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Brian Druker
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Journal Articles

Phase 1b safety run-in study followed by Phase 2 study of ficlatuzumab, azacitidine and venetoclax in untreated Acute Myeloid Leukemia patients aged ≥ 60 years old

Free
Emily Curran, Ying Huang, Shivani Handa, Ronan Swords, Eytan Stein, Maria Baer, Wendy Stock, Yazan Madanat, Rebecca Olin, William Blum, Gary Schiller, Tara Lin, Joshua Zeidner, Bradley Blaser, Molly Martycz, Leonard Rosenberg, Sonja Marcus, Timothy Chen, Mona Stefanos, Ashley Yocum, Ross Levine, Brian Druker, Uma Borate, Alice Mims, John Byrd
Journal: Blood
Blood (2025) 146 (Supplement 1): 3432.
https://doi.org/10.1182/blood-2025-3432
Published: 2025
Journal Articles

Standard tyrosine kinase inhibitor dose versus dose de-escalation prior to treatment-free remission attempt in chronic myeloid leukemia: A single-center 25-year retrospective study

Free
Mark Pusung, Christopher Eide, Nicola Long, Cristina Tognon, Andy Kaempf, Diana Brewer, Theodore Braun, Michael Heinrich, Brian Druker
Journal: Blood
Blood (2025) 146 (Supplement 1): 2011.
https://doi.org/10.1182/blood-2025-2011
Published: 2025
Journal Articles

ANKRD26-related thrombocytopenia: Hematologic malignancy characteristics, clinical outcomes, and precursor states

Free
Lauren Banaszak, Bianca Barredo, Marcin Wlodarski, Sara Lewis, Alejandro Ferrer, Mrinal Patnaik, Lucy Fox, Peng Li, Afaf Osman, Jennie Vagher, Courtney DiNardo, Sarah Pelletier, Brittany Stewart, Hetty Carraway, Moshe Mittelman, Howard Oster, Noa Goldschmidt, Anat Sinai, May Basood, Amy Trottier, Valeria Santini, Gloria Andreossi, Brian Druker, Michael Heinrich, Diana Brewer, Kelcy Smith-Simmer, Kyle Shoger, Gustavo Fonseca, Elise Fiala, Yelena Kemel, Ozge Birsoy-Ceyhan, Diana Mandelker, Andrew Marderstein, Zsofia Stadler, Kenneth Offit, Molly McGuinness, Michael Drazer, Alan Cantor, Jacob Bledsoe, Alexandra Satty, Adrianna Vlachos, Claire Homan, Anna Brown, Jane Churpek
Journal: Blood
Blood (2025) 146 (Supplement 1): 1440.
https://doi.org/10.1182/blood-2025-1440
Published: 2025
Journal Articles

RAS mutations negate the favorable impact of NPM1 in older patients with newly diagnosed Acute Myeloid Leukemia treated with ven/HMA

Free
Fieke Hoff, Alexander Li, Ying Huang, Rina Welkie, Ronan Swords, Elie Traer, Eytan Stein, Tara Lin, Maria Baer, Vu Duong, William Blum, Martha Arellano, Wendy Stock, Olatoyosi Odenike, Joshua Zeidner, Rebecca Olin, Catherine Smith, Gary Schiller, Emily Curran, Shivani Handa, Nyla Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Marcus, Leonard Rosenberg, Brian Druker, Ross Levine, Ashley Yocum, Uma Borate, Alice Mims, John Byrd, Yazan Madanat
Journal: Blood
Blood (2025) 146 (Supplement 1): 995.
https://doi.org/10.1182/blood-2025-995
Published: 2025
Journal Articles

Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML

Free
Clinical Trials & Observations
Fei Yang, Nicola Long, Tauangtham Anekpuritanang, Daniel Bottomly, Jonathan C. Savage, Tiffany Lee, Jose Solis-Ruiz, Uma Borate, Beth Wilmot, Cristina Tognon, Allison M. Bock, Daniel A. Pollyea, Saikripa Radhakrishnan, Srinidhi Radhakrishnan, Prapti Patel, Robert H. Collins, Srinivas Tantravahi, Michael W. Deininger, Guang Fan, Brian Druker, Ujwal Shinde, Jeffrey W. Tyner, Richard D. Press, Shannon McWeeney, Anupriya Agarwal
Journal: Blood
Blood (2022) 139 (8): 1208–1221.
https://doi.org/10.1182/blood.2021011354
Published: 2022
Includes: Supplemental data
Journal Articles

Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon-α treatment

Free
Clinical Trials & Observations
Andreas Hochhaus, Brian Druker, Charles Sawyers, Francois Guilhot, Charles A. Schiffer, Jorge Cortes, Dietger W. Niederwieser, Carlo Gambacorti-Passerini, Richard M. Stone, John Goldman, Thomas Fischer, Stephen G. O'Brien, Jose J. Reiffers, Manisha Mone, Tillmann Krahnke, Moshe Talpaz, Hagop M. Kantarjian
Journal: Blood
Blood (2008) 111 (3): 1039–1043.
https://doi.org/10.1182/blood-2007-07-103523
Published: 2008
Journal Articles

High-Throughput Sequence Analysis of the Tyrosine Kinome in Acute Myeloid Leukemia.

Free
Marc Loriaux, Ross Levine, Jeffrey Tyner, Stephan Frohling, Claudia Scholl, Eric Stoffregen, Gerlinde Wernig, Heidi Erickson, Chris Eide, Roland Berger, Olivier Bernard, James Griffin, Richard Stone, Matthew Meyerson, Michael Heinrich, Michael Deininger, Gary Gilliland, Brian Druker
Journal: Blood
Blood (2007) 110 (11): 886.
https://doi.org/10.1182/blood.V110.11.886.886
Published: 2007
Journal Articles

An MMR Control RNA for Reliable Monitoring of BCR-ABL Transcripts in Treated CML Patients.

Free
Julie Toplin, Courtney Fuller, Linda Fletcher, Stephane Wong, Peter Maslak, Jorge Cortes, Rosemary Mazanet, Susan Branford, Timothy Hughes, Chad Galderisi, Michael Heinrich, Brian Druker, Emmanuel Beillard
Journal: Blood
Blood (2007) 110 (11): 2939.
https://doi.org/10.1182/blood.V110.11.2939.2939
Published: 2007
Journal Articles

In Chronic Lymphocytic Leukemia, Zap70 Identifies a Survival Pathway Signal Cascade Involving p85 PI-3-Kinase, CrkL, and Cbl with Syk En Route to JNK1 and bcl-2.

Free
Amy D. Hartman, MS, Annique Wilson-Weekes, MS, Larry D. Cripe, MD, Brydon Bennett, PhD, Glenn Friedman, PhD, Peter Worland, PhD, Brian Druker, MD, Shuyue Ren, PhD, Tomasz Skorski, PhD, H. Scott Boswell, MD
Journal: Blood
Blood (2006) 108 (11): 584.
https://doi.org/10.1182/blood.V108.11.584.584
Published: 2006
Journal Articles

Therapeutic Drug Monitoring of Imatinib and Impact on Clinical Decision Making.

Free
Carolyn Blasdel, MA, RN, FNP, Yanfeng Wang, PhD, Theodore Lagattuta, BS, Brian Druker, MD, Laurie Letvak, MD, Merrill Egorin, MD FACP
Journal: Blood
Blood (2006) 108 (11): 4820.
https://doi.org/10.1182/blood.V108.11.4820.4820
Published: 2006
Journal Articles

Orally Active Inhibitors of the Imatinib Resistant Bcr-Abl Mutant T315I.

