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Journal Articles

Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria

Richard J. Kelly, Matthew Holt, Jennifer Vidler, Louise M. Arnold, Joanna Large, Briony Forrest, Catherine Barnfield, Alexandra Pike, Morag Griffin, Talha Munir, Petra Muus, Sateesh K. Nagumantry, Abraham Varghese, John R. Davies, Roochi Trikha, Austin G. Kulasekararaj, Lindsay Mitchell, Shreyans Gandhi

Blood (2024) 143 (12): 1157–1166.

https://doi.org/10.1182/blood.2023021762

Published: 2024

Journal Articles

Impact of Somatic Second Hit and Comutations in Myeloid Neoplasms with Germline DDX41 Mutations

Guilherme Mendes Sapinho, Pramila Krishnamurthy, Guy Hannah, Shreyans Gandhi, Victoria Potter, Mili Shah, Nicholas Lea, Clair Engelbrecht, Heidre Bezuidenhout, Katie Snape, Steve Best, Austin Kulasekararaj

Blood (2023) 142 (Supplement 1): 6446.

https://doi.org/10.1182/blood-2023-189451

Published: 2023

Journal Articles

Deciphering the Differential Diagnosis of Inherited Versus Acquired Bone Marrow Failure Syndromes: A Large Cohort Study

Marta Bortolotti, Roochi Trikha, Sarah Salter, Joanna Large, Shreyans Gandhi, Bruno Fattizzo, Wilma Barcellini, Austin Kulasekararaj

Blood (2023) 142 (Supplement 1): 1360.

https://doi.org/10.1182/blood-2023-186516

Published: 2023

Journal Articles

Factor B Inhibition with Oral Iptacopan Monotherapy Demonstrates Sustained Long-Term Efficacy and Safety in Anti-C5-Treated Patients (pts) with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Persistent Anemia: Final 48-Week Results from the Multicenter, Phase III APPLY-PNH Trial

Blood (2023) 142 (Supplement 1): 571.

https://doi.org/10.1182/blood-2023-180780

Published: 2023

Journal Articles

Terminal Complement Inhibition and Control of Hemolysis in Paroxysmal Nocturnal Hemoglobinuria Following Switching from High-Dose Eculizumab to Ravulizumab: An Interim Analysis

Morag Griffin, Shreyans Gandhi, Eden Hicks, Deepak Jain, Richard Kelly, Talha Munir, Petra Muus, Masayo Ogawa, Roochi Trikha, Ji Yu, Austin Kulasekararaj

Blood (2022) 140 (Supplement 1): 2928–2930.

https://doi.org/10.1182/blood-2022-159498

Published: 2022

Journal Articles

Deciphering Treatment Patterns in Non-Severe Aplastic Anemia: An International Observational Study

Bruno Fattizzo, Carmelo Gurnari, Giulio Cassanello, Marta Bortolotti, Hussein Awada, Sabrina Giammarco, Dario Consonni, Simona Sica, Shreyans Gandhi, Roochi Trikha, Jaroslaw P. Maciejewski, Austin Kulasekararaj, Wilma Barcellini

Blood (2022) 140 (Supplement 1): 8638–8640.

https://doi.org/10.1182/blood-2022-166347

Published: 2022

Journal Articles

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Shok Ping Lim, Benedetta Costantini, Syed A. Mian, Pilar Perez Abellan, Shreyans Gandhi, Marc Martinez Llordella, Juan Jose Lozano, Rita Antunes dos Reis, Giovanni A. M. Povoleri, Thanos P. Mourikis, Ander Abarrategi, Linda Ariza-McNaughton, Susanne Heck, Jonathan M. Irish, Giovanna Lombardi, Judith C. W. Marsh, Dominique Bonnet, Shahram Kordasti, Ghulam J. Mufti

Blood (2020) 136 (7): 885–897.

https://doi.org/10.1182/blood.2019001347

Published: 2020

Includes: Supplemental data

Journal Articles

Telomeric Length to Characterize and Prognosticate Bone Marrow Failure, Risk of Clonal Evolution and Multi-System Complications in Aplastic Anemia and Other Hypocellular Cytopenic Disorders, Independent of Telomere Gene Complex Mutations

Shreyans Gandhi, MBBS,MDDNB,MRCP,FRCPath,MPhil, Jie Jiang, PhD, Simon Slade, BSc, Austin Kulasekararaj, MD MRCP, FRCPath, Victoria Potter, BSc, MBBS, FRCPA, Varun Mehra, MBBS,MRCP,FRCPath, Petra Muus, MD PhD, Andrea Da Silva, MBBS, Sudarshan Gurung, MBBS, MRCP, Alice Mason, B.Pharm, Aytug Kizilors, PhD, Nicholas Lea, PhD, Sahar Mansour, MD, Robin M. Ireland, MBBS, FRCP, FRCPath, Ghulam J. Mufti, MBBS, FRCP, FRCPath, DM, Judith Marsh, MD FRCPath

Blood (2019) 134 (Supplement_1): 3749.

