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Stefan K. Bohlander
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Journal Articles

Venetoclax Has Potent Efficacy in NPM1 mutated AML with Acquired Resistance Associated with Either Perturbed Pro-Survival Signalling or NPM1 wild-Type Populations

Chong Chyn Chua, Natasha Anstee, Christoffer Flensburg, Charis Teh, Adam Ivey, Noorul Amin, Rachel Thijssen, Stefan K. Bohlander, Purvi M. Kakadia, Zhen Xu, Chun Yew Fong, Stephen Ting, Sun Loo, Ing Soo Tiong, Daniel Gray, Shaun Fleming, Nadia Davidson, Andrew W. Roberts, Ian Majewski, Andrew H. Wei, Fiona C. Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 423.
https://doi.org/10.1182/blood-2023-185321
Published: 2023
Journal Articles

Signaling Pathway Mutations Cooperate with the PICALM/MLLT10 Fusion in a Knock-in AML Mouse Model

Rhea H. Desai, Peter J. Browett, Purvi M. Kakadia, Stefan K. Bohlander
Journal: Blood
Blood (2023) 142 (Supplement 1): 4128.
https://doi.org/10.1182/blood-2023-178915
Published: 2023
Journal Articles

Picalm/MLLT10 Expression in Zebrafish Is Associated with an Increase of Hematopoietic Stem Cells and Leads to Leukemia

Omid Delfi, Peter J. Browett, Maryam Saberi, Yih Jian Sung, Purvi M. Kakadia, Stefan K. Bohlander
Journal: Blood
Blood (2023) 142 (Supplement 1): 5698.
https://doi.org/10.1182/blood-2023-179490
Published: 2023
Journal Articles

Drug Repurposing in a Zebrafish AML Model

Maryam Saberi, Omid Delfi, Peter J. Browett, Purvi M. Kakadia, Stefan K. Bohlander
Journal: Blood
Blood (2023) 142 (Supplement 1): 5763.
https://doi.org/10.1182/blood-2023-180293
Published: 2023
Journal Articles

Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy

Brief Report
Annatina S. Schnegg-Kaufmann, Julie A. I. Thoms, Golam Sarower Bhuyan, Henry R. Hampton, Lachlin Vaughan, Kayleigh Rutherford, Purvi M. Kakadia, Hui Mei Lee, Emma M. V. Johansson, Timothy W. Failes, Greg M. Arndt, Jason Koval, Robert Lindeman, Pauline Warburton, Alba Rodriguez-Meira, Adam J. Mead, Ashwin Unnikrishnan, Sarah Davidson, Mark N. Polizzotto, Mark Hertzberg, Elli Papaemmanuil, Stefan K. Bohlander, Omid R. Faridani, Christopher J. Jolly, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2023) 141 (11): 1316–1321.
https://doi.org/10.1182/blood.2022018602
Published: 2023
Includes: Supplemental data
Journal Articles

Clinical Response to Azacytidine (AZA) Is Associated with Increased Contribution from Mutated Blood Progenitors: Insights from Single Cell Genotyping of Matched Stem/Progenitor and Mature Blood Cells from MDS/CMML Patients Pre- and Post-AZA Treatment

Julie A.I. Thoms, Annatina Schnegg-Kaufmann, Golam Sarower Bhuyan, Henry R. Hampton, Lachlin Vaughan, Kayleigh Rutherford, Purvi M. Kakadia, Hui Mei Lee, Emma Johansson, Tim W. Failes, Greg M. Arndt, Jason Koval, Sarah Davidson, Robert Lindeman, Pauline Warburton, Alba Rodriguez-Meira, Adam J Mead, Ashwin Unnikrishnan, Mark Hertzberg, Mark N. Polizzotto, Elli Papaemmanuil, Stefan K. Bohlander, Omid Faridani, Christopher J. Jolly, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 9751–9752.
https://doi.org/10.1182/blood-2022-163158
Published: 2022
Journal Articles

In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial

John E. Pimanda, Julie A.I. Thoms, Henry R. Hampton, Sarah Davidson, Swapna Joshi, Chowdhury H. Sarowar, Xin Ying Lim, Andrea C. Nunez, Purvi M. Kakadia, Russell Pickford, Mark Raftery, Sally Hough, Griselda Buckland, Michelle Bailey, Yuvaraj Ghodke, Noorul Absar, Lachlin Vaughan, Leonardo Pasalic, Chun Yew Fong, Melita Kenealy, Devendra Hiwase, Rohanna Stoddart, Soma Mohammed, Linda Lee, Freda H. Passam, Kevin Spring, Kristy K. Skarratt, Patricia Rebeiro, Stephen R Larsen, Peter Presgrave, William S Stevenson, Silvia Ling, Campbell Tiley, Stephen Fuller, Fernando Roncolato, Anoop Kumar Enjeti, Dirk Hoenemann, Charlotte Lemech, Stefan K. Bohlander, Jake Olivier, Mark Hertzberg, Ashwin Unnikrishnan, Mark N. Polizzotto
Journal: Blood
Blood (2022) 140 (Supplement 1): 6927–6929.
https://doi.org/10.1182/blood-2022-157634
Published: 2022
Journal Articles

Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation

James I. Hearn, Taryn N. Green, Colin L. Hisey, Markus Bender, Emma C. Josefsson, Nicholas Knowlton, Juliane Baumann, Raewyn C. Poulsen, Stefan K. Bohlander, Maggie L. Kalev-Zylinska
Journal: Blood
Blood (2022) 139 (17): 2673–2690.
https://doi.org/10.1182/blood.2021014000
Published: 2022
Includes: Supplemental data
Journal Articles

MLL/AF9 Expression Causes Leukemia in Zebrafish

Maryam Saberi, Omid Delfi, Dona Wathsala Madola, Peter J. Browett, Purvi M Kakadia, Stefan K. Bohlander
Journal: Blood
Blood (2021) 138 (Supplement 1): 4330.
https://doi.org/10.1182/blood-2021-154125
Published: 2021
Journal Articles

Characterization of an Acute Myeloid Leukemia Murine Model Driven By MLL/AF9: Effect of Retroviral Insertion Sites and Somatic Mutations on Gene Expression

Hui Mei Lee, Niloofar Zandvakili, Rhea Desai, Peter J. Browett, Purvi M Kakadia, Stefan K. Bohlander
Journal: Blood
Blood (2021) 138 (Supplement 1): 4329.
https://doi.org/10.1182/blood-2021-154012
Published: 2021
Journal Articles

Clonal Evolution in a Murine CALM-AF10 Leukemia: Evidence of Functional Heterogeneity of Leukemia Stem Cells

Niloofar Zandvakili, Hui Mei Lee, Rhea Desai, Alyona Oryshchuk, Peter J. Browett, Purvi M Kakadia, Stefan K. Bohlander
Journal: Blood
Blood (2021) 138 (Supplement 1): 1158.
https://doi.org/10.1182/blood-2021-154068
Published: 2021
Journal Articles

A Murine Immunocompetent Acute Myeloid Leukemia (AML) Model for Testing Immunotherapies

Hui Mei Lee, Niloofar Zandvakilli, Rhea Desai, PhD, Purvi M Kakadia, PhD, Peter Browett, BMedSci, MBChB, FRACP, FRCPA, Stefan K. Bohlander, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-141171
Published: 2020
Journal Articles

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance

Akihiko Numata, Hui Si Kwok, Qi-Ling Zhou, Jia Li, Roberto Tirado-Magallanes, Vladimir Espinosa Angarica, Rebecca Hannah, Jihye Park, Chelsia Qiuxia Wang, Vaidehi Krishnan, Deepa Rajagopalan, Yanzhou Zhang, Siqin Zhou, Robert S. Welner, Motomi Osato, Sudhakar Jha, Stefan K. Bohlander, Berthold Göttgens, Henry Yang, Touati Benoukraf, John W. Lough, Deepak Bararia, Daniel G. Tenen
Journal: Blood
Blood (2020) 136 (15): 1735–1747.
https://doi.org/10.1182/blood.2019001279
Published: 2020
Includes: Supplemental data
Journal Articles

Anti-Leukemic Activity of Single Agent Venetoclax in Newly Diagnosed Acute Myeloid Leukemia: A Sub-Set Analysis of the Caveat Study

Chong Chyn Chua, MBBS, John Reynolds, PhD, Jessica M Salmon, PhD, Chun Fong, Stephen B Ting, MB BS, FRACP, FRCPA, PhD, Ing Soo Tiong, MBBS,FRACP,FRCPA, Shaun Fleming, MBBS,, Sarah MacRaild, Donia M Moujalled, PhD, Giovanna Pomilio, Nik Cummings, Julie McManus, Adam Ivey, BSc, MSc, PhD, Purvi M Kakadia, PhD, Stefan K. Bohlander, MD, Andrew W. Roberts, MBBS, PhD FRACP, FRCPA, Andrew H. Wei, PhD FRACP, FRCPA, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 462.
https://doi.org/10.1182/blood-2019-126640
Published: 2019
Journal Articles

