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Journal Articles

CPX-351 versus daunorubicin, cytarabine plus gemtuzumab ozogamicin in older adults with non-adverse risk AML: NCRI AML18

Open Access
Clinical Trials & Observations
Steven Knapper, Laura W Dillon, Malavika Babu, Abin Thomas, Ian Thomas, Christopher S Hourigan, Georgia M Andrew, Richard James Dillon, Amanda Frances Gilkes, Nuria Marquez-Almuina, Sophie King, Nicholas McCarthy, Reem Bahr, Rasha W Al-Ali, Louisa Stone, Tom Coats, Jennifer L Byrne, Simone Green, Ulrik Malthe Overgaard, Rob S. Sellar, Mike Dennis, Priyanka Mehta, Robert K Hills, Sylvie D Freeman, Nigel H. Russell
Journal: Blood
Blood blood.2025031006.
https://doi.org/10.1182/blood.2025031006
Published: 2025
Includes: Supplemental data
Journal Articles

Real-world overall survival in patients with Acute Myeloid Leukemia treated with ivosidenib plus azacitidine in the USA: Trinetx-based analysis

Free
Joshua Zeidner, Priyanka Mehta, Alfonso Piciocchi, Anna Candoni, Pierre-Yves Dumas, Menno Van Roosmalen, Annett Kucka, Romyka Ferhi, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 3401.
https://doi.org/10.1182/blood-2025-3401
Published: 2025
Journal Articles

FLT3-ITD NGS-MRD refines risk stratification in NPM1 and FLT3 co-mutated AML beyond NPM1 PCR-MRD: Analysis of the UK NCRI AML17 and AML19 trials

Free
Aditya Tedjaseputra, Nicola Potter, Jelena Jovanovic, Adam Ivey, Manohursingh Runglall, William Villiers, Phoebe Aucken, Michael Lim, Thadsha Arumugam, Olivia Grimwade, Amanda Gilkes, Joanna Canham, Sean Johnson, Ian Thomas, Hans Ommen, Ulrik Overgaard, Ruth Spearing, Mike Dennis, Jenny O'Nions, Andrew King, Paul Cahalin, Priyanka Mehta, David Taussig, Ellen Solomon, Alan Burnett, Sylvie Freeman, Steve Knapper, Andrew Wei, Jad Othman, Nigel Russell, Richard Dillon
Journal: Blood
Blood (2025) 146 (Supplement 1): 345.
https://doi.org/10.1182/blood-2025-345
Published: 2025
Journal Articles

Effectiveness and safety of CPX-351 in younger patients <60 years with newly diagnosed secondary Acute Myeloid Leukemia: Pooled analysis of US (V-RULES) and UK (CREST-UK) real-world studies

Free
Thomas LeBlanc, Amir Ali, Victoria Campbell, Onyee Chan, Thomas Coats, Doria Cole, Daniel Cuadras, Nicholas Cunningham, Yngvar Floisand, Gillian Flynn, Jesus Gonzalez-Lugo, Katherine Hodgson, Anjum Khan, Kristin Koenig, Catherine Lai, Alex Legg, Mimi Lo, Amanda Lopez, Mark Lynam, Jamie Maddox, Sateesh Nagumantry, Matthew Newman, Jenny O'Nions, Saemi Park, Montse Pedrós, Giuseppe Piccoli, Melisa Stricherz, David Taussig, Charlotte Wagner, Eunice Wang, Richard Whitmill, George Yaghmour, Rui Zhao, Priyanka Mehta
Journal: Blood
Blood (2025) 146 (Supplement 1): 5215.
https://doi.org/10.1182/blood-2025-5215
Published: 2025
Journal Articles

Real-world analysis of time spent at home for patients with secondary acute myeloid leukemia treated with CPX-351 or venetoclax plus azacitidine in England

Free
Priyanka Mehta, Tomas Skacel, Alexandrina Lambova, Eleanor Ralphs, Gry Wester, Karabo Keapoletswe, Alex Legg
Journal: Blood
Blood (2025) 146 (Supplement 1): 1667.
https://doi.org/10.1182/blood-2025-1667
Published: 2025
Journal Articles

