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Paola De Lorenzo
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Journal Articles

BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Different Clinical Behavior and Relevance of Prognostic Features in Typical ALL and in CML-like Disease

Jan Zuna, Lenka Hovorkova, Justina Krotka, Amelie Koehrmann, Michela Bardini, Lucie Winkowska, Eva Fronkova, Julia Alten, Rolf Koehler, Cornelia Eckert, Lisa Brizzolara, Jan Stuchly, Martin Zimmermann, Paola De Lorenzo, Maria Grazia Valsecchi, Valentino Conter, Jan Stary, Martin Schrappe, Andrea Biondi, Jan Trka, Marketa Zaliova, Giovanni Cazzaniga, Gunnar Cario
Journal: Blood
Blood (2022) 140 (Supplement 1): 9179–9180.
https://doi.org/10.1182/blood-2022-158926
Published: 2022
Journal Articles

Implication of ICOSLG on Relapse in Infant T(4;11) Acute Lymphoblastic Leukemia

Marius Külp, Anna Lena Siemund, Claus Meyer, Patrizia Larghero, Alissa Dietz, Julia Alten, Gunnar Cario, Aurélie Caye-Eude, Hélène Cavé, Michela Bardini, Paola De Lorenzo, Giovanni Cazzaniga, Laura Diehl, Halvard Bonig, Rolf Marschalek
Journal: Blood
Blood (2021) 138 (Supplement 1): 3481.
https://doi.org/10.1182/blood-2021-146181
Published: 2021
Journal Articles

Minimal Residual Disease and Outcome Characteristics in Infant KMT2A-Germline Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Janine Stutterheim, Paola De Lorenzo, Inge M. Van Der Sluis, Julia Alten, Philip Ancliffe, Andishe Attarbaschi, Luis Alberto Aversa, Judith M. Boer, Andrea Biondi, Benoit Brethon, Paulina Diaz, Giovanni Gazzaniga, Gabriele Escherich, Alina Ferster, Rishi S Kotecha, Birgitte Lausen, Alex WK Leung, Franco Locatelli, Lewis B. Silverman, Jan Stary, Tomasz Szczepanski, Vincent H.J. Van Der Velden, Ajay Vora, Jan Zuna, Martin Schrappe, Maria Grazia Valsecchi, Rob Pieters
Journal: Blood
Blood (2021) 138 (Supplement 1): 2383.
https://doi.org/10.1182/blood-2021-145058
Published: 2021
Journal Articles

A Phase 2 Study to Test the Feasibility, Safety and Efficacy of the Addition of Blinatumomab to the Interfant06 Backbone in Infants with Newly Diagnosed KMT2A -Rearranged Acute Lymphoblastic Leukemia. a Collaborative Study of the Interfant Network

Inge M. Van Der Sluis, Paola De Lorenzo, Rishi Sury Kotecha, Andishe Attarbaschi, Gabriele Escherich, Karsten Nysom, Jan Stary, Alina Ferster, Benoit Brethon, Phillip Ancliff, Andrea Biondi, Maria Grazia Valsecchi, Rob Pieters
Journal: Blood
Blood (2021) 138 (Supplement 1): 361.
https://doi.org/10.1182/blood-2021-144843
Published: 2021
Journal Articles

Recurrent genetic fusions redefine MLL germ line acute lymphoblastic leukemia in infants

Grazia Fazio, Michela Bardini, Paola De Lorenzo, Andrea Grioni, Manuel Quadri, Lucia Pedace, Lilia Corral Abascal, Sonia Palamini, Chiara Palmi, Barbara Buldini, Luciana Vinti, Rosanna Parasole, Elena Barisone, Marco Zecca, Claudio Favre, Franco Locatelli, Valentino Conter, Carmelo Rizzari, Maria Grazia Valsecchi, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood
Blood (2021) 137 (14): 1980–1984.
https://doi.org/10.1182/blood.2020009032
Published: 2021
Includes: Supplemental data
Journal Articles

