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Journal Articles

DNMT3A gates IFN-induced MPN HSC exhaustion

Stefan N. Constantinescu, William Vainchenker

Blood (2024) 143 (24): 2445–2446.

https://doi.org/10.1182/blood.2024024448

Published: 2024

Journal Articles

Modulation of human thrombopoietin receptor conformations uncouples JAK2 V617F-driven activation from cytokine-induced stimulation

Nicolas Papadopoulos, Ajda Pristavec, Audrey Nédélec, Gabriel Levy, Judith Staerk, Stefan N. Constantinescu

Blood (2023) 142 (21): 1818–1830.

https://doi.org/10.1182/blood.2022019580

Published: 2023

Includes: Supplemental data

Journal Articles

An Atypical Somatic Calr Variant Acquired in Cis to a Germline Calr variant Induces Constitutive Signaling of the Thrombopoietin Receptor and Results in Essential Thrombocythemia

Laetitia Borderon, Jihyun Song, Soo Jin Kim, Christophe Marzac, Christine Bellanné-Chantelot, Nicolas Papadopoulos, Stefan N. Constantinescu, William Vainchenker, Isabelle Plo, Josef T. Prchal, Caroline Marty

Blood (2023) 142 (Supplement 1): 3161.

https://doi.org/10.1182/blood-2023-179381

Published: 2023

Journal Articles

GATA1 Target Gene CSF2RB Is Functionally Coupled to MPL and Marks a TPO-Dependent Preleukemic TAM Cell Population Sustained By the Fetal Liver but Not Bone Marrow

David Cruz Hernandez, Nicolas Papadopoulos, Elise Sepulchre, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Leila Varghese, Gabriel Levy, Irene Roberts, Stefan N Constantinescu, Paresh Vyas

Blood (2023) 142 (Supplement 1): 404.

https://doi.org/10.1182/blood-2023-174449

Published: 2023

Journal Articles

Chromothripsis Orchestrates Leukemic Transformation in Blast Phase MPN through Targetable Amplification of DYRK1A

Blood (2023) 142 (Supplement 1): 993.

https://doi.org/10.1182/blood-2023-178556

Published: 2023

Journal Articles

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Blood (2023) 141 (8): 917–929.

https://doi.org/10.1182/blood.2022016846

Published: 2023

Includes: Supplemental data

Journal Articles

Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis

Sara Lecomte, Julien Devreux, Grégoire de Streel, Nicolas van Baren, Violaine Havelange, David Schröder, Noora Vaherto, Christophe Vanhaver, Christophe Vanderaa, Noémie Dupuis, Christian Pecquet, Pierre G. Coulie, Stefan N. Constantinescu, Sophie Lucas

Blood (2023) 141 (5): 490–502.

https://doi.org/10.1182/blood.2022017097

Published: 2023

Includes: Supplemental data

Journal Articles

A Novel Autosomal Dominant JAK2 R715T Mutation Causes Polycythemia Vera in 3 Generations

Soo Jin Kim, Jihyun Song, Nicolas Papadopoulos, Jessica Meznarich, Grace Min, Stefan N. Constantinescu, Josef T. Prchal

Blood (2022) 140 (Supplement 1): 6742–6743.

https://doi.org/10.1182/blood-2022-170075

Published: 2022

Journal Articles

Modulation of the Human Thrombopoietin Receptor Conformation Uncouples JAK2 V617F-Driven from Cytokine-Induced Activation

Nicolas Papadopoulos, Ajda Pristavec, Gabriel Levy, Audrey Nédélec, Judith Staerk, Stefan N. Constantinescu

Blood (2022) 140 (Supplement 1): 3878–3879.

https://doi.org/10.1182/blood-2022-166405

Published: 2022

Journal Articles

Canonical Thrombopoietin Receptor Mutants in Myeloproliferative Neoplasms Rely Differently on the Extracellular Domain of the Receptor but Share Similar Mechanisms of Inactivation: An Open Field for the Development of New Therapies

Gabriel Levy, Nicolas Papadopoulos, Christian Pecquet, Jean-Philippe Defour, Emilie Leroy, Nabih Maslah, Bruno Cassinat, Steven Smith, Stefan N Constantinescu

Blood (2022) 140 (Supplement 1): 8736–8737.

https://doi.org/10.1182/blood-2022-168663

Published: 2022

Journal Articles

The 2 faces of ERK2 in MPNs

Violaine Havelange, Stefan N. Constantinescu

Blood (2022) 140 (4): 298–300.

https://doi.org/10.1182/blood.2022016536

Published: 2022

Journal Articles

Degrading JAK2 in ALL by ruxolitinib-based PROTACs

Stefan N. Constantinescu, Christian Pecquet

Blood (2021) 138 (23): 2301–2302.