Prospective Identification of Acute Myeloid Leukemia Patients Who Benefit from Gene-Expression Based Risk Stratification

Diego Chacon, PhD, Ali Braytee, PhD, Yizhou Huang, PhD, Julie Thoms, PhD, Shruthi Subramanian, BSc, Maria Cristina Sauerland, Stefan K. Bohlander, MD, Jan Braess, MD, Bernhard J. Wörmann, MD, Wolfgang E. Berdel, MD, Wolfgang Hiddemann, MD PhD, Bogdan Gabrys, PhD, Klaus H. Metzeler, MD, Tobias Herold, MD, John Pimanda, MBBS, PhD, Dominik Beck, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1397.
https://doi.org/10.1182/blood-2019-129519
Published: 2019
Journal Articles

Clonal Evolution of Relapsed CBFB/MYH11 Rearranged Acute Myeloid Leukemia (AML)

Sabrina Opatz, MD, Sebastian Vosberg, Bianka Ksienzyk, Sebastian Tschuri, Alexander Graf, Stefan Krebs, PhD, Helmut Blum, Dr., Stephanie Schneider, PhD, Martin Neumann, Claudia D. Baldus, MD, Christian Thiede, MD, Jan Moritz Middeke, MD, Friedrich Stoelzel, Stefan K. Bohlander, MD, Karsten Spiekermann, MD, Wolfgang Hiddemann, PhD, Klaus H. Metzeler, MD, Philipp A. Greif, MD PD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2772.
https://doi.org/10.1182/blood-2018-99-115881
Published: 2018
Journal Articles

Molecular Patterns of Response and Outcome in the Chemotherapy and Venetoclax in Elderly AML Trial (CAVEAT study)

Andrew H Wei, MBBS,PhD, Chong Chyn Chua, MBBS, BMedSc, Ing S Tiong, MBChB, Chun Yew Fong, MBBS,FRACP,FRCPA, Stephen B Ting, MB BS, FRACP, FRCPA, PhD, Sarah Macraild, Jessica M Salmon, PhD, Adam Ivey, BSc, MSc, PhD, John Nguyen, Flora Yuen, BBiomedSc, Richard Hall, Shaun Fleming, Stefan K. Bohlander, MD, John Reynolds, PhD, Andrew W. Roberts, MBBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 333.
https://doi.org/10.1182/blood-2018-99-114243
Published: 2018
Journal Articles

Genetic or Pharmacological Inhibition of the Polycomb Group Protein BMI1 Impairs Leukemic Transformation Mediated By the CALM-AF10 Fusion Oncoprotein

Karina O. Barbosa, BSc, Anwesha Ghosh, PhD, Anagha Deshpande, PhD, Sayantanee Dutta, PhD, Scott A. Armstrong, MD PhD, Stefan K. Bohlander, MD, Aniruddha J. Deshpande, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 762.
https://doi.org/10.1182/blood-2018-99-115552
Published: 2018
Journal Articles

NPM1 Variant Allele Frequency and Outcomes in AML

Maja Rothenberg-Thurley, PhD, Tobias Herold, MD, Dennis Görlich, PhD, Cristina Sauerland, Hanna Janke, MD, Victoria V Prassek, MD, Nikola P Konstandin, PhD, Annika Maria Dufour, PhD, Stephanie Schneider, PhD, Bianka Ksienzyk, Evelyn Packeiser, Marion Subklewe, MD, Michael von Bergwelt, MD, Stefan K. Bohlander, MD, Andreas Faldum, PhD, Jan Braess, MD, Bernhard J. Wörmann, MD, Wolfgang E. Berdel, MD, Utz Krug, MD, Wolfgang Hiddemann, Karsten Spiekermann, MD, Klaus H. Metzeler, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1486.
https://doi.org/10.1182/blood-2018-99-112549
Published: 2018
Journal Articles

Aldehyde Dehydrogenase 2 ( ALDH2 ) Expression Predicts a Poor Prognosis in Acute Myeloid Leukemia

Linus Angenendt, Eike Bormann, Jan-Henrik Mikesch, Tobias Herold, Klaus H. Metzeler, MD, Stefan K. Bohlander, MD, Dennis Görlich, Maria Francisca Arteaga, Bernhard J. Wörmann, Georg Lenz, Wolfgang Hiddemann, Karsten Spiekermann, Utz Krug, Christina Sauerland, Wolfgang E. Berdel, Christoph Schliemann
Journal: Blood
Blood (2017) 130 (Supplement 1): 1386.
https://doi.org/10.1182/blood.V130.Suppl_1.1386.1386
Published: 2017