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Niels Asger Jakobsen
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Journal Articles

Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy

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Sven Turkalj, Felix A. Radtke, Bilyana Stoilova, Rabea Mecklenbrauck, Angus J. Groom, Niels Asger Jakobsen, Curtis A. Lachowiez, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Zhihong Zeng, Sanam Loghavi, Jennifer Marvin-Peek, Verena Körber, Farhad Ravandi, Ghayas C. Issa, Tapan M. Kadia, Vasiliki Symeonidou, Anne P. de Groot, Hagop M Kantarjian, Koichi Takahashi, Marina Konopleva, Courtney D. DiNardo, Paresh Vyas
Journal: Blood
Blood blood.2024027948.
https://doi.org/10.1182/blood.2024027948
Published: 2025
Includes: Supplemental data
Journal Articles

Clonal Basis of Resistance and Response to Ivosidenib Combination Therapies Is Established Early during Treatment in IDH1 -Mutated Myeloid Malignancies

Free
Sven Turkalj, Bilyana Stoilova, Angus J Groom, Felix A Radtke, Rabea Mecklenbrauck, Niels Asger Jakobsen, Curtis A Lachowiez, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Zhihong Zeng, Sanam Loghavi, Jennifer Marvin-Peek, Verena Körber, Farhad Ravandi, Ghayas C. Issa, Tapan M. Kadia, Vasiliki Symeonidou, Anne De Groot, Hagop M. Kantarjian, Koichi Takahashi, Marina Konopleva, Courtney D. DiNardo, Paresh Vyas
Journal: Blood
Blood (2024) 144 (Supplement 1): 642.
https://doi.org/10.1182/blood-2024-201970
Published: 2024
Journal Articles

Fractionated vs single-dose gemtuzumab ozogamicin with determinants of benefit in older patients with AML: the UK NCRI AML18 trial

Free
CME Clinical Trials & Observations
Sylvie D. Freeman, Abin Thomas, Ian Thomas, Robert K. Hills, Paresh Vyas, Amanda Gilkes, Marlen Metzner, Niels Asger Jakobsen, Alison Kennedy, Rachel Moore, Nuria Marquez Almuina, Sarah Burns, Sophie King, Georgia Andrew, Kathleen M. E. Gallagher, Rob S. Sellar, Paul Cahalin, Duruta Weber, Mike Dennis, Priyanka Mehta, Steven Knapper, Nigel H. Russell
Journal: Blood
Blood (2023) 142 (20): 1697–1707.
https://doi.org/10.1182/blood.2023020630
Published: 2023
Includes: Supplemental data
Journal Articles

Dynamics of Clonal Hematopoiesis Inferred By Modelling Deep Bulk Whole-Genome Sequencing Data at a Single Time Point

Free
Naser Ansari-Pour, Verena Körber, Niels Asger Jakobsen, Rachel Moore, Nina Claudino, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Simon Newman, Benjamin Kendrick, Adrian Taylor, Rasheed Afinowi-Luitz, Roger Gundle, Bridget Watkins, Kim Wheway, Debra Beazley, Andrew Carr, Paresh Vyas, Thomas Höfer
Journal: Blood
Blood (2022) 140 (Supplement 1): 5753–5754.
https://doi.org/10.1182/blood-2022-166236
Published: 2022
Journal Articles

A Randomized Comparison of the Fractionated Versus Single Dose Schedule of Gemtuzumab Ozogamicin at Induction with Determinants of Benefit for Older AML Patients: UK NCRI AML18 Trial Results

Free
Sylvie D Freeman, Abin Thomas, Ian Thomas, Paresh Vyas, Amanda Gilkes, Marlen Metzner, Niels Asger Jakobsen, Alison Kennedy, Amy Moore, Nuria Marquez Almuina, Sarah Burns, Sophie King, Georgia M. Andrew, Kathleen M.E. Gallagher, Rob Sellar, Paul Cahalin, Duruta Weber, Mike Dennis, Priyanka Mehta, Steve Knapper, Nigel H. Russell
Journal: Blood
Blood (2022) 140 (Supplement 1): 532–533.
https://doi.org/10.1182/blood-2022-162245
Published: 2022
Journal Articles

Single-Cell Analysis of Human Clonal Hematopoiesis Identifies Distinct Impact of DNMT3A and TET2 mutations on Hematopoietic Differentiation

Free
Niels Asger Jakobsen, Sven Turkalj, Bilyana Stoilova, Marlen Metzner, Rachel Moore, Batchimeg Usukhbayar, Mirian Angulo Salazar, Alison Kennedy, Simon Newman, Benjamin Kendrick, Adrian Taylor, Rasheed Afinowi-Luitz, Roger Gundle, Bridget Watkins, Kim Wheway, Debra Beazley, Andrew Carr, Paresh Vyas
Journal: Blood
Blood (2022) 140 (Supplement 1): 2227–2228.
https://doi.org/10.1182/blood-2022-166474
Published: 2022
Journal Articles

Genotyping of Multiple Genomic Loci with Chromatin Accessibility Profiling in Single Cells Links Clonal Hierarchy with Epigenetic Variation in Acute Myeloid Leukemia

Free
Sven Turkalj, Niels Asger Jakobsen, Angus Groom, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Kevin Clark, E. Ravza Gür, Lance D. Hentges, Paul Sopp, James O.J. Davies, Jim R. Hughes, Paresh Vyas
Journal: Blood
Blood (2022) 140 (Supplement 1): 1193–1194.
https://doi.org/10.1182/blood-2022-163139
Published: 2022