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Jason A. Powell
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Journal Articles

Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs

Shruthi Subramanian, Julie A. I. Thoms, Yizhou Huang, Paola Cornejo-Páramo, Forrest C. Koch, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S. Woll, Diego Chacon-Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O'Brien, Annette Trickett, Jason A. Powell, Ian D. Lewis, Stuart M. Pitson, Maher K. Gandhi, Steven W. Lane, Fatemeh Vafaee, Emily S. Wong, Berthold Göttgens, Hamid Alinejad-Rokny, Jason W. H. Wong, John E. Pimanda
Journal: Blood
Blood (2023) 142 (17): 1448–1462.
https://doi.org/10.1182/blood.2023021120
Published: 2023
Includes: Supplemental data
Journal Articles

Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia

Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea, Manjun Li, Gus O. Nwosu, Thao M. Nguyen, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Maurizio Costabile, Saira R. Ali, Chloe A. L. Thompson-Peach, B. Kate Dredge, Andrew G. Bert, Gregory J. Goodall, Paul G. Ekert, Anna L. Brown, Richard D’Andrea, Nirmal Robinson, Melissa R. Pitman, Daniel Thomas, David M. Ross, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson
Journal: Blood
Blood (2022) 139 (26): 3737–3751.
https://doi.org/10.1182/blood.2021013277
Published: 2022
Includes: Supplemental data
Journal Articles

Dual Sphingosine Kinase and Bcl-2 Inhibition Exhibits Synergistic Cell Death in Acute Myeloid Leukemia

Alexander C. Lewis, BSc, Richard D'Andrea, BSc,PhD, Jason A Powell, BSc, PhD, Stuart M Pitson, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2660.
https://doi.org/10.1182/blood.V130.Suppl_1.2660.2660
Published: 2017
Journal Articles

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P. Cameron, Katherine M. Hannan, Nhu-Y N. Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R. Devlin, Amee J. George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J. Harrison, James D. Rozario, Jason A. Powell, Stuart M. Pitson, Johannes Zuber, Ricky W. Johnstone, Mark A. Dawson, Mark A. Guthridge, Andrew Wei, Grant A. McArthur, Richard B. Pearson, Ross D. Hannan
Journal: Blood
Blood (2017) 129 (21): 2882–2895.
https://doi.org/10.1182/blood-2016-05-718171
Published: 2017
Includes: Supplemental data
Journal Articles

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Jason A. Powell, Alexander C. Lewis, Wenying Zhu, John Toubia, Melissa R. Pitman, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Diana Iarossi, Saumya E. Samaraweera, Nik Cummings, Hayley S. Ramshaw, Daniel Thomas, Andrew H. Wei, Angel F. Lopez, Richard J. D’Andrea, Ian D. Lewis, Stuart M. Pitson
Journal: Blood
Blood (2017) 129 (6): 771–782.
https://doi.org/10.1182/blood-2016-06-720433
Published: 2017
Includes: Supplemental data
Journal Articles

STAT5 Is a Critical Component Of The Time-Dependent Sensitivity Of CML Cells To TKI Treatment In a Bcr-Abl-Dependent, But JAK2-Independent Manner

Lisa Schafranek, BSc., (Hons), Eva Nievergall, PhD, Jason A. Powell, BSc, PhD, Devendra K. Hiwase, MBBS, MD, PhD, FRACP, FRCPA, Deborah L. White, PhD, FFSc(RCPA), Timothy P. Hughes, MD, MBBS, FRACP, FRCPA, Tamara Leclercq, PhD
Journal: Blood
Blood (2013) 122 (21): 2705.
https://doi.org/10.1182/blood.V122.21.2705.2705
Published: 2013
Journal Articles

Evaluation Of Sphingosine Kinase 1 As a Therapeutic Target In B-Lineage Acute Lymphoblastic Leukemia

Craig T Wallington-Beddoe, BSc, MBBS, PhD, FRACP, FRCPA, Stuart M Pitson, BAppSc, PhD, Jason A Powell, BSc, PhD, Kenneth F Bradstock, MBBS, PhD, FRACP, FRCPA, Linda J Bendall, BSc, PhD
Journal: Blood
Blood (2013) 122 (21): 1426.
https://doi.org/10.1182/blood.V122.21.1426.1426
Published: 2013
Journal Articles

