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Journal Articles

Dual role of EZH2 in megakaryocyte differentiation

Stefania Mazzi, Philippe Dessen, Mathieu Vieira, Virginie Dufour, Marie Cambot, Mira El Khoury, Iléana Antony-Debré, Brahim Arkoun, Francesca Basso-Valentina, Salwa BenAbdoulahab, Valerie Edmond, Philippe Rameau, Rachel Petermann, Monika Wittner, Bruno Cassinat, Isabelle Plo, Najet Debili, Hana Raslova, William Vainchenker

Blood (2021) 138 (17): 1603–1614.

https://doi.org/10.1182/blood.2019004638

Published: 2021

Includes: Supplemental data

Journal Articles

Palbociclib Prevents CDK4/6 Dependent-Myeloproliferation and Myelofibrosis

Helene Duparc, Delphine Muller, Ileana Antony-Debre, PhD PharmD, Caroline Marty, PhD, Najet Debili, Jean-Luc Villeval, PhD, Isabelle Plo, William Vainchenker, Laure Gilles, PhD, Hana Raslova

Blood (2020) 136 (Supplement 1): 25.

https://doi.org/10.1182/blood-2020-141092

Published: 2020

Journal Articles

Modeling Acute Megakaryoblastic Leukemia of Down Syndrome Using Induced Pluripotent Stem Cells

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-140986

Published: 2020

Journal Articles

Disrupted filamin A/α IIb β 3 interaction induces macrothrombocytopenia by increasing RhoA activity

Alessandro Donada, Nathalie Balayn, Dominika Sliwa, Larissa Lordier, Valentina Ceglia, Francesco Baschieri, Cyril Goizet, Rémi Favier, Lucie Tosca, Gérard Tachdjian, Cecile V. Denis, Isabelle Plo, William Vainchenker, Najet Debili, Jean-Philippe Rosa, Marijke Bryckaert, Hana Raslova

Blood (2019) 133 (16): 1778–1788.

https://doi.org/10.1182/blood-2018-07-861427

Published: 2019

Includes: Supplemental data

Journal Articles

Dynamins 2 and 3 Are Required for Human Megakaryocytes Directional Migration

Praveen K Suraneni, PhD, Seth J. Corey, MD, Michael Hession, BS, Rameez Ishaq, Arinola Awomolo, Shirin Hasan, PhD, Najet Debili, PhD, John D. Crispino, PhD MBA, Elizabeth A. Eklund, MD, Yolande Chen, MD

Blood (2018) 132 (Supplement 1): 2429.

https://doi.org/10.1182/blood-2018-99-118782

Published: 2018

Journal Articles

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L

Fabrizia Favale, Kahia Messaoudi, Leila N. Varghese, Siham Boukour, Christian Pecquet, Vitalina Gryshkova, Jean Philippe Defour, Roxana-Irina Albu, Olivier Bluteau, Paola Ballerini, Guy Leverger, Isabelle Plo, Najet Debili, Hana Raslova, Remi Favier, Stefan N. Constantinescu, William Vainchenker

Blood (2016) 128 (26): 3146–3158.

https://doi.org/10.1182/blood-2016-06-722058

Published: 2016

Includes: Supplemental data

Journal Articles

Activity of nonmuscle myosin II isoforms determines localization at the cleavage furrow of megakaryocytes

Anita Roy, Larissa Lordier, Stefania Mazzi, Yunhua Chang, Valérie Lapierre, Jérome Larghero, Najet Debili, Hana Raslova, William Vainchenker

Blood (2016) 128 (26): 3137–3145.

https://doi.org/10.1182/blood-2016-04-711630

Published: 2016

Includes: Multimedia, Supplemental data

Journal Articles

Calreticulin Mutants Induce an Early Clonal Dominance and a Megakaryocytic Phenotype through the Activation of MPL/JAK2 Pathway in Human Primary Cells

Mira EL Khoury, Gaelle Vertenoeil, Caroline Marty, Christophe Marzac, Matthieu Mosca, Christian Pecquet, PhD, Fabrizia Favale, Robert Kralovics, Najet Debili, Nicole Casadevall, MD, Hana Raslova, PhD, Stefan N. Constantinescu, MD PhD, Isabelle Plo, William Vainchenker, MD PhD

Blood (2016) 128 (22): 1959.

https://doi.org/10.1182/blood.V128.22.1959.1959

Published: 2016

Journal Articles

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

Blood (2016) 127 (3): 333–342.

https://doi.org/10.1182/blood-2015-07-661983

Published: 2016

Includes: Supplemental data

Journal Articles

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

Blood (2015) 125 (6): 930–940.

https://doi.org/10.1182/blood-2014-06-585513

Published: 2015

Includes: Supplemental data

Journal Articles

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

Vladimir T. Manchev, Morgane Hilpert, Eliane Berrou, Ziane Elaib, Achille Aouba, Siham Boukour, Sylvie Souquere, Gerard Pierron, Philippe Rameau, Robert Andrews, François Lanza, Regis Bobe, William Vainchenker, Jean-Philippe Rosa, Marijke Bryckaert, Najet Debili, Remi Favier, Hana Raslova

Blood (2014) 124 (16): 2554–2563.

https://doi.org/10.1182/blood-2014-01-551820

Published: 2014

Includes: Supplemental data

Journal Articles

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

Irina Pleines, Sebastian Dütting, Deya Cherpokova, Anita Eckly, Imke Meyer, Martina Morowski, Georg Krohne, Harald Schulze, Christian Gachet, Najet Debili, Cord Brakebusch, Bernhard Nieswandt

Blood (2013) 122 (18): 3178–3187.