https://doi.org/10.1182/blood.2021012004

Published: 2021

Journal Articles

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

Blood (2021) 138 (22): 2231–2243.

https://doi.org/10.1182/blood.2021010986

Published: 2021

Includes: Supplemental data

Journal Articles

CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag

Francesca Basso-Valentina, Gabriel Levy, Leila N. Varghese, Myriam Oufadem, Benedicte Neven, Charlotte Boussard, Nathalie Balayn, Caroline Marty, William Vainchenker, Isabelle Plo, Paola Ballerini, Stefan N. Constantinescu, Remi Favier, Hana Raslova

Blood (2021) 138 (6): 480–485.

https://doi.org/10.1182/blood.2020010567

Published: 2021

Includes: Supplemental data

Journal Articles

Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor

Ruochen Jia, Thomas Balligand, Vasyl Atamanyuk, Harini Nivarthi, Erica Xu, Leon Kutzner, Jakob Weinzierl, Audrey Nedelec, Stefan Kubicek, Roman Lesyk, Oleh Zagrijtschuk, Stefan N. Constantinescu, Robert Kralovics

Blood (2021) 137 (14): 1920–1931.

https://doi.org/10.1182/blood.2020006264

Published: 2021

Includes: Supplemental data

Journal Articles

MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491

Gabriel Levy, Serge Carillo, Benjamin Papoular, Bruno Cassinat, Jean-Marc Zini, Emilie Leroy, Leila N. Varghese, Ilyas Chachoua, Jean-Philippe Defour, Steven O. Smith, Stefan N. Constantinescu

Blood (2020) 135 (12): 948–953.

https://doi.org/10.1182/blood.2019003240

Published: 2020

Includes: Supplemental data

Journal Articles

MPL membrane domain sequencing goes deep

Stefan N. Constantinescu, Leila N. Varghese

Blood (2020) 135 (4): 236–237.

https://doi.org/10.1182/blood.2019003482

Published: 2020

Journal Articles

JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera

Blood (2019) 134 (26): 2388–2398.

https://doi.org/10.1182/blood.2019001385

Published: 2019

Includes: Supplemental data

Journal Articles

Disease Phenotype and Clonal Amplification in Calreticulin del52 and ins5 Knock-in Mice Are Dependent on the Type of Mutations and Gene Dosage

Camélia Benlabiod, Maira da Costa Cacemiro, PhD, Thomas Balligand, MD, Barbara Panneau-Schmaltz, PhD, Delphine Muller, Laure Touchard, Patrick Gonin, DVM, Jean-Luc Villeval, PhD, Stefan N Constantinescu, MD PhD, Hana Raslova, PhD, William Vainchenker, MD PhD, Isabelle Plo, Caroline Marty, PhD

Blood (2019) 134 (Supplement_1): 311.

https://doi.org/10.1182/blood-2019-127918

Published: 2019

Journal Articles

Results from Treatment of a Large Cohort of ATL Patients from a Country with High HTLV1 Prevalence

Blood (2019) 134 (Supplement_1): 5288.

https://doi.org/10.1182/blood-2019-126434

Published: 2019

NARROW

DNMT3A gates IFN-induced MPN HSC exhaustion

Modulation of human thrombopoietin receptor conformations uncouples JAK2 V617F-driven activation from cytokine-induced stimulation

An Atypical Somatic Calr Variant Acquired in Cis to a Germline Calr variant Induces Constitutive Signaling of the Thrombopoietin Receptor and Results in Essential Thrombocythemia

GATA1 Target Gene CSF2RB Is Functionally Coupled to MPL and Marks a TPO-Dependent Preleukemic TAM Cell Population Sustained By the Fetal Liver but Not Bone Marrow

Chromothripsis Orchestrates Leukemic Transformation in Blast Phase MPN through Targetable Amplification of DYRK1A

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis

A Novel Autosomal Dominant JAK2 R715T Mutation Causes Polycythemia Vera in 3 Generations

Modulation of the Human Thrombopoietin Receptor Conformation Uncouples JAK2 V617F-Driven from Cytokine-Induced Activation

Canonical Thrombopoietin Receptor Mutants in Myeloproliferative Neoplasms Rely Differently on the Extracellular Domain of the Receptor but Share Similar Mechanisms of Inactivation: An Open Field for the Development of New Therapies

The 2 faces of ERK2 in MPNs

Degrading JAK2 in ALL by ruxolitinib-based PROTACs

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag

Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor

MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491

MPL membrane domain sequencing goes deep

JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera

Disease Phenotype and Clonal Amplification in Calreticulin del52 and ins5 Knock-in Mice Are Dependent on the Type of Mutations and Gene Dosage

Results from Treatment of a Large Cohort of ATL Patients from a Country with High HTLV1 Prevalence

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American Society of Hematology

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American Society of Hematology

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