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Irina Pleines
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Journal Articles

Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis

Sascha Geue, Katja Aurbach, Mailin-Christin Manke, Georgi Manukjan, Patrick Münzer, David Stegner, Caroline Brähler, Britta Walker-Allgaier, Melanie Märklin, Carla E. Borst, Leticia Quintanilla-Fend, Dominik Rath, Tobias Geisler, Helmut R. Salih, Peter Seizer, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Harald Schulze, Irina Pleines, Oliver Borst
Journal: Blood
Blood (2019) 134 (21): 1847–1858.
https://doi.org/10.1182/blood.2019000185
Published: 2019
Includes: Multimedia, Supplemental data
Journal Articles

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E. Au, Rachael M. Lane, Katya J. Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E. Jarman, Sarah Ellis, Donald Metcalf, Shaun P. Jackson, Simone M. Schoenwaelder, Benjamin T. Kile, Emma C. Josefsson
Journal: Blood
Blood (2018) 132 (2): 197–209.
https://doi.org/10.1182/blood-2017-11-816355
Published: 2018
Includes: Supplemental data
Journal Articles

CK2β regulates thrombopoiesis and Ca 2+ -triggered platelet activation in arterial thrombosis

Patrick Münzer, Britta Walker-Allgaier, Sascha Geue, Friederike Langhauser, Eva Geuss, David Stegner, Katja Aurbach, Daniela Semeniak, Madhumita Chatterjee, Irene Gonzalez Menendez, Melanie Märklin, Leticia Quintanilla-Martinez, Helmut R. Salih, David W. Litchfield, Thierry Buchou, Christoph Kleinschnitz, Florian Lang, Bernhard Nieswandt, Irina Pleines, Harald Schulze, Meinrad Gawaz, Oliver Borst
Journal: Blood
Blood (2017) 130 (25): 2774–2785.
https://doi.org/10.1182/blood-2017-05-784413
Published: 2017
Includes: Multimedia, Supplemental data
Journal Articles

RhoA/ROCK guides NMII on the way to MK polyploidy

Irina Pleines, Bernhard Nieswandt
Journal: Blood
Blood (2016) 128 (26): 3025–3026.
https://doi.org/10.1182/blood-2016-11-746685
Published: 2016
Journal Articles

Extended Platelet In Vivo Survival Results in Exhausted Platelets

Irina Pleines, Marion Lebois, Amanda E.-L. Au, Rachael M. Lane, Katya J. Henley, Jason Corbin, Ping Cannon, Kate E Jarman, Sarah Ellis, Shaun P Jackson, Simone M. Schoenwaelder, Benjamin T. Kile, Emma C. Josefsson
Journal: Blood
Blood (2015) 126 (23): 416.
https://doi.org/10.1182/blood.V126.23.416.416
Published: 2015
Journal Articles

Mutations in Tropomyosin 4 Cause Macrothrombocytopenia in Mice and Humans

Irina Pleines, PhD, Joanne Woods, PhD, Ernest Turro, PhD, Nicola Foad, PhD, Stephane Chappaz, PhD, Rachael M. Lane, Harriet Manning, Galina Schevzov, PhD, Sarah K Westbury, Andrew D Mumford, Remi Favier, MD, Peter Gunning, PhD, Willem H. Ouwehand, MDPhDFRCPath FMedSci #, Marloes R Tijssen, PhD, Benjamin T Kile, PhD
Journal: Blood
Blood (2014) 124 (21): 571.
https://doi.org/10.1182/blood.V124.21.571.571
Published: 2014
Journal Articles

Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

Zhi-Jian Liu, Karin M. Hoffmeister, Zhongbo Hu, Donald E. Mager, Sihem Ait-Oudhia, Marlyse A. Debrincat, Irina Pleines, Emma C. Josefsson, Benjamin T. Kile, Joseph Italiano, Jr, Haley Ramsey, Renata Grozovsky, Peter Veng-Pedersen, Chaitanya Chavda, Martha Sola-Visner
Journal: Blood
Blood (2014) 123 (22): 3381–3389.
https://doi.org/10.1182/blood-2013-06-508200
Published: 2014
Includes: Supplemental data
Journal Articles

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

Irina Pleines, Sebastian Dütting, Deya Cherpokova, Anita Eckly, Imke Meyer, Martina Morowski, Georg Krohne, Harald Schulze, Christian Gachet, Najet Debili, Cord Brakebusch, Bernhard Nieswandt
Journal: Blood
Blood (2013) 122 (18): 3178–3187.
https://doi.org/10.1182/blood-2013-03-487942
Published: 2013
Includes: Supplemental data
Journal Articles

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

Irina Pleines, Ina Hagedorn, Shuchi Gupta, Frauke May, Lidija Chakarova, Jolanda van Hengel, Stefan Offermanns, Georg Krohne, Christoph Kleinschnitz, Cord Brakebusch, Bernhard Nieswandt
Journal: Blood
Blood (2012) 119 (4): 1054–1063.
https://doi.org/10.1182/blood-2011-08-372193
Published: 2012
Includes: Multimedia, Supplemental data
Journal Articles

ADF/n-cofilin–dependent actin turnover determines platelet formation and sizing

Markus Bender, Anita Eckly, John H. Hartwig, Margitta Elvers, Irina Pleines, Shuchi Gupta, Georg Krohne, Elisabeth Jeanclos, Antje Gohla, Christine Gurniak, Christian Gachet, Walter Witke, Bernhard Nieswandt
Journal: Blood
Blood (2010) 116 (10): 1767–1775.
https://doi.org/10.1182/blood-2010-03-274340
Published: 2010
Includes: Multimedia, Supplemental data
Journal Articles

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets

Irina Pleines, Anita Eckly, Margitta Elvers, Ina Hagedorn, Sandra Eliautou, Markus Bender, Xunwei Wu, Francois Lanza, Christian Gachet, Cord Brakebusch, Bernhard Nieswandt
Journal: Blood
Blood (2010) 115 (16): 3364–3373.
https://doi.org/10.1182/blood-2009-09-242271
Published: 2010
Journal Articles

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

Frauke May, Ina Hagedorn, Irina Pleines, Markus Bender, Timo Vögtle, Johannes Eble, Margitta Elvers, Bernhard Nieswandt
Journal: Blood
Blood (2009) 114 (16): 3464–3472.
https://doi.org/10.1182/blood-2009-05-222273
Published: 2009
Includes: Multimedia, Supplemental data
Journal Articles

Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation

Attila Braun, David Varga-Szabo, Christoph Kleinschnitz, Irina Pleines, Markus Bender, Madeleine Austinat, Michael Bösl, Guido Stoll, Bernhard Nieswandt
Journal: Blood
Blood (2009) 113 (9): 2056–2063.
https://doi.org/10.1182/blood-2008-07-171611
Published: 2009