Clinical Implications of Minimal Residual Disease Detection in Infants with KMT2A -Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Janine Stutterheim, MDPhD, Inge M. van der Sluis, MD PhD, Paola De Lorenzo, Julia Alten, MD, Philip Ancliff, MD, Andishe Attarbaschi, MD, Benoit Brethon, MD, Andrea Biondi, MD, Myriam Campbell, MD, Giovanni Cazzaniga, PhD, Gabriele Escherich, MD, Alina Ferster, MD, Rishi Sury Kotecha, MBBChir, PhD, Birgitte Lausen, MD, Chi Kong Li, MD, Luca Lo Nigro, PhDMD, Franco Locatelli, MD PhD, Rolf Marschalek, PhD, Martin Schrappe, MDPhD, Jan Stary, MD PhD, Ajay Vora, MD, Jan Zuna, PhD, Vincent H.J. Van Der Velden, PhD, Tomasz Szczepanski, MD PhD, Maria Grazia Valsecchi, PhD, Rob Pieters, MDPhDMSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-134303
Published: 2020
Journal Articles

NUTM1 -Rearranged Infant and Pediatric B Cell Precursor Acute Lymphoblastic Leukemia: A Good Prognostic Subtype Identified in a Collaborative International Study

Judith M. Boer, PhD, Maria Grazia Valsecchi, PhD, Femke M. Hormann, MSc, Zeljko Antic, MD, Marketa Zaliova, MD PhD, Claire Schwab, PhD, Giovanni Cazzaniga, PhD, Chloé Arfeuille, MD, Hélène Cavé, PharmD, PhD, Andishe Attarbaschi, MD, Sabine Strehl, PhD, Gabriele Escherich, MD, Toshihiko Imamura, MD PhD, Kentaro Ohki, MD PhD, Tanja A. Gruber, MD PhD, Rosemary Sutton, BSc MSc PhD, Agata Pastorczak, Tim Lammens, PhD, Frederic Lambert, MD, Chi Kong Li, MD, Enrique Carrillo de Santa Pau, PhD, Steve Hoffmann, MD PhD, Anja Möricke, MD, Christine J. Harrison, PhD FRCPath, Monique L. Den Boer, PhD, Paola De Lorenzo, Ronald W. Stam, PhD, Anke K. Bergmann, MD PhD, Rob Pieters, MDPhDMSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-139376
Published: 2020
Journal Articles

Prognostic Value of Minimal Residual Disease Measured By Flow Cytometry in Two Cohorts of Infants with Acute Lymphoblastic Leukemia Treated with MLL-Baby and Interfant Protocols in Large Multicenter Networks

Alexander Popov, MD PhD, Barbara Buldini, MD PhD, Paola De Lorenzo, PhD, Silvia Disaro, Tatiana Verzhbitskaya, MD PhD, Liudmila Movchan, PhD, Emanuela Giarin, Egor Shorikov, MD PhD, Annamaria Di Meglio, Grigory Tsaur, MD PhD, Franco Locatelli, MD PhD, Rosanna Parasole, MD, Natalia Miakova, MD PhD, Elmira Boychenko, MD PhD, Konstantin Kondratchik, MD, Olga Aleinikova, MD PhD, Alexander Karachunskiy, MD PhD, Alexander Roumiantsev, MD PhD, Andrea Biondi, MD PhD, Rob Pieters, MDPhDMSc, Maria Grazia Valsecchi, PhD, Larisa Fechina, MD PhD, Giuseppe Basso, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2747.
https://doi.org/10.1182/blood-2019-130210
Published: 2019
Journal Articles

Outcome of Infants Younger Than 1 Year with Acute Lymphoblastic Leukemia Treated with the Interfant-06 Protocol; Results from an International Randomised Study

Rob Pieters, MDPhDMSc, Paola De Lorenzo, PhD, Philip Ancliffe, Luis Alberto Aversa, MD, Benoit Brethon, Andrea Biondi, MD, Myriam Campbell, Gabriele Escherich, Alina Ferster, MD, Rebecca Gardner, MD, Rishi Sury Kotecha, MBBChir, MRCP, FRACP, PhD, Birgitte Lausen, MD, Chi Kong Li, MD, Franco Locatelli, Andishe Attarbaschi, Christina Peters, MD, Jeffrey Rubnitz, MD PhD, Lewis B. Silverman, MD, Jan Stary, MD PhD, Tomasz Szczepanski, MD PhD, Ajay Vora, MD, Martin Schrappe, MD PhD, Maria Grazia Valsecchi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 655.
https://doi.org/10.1182/blood-2018-99-112854
Published: 2018
Journal Articles

