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Dominik Beck
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Journal Articles

Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs

Shruthi Subramanian, Julie A. I. Thoms, Yizhou Huang, Paola Cornejo-Páramo, Forrest C. Koch, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S. Woll, Diego Chacon-Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O'Brien, Annette Trickett, Jason A. Powell, Ian D. Lewis, Stuart M. Pitson, Maher K. Gandhi, Steven W. Lane, Fatemeh Vafaee, Emily S. Wong, Berthold Göttgens, Hamid Alinejad-Rokny, Jason W. H. Wong, John E. Pimanda
Journal: Blood
Blood (2023) 142 (17): 1448–1462.
https://doi.org/10.1182/blood.2023021120
Published: 2023
Includes: Supplemental data
Journal Articles

Comparative Analysis of Genome-Scale Gene Regulatory Networks in Human Hematopoietic Stem and Myeloid Progenitor Fractions

Shruthi Subramanian, Julie A.I. Thoms, Yizhou Huang, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S Woll, Diego Chacon Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O' Brien, Annette Trickett, Jason Powell, Stuart M Pitson, Maher K. Gandhi, Paola Cornejo, Emily Wong, Steven W Lane, Bertie Gottgens, Hamid Alinejad Rokny, Jason W.H Wong, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 2846–2848.
https://doi.org/10.1182/blood-2022-165620
Published: 2022
Journal Articles

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

Julie A. I. Thoms, Peter Truong, Shruthi Subramanian, Kathy Knezevic, Gregory Harvey, Yizhou Huang, Janith A. Seneviratne, Daniel R. Carter, Swapna Joshi, Joanna Skhinas, Diego Chacon, Anushi Shah, Ineke de Jong, Dominik Beck, Berthold Göttgens, Jonas Larsson, Jason W. H. Wong, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2021) 138 (16): 1441–1455.
https://doi.org/10.1182/blood.2020009707
Published: 2021
Includes: Supplemental data
Journal Articles

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine L. Carmichael, Jueqiong Wang, Thao Nguyen, Oluseyi Kolawole, Aissa Benyoucef, Charlotte De Mazière, Anna R. Milne, Sona Samuel, Kevin Gillinder, Soroor Hediyeh-zadeh, Anh N. Q. Vo, Yizhou Huang, Kathy Knezevic, William R. L. McInnes, Benjamin J. Shields, Helen Mitchell, Matthew E. Ritchie, Tim Lammens, Beatrice Lintermans, Pieter Van Vlierberghe, Nicholas C. Wong, Katharina Haigh, Julie A. I. Thoms, Emma Toulmin, David J. Curtis, Ethan P. Oxley, Ross A. Dickins, Dominik Beck, Andrew Perkins, Matthew P. McCormack, Melissa J. Davis, Geert Berx, Johannes Zuber, John E. Pimanda, Benjamin T. Kile, Steven Goossens, Jody J. Haigh
Journal: Blood
Blood (2020) 136 (8): 957–973.
https://doi.org/10.1182/blood.2019002548
Published: 2020
Includes: Supplemental data
Journal Articles

Prospective Identification of Acute Myeloid Leukemia Patients Who Benefit from Gene-Expression Based Risk Stratification

Diego Chacon, PhD, Ali Braytee, PhD, Yizhou Huang, PhD, Julie Thoms, PhD, Shruthi Subramanian, BSc, Maria Cristina Sauerland, Stefan K. Bohlander, MD, Jan Braess, MD, Bernhard J. Wörmann, MD, Wolfgang E. Berdel, MD, Wolfgang Hiddemann, MD PhD, Bogdan Gabrys, PhD, Klaus H. Metzeler, MD, Tobias Herold, MD, John Pimanda, MBBS, PhD, Dominik Beck, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1397.
https://doi.org/10.1182/blood-2019-129519
Published: 2019
Journal Articles

Shared roles for Scl and Lyl1 in murine platelet production and function

Sung K. Chiu, Stephanie L. Orive, Mitchell J. Moon, Jesslyn Saw, Sarah Ellis, Benjamin T. Kile, Yizhou Huang, Diego Chacon, John E. Pimanda, Dominik Beck, Justin R. Hamilton, Cedric S. Tremblay, David J. Curtis
Journal: Blood
Blood (2019) 134 (10): 826–835.
https://doi.org/10.1182/blood.2019896175
Published: 2019
Includes: Supplemental data
Journal Articles

