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William Blum
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Journal Articles

High incidence of impaired graft function after allogeneic HSCT for myelofibrosis, and successful utilization of stem cell boost

Free
Maria Leon-Camarena, Leah Philips, Joseph Rimando, Colin Vale, Anthony Hunter, Michael Hochman, Amelia Langston, William Blum, Edmund Waller
Journal: Blood
Blood (2025) 146 (Supplement 1): 6394.
https://doi.org/10.1182/blood-2025-6394
Published: 2025
Journal Articles

Mechanistic dissection of venetoclax sensitivity in AML through single-molecule BCL2 protein complex profiling and mutation-specific apoptotic rewiring

Free
Jaewon Choi, Lilly Gu, Yunseo Lee, Yunchan Choi, Saem Hong, Byungsan Choi, Eunyoung Kim, Fizza Iftikhar, Martha Arellano, William Blum, Tae Young Yoon, Hongwon Lee, Janghee Woo
Journal: Blood
Blood (2025) 146 (Supplement 1): 341.
https://doi.org/10.1182/blood-2025-341
Published: 2025
Journal Articles

RAS mutations negate the favorable impact of NPM1 in older patients with newly diagnosed Acute Myeloid Leukemia treated with ven/HMA

Free
Fieke Hoff, Alexander Li, Ying Huang, Rina Welkie, Ronan Swords, Elie Traer, Eytan Stein, Tara Lin, Maria Baer, Vu Duong, William Blum, Martha Arellano, Wendy Stock, Olatoyosi Odenike, Joshua Zeidner, Rebecca Olin, Catherine Smith, Gary Schiller, Emily Curran, Shivani Handa, Nyla Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Marcus, Leonard Rosenberg, Brian Druker, Ross Levine, Ashley Yocum, Uma Borate, Alice Mims, John Byrd, Yazan Madanat
Journal: Blood
Blood (2025) 146 (Supplement 1): 995.
https://doi.org/10.1182/blood-2025-995
Published: 2025
Journal Articles

Preliminary anti-leukemia activity from A phase 1 study of cln-049, a novel anti-FLT3 x anti-CD3 bispecific T-cell engager, in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and myelodysplastic syndrome (MDS)

Free
Maher Abdul-Hay, Colin Vale, Onyee Chan, Namrata Chandhok, Courtney DiNardo, Gary Schiller, Eunice Wang, Sanghee Hong, Kimo Bachiashvili, Mohammed Chaudhry, Kristy Kuplast-Barr, Kaida Wu, Todd Shearer, Thuy Hoang, Irina Shapiro, Máire Quigley, Jeffrey Jones, William Blum, David Sallman, Ghayas Issa
Journal: Blood
Blood (2025) 146 (Supplement 1): 768.
https://doi.org/10.1182/blood-2025-768
Published: 2025
Journal Articles

Analysis of hematologic improvement (HI) by time to response in Relapsed/Refractory Acute Myeloid Leukemia (AML) patients treated with olutasidenib

Free
Shira Dinner, Brian Jonas, Antonio Curti, Stephane De Botton, Pau Montesinos, Karen W.L. Yee, Gail Roboz, William Blum, Gary Schiller, Jorge Cortes, Justin Watts, Andrew Wei, Aaron Sheppard, Hua Tian, Eunice Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 3439.
https://doi.org/10.1182/blood-2025-3439
Published: 2025
Journal Articles

Phase 1b safety run-in study followed by Phase 2 study of ficlatuzumab, azacitidine and venetoclax in untreated Acute Myeloid Leukemia patients aged ≥ 60 years old