A Randomized Comparison of CPX-351 and FLAG-Ida in Patients with High-Risk Acute Myeloid Leukemia (AML)/Myelodysplastic Syndrome (MDS) and MDS-Related Gene Mutations: A Subgroup Analysis of the UK NCRI AML19 Trial

Free
Priyanka Mehta, Roderick Murphy, Saemi Park, Nalina Dronamraju, Tony Wagner, Yana Lutska, Stefan Faderl, Ian Thomas, Joanna Canham, Alex Legg
Journal: Blood
Blood (2024) 144 (Supplement 1): 55.
https://doi.org/10.1182/blood-2024-207094
Published: 2024
Journal Articles

A Randomised Comparison of CPX-351 Versus Standard Daunorubicin and Cytarabine Plus Fractionated Gemtuzumab Ozogamicin in Older Adults with AML without Adverse Risk Cytogenetics: Results of the NCRI AML18 Trial

Free
Steven Knapper, Laura W Dillon, Malavika Babu, Abin Thomas, Ian Thomas, Christopher S. Hourigan, Georgia Andrew, Richard Dillon, Amanda Gilkes, Nuria M Almuina, Sophie King, Thomas Coats, Nicholas McCarthy, Jennifer Byrne, Simone Green, Ulrik Malthe Overgaard, Leanne Berkahn, Louisa Stone, Rasha W Al-Ali, Reem Bahr, Rob Sellar, Mike Dennis, Priyanka Mehta, Robert K Hills, Sylvie D Freeman, Nigel H. Russell
Journal: Blood
Blood (2024) 144 (Supplement 1): 59.
https://doi.org/10.1182/blood-2024-200027
Published: 2024
Journal Articles

Molecular MRD is strongly prognostic in patients with NPM1 -mutated AML receiving venetoclax-based nonintensive therapy

Free
Clinical Trials & Observations Brief Report
Jad Othman, Ing S. Tiong, Jenny O'Nions, Mike Dennis, Katya Mokretar, Adam Ivey, Michael Austin, Anne-Louise Latif, Mariam Amer, Wei Yee Chan, Charles Crawley, Francesca Crolla, Joe Cross, Ray Dang, Johnathon Elliot, Chun Y. Fong, Sofia Galli, Paolo Gallipoli, Francesca Hogan, Pallavi Kalkur, Anjum Khan, Pramila Krishnamurthy, John Laurie, Sun Loo, Scott Marshall, Priyanka Mehta, Vidhya Murthy, Sateesh Nagumantry, Srinivas Pillai, Nicola Potter, Rob Sellar, Tom Taylor, Rui Zhao, Nigel H. Russell, Andrew H. Wei, Richard Dillon
Journal: Blood
Blood (2024) 143 (4): 336–341.
https://doi.org/10.1182/blood.2023021579
Published: 2024
Includes: Supplemental data
Journal Articles

Fractionated vs single-dose gemtuzumab ozogamicin with determinants of benefit in older patients with AML: the UK NCRI AML18 trial

Free
CME Clinical Trials & Observations
Sylvie D. Freeman, Abin Thomas, Ian Thomas, Robert K. Hills, Paresh Vyas, Amanda Gilkes, Marlen Metzner, Niels Asger Jakobsen, Alison Kennedy, Rachel Moore, Nuria Marquez Almuina, Sarah Burns, Sophie King, Georgia Andrew, Kathleen M. E. Gallagher, Rob S. Sellar, Paul Cahalin, Duruta Weber, Mike Dennis, Priyanka Mehta, Steven Knapper, Nigel H. Russell
Journal: Blood
Blood (2023) 142 (20): 1697–1707.
https://doi.org/10.1182/blood.2023020630
Published: 2023
Includes: Supplemental data
Journal Articles

MRD Directed Treatment Intensification with Either FLAG-Ida or DA-Cladribine Improves Survival in Older AML Patients: Results from the NCRI AML18 Randomised Trial

Free
Nigel H. Russell, Abin Thomas, Robert Hills, Ian Thomas, Amanda Gilkes, Nuria Almuina, Sarah Burns, Lucy Marsh, Georgia Andrew, Nicholas McCarthy, Jennifer Byrne, Rob Sellar, Richard J. Kelly, Paul Cahalin, Ulrik Malthe Overgaard, Priyanka Mehta, Mike Dennis, Steve Knapper, Sylvie D Freeman
Journal: Blood
Blood (2023) 142 (Supplement 1): 830.
https://doi.org/10.1182/blood-2023-185956
Published: 2023
Journal Articles

