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Richard J. Kelly
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Journal Articles

Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria

CME Clinical Trials & Observations
Richard J. Kelly, Matthew Holt, Jennifer Vidler, Louise M. Arnold, Joanna Large, Briony Forrest, Catherine Barnfield, Alexandra Pike, Morag Griffin, Talha Munir, Petra Muus, Sateesh K. Nagumantry, Abraham Varghese, John R. Davies, Roochi Trikha, Austin G. Kulasekararaj, Lindsay Mitchell, Shreyans Gandhi
Journal: Blood
Blood (2024) 143 (12): 1157–1166.
https://doi.org/10.1182/blood.2023021762
Published: 2024
Journal Articles

MRD Directed Treatment Intensification with Either FLAG-Ida or DA-Cladribine Improves Survival in Older AML Patients: Results from the NCRI AML18 Randomised Trial

Nigel H. Russell, Abin Thomas, Robert Hills, Ian Thomas, Amanda Gilkes, Nuria Almuina, Sarah Burns, Lucy Marsh, Georgia Andrew, Nicholas McCarthy, Jennifer Byrne, Rob Sellar, Richard J. Kelly, Paul Cahalin, Ulrik Malthe Overgaard, Priyanka Mehta, Mike Dennis, Steve Knapper, Sylvie D Freeman
Journal: Blood
Blood (2023) 142 (Supplement 1): 830.
https://doi.org/10.1182/blood-2023-185956
Published: 2023
Journal Articles

Paroxysmal Nocturnal Haemoglobinuria (PNH) Arising from Non-Canonical Mutations

Alexandra Pike, Stephen John Richards, Claire E McKinley, Louise M Arnold, Abraham Mullasseril Varghese, Talha Munir, Petra Muus, Peter Hillmen, Morag Griffin, Richard J Kelly, Darren Newton
Journal: Blood
Blood (2023) 142 (Supplement 1): 4097.
https://doi.org/10.1182/blood-2023-188755
Published: 2023
Journal Articles

Biomarker Analyses in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Crovalimab and Eculizumab: Results from the Phase III Randomized COMMODORE 2 Trial

Pontus Lundberg, Silvia de la Iglesia, Richard J Kelly, Austin Kulasekararaj, Jun-Ichi Nishimura, Antonio M Risitano, Alexander Roeth, Simon Buatois, Sammy Chebon, Himika Patel, Anna Kiialainen
Journal: Blood
Blood (2023) 142 (Supplement 1): 4088.
https://doi.org/10.1182/blood-2023-178694
Published: 2023
Journal Articles

Efficacy and Safety Is Maintained in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Receiving Pegcetacoplan for up to 3 Years

Carlos M de Castro, Brian Mulherin, Christopher J. Patriquin, Veena Selvaratnam, Raymond SM Wong, Richard J. Kelly, Lisa Tan, Peter Hillmen, Dale Zhang, Jessica Savage, Regis Peffault De Latour
Journal: Blood
Blood (2023) 142 (Supplement 1): 574.
https://doi.org/10.1182/blood-2023-181054
Published: 2023
Journal Articles

Psychometric Evaluation of the PNH Symptom Questionnaire (PNH-SQ) Among Patients with Paroxysmal Nocturnal Hemoglobinuria from Three Phase 2 Clinical Trials with Pozelimab Monotherapy or in Combination with Cemdisiran

Chris Hartford, Paolo Eusebi, Richard J. Kelly, Thibaud Alin, Xinyu Yang, Antoine Regnault, Dimittri Delevry, Ching Lum, Diana Rofail
Journal: Blood
Blood (2023) 142 (Supplement 1): 3752.
https://doi.org/10.1182/blood-2023-181667
Published: 2023
Journal Articles

52-Week Open-Label Extension Data from a Phase 2 Study Evaluating the Safety and Efficacy of Pozelimab and Cemdisiran Combination Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Switched from Eculizumab

Richard J. Kelly, Nicola Houghton, Talha Munir, Petra Muus, Nora Youngs, Lisa Aurand, Kosalai Mohan, Brian Senk, Rodrigo Pavani, Lorah Perlee, Amal Souttou, Morag Griffin
Journal: Blood
Blood (2023) 142 (Supplement 1): 2716.
https://doi.org/10.1182/blood-2023-188671
Published: 2023
Journal Articles

