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Journal Articles

Crebbp Mutations Are Associated with Slow Minimal Residual Response to Upfront Induction Chemotherapy in Pediatric High-Hyperdiploid B-Cell Precursor Acute Lymphoblastic Leukemia Treated in the AIEOP-BFM ALL 2009 Protocol

Giacomo Gotti, Daniela Silvestri, Grazia Fazio, Chiara Palmi, Valentino Conter, Maria Grazia Valsecchi, Carmelo Rizzari, Barbara Buldini, Franco Locatelli, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood
Blood (2023) 142 (Supplement 1): 4344.
https://doi.org/10.1182/blood-2023-187833
Published: 2023
Journal Articles

The RNA Binding Protein Musashi-2 (MSI2) Sustains the Growth and the Leukemogenic Potential of MLL-Rearranged Acute Lymphoblastic Leukemia, and It Is Involved in Glucocorticoid Resistance

Luigia Valsecchi, Simone Naso, Simona Procopio, Mario Mauri, Rocco Piazza, Titus Watrin, Sanil Bhatia, Valentina Pasquale, Elena Sacco, Chiara Palmi, Grazia Fazio, Luca Trentin, Silvia Bresolin, Andrea Biondi, Giovanni Cazzaniga, Michela Bardini
Journal: Blood
Blood (2022) 140 (Supplement 1): 8827–8828.
https://doi.org/10.1182/blood-2022-166313
Published: 2022
Journal Articles

Targeting Hyperactivated Lck in PAX5 Rearranged Pediatric B-Cell Precursors Acute Lymphoblastic Leukemia

Grazia Fazio, Manuel Quadri, Silvia Bresolin, Chiara Palmi, Michela Bardini, Athanasios Oikonomou, Jia-Wey Tu, Katerina Scharov, Alberto Peloso, Titus Watrin, Sanil Bhatia, Arndt Borkhardt, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood
Blood (2022) 140 (Supplement 1): 3107–3108.
https://doi.org/10.1182/blood-2022-169023
Published: 2022
Journal Articles

Novel Drugs to Target JAK2 Rearrangements in Pediatric Acute Lymphoblastic Leukemia

Manuel Quadri, Claudia Saitta, Sonia Palamini, Chiara Palmi, Jia-Wey Tu, Sanil Bhatia, Arndt Borkhardt, Andrea Biondi, Giovanni Cazzaniga, Grazia Fazio
Journal: Blood
Blood (2022) 140 (Supplement 1): 364–365.
https://doi.org/10.1182/blood-2022-169437
Published: 2022
Journal Articles

Ph-like and IKZF1plus Features in Children with Down Syndrome and B Cell Precursor Acute Lymphoblastic Leukemia

Chiara Palmi, Silvia Bresolin, Stefanie V. Junk, Grazia Fazio, Daniela Silvestri, Marketa Zaliova, Athanasios Oikonomou, Katerina Scharov, Martin Stanulla, Anja Moericke, Martin Zimmermann, Martin Schrappe, Barbara Buldini, Claudia Saitta, Marta Galbiati, Michela Bardini, Sanil Bhatia, Arndt Borkhardt, Luca Lo Nigro, Valentino Conter, Maria Grazia Valsecchi, Andrea Biondi, Geertruij Te Kronnie, Gunnar Cario, Giovanni Cazzaniga
Journal: Blood
Blood (2022) 140 (Supplement 1): 6367–6368.
https://doi.org/10.1182/blood-2022-169131
Published: 2022
Journal Articles

Targeting JAK2 Gene Rearrangements with a Novel Kinase Inhibitor in a Preclinical Model of Pediatric Acute Lymphoblastic Leukemia

Manuel Quadri, Claudia Saitta, Sonia Palamini, Chiara Palmi, Andrea Biondi, Giovanni Cazzaniga, Grazia Fazio
Journal: Blood
Blood (2021) 138 (Supplement 1): 1180.
https://doi.org/10.1182/blood-2021-152270
Published: 2021
Journal Articles

Recurrent genetic fusions redefine MLL germ line acute lymphoblastic leukemia in infants

Grazia Fazio, Michela Bardini, Paola De Lorenzo, Andrea Grioni, Manuel Quadri, Lucia Pedace, Lilia Corral Abascal, Sonia Palamini, Chiara Palmi, Barbara Buldini, Luciana Vinti, Rosanna Parasole, Elena Barisone, Marco Zecca, Claudio Favre, Franco Locatelli, Valentino Conter, Carmelo Rizzari, Maria Grazia Valsecchi, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood
Blood (2021) 137 (14): 1980–1984.
https://doi.org/10.1182/blood.2020009032
Published: 2021
Includes: Supplemental data
Journal Articles