Real-World Treatment Patterns and Clinical Outcomes in Newly Diagnosed Acute Myeloid Leukemia with and without mIDH1 Treated with Intensive Chemotherapy from an International Real-World Database (REAL-IDH)

Free
Joshua F. Zeidner, Priyanka Mehta, Benyam Muluneh, Sarah Bertoli, Pierre-Yves Dumas, Arnaud Pigneux, Cédric Fernandez, Hélène Derrien, Christian Recher
Journal: Blood
Blood (2023) 142 (Supplement 1): 3816.
https://doi.org/10.1182/blood-2023-188548
Published: 2023
Journal Articles

CREST-UK: CPX-351 Real-World Effectiveness and Safety Study for the Treatment of Newly Diagnosed Therapy-Related AML and AML with Myelodysplasia-Related Changes in the UK

Free
Priyanka Mehta, Anjum Khan, Jamie Maddox, Yngvar Floisand, Richard Whitmill, Daniel Cuadras, Montse Pedros, Saemi Park, Greg Medalla, Alex Legg, Victoria Louise Campbell
Journal: Blood
Blood (2022) 140 (Supplement 1): 6152–6154.
https://doi.org/10.1182/blood-2022-159496
Published: 2022
Journal Articles

A Randomized Comparison of the Fractionated Versus Single Dose Schedule of Gemtuzumab Ozogamicin at Induction with Determinants of Benefit for Older AML Patients: UK NCRI AML18 Trial Results

Free
Sylvie D Freeman, Abin Thomas, Ian Thomas, Paresh Vyas, Amanda Gilkes, Marlen Metzner, Niels Asger Jakobsen, Alison Kennedy, Amy Moore, Nuria Marquez Almuina, Sarah Burns, Sophie King, Georgia M. Andrew, Kathleen M.E. Gallagher, Rob Sellar, Paul Cahalin, Duruta Weber, Mike Dennis, Priyanka Mehta, Steve Knapper, Nigel H. Russell
Journal: Blood
Blood (2022) 140 (Supplement 1): 532–533.
https://doi.org/10.1182/blood-2022-162245
Published: 2022
Journal Articles

Genomic Correlates of Outcome in a Randomised Comparison of CPX-351 and FLAG-Ida in High-Risk Acute Myeloid Leukaemia and Myelodysplastic Syndrome: Results from the UK NCRI AML19 Trial

Free
Jad Othman, Richard Dillon, Charlotte Wilhelm-Benartzi, Steve Knapper, Leona M Batten, Joanna Canham, Emily L Hinson, William Villiers, Michelle Kleeman, Amanda Gilkes, Nicola Potter, Ulrik Malthe Overgaard, Priyanka Mehta, Panos Kottaridis, Jamie Cavenagh, Claire Hemmaway, Claire Arnold, Mike Dennis, Nigel H. Russell
Journal: Blood
Blood (2022) 140 (Supplement 1): 1036–1038.
https://doi.org/10.1182/blood-2022-159433
Published: 2022
Journal Articles

Venetoclax-Based Non-Intensive Combinations Successfully Salvage Molecular Relapse of Acute Myeloid Leukemia and Are an Important Bridge to Cellular Therapy in Relapsed/Refractory Disease - Real-World Data from a UK-Wide Programme

Free
Henry Wood, Christianne Bourlon, Austin Kulasekararaj, Albert Borg, Jiri Pavlu, Patrick Elder, David C Taussig, Scott Veitch, Steven Knapper, Jad Othman, Richard Dillon, James Aries, Emily Mitchell, Faisal Basheer, Steven Leak, Vidhya Murthy, Joe W Cross, Priyanka Mehta, Manish Jain, Anjum Khan, Ho Lam, Sarah Leong, Jenny O'Nions, Charles Craddock, Victoria Potter, Mhairi Copland, Pramila Krishnamurthy
Journal: Blood
Blood (2022) 140 (Supplement 1): 9016–9018.
https://doi.org/10.1182/blood-2022-167097
Published: 2022
Journal Articles