https://doi.org/10.1182/blood-2019-130754

Published: 2019

Journal Articles

Differential Alemtuzumab Dosage Effects in T-Cell Deplete Allogeneic Haematopoietic Stem Cell Transplants for Myeloid Malignancies- King's College Hospital London Experience

Varun Mehra, MBBS,MRCP,FRCPath, Daniele Avenoso, MD, Ximena Cabrera Castellano, Adrian Choy, Stefani Widya, Mili Shah, FRCPath, Shafqat Inam, MD, Shreyans Gandhi, MBBS,MDDNB,MRCP,FRCPath,MPhil, Austin Kulasekararaj, MD MRCP, FRCPath, Francesco Dazzi, PhD, Ghulam J. Mufti, MBBS, FRCP, FRCPath, DM, Antonio Pagliuca, MBBS, MA, FRCP, FRCPath, Hugues De Lavallade, Victoria Potter, MBBS, BSc, FRACP, FRCPA

Blood (2019) 134 (Supplement_1): 4622.

https://doi.org/10.1182/blood-2019-131239

Published: 2019

Journal Articles

Hypoplastic Myelodysplastic Syndrome: Clinical, Histopathological and Molecular Characterization

ELISA Bono, MD, Donal McLornan, Erica Travaglino, Shreyans Gandhi, MBBS,MDMNAMS, Anna Gallì, Alesia Abigael Khan, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Emanuela Boveri, Kavita Raj, Chiara Elena, Robin M. Ireland, FRCP, Antonio Bianchessi, Jie Jiang, Gabriele Todisco, Luca Malcovati, MD, Judith Marsh, MD, Mario Cazzola, MD, Ghulam Mufti, DM, FRCP, FRCPath

Blood (2017) 130 (Supplement 1): 588.

https://doi.org/10.1182/blood.V130.Suppl_1.588.588

Published: 2017

Journal Articles

Concurrent Treatment of Aplastic Anaemia (AA) with Immunosuppressive Therapy and Paroxysmal Nocturnal Hemoglobinuria (PNH) with Eculizumab: A UK Experience

Morag Griffin, Austin Kulasekararaj, MD, Shreyans Gandhi, MD DNB, MRCP, FRCPath, Peter Hillmen, Talha Munir, Stephen John Richards, PhD, Louise Arnold, BSc, MA, Kathryn Riley, Katherine Pelton, Nana Benson-Quarm, B.Sc, Dip (Nursing), Isabel Duggins, Judith C. W. Marsh, MD FRCP, FRCPath, Anita Hill

Blood (2016) 128 (22): 2683.

https://doi.org/10.1182/blood.V128.22.2683.2683

Published: 2016

Journal Articles

Heterozygous RTEL1 Variants Are Associated with Bone Marrow Failure and Abnormal Clinical Phenotype

Shreyans Gandhi, MD DNB, MRCP, FRCPath, Jie Jiang, Mariam Ibanez, Isabelle Callebaut, Judith CW Marsh, Ghulam J Mufti, MD

Blood (2016) 128 (22): 1043.

https://doi.org/10.1182/blood.V128.22.1043.1043

Published: 2016

Journal Articles

Targeted Sequencing of 647 Patients with Myeloid Malignancies, Marrow Failures and Cytopenia: A Prospective Analysis

Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Steven Best, PhD, Aytug Kizilors, PhD, Shreyans Gandhi, MD DNB, MRCP, FRCPath, Victoria T Potter, Judith C. W. Marsh, MD FRCP, FRCPath, Nicholas Lea, PhD, Robin M. Ireland, FRCP, FRCPath, Ghulam J Mufti, MD

Blood (2016) 128 (22): 1981.

https://doi.org/10.1182/blood.V128.22.1981.1981

Published: 2016

Journal Articles

Telomere Length and Telomerase Assay Assist in Identifying Novel Telomere Gene Complex Mutations in a Cohort of Patients with Aplastic Anemia

Shreyans Gandhi, MBBS,MDDNB,MRCP,FRCPath, Jie Jiang, PhD, Nana Benson-Quarm, B.Sc, Dip (Nursing), Hanna Renshaw, MBBS, MA, Syed A Mian, BSc, M.Phil, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath, Judith C. W. Marsh, MD FRCP, FRCPath

Blood (2015) 126 (23): 667.

https://doi.org/10.1182/blood.V126.23.667.667

Published: 2015

Journal Articles

Telomerase Gene Complex Mutations Are Common in Myelodysplastic Syndromes Patients

Mariam Ibañez, PhD, Jie Jiang, PhD, Shreyans Gandhi, MBBS,MDMNAMS, Mian Syed, Alexander E Smith, Steve Best, PhD, Nicholas Lea, Azim M Mohamedali, Momin Ahmed, Judith C. W. Marsh, Austin G Kulasekararaj, Ghulam J Mufti, FRCP, FRCPath, MD

Blood (2014) 124 (21): 1899.

https://doi.org/10.1182/blood.V124.21.1899.1899

Published: 2014

Journal Articles

Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome

Austin G. Kulasekararaj, Jie Jiang, Alexander E. Smith, Azim M. Mohamedali, Syed Mian, Shreyans Gandhi, Joop Gaken, Barbara Czepulkowski, Judith C. W. Marsh, Ghulam J. Mufti