Pre-Clinical Efficacy of the Novel Kinase Inhibitor Nintedanib on PAX5 Fusion Genes in Pediatric Ph-like B-Cell Precursor Acute Lymphoblastic Leukemia

Grazia Fazio, Silvia Bresolin, Claudia Saitta, Daniela Silvestri, Elena Vendramini, Chiara Palmi, Silvia Rigamonti, Marta Galbiati, Manuel Quadri, Stefano Mecca, Angela Maria Savino, Michela Bardini, Andrea Grioni, Maria Grazia Valsecchi, PhD, Geertruy te Kronnie, Andrea Biondi, MD, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 745.
https://doi.org/10.1182/blood-2019-128509
Published: 2019
Journal Articles

Bone Marrow Mesenchymal Stromal Cells and Inflammation Contribute to ETV6-RUNX1 + Preleukemic Cells Persistence and DNA Damaging

Linda Beneforti, Erica Dander, PhD, Silvia Bresolin, PhD, Clara Bueno, Geertruy te Kronnie, Anthony Ford, Pablo Menendez, Giovanna D'Amico, BSc, PhD MSc, Andrea Biondi, Chiara Palmi, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3918.
https://doi.org/10.1182/blood-2018-99-114791
Published: 2018
Journal Articles

Biological Properties of Mesenchymal Stromal Cells Obtained from Paediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia

Erica Dander, PhD, Federica Portale, Chiara Palmi, Linda Beneforti, Andrea Biondi, MD, Giovanni Cazzaniga, PhD, Giovanna D'Amico, BSc, PhD MSc
Journal: Blood
Blood (2017) 130 (Supplement 1): 4951.
https://doi.org/10.1182/blood.V130.Suppl_1.4951.4951
Published: 2017
Journal Articles

Role of the Histone Deacetylase Inhibitor Givinostat (ITF2357) in Treatment of CRLF2 Rearranged Acute Lymphoblastic Leukemia

Angela Maria Savino, Jolanda Sarno, Luca Trentin, Margherita Vieri, Grazia Fazio, PhD, Michela Bardini, Cristina Bugarin, Gianluca Fossati, Kara L. Davis, DO, Giuseppe Gaipa, PhD, Lueder Hinrich Meyer, MD, Garry P. Nolan, Prof, PhD, Andrea Biondi, Prof, MD, Geertruy Te Kronnie, PhD, Chiara Palmi, PhD, Giovanni Cazzaniga
Journal: Blood
Blood (2015) 126 (23): 2534.
https://doi.org/10.1182/blood.V126.23.2534.2534
Published: 2015
Journal Articles

Isolation and Characterization of Mesenchymal Stromal Cells Derived from Paediatric Patients with B Acute Lymphoblastic Leukemia

Erica Dander, Chiara Palmi, PhD, Federica Portale, Linda Beneforti, Andrea Biondi, Prof, MD, Giovanni Cazzaniga, Giovanna D'Amico
Journal: Blood
Blood (2015) 126 (23): 4771.
https://doi.org/10.1182/blood.V126.23.4771.4771
Published: 2015
Journal Articles

Mass Cytometry Analysis Dissects CRLF2-Driven Signaling Pathways in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)

Jolanda Sarno, Kara L. Davis, DO, Angela Maria Savino, PhD, Cristina Bugarin, Stefania Pinto, Chiara Buracchi, PhD, Astraea Jager, BS, Chiara Palmi, PhD, Ruth C Barber, PhD, Daniela Silvestri, Gianni Cazzaniga, PhD, Martin J.S. Dyer, Prof., Andrea Biondi, Prof, MD, Garry P. Nolan, Prof, PhD, Giuseppe Gaipa, PhD
Journal: Blood
Blood (2015) 126 (23): 906.
https://doi.org/10.1182/blood.V126.23.906.906
Published: 2015
Journal Articles

Prognostic Value of Rare IKZF1 deletions in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: An International Collaborative Study

Judith M. Boer, PhD, Arian van der Veer, MD PhD, Dimitris Rizopoulos, PhD, Marta Fiocco, PhD, Edwin Sonneveld, PhD, Hester A. de Groot-Kruseman, PhD, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, MD PhD, Martin A. Horstmann, MD PhD, Marketa Zaliova, MD PhD, Chiara Palmi, Jan Trka, MD, PhD, Prof., Eva Fronkova, MD, PhD, Mariana Emerenciano, PhD, Maria do Socorro Pombo-de-Oliveira, PhD, Wojciech Mlynarski, MDPhD, Tomasz Szczepanski, MD PhD, Karin Nebral, PhD, Andishe Attarbaschi, MD PhD, Nicola C. Venn, PhD, Rosemary Sutton, PhD, Claire Schwab, BSc, Amir Enshaei, PhD, Ajay J. Vora, Martin Stanulla, MD, Martin Schrappe, MD, Gianni Cazzaniga, PhD, Valentino Conter, MD PhD, Martin Zimmerman, PhD, Anthony V. Moorman, PhD, Rob Pieters, Monique L. Den Boer, MSc, PhD
Journal: Blood
Blood (2014) 124 (21): 368.
https://doi.org/10.1182/blood.V124.21.368.368
Published: 2014
Journal Articles