https://doi.org/10.1182/blood-2013-03-487942

Published: 2013

Includes: Supplemental data

Journal Articles

Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling

Blood (2013) 122 (10): 1695–1706.

https://doi.org/10.1182/blood-2013-03-484550

Published: 2013

Journal Articles

Modeling JAK2 V617F Heterozygous and Homozygous Mutations by Using Induced Pluripotent Stem Cells Derived From Myeloproliferative Neoplasms Patients

Joseph Saliba, PhD Student, Sofiane Hamidi, PhD Student, Antonio Di Stefano, PhD, Thierry Langlois, Gaëlle Lenglet, PhD, Lise Secardin, Anne Galy, PharmD, PhD, Paule Opolon, Najet Debili, PhD, Hana Raslova, PhD, Françoise Norol, Isabelle Plo, Ph.D, William Vainchenker, MD, PhD

Blood (2012) 120 (21): 1758.

https://doi.org/10.1182/blood.V120.21.1758.1758

Published: 2012

Journal Articles

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression

Dominique Bluteau, Ana C. Glembotsky, Anna Raimbault, Nathalie Balayn, Laure Gilles, Philippe Rameau, Paquita Nurden, Marie Christine Alessi, Najet Debili, William Vainchenker, Paula G. Heller, Remi Favier, Hana Raslova

Blood (2012) 120 (13): 2708–2718.

https://doi.org/10.1182/blood-2012-04-422337

Published: 2012

Includes: Supplemental data

Journal Articles

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia

Dominique Bluteau, Laure Gilles, Morgane Hilpert, Iléana Antony-Debré, Chloe James, Najet Debili, Valerie Camara-Clayette, Orianne Wagner-Ballon, Veronique Cordette-Lagarde, Thomas Robert, Hugues Ripoche, Patrick Gonin, Sabina Swierczek, Josef Prchal, William Vainchenker, Remi Favier, Hana Raslova

Blood (2011) 118 (24): 6310–6320.

https://doi.org/10.1182/blood-2010-12-325555

Published: 2011

Includes: Supplemental data

Journal Articles

Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome

Blood (2011) 118 (22): 5928–5937.

https://doi.org/10.1182/blood-2011-07-365601

Published: 2011

Includes: Supplemental data

Journal Articles

Defects in Filamin A (FLNa) in Women with X-Linked Filaminopathies: Abnormalities in Platelet Production and Platelet Function

Paquita Nurden, MD, PhD, Marijke Bryckaert, PhD, Eliane Berrou, PhD, Frédéric Adam, PhD, Jean-Marie Daniel Lamazière, PhD, Anne-Cécile Pons, PhD, Cyril Goizet, MD, PhD, William Vainchenker, MD, PhD, Alan T. Nurden, PhD, Najet Debili, PhD

Blood (2011) 118 (21): 1152.

https://doi.org/10.1182/blood.V118.21.1152.1152

Published: 2011

Journal Articles

RUNX1-Induced Silencing of Non-Muscle Myosin Iib (MYH10) Is Required for Megakaryocyte Polyploidization

Dominique Bluteau, PhD, Larissa Lordier, PhD, Iléana Antony-Debré, Abdelali Jalil, Céline Legrand, Philippe Rameau, Olivier Bluteau, PhD, Dima Jouni, Thomas Mercher, PhD, Catherine Leon, Christian Gachet, MD, PhD, Najet Debili, PhD, William Vainchenker, MD., Ph.D, Yunhua Chang, PhD, Hana Raslova, PhD

Blood (2011) 118 (21): 1308.

https://doi.org/10.1182/blood.V118.21.1308.1308

Published: 2011

Journal Articles

Abnormal Proplatelet Formation and Myosin Activation Status in Patients with MYH9-Related Syndrome

Yolande Chen, MD, Siham Boukour, PhD, Paquita Nurden, MD, PhD, Ababacar Seye, Olivier Bluteau, PhD, Alberta Palazzo, Yunhua Chang, PhD, Larissa Lordier, PhD, Remi Favier, MD, Nicole Schlegel, MD, PhD, Anne Galy, PharmD, PhD, Alan T. Nurden, PhD, Hana Raslova, PhD, William Vainchenker, MD, PhD, Najet Debili, PhD

Blood (2011) 118 (21): 4826.

https://doi.org/10.1182/blood.V118.21.4826.4826

Published: 2011

NARROW

Dual role of EZH2 in megakaryocyte differentiation

Palbociclib Prevents CDK4/6 Dependent-Myeloproliferation and Myelofibrosis

Modeling Acute Megakaryoblastic Leukemia of Down Syndrome Using Induced Pluripotent Stem Cells

Disrupted filamin A/α IIb β 3 interaction induces macrothrombocytopenia by increasing RhoA activity

Dynamins 2 and 3 Are Required for Human Megakaryocytes Directional Migration

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L

Activity of nonmuscle myosin II isoforms determines localization at the cleavage furrow of megakaryocytes

Calreticulin Mutants Induce an Early Clonal Dominance and a Megakaryocytic Phenotype through the Activation of MPL/JAK2 Pathway in Human Primary Cells

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling

Modeling JAK2 V617F Heterozygous and Homozygous Mutations by Using Induced Pluripotent Stem Cells Derived From Myeloproliferative Neoplasms Patients

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia

Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome

Defects in Filamin A (FLNa) in Women with X-Linked Filaminopathies: Abnormalities in Platelet Production and Platelet Function

RUNX1-Induced Silencing of Non-Muscle Myosin Iib (MYH10) Is Required for Megakaryocyte Polyploidization

Abnormal Proplatelet Formation and Myosin Activation Status in Patients with MYH9-Related Syndrome

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American Society of Hematology

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American Society of Hematology

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