Free
Emily Curran, Ying Huang, Shivani Handa, Ronan Swords, Eytan Stein, Maria Baer, Wendy Stock, Yazan Madanat, Rebecca Olin, William Blum, Gary Schiller, Tara Lin, Joshua Zeidner, Bradley Blaser, Molly Martycz, Leonard Rosenberg, Sonja Marcus, Timothy Chen, Mona Stefanos, Ashley Yocum, Ross Levine, Brian Druker, Uma Borate, Alice Mims, John Byrd
Journal: Blood
Blood (2025) 146 (Supplement 1): 3432.
https://doi.org/10.1182/blood-2025-3432
Published: 2025
Journal Articles

Prognostic risk integration for survival modeling (PRISM) in newly diagnosed acute myeloid leukemia treated with venetoclax:  a multinational retrospective cohort study

Free
Curtis Lachowiez, Andy Kaempf, Jad Othman, Seongseok Yun, Mael Heiblig, Michael Heuser, Rabia Shahswar, Anand Patel, Rafael Madero-Marroquin, Joseph Cannova, Irene Zacheo, Federica Monaco, Dimitrios Drekolias, Fatima Tuz Zahra, Amine Belhabri, Urbain Tauveron-Jalenques, Emmanuelle Tavernier, Martin Carre, Gaspar Aspas Requena, Nicola Long, Rachel Cook, Elie Traer, Ronan Swords, Jennifer Saultz, Jenny O'Nions, Faisal Basheer, John Laurie, Shivani Handa, Eytan Stein, Maria Baer, Wendy Stock, Rebecca Olin, William Blum, Gary Schiller, Tara Lin, Emily Curran, Ying Huang, Rina Welkie, Ashley Yocum, Giovanni Marconi, Ellen Madarang, Justin Watts, Yazan Madanat, Richard Dillon, Sanam Loghavi, Joshua Zeidner, Daniel Pollyea, Elsa Bernard
Journal: Blood
Blood (2025) 146 (Supplement 1): 453.
https://doi.org/10.1182/blood-2025-453
Published: 2025
Journal Articles

Pentostatin Low-Dose TBI Is an Effective Conditioning Regimen That Permits Donor Engraftment in Patients with High Co-Morbidities Undergoing the First Transplant or Prior to a Second Transplant

Free
Ani Gvajaia, Joseph Rimando, William Blum, Colin A. Vale, Cynthia R. Giver, Elaina L. Corbett, Kevin Hall, Kristina Murphy, Mary Jo Lechowicz, Michel Conn, Minal Surati, Muna Qayed, Amelia Langston, Edmund K. Waller
Journal: Blood
Blood (2024) 144 (Supplement 1): 7325.
https://doi.org/10.1182/blood-2024-211880
Published: 2024
Journal Articles

A Phase 1, Open-Label, Dose Escalation and Dose Expansion, Multicenter Clinical Trial to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of Lomonitinib (ZE46-0134) in Adults with FLT3 -Mutated Relapsed or Refractory Acute Myeloid Leukemia

Free
Tara L. Lin, Kristin L Koenig, Ronan T. Swords, Eytan M. Stein, Maria R. Baer, Wendy Stock, Yazan F Madanat, Rebecca Olin, William Blum, Gary J. Schiller, Joshua F Zeidner, Emily K Curran, Molly Martycz, Leonard Rosenberg, Sonja Gullen Marcus, Timothy Chen, Mona Stefanos, Amy Burd, Ashley Owen Yocum, Ross L Levine, Brian J. Druker, Uma Borate, John C. Byrd, Alice Mims
Journal: Blood
Blood (2024) 144 (Supplement 1): 2883.4.
https://doi.org/10.1182/blood-2024-208822
Published: 2024
Journal Articles

Time to Response and Overall Survival in Patients with m IDH1 Relapsed/Refractory Acute Myeloid Leukemia Treated with Olutasidenib

Free
Eunice S. Wang, Jorge E. Cortes, Justin M. Watts, Brian A. Jonas, Andrew H Wei, Jay Yang, Joseph G Jurcic, Gail J. Roboz, Karen Seiter, Alice Mims, Karen Yee, Brent Ferrell, Shira N. Dinner, William B. Donnellan, William Blum, Francois Di Trapani, Hua Tian, Stephane De Botton
Journal: Blood
Blood (2024) 144 (Supplement 1): 1514.
https://doi.org/10.1182/blood-2024-198504
Published: 2024
Journal Articles

