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Journal Articles

Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation

James I. Hearn, Taryn N. Green, Colin L. Hisey, Markus Bender, Emma C. Josefsson, Nicholas Knowlton, Juliane Baumann, Raewyn C. Poulsen, Stefan K. Bohlander, Maggie L. Kalev-Zylinska

Blood (2022) 139 (17): 2673–2690.

https://doi.org/10.1182/blood.2021014000

Published: 2022

Includes: Supplemental data

Journal Articles

The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production

Shen Y. Heazlewood, Tanveer Ahmad, Monika Mohenska, Belinda B. Guo, Pradnya Gangatirkar, Emma C. Josefsson, Sarah L. Ellis, Madara Ratnadiwakara, Huimin Cao, Benjamin Cao, Chad K. Heazlewood, Brenda Williams, Madeline Fulton, Jacinta F. White, Mirana Ramialison, Susan K. Nilsson, Minna-Liisa Änkö

Blood (2022) 139 (9): 1359–1373.

https://doi.org/10.1182/blood.2021013826

Published: 2022

Includes: Supplemental data

Journal Articles

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E. Au, Rachael M. Lane, Katya J. Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E. Jarman, Sarah Ellis, Donald Metcalf, Shaun P. Jackson, Simone M. Schoenwaelder, Benjamin T. Kile, Emma C. Josefsson

Blood (2018) 132 (2): 197–209.

https://doi.org/10.1182/blood-2017-11-816355

Published: 2018

Includes: Supplemental data

Journal Articles

Regulation of Platelet Lifespan in the Presence and Absence of TPO Signaling

Marion Lebois, Mark R. Dowling, Philip D. Hodgkin, Benjamin T. Kile, Warren S. Alexander, Emma C. Josefsson

Blood (2015) 126 (23): 11.

https://doi.org/10.1182/blood.V126.23.11.11

Published: 2015

Journal Articles

Extended Platelet In Vivo Survival Results in Exhausted Platelets

Irina Pleines, Marion Lebois, Amanda E.-L. Au, Rachael M. Lane, Katya J. Henley, Jason Corbin, Ping Cannon, Kate E Jarman, Sarah Ellis, Shaun P Jackson, Simone M. Schoenwaelder, Benjamin T. Kile, Emma C. Josefsson

Blood (2015) 126 (23): 416.

https://doi.org/10.1182/blood.V126.23.416.416

Published: 2015

Journal Articles

Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL

Kathryn S. Potts, Tobias J. Sargeant, Caleb A. Dawson, Emma C. Josefsson, Douglas J. Hilton, Warren S. Alexander, Samir Taoudi

Blood (2015) 126 (6): 807–816.

https://doi.org/10.1182/blood-2014-12-616607

Published: 2015

Includes: Supplemental data

Journal Articles

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

Stanley C. W. Lee, Sarah Miller, Craig Hyland, Maria Kauppi, Marion Lebois, Ladina Di Rago, Donald Metcalf, Sarah A. Kinkel, Emma C. Josefsson, Marnie E. Blewitt, Ian J. Majewski, Warren S. Alexander

Blood (2015) 126 (2): 167–175.

https://doi.org/10.1182/blood-2014-12-615898

Published: 2015

Includes: Supplemental data

Journal Articles

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo

Kathryn S. Potts, Tobias J. Sargeant, John F. Markham, Wei Shi, Christine Biben, Emma C. Josefsson, Lachlan W. Whitehead, Kelly L. Rogers, Anna Liakhovitskaia, Gordon K. Smyth, Benjamin T. Kile, Alexander Medvinsky, Warren S. Alexander, Douglas J. Hilton, Samir Taoudi

Blood (2014) 124 (17): 2725–2729.

https://doi.org/10.1182/blood-2014-02-559468

Published: 2014

Includes: Supplemental data

Journal Articles

Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

Zhi-Jian Liu, Karin M. Hoffmeister, Zhongbo Hu, Donald E. Mager, Sihem Ait-Oudhia, Marlyse A. Debrincat, Irina Pleines, Emma C. Josefsson, Benjamin T. Kile, Joseph Italiano, Jr, Haley Ramsey, Renata Grozovsky, Peter Veng-Pedersen, Chaitanya Chavda, Martha Sola-Visner

Blood (2014) 123 (22): 3381–3389.

https://doi.org/10.1182/blood-2013-06-508200

Published: 2014

Includes: Supplemental data

Journal Articles

Platelet Production Occurs Independently of Both the Intrinsic and Extrinsic Apoptosis Pathways

Emma C. Josefsson, Deborah L. Burnett, Marlyse A. Debrincat, Katya J. Henley, Rachael M. Lane, Marion Lebois, Lorraine A. O'Reilly, Marc Pellegrini, Simon P. Preston, Ben A. Croker, Donald Metcalf, Andreas Strasser, Benjamin T. Kile

Blood (2012) 120 (21): 389.

https://doi.org/10.1182/blood.V120.21.389.389

Published: 2012

Journal Articles

The origin and function of platelet glycosyltransferases

Hans H. Wandall, Viktoria Rumjantseva, Anne Louise Tølbøll Sørensen, Sunita Patel-Hett, Emma C. Josefsson, Eric P. Bennett, Joseph E. Italiano, Jr, Henrik Clausen, John H. Hartwig, Karin M. Hoffmeister

Blood (2012) 120 (3): 626–635.

