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Journal Articles

Therapy-Related Myeloid Neoplasms with Balanced Chromosome Rearrangements Frequently Arise from Pre-Existing Clonal Haematopoiesis

Richard Dillon, MA, PhD MRCP, FRCPath, Jelena Jovanovic, PhD, Nicola Potter, PhD, Nicola Foot, MSc, Matthew J Ahearne, MD MBBS, Sandrine Jayne, PhD, Michael Dennis, MD MRCP, FRCPath, Ann E. Hunter, MBBS, FRCP, FRCPath, Martin J.S. Dyer, Paresh Vyas, Lynn Quek, FRCPath, DPhil, MBBS, Nigel H. Russell, Robert K. Hills, MA, DPhil, MSc, Ellen Solomon, PhD, David Grimwade, PhD MRCP, MRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 2570.
https://doi.org/10.1182/blood-2018-99-114233
Published: 2018
Journal Articles

Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice

Edwige Voisset, Eva Moravcsik, Eva W. Stratford, Amie Jaye, Christopher J. Palgrave, Robert K. Hills, Paolo Salomoni, Scott C. Kogan, Ellen Solomon, David Grimwade
Journal: Blood
Blood (2018) 131 (6): 636–648.
https://doi.org/10.1182/blood-2017-07-794784
Published: 2018
Includes: Supplemental data
Journal Articles

Pml Nuclear Body Disruption Cooperates in APL Pathogenesis, Impacting DNA Damage Repair Pathways

Edwige Voisset, PhD, Eva Moravcsik, Eva W Stratford, Amie Jaye, Christopher J Palgrave, Robert K Hills, DPhil, Paolo Salomoni, Scott C. Kogan, MD, Ellen Solomon, David Grimwade, PhD FRCPath
Journal: Blood
Blood (2016) 128 (22): 742.
https://doi.org/10.1182/blood.V128.22.742.742
Published: 2016
Journal Articles

Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia

Clinical Trials & Observations
Andrea Kühnl, Peter J. M. Valk, Mathijs A. Sanders, Adam Ivey, Robert K. Hills, Ken I. Mills, Rosemary E. Gale, Martin F. Kaiser, Richard Dillon, Melanie Joannides, Amanda Gilkes, Torsten Haferlach, Susanne Schnittger, Estelle Duprez, David C. Linch, Ruud Delwel, Bob Löwenberg, Claudia D. Baldus, Ellen Solomon, Alan K. Burnett, David Grimwade
Journal: Blood
Blood (2015) 125 (19): 2985–2994.
https://doi.org/10.1182/blood-2014-12-613703
Published: 2015
Includes: Supplemental data
Journal Articles

Molecular Detection of Minimal Residual Disease Provides the Most Powerful Independent Prognostic Factor Irrespective of Clonal Architecture in Nucleophosmin (NPM1) Mutant Acute Myeloid Leukemia

Adam Ivey, Robert K Hills, Michael A Simpson, Jelena V Jovanovic, Amanda F Gilkes, MSc, Yashma Patel, Neesa Bhudia, Hassan Farah, Joanne Mason, Kerry Wall, Susanna Akiki, Ellen Solomon, Frank McCaughan, David C Linch, FMedSci, Rosemary E Gale, PhD, Paresh Vyas, Sylvie D Freeman, Nigel Russell, Alan K. Burnett, MDFRCP, David Grimwade
Journal: Blood
Blood (2014) 124 (21): 70.
https://doi.org/10.1182/blood.V124.21.70.70
Published: 2014
Journal Articles

The IRF2BP2-RARα Fusion Generated By a Cryptic Rearrangement Transforms Hematopoietic Stem/Progenitor Cells and Induces Retinoid Sensitive Acute Promyelocytic Leukemia (APL)

Jelena V Jovanovic, M Carmen Chillón, Christelle Vincent-Fabert, Richard Dillon, Edwige Voisset, Norma C Gutiérrez, Ellen Solomon, Ramón Garcí­a Sanz, Ana A. Martin Lopez, Yvonne G Morgan, Jennie Lok, Estelle Duprez, PhD, Marcos González Díaz, David Grimwade
Journal: Blood
Blood (2014) 124 (21): 2325.
https://doi.org/10.1182/blood.V124.21.2325.2325
Published: 2014
Journal Articles

Identification of PLZF-Dmrs in Hematopoiesis Highlight a Novel Role of PLZF As a Guardian of Hematopoietic Genome Integrity

Fabien Guidez, PhD, Laetitia Durand, Technician, Valerie Vidal, William Puszyk, PhD, David Grimwade, Ellen Solomon, Christine Chomienne, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2904.
https://doi.org/10.1182/blood.V124.21.2904.2904
Published: 2014
Journal Articles

Disruption Of PML Nuclear Bodies Cooperates In The Pathogenesis Of Acute Promyelocytic Leukemia

Eva Moravcsik, Melanie Joannides, Edwige Voisset, Eva Wessel Stratford, Bernd B. Zeisig, Jo Morris, Ruth Densham, Chris Palgrave, Gordon Stamp, Emma Nye, Robert K. Hills, Paolo Salomoni, Chi Wai Eric So, PHD, Scott C. Kogan, Ellen Solomon, David Grimwade, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3721.
https://doi.org/10.1182/blood.V122.21.3721.3721
Published: 2013
Journal Articles

Downregulation Of The Wnt Inhibitor CXXC5 Predicts a Better Prognosis In Acute Myeloid Leukemia

