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Journal Articles

HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia

Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan M. A. Azazi, Sarah J. Horton, Cecile K. Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J. P. Huntly

Blood (2023) 141 (14): 1737–1754.

https://doi.org/10.1182/blood.2022016528

Published: 2023

Includes: Supplemental data

Journal Articles

Transcriptional Heterogeneity Governs Cell Fate Diversification during Pre-Leukemia to Leukemia Progression

Shikha Gupta, MS, Ana Filipa Domingues, Oliwia Cyran, George Giotopoulos, PhD, Sudhakaran Prabakaran, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, Oliver M. Dovey, PhD, George S. Vassiliou, MD PhD FRCPath, MRCP, Cristina Pina, MDDPhil

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-136504

Published: 2020

Journal Articles

CML: new tools to answer old questions

George Giotopoulos, Brian J. P. Huntly

Blood (2020) 135 (26): 2327–2328.

https://doi.org/10.1182/blood.2020005599

Published: 2020

Journal Articles

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Daniel Sasca, Haiyang Yun, George Giotopoulos, Jakub Szybinski, Theo Evan, Nicola K. Wilson, Moritz Gerstung, Paolo Gallipoli, Anthony R. Green, Robert Hills, Nigel Russell, Cameron S. Osborne, Elli Papaemmanuil, Berthold Göttgens, Peter Campbell, Brian J. P. Huntly

Blood (2019) 134 (24): 2195–2208.

https://doi.org/10.1182/blood.2019001553

Published: 2019

Includes: Supplemental data

Journal Articles

Genetic Vulnerabilities of DNMT3A R882H in Myeloid Malignancies

Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Konstantinos Tzelepis, Aristi Damaskou, MSc, Vijay Baskar, PhD, Penny Wright, Graham Duddy, Eshwar Meduri, PhD, Milena Mazan, PhD, Kosuke Yusa, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, George S. Vassiliou, FRCPath, MRCP, PhD

Blood (2019) 134 (Supplement_1): 111.

https://doi.org/10.1182/blood-2019-126505

Published: 2019

Journal Articles

Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction

Haiyang Yun, PhD, Shabana Vohra, PhD, Annalisa Mupo, PhD, George Giotopoulos, PhD, Daniel Sasca, MD, Sarah J. Horton, PhD, Shuchi Agrawal-Singh, PhD, Eshwar Meduri, PhD, Faisal Basheer, MBBChir, MA, PhD, Ludovica Marando, Malgorzata Gozdecka, PhD, Oliver M. Dovey, PhD, Xiaonan Wang, PhD, Paolo Gallipoli, PhD, Cameron Osborne, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath

Blood (2019) 134 (Supplement_1): 278.

https://doi.org/10.1182/blood-2019-122413

Published: 2019

Journal Articles

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S. H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M. L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza, Brian J. P. Huntly

Blood (2018) 131 (15): 1639–1653.

https://doi.org/10.1182/blood-2017-12-820035

Published: 2018

Includes: Supplemental data

Journal Articles

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

David Grimwade, Adam Ivey, Brian J. P. Huntly

Blood (2016) 127 (1): 29–41.

https://doi.org/10.1182/blood-2015-07-604496

Published: 2016

Journal Articles

Role of Epigenetic Readers in Pathogenesis and Therapy of Acute Leukemias

Brian J. P. Huntly, MD, PhD

Blood (2013) 122 (21): SCI-20.

https://doi.org/10.1182/blood.V122.21.SCI-20.SCI-20

Published: 2013

Journal Articles

Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms

Shubha Anand, Frances Stedham, Emma Gudgin, Peter Campbell, Philip Beer, Anthony R. Green, Brian J. P. Huntly

Blood (2011) 118 (6): 1610–1621.

https://doi.org/10.1182/blood-2011-02-335042

Published: 2011

Includes: Supplemental data

Journal Articles

Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms

Shubha Anand, Frances Stedham, Philip Beer, Emma Gudgin, Christina A. Ortmann, Anthony Bench, Wendy Erber, Anthony R. Green, Brian J. P. Huntly

Blood (2011) 118 (1): 177–181.

https://doi.org/10.1182/blood-2010-12-327593

Published: 2011

Includes: Supplemental data

Journal Articles

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia

Juan Li, Dominik Spensberger, Jong Sook Ahn, Shubha Anand, Philip A. Beer, Cedric Ghevaert, Edwin Chen, Ariel Forrai, Linda M. Scott, Rita Ferreira, Peter J. Campbell, Steve P. Watson, Pentao Liu, Wendy N. Erber, Brian J. P. Huntly, Katrin Ottersbach, Anthony R. Green