Combination of Olutasidenib and Azacitidine Induces Durable Complete Remissions in m IDH1 Acute Myeloid Leukemia: A Multicohort Open-Label Phase 1/2 Trial

Free
Jorge E. Cortes, Gail J. Roboz, Justin M. Watts, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, Brent Ferrell, Jay Yang, Eunice S. Wang, William Blum, Alice Mims
Journal: Blood
Blood (2024) 144 (Supplement 1): 2886.
https://doi.org/10.1182/blood-2024-201710
Published: 2024
Journal Articles

Demographics, Characteristics, Survival and Outcomes in Older, Untreated, Acute Myeloid Leukemia Patients with NPM1 Mutations or KMT2A rearrangements from the Beat AML Master Clinical Trial

Free
Uma Borate, Rina Li Welkie, Ying Huang, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Yazan F Madanat, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Alice Mims, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 1564.
https://doi.org/10.1182/blood-2024-211261
Published: 2024
Journal Articles

Intermediate Dose Post-Transplant Cyclophosphamide Is Associated with Faster Engraftment and Similar Other Outcomes When Compared with Full Dose Post-Transplant Cyclophosphamide Among Patients Undergoing Allogeneic Transplantation: A Single Center Retrospective Analysis

Free
Joseph Rimando, Michel Conn, William Blum, Jason T Romancik, Colin Vale, Amelia Langston, Edmund K. Waller, Kevin Hall
Journal: Blood
Blood (2024) 144 (Supplement 1): 3521.
https://doi.org/10.1182/blood-2024-198921
Published: 2024
Journal Articles

IO-202, a Novel Anti-LILRB4 Antibody, with Azacitidine for Hypomethylating Agent-Naive Chronic Myelomonocytic Leukemia: Phase 1b Expansion Cohort Results

Free
Gabriel N Mannis, Ahmed Aribi, Neil Dunavin, Hetty E. Carraway, Jennifer N. Saultz, Gail J. Roboz, Brian A. Jonas, Yazan F Madanat, Guillermo Garcia-Manero, Deepa Jeyakumar, Daniel A Pollyea, Olatoyosi Odenike, William Blum, Gary J. Schiller, Yasuhiro Tabata, Donna Valencia, Tao Huang, Wen Hong Lin, Hong Xiang, Charlene Liao, Courtney D. DiNardo
Journal: Blood
Blood (2024) 144 (Supplement 1): 1008.
https://doi.org/10.1182/blood-2024-206538
Published: 2024
Journal Articles

BRAF -Mutated Acute Myeloid Leukemia (AML) Represents a Prognostically Poor Subgroup Enriched for Myelodysplasia-Related Subtypes and Distinct from Other RAS Pathway Mutant AML

Free
Darren Lee, Yazan Abu-Shihab, Deedra Nicolet, Krzysztof Mrózek, Mark Routbort, Keyur P. Patel, Christopher J. Walker, Jill Buss, Andrew Stiff, Andrea Laganson, Courtney D. DiNardo, Naval Daver, Gautam Borthakur, Tapan M. Kadia, Farhad Ravandi, Andrew J. Carroll, Jonathan E Kolitz, Bayard L Powell, William Blum, Maria R. Baer, Guido Marcucci, Geoffrey L. Uy, Wendy Stock, Richard M. Stone, L. Jeffrey Medeiros, Jeffrey W. Tyner, Robert L. Bowman, John C. Byrd, James S. Blachly, Sanam Loghavi, Ann-Kathrin Eisfeld, Linde A. Miles
Journal: Blood
Blood (2024) 144 (Supplement 1): 2921.
https://doi.org/10.1182/blood-2024-210110
Published: 2024
Journal Articles