Free
William C. Shakespeare, PhD, Frank Wang, Ph.D., Qihong Xu, Ph.D., Xiaotian Zhu, Ph.D., Narayana Narasimham, Ph.D., Chester A. Metcalf, Ph.D., Yihan Wang, Ph.D., Raji Sundaramoorthi, Ph.D., Wei-Sheng Huang, Ph.D., Dong Zou, Ph.D., Mathew Thomas, Ph.D., Jan Romero, Ph.D., David Wen, M.S., Ingrid Chen, B.S., Lisi Cai, M.S., Shuangying Liu, M.S., Scott Wardwell, B.S., Yaoyu Ning, M.S., Jeff Keats, B.S., Joseph Snodgrass, Ph.D., Karin Russian, M.S., Marc Broudy, B.S., Thomas O’Hare, Ph.D., Caitlyn Smith, B.S., Amie Corbin, Ph.D., Brian Druker, M.D., John Iuliucci, Ph.D., David Dalgarno, Ph.D., Tomi K. Sawyer, Ph.D., Tim Clackson, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 2180.
https://doi.org/10.1182/blood.V108.11.2180.2180
Published: 2006
Journal Articles

Retrospective Comparison of Imatinib Versus Interferon Plus Cytarabine (IFN/Ara-c) for Chronic Myelogenous Leukemia (CML) Patients in Chronic Phase (CP).

Free
Francois Guilhot, MD, Lydia Roy, MD, Joelle Guilhot, BS, Tillmann Krahnke, BSR, Agnes Guerci, MD, Brian Druker, MD, Richard Larson, MD, Steve O’Brien, MD, Charlene So, PharmD, Giorgio Massimini, MD
Journal: Blood
Blood (2005) 106 (11): 165.
https://doi.org/10.1182/blood.V106.11.165.165
Published: 2005
Journal Articles

Preliminary Results from a Phase 2 Trial of AG-858, an Autologous Heat Shock Protein-Peptide Vaccine, in Combination with Imatinib in Patients with Chronic Phase Chronic Myeloid Leukemia (CML) Resistant to Prior Imatinib Monotherapy.

Free
David Marin, MD, Michael Mauro, MD, John Goldman, MD, Brian Druker, MD, Steven Devine, MD, Richard E. Clark, MD, Ronald Paquette, MD, Asad Bashey, MD, Martin S. Tallman, MD, April Dovholuk, Axel Hoos, MD, PhD, Pramod Srivastava, PhD
Journal: Blood
Blood (2005) 106 (11): 1094.
https://doi.org/10.1182/blood.V106.11.1094.1094
Published: 2005
Journal Articles

The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

Free
Clinical Trials & Observations Brief Report
Ross L. Levine, Marc Loriaux, Brian J. P. Huntly, Mignon L. Loh, Miroslav Beran, Eric Stoffregen, Roland Berger, Jennifer J. Clark, Stephanie G. Willis, Kim T. Nguyen, Nikki J. Flores, Elihu Estey, Norbert Gattermann, Scott Armstrong, A. Thomas Look, James D. Griffin, Olivier A. Bernard, Michael C. Heinrich, D. Gary Gilliland, Brian Druker, Michael W. N. Deininger
Journal: Blood
Blood (2005) 106 (10): 3377–3379.
https://doi.org/10.1182/blood-2005-05-1898
Published: 2005
Journal Articles

Various Mechanisms Underlie Cytogenetic Refractoriness to Imatinib.

Free
Lucy Crossman, Michael Heinrich, Richard Press, Stephanie Willis, Michael Deininger, Brian Druker
Journal: Blood
Blood (2004) 104 (11): 2091.
https://doi.org/10.1182/blood.V104.11.2091.2091
Published: 2004
Journal Articles

TEL/PDGFβR Induces Hematologic Malignancies in Mice That Respond to a Specific Tyrosine Kinase Inhibitor

Free
Michael H. Tomasson, Ifor R. Williams, Robert Hasserjian, Chirayu Udomsakdi, Shannon M. McGrath, Juerg Schwaller, Brian Druker, D. Gary Gilliland
Journal: Blood
Blood (1999) 93 (5): 1707–1714.
https://doi.org/10.1182/blood.V93.5.1707
Published: 1999