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Daniel Thomas, Jason A. Powell, Francois Vergez, David H. Segal, Nhu-Y. N. Nguyen, Adele Baker, Tse-Chieh Teh, Emma F. Barry, Jean-Emmanuel Sarry, Erwin M. Lee, Tracy L. Nero, Anissa M. Jabbour, Giovanna Pomilio, Benjamin D. Green, Stéphane Manenti, Stefan P. Glaser, Michael W. Parker, Angel F. Lopez, Paul G. Ekert, Richard B. Lock, David C. S. Huang, Susie K. Nilsson, Christian Récher, Andrew H. Wei, Mark A. Guthridge
Journal: Blood
Blood (2013) 122 (5): 738–748.
https://doi.org/10.1182/blood-2012-08-447441
Published: 2013
Includes: Supplemental data
Journal Articles

Commitment of CML Cells to Apoptotic Cell Death Depends On the Length of Exposure to Das and the Level of STAT5 Activity

Lisa Schafranek, BSc., (Hons), Eva Nievergall, PhD, Jason A Powell, PhD, Devendra K. Hiwase, MBBS, MD, PhD, FRACP, FRCPA, Deborah L. White, PhD, FFSc(RCPA), Timothy P. Hughes, MD, MBBS
Journal: Blood
Blood (2012) 120 (21): 3736.
https://doi.org/10.1182/blood.V120.21.3736.3736
Published: 2012
Journal Articles

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

Jason A. Powell, Daniel Thomas, Emma F. Barry, Chung H. Kok, Barbara J. McClure, Anna Tsykin, L. Bik To, Anna Brown, Ian D. Lewis, Kirsten Herbert, Gregory J. Goodall, Terence P. Speed, Norio Asou, Bindya Jacob, Motomi Osato, David N. Haylock, Susan K. Nilsson, Richard J. D'Andrea, Angel F. Lopez, Mark A. Guthridge
Journal: Blood
Blood (2009) 114 (23): 4859–4870.
https://doi.org/10.1182/blood-2009-02-204818
Published: 2009
Includes: Supplemental data
Journal Articles

Expression Profiling of a Hemopoietic Cell Survival Transcriptome Identifies a Functional Prognostic Gene Signature in Normal Karyotype AML.

Mark Guthridge, Daniel Thomas, MD, Emma F Barry, Kok H Chung, Barbara J McClure, L. Bik To, MD, Greg Goodall, Terry P Speed, Motomi Osato, David Haylock, Susie Nilsson, MD, Richard D'Andrea, PhD, Angel Lopez, Jason A Powell, PhD
Journal: Blood
Blood (2009) 114 (22): 1618.
https://doi.org/10.1182/blood.V114.22.1618.1618
Published: 2009
Journal Articles

Blocking of Cytokine Survival Signals along with Intense Bcr-Abl Kinase Inhibition May Eradicate CML Progenitor Cells.

Devendra K Hiwase, MD, Deborah L White, PhD, Jason A Powell, PhD, Verity A Saunders, Stephanie Zrim, Amity Frede, Mark Guthridge, Richard D'Andrea, PhD, L. Bik To, MD, Junia V. Melo, MD, PhD, Sharad Kumar, PhD, Timothy Hughes, MD
Journal: Blood
Blood (2009) 114 (22): 3250.
https://doi.org/10.1182/blood.V114.22.3250.3250
Published: 2009
Journal Articles

A Molecular Signature for a Cytokine Receptor Survival Pathway in AML Identifies Unique Prognostic Indicators and Therapeutic Targets

Daniel Thomas, MD, Jason A Powell, PhD, Emma F Barry, Luen Bik To, MD, Angel Lopez, Mark A Guthridge
Journal: Blood
Blood (2008) 112 (11): 2893.
https://doi.org/10.1182/blood.V112.11.2893.2893
Published: 2008
Journal Articles

Lipid and Protein Substrates of PI3K in Cytokine Receptor Survival Signalling: Deregulation in Leukemia

Daniel Thomas, MD, Joanna Woodcock, PhD, Jason A Powell, PhD, Emma F Barry, Angel F Lopez, Mark A Guthridge, PhD
Journal: Blood
Blood (2008) 112 (11): 3864.
https://doi.org/10.1182/blood.V112.11.3864.3864
Published: 2008