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Journal Articles

Chromothripsis Orchestrates Leukemic Transformation in Blast Phase MPN through Targetable Amplification of DYRK1A

Charlotte K Brierley, Bon Ham Yip, Giulia Orlando, Harsh Goyal, Sean Wen, Jeremy Wen, Max F. Levine, Alba Rodriguez-Meira, Assunta Adamo, Matthew Bashton, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Lauren Murphy, Aude-Anais Olijnik, Anitria Cotton, Shilpa Narina, Shondra Pruett-Miller, Amir Enshaei, Claire N Harrison, Mark W. Drummond, Steve Knapper, Ayalew Tefferi, Ileana antony-Debre, Supat Thongjuea, Stefan N Constantinescu, Elli Papaemmanuil, Bethan Psaila, John D. Crispino, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 993.
https://doi.org/10.1182/blood-2023-178556
Published: 2023
Journal Articles

Robust Validation of the UKALL High Hyperdiploid Risk Profile Using Individual Patient Data Collected By the Harmony Alliance

Amir Enshaei, Javier Martinez Martínez Elicegui, Esther Anguiano, Jude Gibson, Mirella Ampatzidou, Michael Doubek, Adele K. Fielding, Edoardo La Sala, Elizabeth Middleton, Anita W. Rijneveld, Amin T. Turki, Ajay Vora, Martin Zimmermann, Anthony V. Moorman
Journal: Blood
Blood (2022) 140 (Supplement 1): 6369–6370.
https://doi.org/10.1182/blood-2022-157680
Published: 2022
Journal Articles

The Prognostic Effect of IKZF1 Deletions in ETV6 :: RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia

Anna Østergaard, Amir Enshaei, Rob Pieters, Ajay Vora, Martin A. Horstmann, Gabriele Escherich, Bertil Johansson, Mats Heyman, Kjeld Schmiegelow, Peter M. Hoogerbrugge, Monique L. den Boer, Roland P. Kuiper, Anthony V. Moorman, Judith M. Boer, Frank N van Leeuwen
Journal: Blood
Blood (2022) 140 (Supplement 1): 3483–3485.
https://doi.org/10.1182/blood-2022-157431
Published: 2022
Journal Articles

Single-Cell Multi-Omics Reveals the Genetic, Cellular and Molecular Landscape of TP53 Mutated Leukemic Transformation in MPN

Alba Rodriguez-Meira, Haseeb Rahman, Ruggiero Norfo, Wei Wen, Agathe Chédeville, Jennifer O'Sullivan, Guanlin Wang, Aimee Paterson, Eleni Louka, Charlotte K Brierley, Warren W Kretzschmar, Francois Girodon, Zemin Ren, Matthew Bashton, Amir Enshaei, Mark W. Drummond, Florence Pasquier, Christophe Marzac, Claire N. Harrison, Isabelle Plo, Sten Eirik W Jacobsen, Supat Thongjuea, Bethan Psaila, Ileana Antony-Debre, Adam J. Mead
Journal: Blood
Blood (2021) 138 (Supplement 1): 3.
https://doi.org/10.1182/blood-2021-150191
Published: 2021
Journal Articles

Molecular Characterisation of Participants in the Phazar Trial Reveals Prognostic Impact of Mutations in Advanced-Phase-MPN

Charlotte K Brierley, MRCP, MD, Alba Rodriguez-Meira, PhD, Matthew Bashton, PhD, Angela Hamblin, MD PhD, Rachel S Fletcher, PhD, Sonia Fox, Charlotte Gaskell, BSc, MSc, Aimee Jackson, BSc, MSc, Jennifer O'Sullivan, MD, Lauren C Murphy, Nikolaos Sousos, MDMSc, Amir Enshaei, PhD, Claire Harrison, DM, FRCP, FRCPath, Mark W. Drummond, PhD FRCPath, Steve Knapper, BMBCh, MRCP, FRCPath, DM, Bethan Psaila, MD PhD, Adam J. Mead, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-139520
Published: 2020
Journal Articles

A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Amir Enshaei, David O’Connor, Jack Bartram, Jeremy Hancock, Christine J. Harrison, Rachael Hough, Sujith Samarasinghe, Monique L. den Boer, Judith M. Boer, Hester A. de Groot-Kruseman, Hanne V. Marquart, Ulrika Noren-Nystrom, Kjeld Schmiegelow, Claire Schwab, Martin A. Horstmann, Gabriele Escherich, Mats Heyman, Rob Pieters, Ajay Vora, John Moppett, Anthony V. Moorman
Journal: Blood
Blood (2020) 135 (17): 1438–1446.
https://doi.org/10.1182/blood.2019003191
Published: 2020
Includes: Supplemental data
Journal Articles

Single Nucleotide Polymorphism Array-Based Signature of Genetic Ploidy Groups in Acute Lymphoblastic Leukemia