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

Rabab Nasrallah, Eva M. Fast, Parham Solaimani, Kathy Knezevic, Alexia Eliades, Rahima Patel, Roshana Thambyrajah, Ashwin Unnikrishnan, Julie Thoms, Dominik Beck, Chris S. Vink, Aileen Smith, Jason Wong, Mairi Shepherd, David Kent, Rahul Roychoudhuri, Fabian Paul, Julia Klippert, Annette Hammes, Thomas Willnow, Bertie Göttgens, Elaine Dzierzak, Leonard I. Zon, George Lacaud, Valerie Kouskoff, John E. Pimanda
Journal: Blood
Blood (2016) 128 (15): 1928–1939.
https://doi.org/10.1182/blood-2016-02-697870
Published: 2016
Includes: Supplemental data
Journal Articles

An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

Roberto Avellino, Marije Havermans, Claudia Erpelinck, Mathijs A. Sanders, Remco Hoogenboezem, Harmen J. G. van de Werken, Elwin Rombouts, Kirsten van Lom, Paulina M. H. van Strien, Claudia Gebhard, Michael Rehli, John Pimanda, Dominik Beck, Stefan Erkeland, Thijs Kuiken, Hans de Looper, Stefan Gröschel, Ivo Touw, Eric Bindels, Ruud Delwel
Journal: Blood
Blood (2016) 127 (24): 2991–3003.
https://doi.org/10.1182/blood-2016-01-695759
Published: 2016
Includes: Supplemental data
Journal Articles

An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML

Ashwin Unnikrishnan, PhD, Elli Papaemmanuil, PhD, Dominik Beck, PhD, Arjun Verma, B.Sc., Ashu Kumari, PhD, Laura A. Richards, Kathy Knezevic, Vashe Chandrakanthan, PhD, Julie A.I. Thoms, PhD, Melinda L. Tursky, PhD, Yizhou Huang, Sally Galbraith, PhD, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Magnus Tobiasson, MD, Petter S. Woll, PhD, Andrea Pellagatti, PhD, Susan R. Wilson, PhD, Robert Lindeman, MD, Jacqueline Boultwood, PhD, Kevin Lynch, MBBS, Sten Eirik Jacobsen, Ghulam J Mufti, FRCP, FRCPath, Eva Hellstrom-Lindberg, MD PhD, Karen Lee Mackenzie, PhD, Jason W.H. Wong, PhD, Peter J Campbell, MD PhD, John E. Pimanda, MDPhD
Journal: Blood
Blood (2015) 126 (23): 710.
https://doi.org/10.1182/blood.V126.23.710.710
Published: 2015
Journal Articles

A Tissue-Specific Transcriptional Element for C/ebpa Is Required for HSC Maintenance and Neutrophil Development

Roberto Avellino, Marije Havermans, Claudia Erpelinck, Mathijs Sanders, Stefan Groeschel, Harmen Vandewerken, Remco M. Hoogenboezem, M.Sc., Elwin Rombouts, Kirsten Van Lom, Paulette Van Strien, Hans De Looper, Claudia Christine Gebhard, Michael Rehli, Dominik Beck, PhD, Julie A.I. Thoms, PhD, Stefan Erkeland, Ivo Touw, John E. Pimanda, MDPhD, Eric JM Bindels, Ruud Delwel
Journal: Blood
Blood (2015) 126 (23): 301.
https://doi.org/10.1182/blood.V126.23.301.301
Published: 2015
Journal Articles

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells

Duohui Jing, Vivek A. Bhadri, Dominik Beck, Julie A. I. Thoms, Nurul A. Yakob, Jason W. H. Wong, Kathy Knezevic, John E. Pimanda, Richard B. Lock
Journal: Blood
Blood (2015) 125 (2): 273–283.
https://doi.org/10.1182/blood-2014-05-576470
Published: 2015
Includes: Supplemental data
Journal Articles

Identification of a Prognostic Gene Expression Signature for AZA Response in MDS and CMML Patients

