymphoblastic Leukemia but Only When the ABL1 SH3 Domain Is Present

Laura N Eadie, Caitlin E Schutz, Elyse C Page, Tace S Conlin, Susan L Heatley, Elias Lagonik, Jacqueline A Rehn, David T Yeung, Timothy P Hughes, Deborah L White
Journal: Blood
Blood (2023) 142 (Supplement 1): 1602.
https://doi.org/10.1182/blood-2023-184647
Published: 2023
Journal Articles

Single-Hit TP53 mut Is Associated with Poor Outcomes in Therapy-Related but Not De Novo Myelodysplastic Syndromes: Importance of Clinical History

Devendra Hiwase, Anmol Baranwal, Syed Shah, Monika Kutyna, Christopher Norman Hahn, Maymona Abdelmajid, Danielle Rud, Rakchha Chhetri, Kaaren K. Reichard, Dong Chen, Thomas Wiseman, Anna Brown, Hamish S Scott, David T Yeung, David M. Ross, Daniel Thomas, Aref Al-Kali, Hassan Alkhateeb, James M. Foran, Cecilia Y. Arana Yi, Naseema Gangat, Mrinal M. Patnaik, Ayalew Tefferi, Chung Hoow Kok, Rong He, Mithun V Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 4608.
https://doi.org/10.1182/blood-2023-187905
Published: 2023
Journal Articles

Cytokine and Mutation Profiling Reveal Patterns of Complete Remission Rates with Lenzilumab Combination Therapy in Chronic Myelomonocytic Leukemia

Monika Kutyna, Maha M Kamel, David M. Ross, Agnes S. M. Yong, Chun Yew Fong, Chloe Thompson-Peach, Steven W. Lane, David T Yeung, Timothy P Hughes, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 1852.
https://doi.org/10.1182/blood-2023-179706
Published: 2023
Journal Articles

Lenzilumab in Addition to Azacitidine Improves Complete Response Rates in Chronic Myelomonocytic Leukemia

Devendra Hiwase, David M. Ross, Steven W. Lane, Chloe Thompson-Peach, Chun Yew Fong, Agnes S. M. Yong, David T Yeung, Timothy P Hughes, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 1847.
https://doi.org/10.1182/blood-2023-179688
Published: 2023
Journal Articles

PTPN11 Mutations Drive Tyrosine Kinase Inhibitor As Well As Venetoclax Resistance in Ph+ ALL Cells, but Are Sensitive to the Combination

Govinda Poudel, David T Yeung, Deborah L White, Timothy Hughes, Ilaria S Pagani
Journal: Blood
Blood (2022) 140 (Supplement 1): 3128–3129.
https://doi.org/10.1182/blood-2022-162194
Published: 2022
Journal Articles

Personalized Prediction Model to Risk Stratify Patients with Therapy-Related Myeloid Neoplasms

Chung Hoow Kok, Elizabeth Ngoc Hoa Tran, Dariusz Ladon, Rakchha Chhetri, Anmol Baranwal, Kirsty M Sharplin, Hassan B. Alkhateeb, Deepak Singhal, Aref Al-Kali, Naseema Gangat, David T Yeung, Mark R. Litzow, David M Ross, William J. Hogan, Ashanka Begna Kebede, Abhishek A. Mangaonkar, Mrinal M. Patnaik, Ayalew Tefferi, Naranie Shanmuganathan, Sharad Kumar, Daniel Thomas, Mithun V. Shah, Devendra Hiwase
Journal: Blood
Blood (2022) 140 (Supplement 1): 6962–6963.
https://doi.org/10.1182/blood-2022-167978
Published: 2022
Journal Articles

Clonal Hematopoiesis Detected at the Time of Tyrosine Kinase Inhibitor Cessation Is Associated with Delayed Molecular Recurrence after Treatment-Free Remission in Patients with CML

Susan Branford, Naranie Shanmuganathan, Carol Wadham, Nur Hezrin Shahrin, Adelina Fernandes, Jinghua Feng, Andreas W Schreiber, Chung Hoow Kok, Verity A Saunders, Rob King, Ming Lin, Ilaria S Pagani, David T Yeung, David M Ross, Agnes S.M. Yong, Timothy Hughes
Journal: Blood
Blood (2022) 140 (Supplement 1): 3916–3917.
https://doi.org/10.1182/blood-2022-158735
Published: 2022
Journal Articles

Clinical Outcomes of Chronic Myeloid Leukaemia (CML) Patients on Asciminib through the Managed Access Program (MAP) in Australia

Lynette C.Y. Chee, Nora Lee, Andrew Grigg, Melissa Chen, Anthony Schwarer, Jeff Szer, David T Yeung, Timothy Hughes, Naranie Shanmuganathan
Journal: Blood
Blood (2022) 140 (Supplement 1): 6800–6802.
https://doi.org/10.1182/blood-2022-163221
Published: 2022
Journal Articles

Additional Mutational Events at Diagnosis of CML Confer Inferior Failure-Free Survival and Molecular Response for Patients Treated with Frontline Imatinib but Not for Patients Treated with Frontline Second-Generation Tyrosine Kinase Inhibitors

Naranie Shanmuganathan, David T Yeung, Carol Wadham, Nur Hezrin Shahrin, Adelina Fernandes, Jinghua Feng, Verity A Saunders, Ming Lin, Rosalie Kenyon, Rob King, Paul Wang, David M Ross, Andreas W Schreiber, Timothy Hughes, Susan Branford
Journal: Blood
Blood (2022) 140 (Supplement 1): 805–806.
https://doi.org/10.1182/blood-2022-158743
Published: 2022