Thomas Creasey, MBBS, Amir Enshaei, PhD, Kathryn Watts, BSc, Gavin Cuthbert, BSc, Claire Schwab, PhD, Christine J. Harrison, PhD FRCPath, Ajay Vora, Adele K. Fielding, MBBS,PhDFRCP,FRCPath, Anthony V. Moorman
Journal: Blood
Blood (2019) 134 (Supplement_1): 1473.
https://doi.org/10.1182/blood-2019-122556
Published: 2019
Journal Articles

Minimal Residual Disease and IKZF1 As Predictors of Relapse, and Increased Treatment Related Mortality in Down Syndrome Acute Lymphoblastic Leukemia: A Unique and Large International Matched Case-Control Study

Naomi Michels, BSc, Judith M. Boer, PhD, Marta Lopez-Yurda, PhD, Hester A. De Groot-Kruseman, PhD, Vincent van der Velden, PhD, Anthony V. Moorman, Amir Enshaei, PhD, Ajay Vora, Rosemary Sutton, BSc MSc PhD, Toby Trahair, PhD, Luciano Dalla-Pozza, MBBS FRACP, Rob Pieters, MDPhDMSc, Michel C Zwaan, MD PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 827.
https://doi.org/10.1182/blood-2019-124290
Published: 2019
Journal Articles

Integrating Genetic Risk Factors with Age, Presenting White Cell Count and MRD Response As Continuous Variables to Predict Relapse in Paediatric Acute Lymphoblastic Leukemia (ALL)

Anthony V. Moorman, PhD, Amir Enshaei, PhD, David O'Connor, MD PhD, Jack Bartram, MD, Jeremy Hancock, PhD, Christine Harrison, Sujith Samarasinghe, MD PhD, John Moppett, MD PhD, Ajay J. Vora, Nicholas Goulden, MD PhD
Journal: Blood
Blood (2016) 128 (22): 603.
https://doi.org/10.1182/blood.V128.22.603.603
Published: 2016
Journal Articles

The Frequency and Outcome of Ph-like ALL Associated Abnormalities in Childhood Acute Lymphoblastic Leukaemia Treated on MRC UKALL2003

Claire Schwab, Amir Enshaei, PhD, Kathryn G. Roberts, PhD, Lisa J. Russell, PhD, Richard C Harvey, PhD, I-Ming L. Chen, DVM, MS, Cheryl L. Willman, Charles Mullighan, MBBS, MSc, MD, Ajay J. Vora, Anthony V. Moorman, PhD, Christine Harrison
Journal: Blood
Blood (2016) 128 (22): 2914.
https://doi.org/10.1182/blood.V128.22.2914.2914
Published: 2016
Journal Articles

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia

CME Clinical Trials & Observations
Julie A. E. Irving, Amir Enshaei, Catriona A. Parker, Rosemary Sutton, Roland P. Kuiper, Amy Erhorn, Lynne Minto, Nicola C. Venn, Tamara Law, Jiangyan Yu, Claire Schwab, Rosanna Davies, Elizabeth Matheson, Alysia Davies, Edwin Sonneveld, Monique L. den Boer, Sharon B. Love, Christine J. Harrison, Peter M. Hoogerbrugge, Tamas Revesz, Vaskar Saha, Anthony V. Moorman
Journal: Blood
Blood (2016) 128 (7): 911–922.
https://doi.org/10.1182/blood-2016-03-704973
Published: 2016
Includes: Supplemental data
Journal Articles

Long Term Overall Survival of Greater Than 98% in Childhood ALL Patients with Good Risk Features and Low Risk MRD:Â Results from a Large Multi-Center Randomized Controlled Trial, UKALL 2003

Jack Bartram, MD, David O'Connor, MD PhD, Amir Enshaei, PhD, Anthony V Moorman, PhD, Christine Harrison, PhDFRCPath FMedSci, Rachel Wade, MSc, Rachel Clack, MSc, Jeremy Hancock, PhD, Sujith Samarasinghe, MD PhD, John Moppett, MD PhD, Ajay J. Vora, Nicholas Goulden, MD PhD
Journal: Blood
Blood (2015) 126 (23): 806.
https://doi.org/10.1182/blood.V126.23.806.806
Published: 2015
Journal Articles

Risk Factor Analysis in Paediatric Acute Lymphoblastic Leukaemia with High Hyperdiploidy

Amir Enshaei, PhD, Claire Schwab, Lucy Chilton, PhD, Rachel Wade, MSc, Jeremy Hancock, PhD, Christopher Mitchell, MBBS, PhD FRCP, Sally E Kinsey, Nicholas Goulden, MD PhD, Ajay J. Vora, Christine Harrison, PhDFRCPath FMedSci, Anthony V. Moorman, PhD
Journal: Blood
Blood (2015) 126 (23): 805.
https://doi.org/10.1182/blood.V126.23.805.805
Published: 2015
Journal Articles

Integration of Minimal Residual Disease with Other Patient Risk Factors Identifies a Population with Very Poor Overall Survival in Pediatric ALL: Results from the UKALL 2003 Trial