Efficacy and Safety of Uproleselan Combined with Chemotherapy Vs. Chemotherapy Alone in Relapsed/Refractory Acute Myeloid Leukemia: Findings from an International Phase 3 Trial

Free
Daniel J. DeAngelo, Andre C. Schuh, Brian A. Jonas, Pamela S. Becker, Anjali S. Advani, Geoffrey L. Uy, Janusz Krawczyk, Harry P. Erba, Gabriel N Mannis, Chun Yew Fong, Florian Kuchenbauer, Mary-Elizabeth M. Percival, Jane L. Liesveld, William Blum, Brenda W Cooper, Alice Mims, Francesco Lanza, Jeroen J.W.M. Janssen, Juan Miguel Bergua Burgues, Tibor Kovacsovics, Norbert Vey, Martina V. Hemmer, Gaetano Bonifacio, Edwin Rock, Pau Montesinos
Journal: Blood
Blood (2024) 144 (Supplement 1): 733.
https://doi.org/10.1182/blood-2024-209097
Published: 2024
Journal Articles

A Randomized Phase 2 Trial of 28-Day (Arm A) Versus 14-Day (Arm B) Schedule of Venetoclax + Azacitidine in Newly Diagnosed Acute Myeloid Leukemia Patients ≥ 60 Years

Free
Uma Borate, Ying Huang, Joshua F Zeidner, Ronan T. Swords, Kristin L Koenig, Eytan M. Stein, Maria R. Baer, Wendy Stock, Yazan F Madanat, Rebecca Olin, William Blum, Gary J. Schiller, Tara L. Lin, Emily K Curran, Molly Martycz, Leonard Rosenberg, Sonja Gullen Marcus, Timothy Chen, Mona Stefanos, Ross L Levine, Brian J. Druker, Ashley Owen Yocum, Amy Burd, Alice Mims, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 2907.2.
https://doi.org/10.1182/blood-2024-210967
Published: 2024
Journal Articles

IDH2 Mutation Is Associated with Favorable Outcome Among Older Adults with Newly Diagnosed Acute Myeloid Leukemia Treated with Lower-Intensity Therapy

Free
Fieke W Hoff, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Uma Borate, Alice Mims, John C. Byrd, Yazan F. Madanat
Journal: Blood
Blood (2024) 144 (Supplement 1): 4325.
https://doi.org/10.1182/blood-2024-202596
Published: 2024
Journal Articles

Outcomes and Survival in Newly Diagnosed, Older, Acute Myeloid Leukemia Patients from the Beat AML Master Trial in the Venetoclax/Azacitidine Age

Free
Uma Borate, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Yazan F Madanat, Prapti A. Patel, Robert H. Collins, Maria R. Baer, Vu H. Duong, William Blum, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Robert L. Redner, Tibor J. Kovacsovics, Michael W. Deininger, Joshua F Zeidner, Rebecca Olin, Catherine C. Smith, James M. Foran, Gary J. Schiller, Emily K Curran, Kristin L Koenig, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja Gullen Marcus, Leonard Rosenberg, Brian J. Druker, Ross L Levine, Amy Burd, Ashley Owen Yocum, Alice Mims, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 4324.
https://doi.org/10.1182/blood-2024-211178
Published: 2024
Journal Articles

Factors Impacting Response to Olutasidenib in Patients with mIDH1 Acute Myeloid Leukemia

Free
Eunice S. Wang, Brian A. Jonas, Justin M. Watts, Joseph Jurcic, P. Brent Ferrell, Jr., Shira N. Dinner, Jay Yang, Karen Seiter, Alice Mims, William B. Donnellan, William Blum, Jorge Cortes
Journal: Blood
Blood (2023) 142 (Supplement 1): 6047.
https://doi.org/10.1182/blood-2023-187584
Published: 2023