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David Grimwade
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Journal Articles

Molecular MRD status and outcome after transplantation in NPM1 -mutated AML

Clinical Trials & Observations
Richard Dillon, Robert Hills, Sylvie Freeman, Nicola Potter, Jelena Jovanovic, Adam Ivey, Anju Shankar Kanda, Manohursingh Runglall, Nicola Foot, Mikel Valganon, Asim Khwaja, Jamie Cavenagh, Matthew Smith, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Steven Knapper, Harpreet Kaur, David Taussig, Priyanka Mehta, Kavita Raj, Igor Novitzky-Basso, Emmanouil Nikolousis, Robert Danby, Pramila Krishnamurthy, Kate Hill, Damian Finnegan, Samah Alimam, Erin Hurst, Peter Johnson, Anjum Khan, Rahuman Salim, Charles Craddock, Ruth Spearing, Amanda Gilkes, Rosemary Gale, Alan Burnett, Nigel H. Russell, David Grimwade
Journal: Blood
Blood (2020) 135 (9): 680–688.
https://doi.org/10.1182/blood.2019002959
Published: 2020
Includes: Supplemental data
Journal Articles

Therapy-Related Myeloid Neoplasms with Balanced Chromosome Rearrangements Frequently Arise from Pre-Existing Clonal Haematopoiesis

Richard Dillon, MA, PhD MRCP, FRCPath, Jelena Jovanovic, PhD, Nicola Potter, PhD, Nicola Foot, MSc, Matthew J Ahearne, MD MBBS, Sandrine Jayne, PhD, Michael Dennis, MD MRCP, FRCPath, Ann E. Hunter, MBBS, FRCP, FRCPath, Martin J.S. Dyer, Paresh Vyas, Lynn Quek, FRCPath, DPhil, MBBS, Nigel H. Russell, Robert K. Hills, MA, DPhil, MSc, Ellen Solomon, PhD, David Grimwade, PhD MRCP, MRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 2570.
https://doi.org/10.1182/blood-2018-99-114233
Published: 2018
Journal Articles

Pre-Transplant NPM1 Mutant Transcript Level Is Highly Predictive of Outcome after Allograft and Thresholds Are Dependent on FLT3 ITD Status

Richard Dillon, MA, PhD MRCP, FRCPath, Robert K. Hills, MA, DPhil, MSc, Sylvie D Freeman, MBChB, DPhil, Nicola Potter, PhD, Adam Ivey, BSc, MSc, PhD, Jelena Jovanovic, PhD, Anju Kanda, MSc, Manohursingh Runglall, MSc, Nicola Foot, MSc, Laura Upton, Asim Khwaja, MD PhD, Jamie Cavenagh, MD PhD, Ruth Spearing, MD, Alan K. Burnett, MD, Nigel H. Russell, David Grimwade, PhD MRCP, MRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 2739.
https://doi.org/10.1182/blood-2018-99-113662
Published: 2018
Journal Articles

Attenuated arsenic trioxide plus ATRA therapy for newly diagnosed and relapsed APL: long-term follow-up of the AML17 trial

Clinical Trials & Observations
Nigel Russell, Alan Burnett, Robert Hills, Sophie Betteridge, Mike Dennis, Jelena Jovanovic, Richard Dillon, David Grimwade
Journal: Blood
Blood (2018) 132 (13): 1452–1454.
https://doi.org/10.1182/blood-2018-05-851824
Published: 2018
Journal Articles

Risk-adapted treatment of acute promyelocytic leukemia: results from the International Consortium for Childhood APL

Clinical Trials & Observations
Anna Maria Testi, Andrea Pession, Daniela Diverio, David Grimwade, Brenda Gibson, Amilcar Cardoso de Azevedo, Lorena Moran, Guy Leverger, Sarah Elitzur, Henrik Hasle, Jutte van der Werff ten Bosch, Owen Smith, Marisa De Rosa, Alfonso Piciocchi, Francesco Lo Coco, Robin Foà, Franco Locatelli, Gertjan J. L. Kaspers
Journal: Blood
Blood (2018) 132 (4): 405–412.
https://doi.org/10.1182/blood-2018-03-836528
Published: 2018
Includes: Supplemental data
Journal Articles

Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party

Clinical Trials & Observations
Gerrit J. Schuurhuis, Michael Heuser, Sylvie Freeman, Marie-Christine Béné, Francesco Buccisano, Jacqueline Cloos, David Grimwade, Torsten Haferlach, Robert K. Hills, Christopher S. Hourigan, Jeffrey L. Jorgensen, Wolfgang Kern, Francis Lacombe, Luca Maurillo, Claude Preudhomme, Bert A. van der Reijden, Christian Thiede, Adriano Venditti, Paresh Vyas, Brent L. Wood, Roland B. Walter, Konstanze Döhner, Gail J. Roboz, Gert J. Ossenkoppele
Journal: Blood
Blood (2018) 131 (12): 1275–1291.
https://doi.org/10.1182/blood-2017-09-801498
Published: 2018
Includes: Supplemental data
Journal Articles

Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice

Edwige Voisset, Eva Moravcsik, Eva W. Stratford, Amie Jaye, Christopher J. Palgrave, Robert K. Hills, Paolo Salomoni, Scott C. Kogan, Ellen Solomon, David Grimwade
Journal: Blood
Blood (2018) 131 (6): 636–648.
https://doi.org/10.1182/blood-2017-07-794784
Published: 2018
Includes: Supplemental data
Journal Articles

HMGA2 Gene Expression Profile Improves Risk Stratification in Acute Myeloid Leukemia

Miriam Marquis, PhD, Cyrielle Beaubois, Vincent-Philippe Lavallee, MD, Michal Abrahamowicz, PhD, Coraline Danieli, PhD, Sébastien Lemieux, PhD, Imran Ahmad, MD, Andrew Wei, MBBS, FRACP, FRCPA, PhD, Stephen B Ting, MD PhD, Shaun Fleming, MBBS(Hons) FRACP FRCPA, Anthony P Schwarer, MD MBBS (Hons), FRACP, FRCPA, William Grey, PhD, David Grimwade, MD PhD, Robert K. Hills, DPhil, Paresh Vyas, MD PhD, Nigel H. Russell, MD, Guy Sauvageau, MD, PhD, Josee Hebert, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1402.
https://doi.org/10.1182/blood.V130.Suppl_1.1402.1402
Published: 2017
Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1208.
https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208
Published: 2017
Journal Articles

Characteristics and Outcome of Patients with Acute Myeloid Leukemia and t(6;9)(p22;q34)

Sabine Kayser, MD, Robert K. Hills, DPhil, Marlise R. Luskin, MD, Andrew M. Brunner, MD, Carole Shaw, Joerg Westermann, MD, Kamal Menghrajani, MD, Maria R. Baer, MD, Michelle A. Elliott, MD, Alexander E. Perl, MD, Christine Terré, PharmD, PhD, Zdenek Racil, MD, Jiri Mayer, Prof, MD SCs, Pavel Zak, MD, Tomas Szotkowski, MD, David Grimwade, Karin Mayer, MD, Roland B. Walter, MD PhD, Alwin Krämer, MD, Alan K. Burnett, MD, Anthony D. Ho, Richard M. Stone, MD, Martin S. Tallman, MD, Elihu H. Estey, MD, Carsten Müller-Tidow, Nigel H. Russell, Richard F. Schlenk, MD, Mark J. Levis, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3906.
https://doi.org/10.1182/blood.V130.Suppl_1.3906.3906
Published: 2017
Journal Articles

Flow Cytometric Minimal Residual Disease As Risk Stratification Tool in Younger Adults with NPM1 Wild Type Standard Risk Acute Myeloid Leukemia

Sylvie D Freeman, MBChB, DPhil, Robert K. Hills, DPhil, Paul Virgo, Naeem Khan, PhD, Stephen Couzens, Richard James Dillon, MA, PhD MRCP, FRCPath, Laura Upton, Lars Kjeldsen, MD, Ian Thomas, David Grimwade, Alan K. Burnett, MD, Nigel H. Russell
Journal: Blood
Blood (2017) 130 (Supplement 1): 468.
https://doi.org/10.1182/blood.V130.Suppl_1.468.468
Published: 2017
Journal Articles

Combining Gene Mutation with Gene Expression Data Improves Outcomes Prediction in Acute Promyelocytic Leukemia

Antonio R. Lucena-Araujo, PhD, Diego A Pereira-Martins, MD, Luisa C A Koury, MD, Juan Luiz Coelho-Silva, BSc, MSc, Raul Antônio Morais Melo, MD PhD, Rosane Bittencourt, MD, Katia B Pagnano, MD, Ricardo Pasquini, MD, Carlos Chiattone, MD, Evandro Maranhão Fagundes, MD, Maria de Lourdes Chauffaille, MD PhD, Stanley L. Schrier, MD, Martin S. Tallman, MD, Raul C. Ribeiro, MD, David Grimwade, Arnold Ganser, MD, Bob Lowenberg, MD PhD, Francesco Lo Coco, MD, Miguel A. Sanz, MD, Nancy Berliner, MD, Eduardo Magalhães Rego, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2696.
https://doi.org/10.1182/blood.V130.Suppl_1.2696.2696
Published: 2017
Journal Articles

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

Clinical Trials & Observations
Hartmut Döhner, Elihu Estey, David Grimwade, Sergio Amadori, Frederick R. Appelbaum, Thomas Büchner, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Richard A. Larson, Ross L. Levine, Francesco Lo-Coco, Tomoki Naoe, Dietger Niederwieser, Gert J. Ossenkoppele, Miguel Sanz, Jorge Sierra, Martin S. Tallman, Hwei-Fang Tien, Andrew H. Wei, Bob Löwenberg, Clara D. Bloomfield
Journal: Blood
Blood (2017) 129 (4): 424–447.
https://doi.org/10.1182/blood-2016-08-733196
Published: 2017
Journal Articles