https://doi.org/10.1182/blood-2012-02-409235

Published: 2012

Includes: Supplemental data

Journal Articles

Mcl-1 and Bcl-x L coordinately regulate megakaryocyte survival

Marlyse A. Debrincat, Emma C. Josefsson, Chloé James, Katya J. Henley, Sarah Ellis, Marion Lebois, Kelly L. Betterman, Rachael M. Lane, Kelly L. Rogers, Michael J. White, Andrew W. Roberts, Natasha L. Harvey, Donald Metcalf, Benjamin T. Kile

Blood (2012) 119 (24): 5850–5858.

https://doi.org/10.1182/blood-2011-12-398834

Published: 2012

Journal Articles

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Michael J. White, Simone M. Schoenwaelder, Emma C. Josefsson, Kate E. Jarman, Katya J. Henley, Chloé James, Marlyse A. Debrincat, Shaun P. Jackson, David C. S. Huang, Benjamin T. Kile

Blood (2012) 119 (18): 4283–4290.

https://doi.org/10.1182/blood-2011-11-394858

Published: 2012

Includes: Supplemental data

Journal Articles

Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice

A. J. Gerard Jansen, Emma C. Josefsson, Viktoria Rumjantseva, Qiyong Peter Liu, Hervé Falet, Wolfgang Bergmeier, Stephen M. Cifuni, Robert Sackstein, Ulrich H. von Andrian, Denisa D. Wagner, John H. Hartwig, Karin M. Hoffmeister

Blood (2012) 119 (5): 1263–1273.

https://doi.org/10.1182/blood-2011-05-355628

Published: 2012

Includes: Supplemental data

Journal Articles

Inhibition of Sialic Acid Loss Greatly Improves Survival of Refrigerated Platelets

Gerard Jansen, MD, PhD, MSC, Emma C Josefsson, PhD, Qiyong Peter Liu, PhD, Viktoria Rumjantseva, PhD, Herve Falet, PhD, Renata Grozovsky, PhD, Wolfgang Bergmeier, PhD, Denisa D. Wagner, PhD, John H. Hartwig, PhD, Karin M. Hoffmeister, MD

Blood (2011) 118 (21): 1133.

https://doi.org/10.1182/blood.V118.21.1133.1133

Published: 2011

Journal Articles

Bcl-x L –inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Simone M. Schoenwaelder, Kate E. Jarman, Elizabeth E. Gardiner, My Hua, Jianlin Qiao, Michael J. White, Emma C. Josefsson, Imala Alwis, Akiko Ono, Abbey Willcox, Robert K. Andrews, Kylie D. Mason, Hatem H. Salem, David C. S. Huang, Benjamin T. Kile, Andrew W. Roberts, Shaun P. Jackson

Blood (2011) 118 (6): 1663–1674.

https://doi.org/10.1182/blood-2011-04-347849

Published: 2011

Includes: Supplemental data

Journal Articles

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor–induced thrombocytopenia

Mark J. Bishton, Simon J. Harrison, Benjamin P. Martin, Nicole McLaughlin, Chloé James, Emma C. Josefsson, Katya J. Henley, Benjamin T. Kile, H. Miles Prince, Ricky W. Johnstone

Blood (2011) 117 (13): 3658–3668.

https://doi.org/10.1182/blood-2010-11-318055

Published: 2011

Includes: Supplemental data

Journal Articles

The Effect of Eltrombopag on Human Platelet Resistance to Apoptosis: The Role of the Bcl-Xl Pathway

W. Beau Mitchell, MD, Michele N Edison, BS, Mariana P Pinheiro, MD, Nayla Boulad, BA, Bethan Psaila, MD, PhD, Marissa Karpoff, BS, David Kaplan, MD, Benjamin T Kile, PhD, Michael J White, Emma C Josefsson, James B. Bussel, MD

Blood (2010) 116 (21): 2520.

https://doi.org/10.1182/blood.V116.21.2520.2520

Published: 2010

Journal Articles

Megakaryocytes Possess a Functional Intrinsic Apoptosis Pathway That Must Be Restrained In Order to Survive and Produce Platelets

Emma C Josefsson, Chloé James, Katya J Henley, Marlyse A Debrincat, Kelly L Rogers, Mark R Dowling, Michael J White, Elizabeth A Kruse, Sarah Ellis, Paquita Nurden, Cassandra J Vandenberg, Kylie D Mason, A O'Reilly Lorraine, Donald Metcalf, Andrew W Roberts, David CS Huang, Benjamin T Kile

Blood (2010) 116 (21): 550.

https://doi.org/10.1182/blood.V116.21.550.550

Published: 2010

Journal Articles

Platelet senescence is regulated by an internal timer, not damage inflicted by hits

Mark R. Dowling, Emma C. Josefsson, Katya J. Henley, Philip D. Hodgkin, Benjamin T. Kile

Blood (2010) 116 (10): 1776–1778.

https://doi.org/10.1182/blood-2009-12-259663

Published: 2010

Includes: Supplemental data

NARROW

Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation

The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Regulation of Platelet Lifespan in the Presence and Absence of TPO Signaling

Extended Platelet In Vivo Survival Results in Exhausted Platelets

Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo

Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

Platelet Production Occurs Independently of Both the Intrinsic and Extrinsic Apoptosis Pathways

The origin and function of platelet glycosyltransferases

Mcl-1 and Bcl-x L coordinately regulate megakaryocyte survival

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice

Inhibition of Sialic Acid Loss Greatly Improves Survival of Refrigerated Platelets

Bcl-x L –inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor–induced thrombocytopenia

The Effect of Eltrombopag on Human Platelet Resistance to Apoptosis: The Role of the Bcl-Xl Pathway

Megakaryocytes Possess a Functional Intrinsic Apoptosis Pathway That Must Be Restrained In Order to Survive and Produce Platelets

Platelet senescence is regulated by an internal timer, not damage inflicted by hits

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