A Treatment Protocol with Imatinib and Intensive Chemotherapy for Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia Patients: A Single-Arm, Intergroup Study (EsPhALL 2010-2014)

Andrea Biondi, MD, Virginie Gandemer, MDPhD, Myriam Campbell, MD, Anders Castor, MD PhD, Rob Pieters, MD PhD, Paola De Lorenzo, PhD, Veronica Leoni, MD, Jan Stary, Gabriele Escherich, MD, Chi Kong Li, MD, Giovanni Cazzaniga, PhD, Helene Cave, PharmD, PhD, Silja Roettgers, PhD, Valentino Conter, MD, Vaskar Saha, MD PhD, Martin Schrappe, MD PhD, Maria Grazia Valsecchi, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 97.
https://doi.org/10.1182/blood.V130.Suppl_1.97.97
Published: 2017
Journal Articles

Clonal Evolution and Lack of BCR-ABL1 Mutations in Pediatric Ph+ ALL Patients Resistant/Refractory to Imatinib Treatment

Valeria Cazzaniga, PhD, Paola De Lorenzo, Federica Mottadelli, Grazia Fazio, PhD, Tiziana Villa, Vincenzo Rossi, Martina Pigazzi, PhD, Marcela B. Mansur, PhD, Marco Zecca, MD, Elena Barisone, MD, Franco Locatelli, MD, Giuseppe Basso, Prof, MD, Maria Grazia Valsecchi, PhD, Mel Greaves, FRS, Andrea Biondi, Prof, MD, Anthony M Ford, Giovanni Cazzaniga
Journal: Blood
Blood (2015) 126 (23): 2622.
https://doi.org/10.1182/blood.V126.23.2622.2622
Published: 2015
Journal Articles

Comparison of MRD Monitoring By IG/TR Rearrangement and BCR/ABL1 Transcript in Ph+ Pediatric Acute Lymphoblastic Leukemia Patients Treated with Imatinib in the Esphall Study

Giovanni Cazzaniga, Paola de Lorenzo, Anders Castor, Hans O Madsen, Virginie Gandemer, Hélène Cavé, Rob Pieters, Vincent van der Velden, Jan Stary, Jan Zuna, Gabriele Escherich, MD, Udo zur Stadt, Silja Rottgers, Julia Alten, Jeremy Hancock, Giulia Ferrari, Maurizio Arico', Vaskar Saha, Martin Schrappe, Maria Grazia Valsecchi, Andrea Biondi
Journal: Blood
Blood (2014) 124 (21): 3782.
https://doi.org/10.1182/blood.V124.21.3782.3782
Published: 2014
Journal Articles

Refinement of IKZF1 Genomic Status in Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia

Tobia Lana, Paola de Lorenzo, Silvia Bresolin, PhD, Ilaria Bronzini, Monique L. Den Boer, MSc, PhD, Helene Cave, PhD, Eva Fronkova, MD, PhD, Martin Stanulla, MD, Marketa Zaliova, Christine J. Harrison, Hester de Groot-Kruseman, Claire Schwab, Maria Grazia Valsecchi, Andrea Biondi, Giuseppe Basso, MD, Giovanni Cazzaniga, PhD, Geertruy te Kronnie
Journal: Blood
Blood (2014) 124 (21): 3785.
https://doi.org/10.1182/blood.V124.21.3785.3785
Published: 2014
Journal Articles

IKZF1 status as a prognostic feature in BCR-ABL1– positive childhood ALL

Arian van der Veer, Marketa Zaliova, Federica Mottadelli, Paola De Lorenzo, Gertruuy te Kronnie, Christine J. Harrison, Hélène Cavé, Jan Trka, Vaskar Saha, Martin Schrappe, Rob Pieters, Andrea Biondi, Maria Grazia Valsecchi, Martin Stanulla, Monique L. den Boer, Giovanni Cazzaniga
Journal: Blood
Blood (2014) 123 (11): 1691–1698.
https://doi.org/10.1182/blood-2013-06-509794
Published: 2014
Includes: Supplemental data
Journal Articles