Long Term Follow up from the NCRI AML17 Trial of Attenuated Arsenic Trioxide and ATRA Therapy for Newly Diagnosed and Relapsed Acute Promyelocytic Leukaemia

Nigel H Russell, MD, Alan K. Burnett, MD FRCP, Robert K Hills, DPhil, Sophie Betteridge, PhD, Michael Dennis, FRCPath, Richard Dillon, MA, MRCP, FRCPath, David Grimwade, PhD FRCPath
Journal: Blood
Blood (2016) 128 (22): 897.
https://doi.org/10.1182/blood.V128.22.897.897
Published: 2016
Journal Articles

Pml Nuclear Body Disruption Cooperates in APL Pathogenesis, Impacting DNA Damage Repair Pathways

Edwige Voisset, PhD, Eva Moravcsik, Eva W Stratford, Amie Jaye, Christopher J Palgrave, Robert K Hills, DPhil, Paolo Salomoni, Scott C. Kogan, MD, Ellen Solomon, David Grimwade, PhD FRCPath
Journal: Blood
Blood (2016) 128 (22): 742.
https://doi.org/10.1182/blood.V128.22.742.742
Published: 2016
Journal Articles

Just 1 test to diagnose AML?!!

Richard Dillon, David Grimwade
Journal: Blood
Blood (2016) 128 (1): 8–10.
https://doi.org/10.1182/blood-2016-05-715060
Published: 2016
Journal Articles

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

Clinical Trials & Observations
David Grimwade, Adam Ivey, Brian J. P. Huntly
Journal: Blood
Blood (2016) 127 (1): 29–41.
https://doi.org/10.1182/blood-2015-07-604496
Published: 2016
Journal Articles

Risk-Group Stratified and Minimal Residual Disease (MRD)-Guided Treatment with Extended ATRA and Reduced-Anthracycline Chemotherapy in Childhood Acute Promyelocytic Leukemia (APL): Results from ICC APL Study 01 (NCT01226303; EudraCT 2008-002311-40)

Anna Maria Testi, MD, Andrea Pession, MD, David Grimwade, PhD FRCPath, Daniela Diverio, PhD, Christine Ragu, PhD, Sarah Elitzur, MD, Alcira Fynn, MD, Henrik Hasle, MD PhD, Jutte Van der Werff ten Bosch, MD PhD, Owen Smith, MD, Brenda Gibson, MD, Franco Locatelli, MD PhD, Gertjan J.L. Kaspers, MD PhD
Journal: Blood
Blood (2015) 126 (23): 563.
https://doi.org/10.1182/blood.V126.23.563.563
Published: 2015
Journal Articles

Divergent Dynamics of Epigenetic and Genetic Heterogeneity in Relapsed Acute Myeloid Leukemia

Francine E. Garrett-Bakelman, MD PhD, Sheng Li, PhD, Stephen S. Chung, MD, Todd Hricik, Rapaport Franck, Jay Patel, Richard Dillon, MA, MRCP, FRCPath, Priyanka Vijay, Anna L Brown, PhD, Alexander E. Perl, MD, B. Joy Cannon, Mathijs A. Sanders, PhD, Peter J M Valk, PhD, Lars Bullinger, MD, Selina Luger, MD, Michael W. Becker, MD, Ian D. Lewis, MBBS PhDFRACP FRCPA, L. Bik To, MD, Richard J D'Andrea, PhD, David Grimwade, MD PhD, Ruud Delwel, PhD, Bob Lowenberg, MD PhD, Hartmut Dohner, MD, Konstanze Dohner, MD, Duane C Hassane, PhD, Monica L. Guzman, PhD, Gail J Roboz, MD, Martin Carroll, MD, Christopher Y. Park, MD, PhD, Donna S. Neuberg, Sc.D., Ross L. Levine, MD, Christopher Mason, PhD, Ari Melnick, MD
Journal: Blood
Blood (2015) 126 (23): 306.
https://doi.org/10.1182/blood.V126.23.306.306
Published: 2015
Journal Articles

Significance of Blast CD33 Expression for Effect of Gemtuzumab Ozogamicin at Different Doses in Adult Acute Myeloid Leukemia: Results from the UK NCRI AML16/17 Trials

Khan Naeem, PhD, Robert K. Hills, MA, MSc, DPhil, Paul Virgo, BSc,, Stephen Couzens, Nithiya Clark, Amanda Gilkes, Angela Grech, Peter Richardson, Steven Knapper, David Grimwade, PhD FRCPath, Nigel H. Russell, MD, Alan K. Burnett, MDFRCP, Sylvie Freeman, PhDFRCPath
Journal: Blood
Blood (2015) 126 (23): 320.
https://doi.org/10.1182/blood.V126.23.320.320
Published: 2015