Blood (2010) 116 (9): 1528–1538.

https://doi.org/10.1182/blood-2009-12-259747

Published: 2010

Includes: Supplemental data

Journal Articles

Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation

Peter J. Campbell, E. Joanna Baxter, Philip A. Beer, Linda M. Scott, Anthony J. Bench, Brian J. P. Huntly, Wendy N. Erber, Rajko Kusec, Thomas Stauffer Larsen, Stéphane Giraudier, Marie-Caroline Le Bousse-Kerdilès, Martin Griesshammer, John T. Reilly, Betty Y. Cheung, Claire N. Harrison, Anthony R. Green

Blood (2006) 108 (10): 3548–3555.

https://doi.org/10.1182/blood-2005-12-013748

Published: 2006

Journal Articles

The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

Blood (2005) 106 (10): 3377–3379.

https://doi.org/10.1182/blood-2005-05-1898

Published: 2005

Journal Articles

Constitutively activated FGFR3 mutants signal through PLCγ-dependent and -independent pathways for hematopoietic transformation

Jing Chen, Ifor R. Williams, Benjamin H. Lee, Nicole Duclos, Brian J. P. Huntly, Daniel J. Donoghue, D. Gary Gilliland

Blood (2005) 106 (1): 328–337.

https://doi.org/10.1182/blood-2004-09-3686

Published: 2005

Journal Articles

The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA –positive chronic eosinophilic leukemia

Jan Cools, Hilmar Quentmeier, Brian J. P. Huntly, Peter Marynen, James D. Griffin, Hans G. Drexler, D. Gary Gilliland

Blood (2004) 103 (7): 2802–2805.

https://doi.org/10.1182/blood-2003-07-2479

Published: 2004

Journal Articles

Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions

Brian J. P. Huntly, Francois Guilhot, Alistair G. Reid, George Vassiliou, Evelin Hennig, Christina Franke, Jennie Byrne, Andre Brizard, Dietger Niederwieser, Julie Freeman-Edward, Gavin Cuthbert, Nick Bown, Richard E. Clark, Elizabeth P Nacheva, Anthony R Green, Michael W. N. Deininger

Blood (2003) 102 (6): 2205–2212.

https://doi.org/10.1182/blood-2002-09-2763

Published: 2003

Journal Articles

Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia

Brian J. P. Huntly, Anthony Bench, Anthony R. Green

Blood (2003) 102 (4): 1160–1168.

https://doi.org/10.1182/blood-2003-01-0123

Published: 2003

Journal Articles

Derivative chromosome 9 deletions in chronic myeloid leukemia: poor prognosis is not associated with loss of ABL-BCR expression, elevated BCR-ABL levels, or karyotypic instability

Brian J. P. Huntly, Anthony J. Bench, Eric Delabesse, Alistair G. Reid, Juan Li, Mike A. Scott, Lynda Campbell, Jennie Byrne, Eleanor Pinto, Andre Brizard, Deitger Niedermeiser, Elizabeth P. Nacheva, Francois Guilhot, Michael Deininger, Anthony R. Green

Blood (2002) 99 (12): 4547–4553.

https://doi.org/10.1182/blood.V99.12.4547

Published: 2002

Journal Articles

Deletions of the derivative chromosome 9 do not account for the poor prognosis associated with Philadelphia-positive acute lymphoblastic leukemia

Alistair G. Reid, Brian J. P. Huntly, Eveline Hennig, Dietger Niederwieser, Lynda J. Campbell, Nick Bown, Nick Telford, Helen Walker, Colin D. Grace, Michael W. Deininger, Anthony R. Green, Elisabeth P. Nacheva

Blood (2002) 99 (6): 2274–2275.

https://doi.org/10.1182/blood.V99.6.2274

Published: 2002

NARROW

HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia

Transcriptional Heterogeneity Governs Cell Fate Diversification during Pre-Leukemia to Leukemia Progression

CML: new tools to answer old questions

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Genetic Vulnerabilities of DNMT3A R882H in Myeloid Malignancies

Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

Role of Epigenetic Readers in Pathogenesis and Therapy of Acute Leukemias

Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms

Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia

Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation

The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

Constitutively activated FGFR3 mutants signal through PLCγ-dependent and -independent pathways for hematopoietic transformation

The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA –positive chronic eosinophilic leukemia

Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions

Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia

Derivative chromosome 9 deletions in chronic myeloid leukemia: poor prognosis is not associated with loss of ABL-BCR expression, elevated BCR-ABL levels, or karyotypic instability

Deletions of the derivative chromosome 9 do not account for the poor prognosis associated with Philadelphia-positive acute lymphoblastic leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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