Ashwin Unnikrishnan, PhD, Dominik Beck, PhD, Arjun Verma, Laura A Richards, Julie A I Thoms, PhD, Ashu Kumari, PhD, Sally Galbraith, PhD, Austin Kulasekararaj, Magnus Tobiasson, MD, Petter S Woll, PhD, Andrea Pellagatti, PhD, Elli Papaemmanuil, PhD, Susan R Wilson, PhD, Robert Lindeman, MD, Peter J Campbell, PhD, Jacqueline Boultwood, PhD, Kevin Lynch, MBBS, Sten Eirik W Jacobsen, MD PhD, Ghulam J. Mufti, DM, FRCP, FRCPath, Eva Hellstrom-Lindberg, MD PhD, Karen L MacKenzie, PhD, Jason WH Wong, PhD, John E Pimanda, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4601.
https://doi.org/10.1182/blood.V124.21.4601.4601
Published: 2014
Journal Articles

Integrative Analysis of Lincrna Expression and Clinical Annotations Reveals a Signature of 17 Genes with Prognostic Significance in Acute Myeloid Leukemia (AML)

Dominik Beck, PhD, Cintia Palu, MSc, Anushi Shah, PhD, Tobias Herold, MD, Jake Olivier, PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Stefan K Bohlander, MD, Jason W Wong, DPhil, John E Pimanda, MD PhD
Journal: Blood
Blood (2014) 124 (21): 483.
https://doi.org/10.1182/blood.V124.21.483.483
Published: 2014
Journal Articles

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

Liat Goldberg, Marloes R. Tijssen, Yehudit Birger, Rebecca L. Hannah, Sarah J. Kinston, Judith Schütte, Dominik Beck, Kathy Knezevic, Ginette Schiby, Jasmine Jacob-Hirsch, Anat Biran, Yoel Kloog, Guido Marcucci, Clara D. Bloomfield, Peter D. Aplan, John E. Pimanda, Berthold Göttgens, Shai Izraeli
Journal: Blood
Blood (2013) 122 (15): 2694–2703.
https://doi.org/10.1182/blood-2013-01-477133
Published: 2013
Includes: Supplemental data
Journal Articles

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes

e-blood
Dominik Beck, Julie A. I. Thoms, Dilmi Perera, Judith Schütte, Ashwin Unnikrishnan, Kathy Knezevic, Sarah J. Kinston, Nicola K. Wilson, Tracey A. O’Brien, Berthold Göttgens, Jason W. H. Wong, John E. Pimanda
Journal: Blood
Blood (2013) 122 (14): e12–e22.
https://doi.org/10.1182/blood-2013-03-490425
Published: 2013
Includes: Supplemental data
Journal Articles

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

Eva Diffner, Dominik Beck, Emma Gudgin, Julie A. I. Thoms, Kathy Knezevic, Clare Pridans, Sam Foster, Debbie Goode, Weng Khong Lim, Lies Boelen, Klaus H. Metzeler, Gos Micklem, Stefan K. Bohlander, Christian Buske, Alan Burnett, Katrin Ottersbach, George S. Vassiliou, Jake Olivier, Jason W. H. Wong, Berthold Göttgens, Brian J. Huntly, John E. Pimanda
Journal: Blood
Blood (2013) 121 (12): 2289–2300.
https://doi.org/10.1182/blood-2012-07-446120
Published: 2013
Includes: Supplemental data
Journal Articles

Activity of a Heptad of Transcription Factors Is Associated with Stem Cell Programs and Clinical Outcome in Acute Myeloid Leukaemia

Eva Diffner, PhD, Dominik Beck, PhD, Emma Gudgin, MBBS, MRCP, Julie Thoms, PhD, Kathy Knezevic, BSc (Hons), Clare Pridans, PhD, Sam Foster, PhD, Debbie Goode, PhD, Wheng Khong Lim, PhD, Lies Boelen, PhD, Klaus H. Metzeler, MD, Gos Micklem, PhD, Stefan K Bohlander, MD, Christian Buske, MD, Alan K Burnett, MD, Katrin Ottersbach, PhD, George Vassiliou, MD, PhD, Jake Olivier, PhD, Jason WH Wong, PhD, Berthold Gottgens, Ph.D., Brian Huntly, MD, PHD, John E Pimanda, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3525.
https://doi.org/10.1182/blood.V120.21.3525.3525
Published: 2012
Journal Articles

Role of Erythropoietin Receptor in t(12;21) Positive Acute Lymphoblastic Leukemia.

Renate Panzer-Gruemayer, MD, Gerd Krapf, MSc, Dominik Beck, MSc, Gerhard Fuka, MSc, Christian Bieglmayer, MD, Georg Mann, MD, Andrea Inthal, MSc.
Journal: Blood
Blood (2007) 110 (11): 2792.
https://doi.org/10.1182/blood.V110.11.2792.2792
Published: 2007