FLAG-Ida Combined with Gemtuzumab Ozogamicin (GO) Improves Event Free Survival in Younger Patients with Newly Diagnosed Acute Myeloid Leukaemia (AML) and Shows an Overall Survival Benefit in NPM1 and FLT3 mutated Subgroups. Results from the UK NCRI AML19 Trial

Free
Nigel H. Russell, Charlotte Wilhelm-Benartzi, Steve Knapper, Leona M Batten, Joanna Canham, Emily L Hinson, Ulrik Malthe Overgaard, Amanda Gilkes, Jad Othman, Nicola Potter, Richard Dillon, Priyanka Mehta, Panagiotis Kottaridis, Jamie Cavenagh, Claire Hemmaway, Claire Arnold, Sylvie D Freeman, Mike Dennis
Journal: Blood
Blood (2022) 140 (Supplement 1): 526–528.
https://doi.org/10.1182/blood-2022-162377
Published: 2022
Journal Articles

A Randomised Evaluation of Low-Dose Ara-C Plus BCT-100 Versus Low Dose Ara-C in Older Patients with Acute Myeloid Leukaemia: Results from the LI-1 Trial

Free
Francis J. Mussai, Ian Thomas, Cono Ariti, Laura Upton, Mia Sydenham, Alan K. Burnett, Steve Knapper, Priyanka Mehta, Mary Frances McMullin, Mhairi Copland, Nigel H. Russell, Robert Hills
Journal: Blood
Blood (2021) 138 (Supplement 1): 2355.
https://doi.org/10.1182/blood-2021-148323
Published: 2021
Journal Articles

Prediction of Early Mortality with Non-Intensive Acute Myeloid Leukemia (AML) Therapies: Analysis of 1336 Patients from MRC/NCRI and SWOG

Free
Xu Wang, Ian Thomas, Cono Ariti, Mike Dennis, Priyanka Mehta, Nigel H Russel, Mia Sydenham, Robert Hills, Alan K. Burnett, Sucha Nand, Sarit Assouline, Laura C. Michaelis, Harry P. Erba, Kathleen Kerr, Roland B. Walter, Megan Othus
Journal: Blood
Blood (2021) 138 (Supplement 1): 220.
https://doi.org/10.1182/blood-2021-151597
Published: 2021
Journal Articles

A Randomised Evaluation of Low-Dose Cytarabine Arabinoside Plus Lenalidomide Versus Single-Agent Low-Dose Cytarabine Arabinoside in Older Patients with Acute Myeloid Leukaemia: Results from the LI-1 Trial

Free
Mhairi Copland, Cono Ariti, Ian Thomas, Laura Upton, Mia Sydenham, Priyanka Mehta, Shahidul Islam, Lars Kjeldsen, Alan K. Burnett, Robert Hills, Nigel H. Russell, Mike Dennis
Journal: Blood
Blood (2021) 138 (Supplement 1): 1266.
https://doi.org/10.1182/blood-2021-147802
Published: 2021
Journal Articles

Low Incidence of COVID-19 Infection in Patients with Acute Myeloid Leukemia Undergoing Reduced Intensity/Venetoclax Based Treatment: Initial Results of the PACE Prospective Clinical Study from the UK Trials Acceleration Program

Free
(Justin) Ching Ting Loke, Charlotte Gaskell, Sonia Fox, Rachel Fletcher, Catherine Thomas, Louise Hopkins, Anita Kumari, Rebecca H. Boucher, Jane Nunnick, Steve Knapper, Arpad Toth, Jennifer Byrne, Jenny O'Nions, Anjum Khan, Rui Zhao, Arvind Pillai, Eleni Tholouli, Moez Dungarwalla, Katie Randall, Richard Dillon, Duncan Murray, Dominic Culligan, Mary Frances McMullin, Yuen Ling Tracey Chan, Victoria Drew, Vidhya Murthy, Pramila Krishnamurthy, Pratap Neelakantan, Tom Rider, Farooq A Wandroo, Mark Rafferty, Ya-Wen Huang, Sally Moore, Priyanka Mehta, David G Partridge, Charles Craddock, David Lowe, Simon J. Stanworth
Journal: Blood
Blood (2021) 138 (Supplement 1): 1942.
https://doi.org/10.1182/blood-2021-146061
Published: 2021