Sars-Cov-2 Antibody and T-Cell Responses in Patients with Paroxysmal Nocturnal Hemoglobinuria and Aplastic Anemia after Four COVID-19 Vaccinations

Alexandra Pike, Natalie Fox, Claire E McKinley, Louise M Arnold, Mark Harland, Deborah Clarke, Briony Forrest, Nicola Houghton, Nora Youngs, Emily Charlton, Tapiwa Zhakata, Catherine Barnfield, Ruth Harvey, Mary Wu, Caitlin Kavanagh, Stephen John Richards, Daniel Payne, Abraham Mullasseril Varghese, Sateesh Nagumantry, Talha Munir, Petra Muus, Morag Griffin, Darren Newton, Peter Hillmen, Richard J Kelly
Journal: Blood
Blood (2023) 142 (Supplement 1): 2712.
https://doi.org/10.1182/blood-2023-190393
Published: 2023
Journal Articles

Monitoring Patient Reported Outcomes in PNH: Interim Results of a Market Research with florio ® PNH

Louise M Arnold, Holger Brondke, Katharina Steinitz, Richard J. Kelly
Journal: Blood
Blood (2023) 142 (Supplement 1): 7211.
https://doi.org/10.1182/blood-2023-185560
Published: 2023
Journal Articles

Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: a deficiency of NK cells, but not an NK cell deficiency

Yasser M. El-Sherbiny, Gina M. Doody, Richard J. Kelly, Anita Hill, Peter Hillmen, Graham P. Cook
Journal: Blood
Blood (2015) 125 (8): 1351–1352.
https://doi.org/10.1182/blood-2014-07-591255
Published: 2015
Includes: Supplemental data
Journal Articles

Eculizumab Treatment Improves Outcomes of Pregnancy in Patients with Paroxysmal Nocturnal Hemoglobinuria

Richard J Kelly, MBChB, PhD, Britta Höchsmann, MD, Austin Kulasekararaj, Sophie de Guibert, MD, Alexander Röth, MD, Ilene C Weitz, MD, Elina Armstrong, MD PhD, Anita Hill, MBChB, PhD, Antonio M. Risitano, MD PhD, Christopher J Patriquin, MDFRCPC, Louis Terriou, MD, Petra Muus, MD PhD, Michelle P Turner, MS in Biostatistics, Hubert Schrezenmeier, MD PhD, Jeffrey Szer, MB BS FRACP, Regis Peffault de Latour, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4393.
https://doi.org/10.1182/blood.V124.21.4393.4393
Published: 2014
Journal Articles

“Red Cell Complement Loading In PNH Patients On Eculizumab Is Associated With a C3 Polymorphism Which Influences C3 Function, Predicts For Increased Extravascular Hemolysis and Provides a Rationale For C3 Inhibition.”

Praveen Kaudlay, MBBS, MRCP, Haiying Hua, MD, Guansheng He, MD, Darren J Newton, PhD, Abraham M Varghese, MB ChB, Talha Munir, MBBS, MRCP, FRCPath, Anita Hill, MBChB, PhD, Richard J Kelly, MBChB, Stephen John Richards, PhD, Peter Hillmen, MB ChB, PhD
Journal: Blood
Blood (2013) 122 (21): 2466.
https://doi.org/10.1182/blood.V122.21.2466.2466
Published: 2013
Journal Articles

Altered natural killer cell subset homeostasis and defective chemotactic responses in paroxysmal nocturnal hemoglobinuria

Brief Report
Yasser M. El-Sherbiny, Richard J. Kelly, Anita Hill, Gina M. Doody, Peter Hillmen, Graham P. Cook
Journal: Blood
Blood (2013) 122 (11): 1887–1890.
https://doi.org/10.1182/blood-2013-06-507574
Published: 2013
Includes: Supplemental data
Journal Articles

Thrombosis in paroxysmal nocturnal hemoglobinuria

CME
Anita Hill, Richard J. Kelly, Peter Hillmen
Journal: Blood
Blood (2013) 121 (25): 4985–4996.
https://doi.org/10.1182/blood-2012-09-311381
Published: 2013
Journal Articles

Eculizumab in Paroxysmal Nocturnal Hemoglobinuria (PNH): A Report of All 153 Patients Treated in the UK