CRLF2 over-Expression Is a Poor Prognostic Marker in Children with High Risk T-Cell Acute Lymphoblastic Leukemia

Chiara Palmi, Daniela Silvestri, Ilaria Bronzini, Gunnar Cario, Angela Savino, Maddalena Paganin, Barbara Buldini, Marta Galbiati, Martina U. Muckenthaler, Maurizio Arico, Elena Barisone, Fiorina Casale, Franco Locatelli, Luca Lo Nigro, Concetta Micalizzi, Rosanna Parasole, Andrea Pession, Maria Caterina Putti, Nicola Santoro, Anna Maria Testi, Ottavio Ziino, Andreas E Kulozik, Martin Zimmermann, PhD, Martin Schrappe, Giuseppe Basso, Andrea Biondi, Maria Grazia Valsecchi, Martin Stanulla, Valentino Conter, Geertruy te Kronnie, Giovanni Cazzaniga
Journal: Blood
Blood (2014) 124 (21): 1071.
https://doi.org/10.1182/blood.V124.21.1071.1071
Published: 2014
Journal Articles

PAX5 Fusion Genes Activate The STAT5 Signaling Pathway Through Lck Over-Expression

Valeria Cazzaniga, Marco Giordan, Cristina Bugarin, Chiara Palmi, Angela Savino, Geertruy te Kronnie, Giuseppe Gaipa, Andrea Biondi, Grazia Fazio, PhD, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2013) 122 (21): 3738.
https://doi.org/10.1182/blood.V122.21.3738.3738
Published: 2013
Journal Articles

CRLF2 Rearrangement Is Not Associated with Activated mTOR Pathway in NOD/SCID/huALL Xenograft Mouse Model.

Md. Nabiul Hasan, MSc, Silvia Bresolin, PhD, Ilaria Bronzini, PhD, Chiara Palmi, PhD, Manon Queudeville, MD, Sarah Mirjam Eckhoff, MD, Luca Trentin, PhD, Giovanni Cazzaniga, PhD, Geertury te Kronnie, PhD, Klaus-Michael Debatin, MD, PhD, Lüder-Hinrich Meyer, MD
Journal: Blood
Blood (2012) 120 (21): 2518.
https://doi.org/10.1182/blood.V120.21.2518.2518
Published: 2012
Journal Articles

Fine Tuning of Surface CRLF2 Expression and Its Associated Signalling Profile in Childhood B Cell Precursor Acute Lymphoblastic Leukemia

Giuseppe Gaipa, PhD, Cristina Bugarin, Chiara Palmi, PhD, Jolanda Sarno, Angela Savino, Oscar Maglia, Geertruy te Kronnie, Giovanni Cazzaniga, Andrea Biondi, MD
Journal: Blood
Blood (2012) 120 (21): 1409.
https://doi.org/10.1182/blood.V120.21.1409.1409
Published: 2012
Journal Articles

A Childhood Leukaemia Cluster in Milan: Possible Role of Pandemic AH1N1 Swine Flu Virus.

Giovanni Cazzaniga, PhD, Luigi A. Bisanti, Chiara Palmi, PhD, Giorgia Randi, Fabrizio Pregliasco, Silvia Deandrea, Silvia Bungaro, Maria Grazia Valsecchi, Giuseppe Masera, Andrea Biondi, MD, Mel Greaves, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2496.
https://doi.org/10.1182/blood.V120.21.2496.2496
Published: 2012
Journal Articles

Poor Prognosis for IKZF1 Intra-Gene Deletions in Pediatric Ph − B-Cell Precursor Acute Lymphoblastic Leukemia,

Chiara Palmi, Daniela Silvestri, Giulia Longinotti, Elena Vendramini, Valentino Conter, Giuseppe Basso, Andrea Biondi, MD, Maria Grazia Valsecchi, Geertruy te Kronnie, PhD, Giovanni Cazzaniga
Journal: Blood
Blood (2011) 118 (21): 3518.
https://doi.org/10.1182/blood.V118.21.3518.3518
Published: 2011