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Jennifer O Sullivan
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Journal Articles

Phase 3 randomized double-blind study evaluating selinexor, an XPO1 inhibitor, plus ruxolitinib in jaki-naïve myelofibrosis: Study rationale and preliminary patient characteristics

Free
Sebastian Grosicki, Haris Ali, Haifa Kathrin Al-Ali, Emanuele Ammatuna, Prithviraj Bose, Laura Gabriela Urian, Zhanet Grudeva-Popova, Valentín García Gutiérrez, Antonin Hlusi, Hsin-An Hou, Sung-Eun Lee, Michael Loschi, Jennifer O Sullivan, Andrea Patriarca, Raajit Rampal, Srinivas Tantravahi, Pankit Vachhani, Yi Chai, Pietro Taverna, Darko Miljkovic, Antonio Galleu, Von Potter, John Mascarenhas
Journal: Blood
Blood (2025) 146 (Supplement 1): 7353.
https://doi.org/10.1182/blood-2025-7353
Published: 2025
Journal Articles

Fedora preliminary analysis of a Phase II study evaluating the tolerability, safety and activity of fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis.

Free
Mary Frances McMullin, Fitsum Ghebretinsea, Rebecca Boucher, Sebastian Francis, Gillian Horne, Hayder Hussein, Steve Knapper, Donal McLornan, Srinivasan Narayanan, Jennifer O Sullivan, Tim Somervaille, Chun Teh, Frances Wadelin, Chhaya Sankhalpara, Emily Yafai, Catherine Thomas, Rupen Hargreaves, Nawshad Hayder, Graham Mcllroy, Claire Harrison, Adam Mead
Journal: Blood
Blood (2025) 146 (Supplement 1): 486.
https://doi.org/10.1182/blood-2025-486
Published: 2025
Journal Articles

RUX-AZA Response in AP/BP-MPN Is Driven By Release of the Differentiation Block in Mutant HSPCs: A Single-Cell Multi-Omic Analysis of Responders on the Phase Ib Phazar Study

Free
Charlotte K Brierley, Charlotte Gaskell, Claire Harrison, Christina Yap, Aimee Jackson, Jennifer Byrne, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Alba Rodriguez-Meira, Lauren Murphy, Fiona Jane Clarke, Srinivasan Narayanan, David T. Bowen, Emma Gudgin, Dragana Milojkovic, Rebecca Collings, Bethan Psaila, Steve Knapper, Mark W. Drummond, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 3146.
https://doi.org/10.1182/blood-2024-204818
Published: 2024
Journal Articles

Rapid and Sustained Recovery of Cellular Immunity in Patients with Myelofibrosis on Momelotinib Therapy

Free
Jasmine Makker, Kyaw Htin Thaw, Amna Sheikh, Llywelyn Cadman-Davies, Andrea Duminuco, Elena Torre, Claire Woodley, Susan Asirvatham, Jennifer O' Sullivan, Natalia Curto-Garcia, Priya Sriskandarajah, Deepti H. Radia, Hugues de Lavallade, Shahram Kordasti, Claire Harrison, Patrick Harrington
Journal: Blood
Blood (2024) 144 (Supplement 1): 4547.
https://doi.org/10.1182/blood-2024-201299
Published: 2024
Journal Articles

Cooperation between SF3B1 and JAK2 V617F Mutations Accelerates Fibrotic Progression in Myeloproliferative Neoplasms By Enhancing STAT1 Signaling

Free
Jennifer O Sullivan, Sean Wen, Affaf Aliouat, Alba Rodriguez-Meira, Sally-Ann Clark, Neil Ashley, Amy Wood, Ramy Slama, Guanlin Wang, Angela Hamblin, Lauren Murphy, Christina Simoglou Karali, Charlotte K Brierley, Adam P Cribbs, Aimee Paterson, Claire N Harrison, Bethan Psaila, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 861.
https://doi.org/10.1182/blood-2023-185118
Published: 2023
Journal Articles

Single-Cell Mutation Profiling and Alternative Splicing Analysis Reveals Distinct Aberrant Splicing of U2AF1 S34 and U2AF1 Q157 in Myeloid Malignancies

Free
Sean Wen, Jennifer O Sullivan, Joanna Baxter, Nikolaos Sousos, Adam J Mead, Alba Rodriguez-Meira
Journal: Blood
Blood (2023) 142 (Supplement 1): 4133.
https://doi.org/10.1182/blood-2023-185999
Published: 2023
Journal Articles

The SF3B1 K666 Hotspot Mutation Confers Unfavourable Disease Risk across Major Myeloid Neoplasm Subgroups

Free
Jennifer O Sullivan, Amy Wood, Sean Wen, Angela Hamblin, Sonia Fox, Christina Yap, Mary Frances McMullin, Nicholas C. P. Cross, Claire N Harrison, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 4552.
https://doi.org/10.1182/blood-2023-185043
Published: 2023
Journal Articles

Chromothripsis Orchestrates Leukemic Transformation in Blast Phase MPN through Targetable Amplification of DYRK1A

Free
Charlotte K Brierley, Bon Ham Yip, Giulia Orlando, Harsh Goyal, Sean Wen, Jeremy Wen, Max F. Levine, Alba Rodriguez-Meira, Assunta Adamo, Matthew Bashton, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Lauren Murphy, Aude-Anais Olijnik, Anitria Cotton, Shilpa Narina, Shondra Pruett-Miller, Amir Enshaei, Claire N Harrison, Mark W. Drummond, Steve Knapper, Ayalew Tefferi, Ileana antony-Debre, Supat Thongjuea, Stefan N Constantinescu, Elli Papaemmanuil, Bethan Psaila, John D. Crispino, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 993.
https://doi.org/10.1182/blood-2023-178556
Published: 2023