David O'Connor, MD PhD, Jack Bartram, MD, Amir Enshaei, PhD, Anthony V Moorman, PhD, Christine Harrison, PhDFRCPath FMedSci, Rachel Wade, MSc, Rachel Clack, MSc, Jeremy Hancock, PhD, Sujith Samarasinghe, MD PhD, John Moppett, MD PhD, Ajay J. Vora, Nicholas Goulden, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1412.
https://doi.org/10.1182/blood.V126.23.1412.1412
Published: 2015
Journal Articles

Clincial and Genetic Landscapes Differ Between IGH-CRLF2 and P2RY8-CRLF2 Acute Lymphoblastic Leukaemia

Lisa Jane Russell, PhD, Lisa Jones, BSc, Amir Enshaei, PhD, Jamie Rutherford, BSc, Stefano Tonin, PhD, Sarra Ryan, PhD, Jeyanthy Eswaran, PhD, Elli Papaemmanuil, PhD, Jose Tubio, PhD, Peter J Campbell, MD PhD, Anthony V Moorman, PhD, Christine Harrison, PhDFRCPath FMedSci
Journal: Blood
Blood (2015) 126 (23): 1426.
https://doi.org/10.1182/blood.V126.23.1426.1426
Published: 2015
Journal Articles

A Targeted Functional Clone Tracking Assay for the Identification of Tumour Suppressor Genes in BCP- ALL Implicates the Transcription Factors FOXO3 and PRDM1

Paul Sinclair, PhD, Joanna Cheng, Prahlad Raninga, Rebecca Hanna, Shaun Hollern, Amir Enshaei, PhD, Helen Blair, PhD, Sirintra Nakjang, Sarra Ryan, PhD, Jeyanthy Eswaran, PhD, Lars Buechler, Olaf Heidenreich, PhD, Christine Harrison, PhDFRCPath FMedSci
Journal: Blood
Blood (2015) 126 (23): 2449.
https://doi.org/10.1182/blood.V126.23.2449.2449
Published: 2015
Journal Articles

Genetic Characterisation of Immunoglobulin Heavy Chain Locus CCAAT Enhancer-Binding Protein Translocated Acute Lymphoblastic Leukaemia

Dino Mašić, MRes, Amir Enshaei, PhD, Lisa Jones, BSc, Christine Harrison, PhDFRCPath FMedSci, Lisa Jane Russell, PhD
Journal: Blood
Blood (2015) 126 (23): 2624.
https://doi.org/10.1182/blood.V126.23.2624.2624
Published: 2015
Journal Articles

Prognostic Value of Rare IKZF1 deletions in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: An International Collaborative Study

Judith M. Boer, PhD, Arian van der Veer, MD PhD, Dimitris Rizopoulos, PhD, Marta Fiocco, PhD, Edwin Sonneveld, PhD, Hester A. de Groot-Kruseman, PhD, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, MD PhD, Martin A. Horstmann, MD PhD, Marketa Zaliova, MD PhD, Chiara Palmi, Jan Trka, MD, PhD, Prof., Eva Fronkova, MD, PhD, Mariana Emerenciano, PhD, Maria do Socorro Pombo-de-Oliveira, PhD, Wojciech Mlynarski, MDPhD, Tomasz Szczepanski, MD PhD, Karin Nebral, PhD, Andishe Attarbaschi, MD PhD, Nicola C. Venn, PhD, Rosemary Sutton, PhD, Claire Schwab, BSc, Amir Enshaei, PhD, Ajay J. Vora, Martin Stanulla, MD, Martin Schrappe, MD, Gianni Cazzaniga, PhD, Valentino Conter, MD PhD, Martin Zimmerman, PhD, Anthony V. Moorman, PhD, Rob Pieters, Monique L. Den Boer, MSc, PhD
Journal: Blood
Blood (2014) 124 (21): 368.
https://doi.org/10.1182/blood.V124.21.368.368
Published: 2014
Journal Articles

A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Anthony V. Moorman, Amir Enshaei, Claire Schwab, Rachel Wade, Lucy Chilton, Alannah Elliott, Stacey Richardson, Jeremy Hancock, Sally E. Kinsey, Christopher D. Mitchell, Nicholas Goulden, Ajay Vora, Christine J. Harrison
Journal: Blood
Blood (2014) 124 (9): 1434–1444.
https://doi.org/10.1182/blood-2014-03-562918
Published: 2014
Includes: Supplemental data
Journal Articles

Integration Of Cytogenetic and Copy Number Alteration (CNA) Data Into a Single Risk Profile For Paediatric Acute Lymphoblastic Leukaemia (ALL)

Anthony V. Moorman, Amir Enshaei, Claire Schwab, BSc, Lucy Chilton, Rachel Wade, Nicholas Goulden, Ajay J Vora, Christine J Harrison, PhD
Journal: Blood
Blood (2013) 122 (21): 1308.
https://doi.org/10.1182/blood.V122.21.1308.1308
Published: 2013