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Journal Articles

Pozelimab, a Human Monoclonal Antibody Against Complement Factor C5, Provided Inhibition of Intravascular Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria

Jun-Ho Jang, Jonathan Weyne, Umesh Chaudhari, Olivier Harari, Jutta Miller, Bradley Dain, Karoline A Meagher, Merideth L Rodgers, Lorah Perlee, Lori Morton, David M Weinreich, George D. Yancopoulos, Morag Griffin
Journal: Blood
Blood (2021) 138 (Supplement 1): 1128.
https://doi.org/10.1182/blood-2021-146178
Published: 2021
Journal Articles

Interim Analysis of an Open-Label, Ascending-Dose, Phase 1 Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Doses of the Subcutaneously Administered Human Monoclonal Antibody Pozelimab in Combination with Single Doses of the Subcutaneously Administered siRNA Cemdisiran in Healthy Volunteers

Tavé van Zyl, Jonathan Weyne, Umesh Chaudhari, Olivier Harari, Oren Levy, Jutta Miller, Yiziying Chen, Karoline A Meagher, Merideth L Rodgers, Lorah Perlee, Lori Morton, David M Weinreich, George D. Yancopoulos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1998.
https://doi.org/10.1182/blood-2021-146205
Published: 2021
Journal Articles

Pozelimab, a Human Antibody Against Complement Factor C5, Demonstrates Robust Inhibition of Alternative Complement Activity Both in Normal Human Serum and in Phase I Normal Healthy Volunteers

Kishor Devalaraja-Narashimha, PhD DVM, Yan G Ni, PhD, Cong Huang, Ming-Dauh Wang, PhD, Umesh Chaudhari, MD, Srinivasa Prasad, PhD, Olivier Harari, MD PhD, Andrew J Rankin, PhD, Lori Morton, PhD, Jonathan Weyne, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2278.
https://doi.org/10.1182/blood-2019-129865
Published: 2019
Journal Articles

A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study of the Pharmacokinetics and Pharmacodynamics of REGN3918, a Human Antibody Against Complement Factor C5, in Healthy Volunteers

Jonathan Weyne, MD, Yan Ni, PhD, Richard DelGizzi, PA, MS, Stephen Godin, PhD, Lori Morton, PhD, Srinivasa Prasad, PhD, Andrew J Rankin, PhD, Melissa Simek-Lemos, MPH, ming-Dauh Wang, PhD, Ronda Rippley, PhD, Olivier Harari, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1039.
https://doi.org/10.1182/blood-2018-99-112262
Published: 2018