Blood (2014) 124 (17): 2698–2704.

https://doi.org/10.1182/blood-2014-05-574889

Published: 2014

Includes: Supplemental data

Journal Articles

Telomere Length In MDS Patients Bone Marrow Is Highly Correlated with Complex Cytogenetics, IPSS Risk Groups and Transfusion Dependency,

Jie Jiang, PhD, Austin G Kulasekararaj, Pramila Krishnamurthy, Alexander E Smith, PhD, Syed A Mian, Shreyans Gandhi, Janet Hayden, Joop Gaken, Modupe Elebute, Robin M. Ireland, FRCP, FRCPath, ZiYi Lim, MD, Judith C. W. Marsh, Prof MD PhD, Ghulam J. Mufti, MD

Blood (2011) 118 (21): 3826.

https://doi.org/10.1182/blood.V118.21.3826.3826

Published: 2011

Journal Articles

HIV Status Does Not Impact on Outcome in Patients with Hodgkin Lymphoma Treated with ABVD Chemotherapy in the HAART Era,

Silvia Montoto, MD, Kate Shaw, Jessica Okosun, Shreyans Gandhi, Paul Fields, MD, PhD, Andrew Wilson, Milensu Shanyinde, Kate Cwynarski, Robert E. Marcus, MBBS, FRCP, FRCPath, Johannes de Vos, Anna Marie Young, Melinda Tenant-Flowers, FRCP MSc, Chloe Orkin, Margaret Johnson, Daniella Chilton, John G. Gribben, MD, DSc, Mark Bower, MD

Blood (2011) 118 (21): 3646.

https://doi.org/10.1182/blood.V118.21.3646.3646

Published: 2011

Journal Articles

Use of Intravenous Busulphan for Reduced Intensity Conditioning (RIC) Haematopoietic Stem Cell Transplantation (HSCT) Is Associated with Delayed T-Cell Full Donor Chimerism and Lower Incidence of Acute Graft Versus Host Disease.

ZiYi Lim, Murugaiyan Thanigaikumar, Shreyans Gandhi, Laurence Pearce, Michelle Kenyon, Aloysius Y.L. Ho, Stephen Devereux, Antonio Pagliuca, Ghulam J. Mufti

Blood (2007) 110 (11): 1994.

https://doi.org/10.1182/blood.V110.11.1994.1994

Published: 2007

NARROW

Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria

Impact of Somatic Second Hit and Comutations in Myeloid Neoplasms with Germline DDX41 Mutations

Deciphering the Differential Diagnosis of Inherited Versus Acquired Bone Marrow Failure Syndromes: A Large Cohort Study

Factor B Inhibition with Oral Iptacopan Monotherapy Demonstrates Sustained Long-Term Efficacy and Safety in Anti-C5-Treated Patients (pts) with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Persistent Anemia: Final 48-Week Results from the Multicenter, Phase III APPLY-PNH Trial

Terminal Complement Inhibition and Control of Hemolysis in Paroxysmal Nocturnal Hemoglobinuria Following Switching from High-Dose Eculizumab to Ravulizumab: An Interim Analysis

Deciphering Treatment Patterns in Non-Severe Aplastic Anemia: An International Observational Study

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Telomeric Length to Characterize and Prognosticate Bone Marrow Failure, Risk of Clonal Evolution and Multi-System Complications in Aplastic Anemia and Other Hypocellular Cytopenic Disorders, Independent of Telomere Gene Complex Mutations

Differential Alemtuzumab Dosage Effects in T-Cell Deplete Allogeneic Haematopoietic Stem Cell Transplants for Myeloid Malignancies- King's College Hospital London Experience

Hypoplastic Myelodysplastic Syndrome: Clinical, Histopathological and Molecular Characterization

Concurrent Treatment of Aplastic Anaemia (AA) with Immunosuppressive Therapy and Paroxysmal Nocturnal Hemoglobinuria (PNH) with Eculizumab: A UK Experience

Heterozygous RTEL1 Variants Are Associated with Bone Marrow Failure and Abnormal Clinical Phenotype

Targeted Sequencing of 647 Patients with Myeloid Malignancies, Marrow Failures and Cytopenia: A Prospective Analysis

Telomere Length and Telomerase Assay Assist in Identifying Novel Telomere Gene Complex Mutations in a Cohort of Patients with Aplastic Anemia

Telomerase Gene Complex Mutations Are Common in Myelodysplastic Syndromes Patients

Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome

Telomere Length In MDS Patients Bone Marrow Is Highly Correlated with Complex Cytogenetics, IPSS Risk Groups and Transfusion Dependency,

HIV Status Does Not Impact on Outcome in Patients with Hodgkin Lymphoma Treated with ABVD Chemotherapy in the HAART Era,

Use of Intravenous Busulphan for Reduced Intensity Conditioning (RIC) Haematopoietic Stem Cell Transplantation (HSCT) Is Associated with Delayed T-Cell Full Donor Chimerism and Lower Incidence of Acute Graft Versus Host Disease.

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American Society of Hematology

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American Society of Hematology

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