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Lorah Perlee
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Journal Articles

Single Ascending Doses of REGN7999, a Monoclonal Antibody Inhibitor of TMPRSS6, Increase Serum Hepcidin and Cause Deep, Sustained Reductions in Serum Iron in Healthy Human Volunteers

Sylvie Rottey, Nikhil Singh, Emily Labriola-Tompkins, Heinrich E Lob, Kusha Mohammadi, Hazem Hassan, Lorna Farrelly, Swati Duggal, Harvey Chin, Sarah Hatsell, Michael E. Burczynski, Olivier Harari, Lorah Perlee, Griet Van Lancker
Journal: Blood
Blood (2023) 142 (Supplement 1): 3841.
https://doi.org/10.1182/blood-2023-187643
Published: 2023
Journal Articles

52-Week Open-Label Extension Data from a Phase 2 Study Evaluating the Safety and Efficacy of Pozelimab and Cemdisiran Combination Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Switched from Eculizumab

Richard J. Kelly, Nicola Houghton, Talha Munir, Petra Muus, Nora Youngs, Lisa Aurand, Kosalai Mohan, Brian Senk, Rodrigo Pavani, Lorah Perlee, Amal Souttou, Morag Griffin
Journal: Blood
Blood (2023) 142 (Supplement 1): 2716.
https://doi.org/10.1182/blood-2023-188671
Published: 2023
Journal Articles

Blockade of Common Gamma Chain Cytokine Signaling with REGN7257, an Interleukin 2 Receptor Gamma (IL2RG) Monoclonal Antibody, Protected Mice from Inflammatory and Autoimmune Diseases

Audrey Le Floch-Ramondou, Kirsten Nagashima, Pamela Farrales, Amanda Tay, Olivier Herbin, Dharani Ajithdoss, Thomas Norton, Lorah Perlee, Andrew J. Murphy, Matthew Sleeman, Jamie Orengo
Journal: Blood
Blood (2022) 140 (Supplement 1): 473–474.
https://doi.org/10.1182/blood-2022-159209
Published: 2022
Journal Articles

A Phase 2, Open-Label Study Evaluating the Safety and Efficacy of Combination Pozelimab and Cemdisiran Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Switch from Eculizumab

Richard Kelly, Nicola Houghton, Talha Munir, Petra Muus, Nora Youngs, Lisa Aurand, Bradley Dain, Rodrigo Pavani, Lorah Perlee, Amal Souttou, Morag Griffin
Journal: Blood
Blood (2022) 140 (Supplement 1): 8174–8175.
https://doi.org/10.1182/blood-2022-166547
Published: 2022
Journal Articles

A Phase 2, Randomized Trial Evaluating the Safety and Efficacy of Pozelimab and Cemdisiran in Patients with Paroxysmal Nocturnal Hemoglobinuria

Jun Ho Jang, Raymond Wong, Rodrigo Pavani, Lisa Aurand, Bradley Dain, Lorah Perlee, Amal Souttou, Jonathan Weyne, Richard Kelly
Journal: Blood
Blood (2022) 140 (Supplement 1): 8172–8173.
https://doi.org/10.1182/blood-2022-163236
Published: 2022
Journal Articles

Evaluation of Common Gamma Chain Cytokine Signaling Blockade with REGN7257, an Interleukin 2 Receptor Gamma (IL2RG) Monoclonal Antibody, on Immune Cell Populations in Monkey and Human

Audrey Le Floch-Ramondou, Kirsten Nagashima, Kaitlyn Gayvert, Hao Pan, Chandrashekhar Korgaonkar, Hassan Shakil, Erica Ullman, Thomas Norton, Lorah Perlee, Andrew J. Murphy, Matthew Sleeman, Jamie Orengo
Journal: Blood
Blood (2022) 140 (Supplement 1): 2924–2925.
https://doi.org/10.1182/blood-2022-159629
Published: 2022
Journal Articles

Pozelimab, a Human Monoclonal Antibody Against Complement Factor C5, Provided Inhibition of Intravascular Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria

Jun-Ho Jang, Jonathan Weyne, Umesh Chaudhari, Olivier Harari, Jutta Miller, Bradley Dain, Karoline A Meagher, Merideth L Rodgers, Lorah Perlee, Lori Morton, David M Weinreich, George D. Yancopoulos, Morag Griffin
Journal: Blood
Blood (2021) 138 (Supplement 1): 1128.
https://doi.org/10.1182/blood-2021-146178
Published: 2021
Journal Articles

Interim Analysis of an Open-Label, Ascending-Dose, Phase 1 Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Doses of the Subcutaneously Administered Human Monoclonal Antibody Pozelimab in Combination with Single Doses of the Subcutaneously Administered siRNA Cemdisiran in Healthy Volunteers

Tavé van Zyl, Jonathan Weyne, Umesh Chaudhari, Olivier Harari, Oren Levy, Jutta Miller, Yiziying Chen, Karoline A Meagher, Merideth L Rodgers, Lorah Perlee, Lori Morton, David M Weinreich, George D. Yancopoulos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1998.
https://doi.org/10.1182/blood-2021-146205
Published: 2021