Andrea Kühnl, Peter J. M. Valk, Mathijs A. Sanders, Robert K. Hills, MA, MSc, DPhil, Ken I. Mills, PhD, Rosemary E Gale, PhD, Martin Kaiser, MD, Richard Dillon, Melanie Joannides, Adam Ivey, Amanda F Gilkes, MSc, Torsten Haferlach, MD, Susanne Schnittger, PhD, Estelle Duprez, David Linch, FMedSci, Ruud Delwel, Bob Löwenberg, MD, PhD, Claudia D. Baldus, MD, PhD, Ellen Solomon, Alan K Burnett, MD, David Grimwade, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 52.
https://doi.org/10.1182/blood.V122.21.52.52
Published: 2013
Journal Articles

Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

Brief Report
Ashley N. Mays, Neil Osheroff, Yuanyuan Xiao, Joseph L. Wiemels, Carolyn A. Felix, Jo Ann W. Byl, Kandeepan Saravanamuttu, Andrew Peniket, Robert Corser, Cherry Chang, Christine Hoyle, Anne N. Parker, Syed K. Hasan, Francesco Lo-Coco, Ellen Solomon, David Grimwade
Journal: Blood
Blood (2010) 115 (2): 326–330.
https://doi.org/10.1182/blood-2009-07-235051
Published: 2010
Includes: Supplemental data
Journal Articles

Defining the Landscape of Resistance Mutations in the Context of Modern Treatment Protocols for Acute Promyelocytic Leukemia (APL).

Jelena V Jovanovic, Fabien Guidez, Farhad Ravandi, Estelle Duprez, Mukunder Patel, Ken Mills, Steven Kornblau, Maadh Aldouri, Martin Auger, Alan K Burnett, Ellen Solomon, David Grimwade
Journal: Blood
Blood (2008) 112 (11): 1492.
https://doi.org/10.1182/blood.V112.11.1492.1492
Published: 2008
Journal Articles

Molecular Characterization of the t(15;17)(q22;21) in Epirubicin-Related Acute Promyelocytic Leukaemia

Ashley Nicole Mays, Neil Osheroff, Carolyn Felix, Jo Ann Byl, Kandeepan Saravanamuttu, Andrew Peniket, Robert Corser, Cherry Chang, Christine Hoyle, Anne N Parker, Syed K Hasan, Francesco Lo-Coco, Ellen Solomon, David Grimwade
Journal: Blood
Blood (2008) 112 (11): 791.
https://doi.org/10.1182/blood.V112.11.791.791
Published: 2008
Journal Articles

Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFRA –positive chronic eosinophilic leukemia

Clinical Trials & Observations
Jelena V. Jovanovic, Joannah Score, Katherine Waghorn, Daniela Cilloni, Enrico Gottardi, Georgia Metzgeroth, Philipp Erben, Helena Popp, Christoph Walz, Andreas Hochhaus, Catherine Roche-Lestienne, Claude Preudhomme, Ellen Solomon, Jane Apperley, Michela Rondoni, Emanuela Ottaviani, Giovanni Martinelli, Finella Brito-Babapulle, Giuseppe Saglio, Rüdiger Hehlmann, Nicholas C. P. Cross, Andreas Reiter, David Grimwade
Journal: Blood
Blood (2007) 109 (11): 4635–4640.
https://doi.org/10.1182/blood-2006-10-050054
Published: 2007
Includes: Supplemental data
Journal Articles

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

Clinical Trials & Observations
Rosemary E. Gale, Robert Hills, Arnold R. Pizzey, Panagiotis D. Kottaridis, David Swirsky, Amanda F. Gilkes, Elizabeth Nugent, Kenneth I. Mills, Keith Wheatley, Ellen Solomon, Alan K. Burnett, David C. Linch, David Grimwade, for the NCRI Adult Leukaemia Working Party
Journal: Blood
Blood (2005) 106 (12): 3768–3776.
https://doi.org/10.1182/blood-2005-04-1746
Published: 2005
Includes: Supplemental data
Journal Articles

Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party

Clinical Trials & Observations
David Grimwade, Andrea Biondi, Marie-Joëlle Mozziconacci, Anne Hagemeijer, Roland Berger, Michael Neat, Kathy Howe, Nicole Dastugue, Joop Jansen, Isabelle Radford-Weiss, Francesco Lo Coco, Michel Lessard, Jesus-Maria Hernandez, Eric Delabesse, David Head, Vincenzo Liso, Danielle Sainty, Georges Flandrin, Ellen Solomon, Françoise Birg, Marina Lafage-Pochitaloff
Journal: Blood
Blood (2000) 96 (4): 1297–1308.
https://doi.org/10.1182/blood.V96.4.1297
Published: 2000
Journal Articles

Presenting White Blood Cell Count and Kinetics of Molecular Remission Predict Prognosis in Acute Promyelocytic Leukemia Treated With All- Trans Retinoic Acid: Result of the Randomized MRC Trial

Alan K. Burnett, David Grimwade, Ellen Solomon, Keith Wheatley, Anthony H. Goldstone
Journal: Blood
Blood (1999) 93 (12): 4131–4143.
https://doi.org/10.1182/blood.V93.12.4131
Published: 1999
Journal Articles

Characterization of Cryptic Rearrangements and Variant Translocations in Acute Promyelocytic Leukemia

David Grimwade, Patricia Gorman, Estelle Duprez, Kathy Howe, Stephen Langabeer, Fiona Oliver, Helen Walker, Dominic Culligan, Jonathan Waters, Mark Pomfret, Anthony Goldstone, Alan Burnett, Paul Freemont, Denise Sheer, Ellen Solomon
Journal: Blood
Blood (1997) 90 (12): 4876–4885.
https://doi.org/10.1182/blood.V90.12.4876
Published: 1997