Cytogenetics and Outcome Of Infants With Acute Lymphoblastic Leukemia and Absence Of MLL Rearrangements

Christine J Harrison, PhD, Anthony V. Moorman, PhD, Paola de Lorenzo, Rob Pieters, Zoann E. Dreyer, MD, Nyla A. Heerema, PhD, Andrew J. Carroll, PhD, Stephen P. Hunger, MD, Richard C. Harvey, PhD, Cheryl L. Willman, MD, Meenakshi Devidas, PhD, Maria Grazia Valsecchi
Journal: Blood
Blood (2013) 122 (21): 1349.
https://doi.org/10.1182/blood.V122.21.1349.1349
Published: 2013
Journal Articles

Identification Of Low Risk Group In Infants With Acute Lymphoblastic Leukemia By Flow Cytometric Minimal Residual Disease Measurement At Day 15 Of Interfant-99 and Interfant-06 Protocols Treatment

Alexander Popov, MD, PhD, Barbara Buldini, Paola de Lorenzo, Emanuella Giarin, Annamaria Di Meglio, Franco Locatelli, Rosanna Parasole, Larisa Fechina, Grigory Tsaur, MD, PhD, Andrea Biondi, MD, Maria Grazia Valsecchi, Giuseppe Basso
Journal: Blood
Blood (2013) 122 (21): 1333.
https://doi.org/10.1182/blood.V122.21.1333.1333
Published: 2013
Journal Articles

Role of MRD in Ph+ Pediatric Acute Lymphoblastic Leukemia Patients Treated with and without Tirosine Kinase Inhibitor in the Esphall Study

Giovanni Cazzaniga, Martin Schrappe, Paola de Lorenzo, Anders Castor, Giovanna Lucchini, Virginie Gandemer, Rob Pieters, MD, PhD, Jan Stary, Gabriele Escherich, Jeremy Hancock, Maurizio Arico', Silja Röttgers, Vaskar Saha, Andrea Biondi, MD, Maria Grazia Valsecchi
Journal: Blood
Blood (2012) 120 (21): 1467.
https://doi.org/10.1182/blood.V120.21.1467.1467
Published: 2012
Journal Articles

Prognostic Value of Immunophenotype In Infant ALL – Results of the INTERFANT'99 Study

Tomasz Szczepanski, Lukasz Sedek, Paola de Lorenzo, Martin Schrappe, Richard Ratei, Goran Gustaffson, Liisa Hovi, Ajay J. Vora, Giuseppe Basso, Andrea Biondi, Jorge Rossi, Maria S Felice, Elisabeth van Wering, Thierry Leblanc, Gritta Janka, Ester Mejstrikowa, Myriam Campbell, Ram Suppiah, Maria Grazia Valsecchi, Rob Pieters
Journal: Blood
Blood (2010) 116 (21): 2700.
https://doi.org/10.1182/blood.V116.21.2700.2700
Published: 2010
Journal Articles

Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia ( MLL )–rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study

Clinical Trials & Observations
Georg Mann, Andishe Attarbaschi, Martin Schrappe, Paola De Lorenzo, Christina Peters, Ian Hann, Giulio De Rossi, Maria Felice, Birgitte Lausen, Thierry LeBlanc, Tomasz Szczepanski, Alina Ferster, Gritta Janka-Schaub, Jeffrey Rubnitz, Lewis B. Silverman, Jan Stary, Myriam Campbell, Chi Kong Li, Ram Suppiah, Andrea Biondi, Ajay Vora, Maria Grazia Valsecchi, Rob Pieters, on behalf of the Interfant-99 Study Group
Journal: Blood
Blood (2010) 116 (15): 2644–2650.
https://doi.org/10.1182/blood-2010-03-273532
Published: 2010
Journal Articles

Gene expression profiling–based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

Ronald W. Stam, Pauline Schneider, Jill A. P. Hagelstein, Marieke H. van der Linden, Dominique J. P. M. Stumpel, Renee X. de Menezes, Paola de Lorenzo, Maria G. Valsecchi, Rob Pieters
Journal: Blood
Blood (2010) 115 (14): 2835–2844.
https://doi.org/10.1182/blood-2009-07-233049
Published: 2010
Includes: Supplemental data