Anita Hill, MBChB, PhD, Richard J Kelly, MBChB, Austin G Kulasekararaj, MBBS, MD, Shreyans A Gandhi, MBBS, MD, Lindsay D Mitchell, MBChB, Modupe Elebute, MBChB, MD, Stephen John Richards, PhD, Matthew Cullen, MSc, Louise M Arnold, RN, BSc, Joanna Large, RN, BSc, Alexandra Wood, RN, BSc, Gemma L Brooksbank, RN, BSc, Tracy Downing, Claire McKinley, BSc, Dena Cohen, BSc, MSc, Walter M Gregory, PhD, Judith C. W. Marsh, MD, PhD, Ghulam J. Mufti, MD, Peter Hillmen, MBChB, PhD
Journal: Blood
Blood (2012) 120 (21): 3472.
https://doi.org/10.1182/blood.V120.21.3472.3472
Published: 2012
Journal Articles

Improved Outcomes of Budd-Chiari Syndrome in Paroxysmal Nocturnal Hemoglobinuria with Eculizumab Therapy

Joanna Haughton, MBChB, Richard J Kelly, MBChB, Stephen J Richards, PhD, Louise M Arnold, RN, BSc, Alexandra Wood, RN, BSc, Tracy Downing, Claire McKinley, BSc, Mervyn Davies, MBChB, Peter Hillmen, MBChB, PhD, Anita Hill, MBChB, PhD
Journal: Blood
Blood (2012) 120 (21): 3478.
https://doi.org/10.1182/blood.V120.21.3478.3478
Published: 2012
Journal Articles

An In Vitro model of the Bone Marrow in Paroxysmal Nocturnal Hemoglobinuria Showing a Direct Effect of T-Cells within the Bone Marrow Allowing Clonal Expansion

Richard J Kelly, MBChB, FRCPath, Stephen John Richards, PhD, FRCPath, Matthew Cullen, MSc, Louise M Arnold, RN, BSc, hons, Gemma L Brooksbank, RN, BSc, hons, Anita Hill, MBChB, PhD, Reuben Tooze, PhD, Gina M Doody, PhD, Peter Hillmen, MBChB, PhD
Journal: Blood
Blood (2011) 118 (21): 731.
https://doi.org/10.1182/blood.V118.21.731.731
Published: 2011
Journal Articles

Continued Benefit From Prolonged Treatment with Eculizumab in 130 Patients with PNH in the UK: Home Delivery of Eculizumab Is Safe, Convenient and Associated with Very High Levels of Patient Satisfaction

Louise M Arnold, RN, BSc, hons, Gemma L Brooksbank, RN, BSc, hons, Richard J Kelly, MBChB, FRCPath, Anita Hill, MBChB, PhD, Stephen John Richards, PhD, FRCPath, Rachel Senior, MPharm, Tracy Downing, Claire McKinley, BSc, James Brown, BMus, Ibrahim Momoh, RN, Modupe Elebute, MBBS, MD, Peter Hillmen, MBChB, PhD
Journal: Blood
Blood (2011) 118 (21): 4368.
https://doi.org/10.1182/blood.V118.21.4368.4368
Published: 2011
Journal Articles

Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival

CME
Richard J. Kelly, Anita Hill, Louise M. Arnold, Gemma L. Brooksbank, Stephen J. Richards, Matthew Cullen, Lindsay D. Mitchell, Dena R. Cohen, Walter M. Gregory, Peter Hillmen
Journal: Blood
Blood (2011) 117 (25): 6786–6792.
https://doi.org/10.1182/blood-2011-02-333997
Published: 2011
Journal Articles

Long Term Treatment with Eculizumab In Paroxysmal Nocturnal Hemoglobinuria (PNH): Sustained Efficacy and Improved Survival

Richard J Kelly, MBChB, MRCP(UK), FRCPath, Anita Hill, MBChB, MRCP(UK), FRCPath, PhD, Lindsay D Mitchell, MBChB, MRCP(UK), FRCPath, Stephen John Richards, PhD, FRCPath, Louise M Arnold, RN, BSc, hons, Gemma L Valters, RN, BSc, hons, Matthew Cullen, MSc, Dena R Cohen, MSc, Walter M Gregory, PhD, Peter Hillmen, MBChB, FRCP, FRCPath, PhD
Journal: Blood
Blood (2010) 116 (21): 639.
https://doi.org/10.1182/blood.V116.21.639.639
Published: 2010